White matter changes in patients with hypoxic amnesia.

Abstract:

:A deficit of declarative memory is a common sequela after a hypoxic episode. While the role of gray matter changes (i.e., atrophy of hippocampal formation) as mainly responsible for memory loss has been emphasized, the role of the white matter damage has so far been neglected. The present study was aimed at evaluating whether white matter damage, within the neural circuitry responsible for declarative memory functioning, is present in anoxic patients. We assessed, by means of voxel-based morphometry, the integrity of white matter regions in five patients with hypoxic amnesia. When anoxic patients were compared to healthy controls, significantly less white matter density was detected in the fornix, anterior portion of the cingulum bundle and uncinate fasciculus bilaterally. We conclude that cerebral hypoxia may alter, together with the hippocampi, the integrity of white matter fibers throughout the memory-limbic system.

journal_name

Neurocase

journal_title

Neurocase

authors

Di Paola M,Moscatelli A,Bigler ED,Caltagirone C,Carlesimo GA

doi

10.1080/13554794.2010.497155

subject

Has Abstract

pub_date

2011-02-01 00:00:00

pages

46-56

issue

1

eissn

1355-4794

issn

1465-3656

pii

928663690

journal_volume

17

pub_type

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