Bilateral renal tumors; conventional clear cell carcinoma and contralateral t(6;11)/t(X;17)-like tumor Histomorphologic, immunohistochemical, ultrastructural and molecular genetic studies including the report of a novel mutation in the VHL gene.

abstract：:A total of sixty samples from human breast, uterus, liver, skin and abdominal fat were fixed for 8; 24 and 48 hours at a room temperature of 20 to 22°C with neutral buffered formalin (NBF) with volume to tissue ratios of 1:1; 2:1; 5:1 and 10:1 and manually processed with isopropyl alcohol and mineral oil mixtures. All...

journal_title：Annals of diagnostic pathology

authors： Buesa RJ,Peshkov MV

更新日期：2012-06-01 00:00:00

abstract：:In hematoxylin-eosin-stained sections of 20 pediatric sarcomas the mitotic index was assessed by four experienced pathologists and four less-experienced observers without prior instructions. In adjacent sections immunolabeled for MIB-1, the proliferation index was assessed as the estimated percentage of labeled cells ...

journal_title：Annals of diagnostic pathology

authors： Molenaar WM,Plaat BE,Berends ER,te Meerman GJ

更新日期：2000-08-01 00:00:00

abstract：:Clear cell papillary renal cell carcinoma (ccpRCC) is a recently recognized subtype of renal cell carcinoma. In this study, we investigated the clinicopathological and immunohistochemical features in a group of 26 cases of ccpRCC, with a special emphasis on the expression of vitamin D receptor (VDR). The mean age of p...

journal_title：Annals of diagnostic pathology

authors： Wang Y,Ding Y,Qin C,Gu M,Wang Z,Han C,Liu X,Li H,Hua H

更新日期：2018-10-01 00:00:00

abstract：:In the recent years, basaloid squamous cell carcinomas (BSCCs) have gained attention because of (1) observation of a relative increase in the number of tumors arising particularly in head and neck sites, (2) identification of human papillomavirus (HPV) in BSCCs arising predominantly in the oropharynx, and (3) controve...

journal_title：Annals of diagnostic pathology

authors： Jayasooriya PR,Tilakaratne WM,Mendis BR,Lombardi T

更新日期：2013-12-01 00:00:00

abstract：:Breast carcinoma with osteoclast-like giant cells (OGCs) is a rare disease characterized by the infiltration of OGCs in the tumor; however, cytological aspects of this tumor type remain elusive. We examined the cytological features in fine needle aspiration (FNA) biopsy smears obtained from 5 patients who were histolo...

journal_title：Annals of diagnostic pathology

authors： Ohashi R,Hayama A,Matsubara M,Watarai Y,Sakatani T,Naito Z,Shimizu A

更新日期：2018-04-01 00:00:00

abstract：:An uncommon manifestation of plasma cell neoplasia occurs outside the bone marrow and is designated "extramedullary plasmacytoma." These are usually encountered in mucosal sites of the head and neck region. The gastrointestinal tract may be secondarily involved in multiple myeloma or be the site of primary extramedull...

journal_title：Annals of diagnostic pathology

authors： Chetty R,Bramdev A,Reddy AD

更新日期：2003-06-01 00:00:00

abstract：:The hematoxylin and eosin slides of 100 consecutive cases diagnosed as CIN 1-2 were combined with 25 CIN 1 and 25 negative for CIN as documented by in situ HPV testing. The 150 cases were then reviewed blinded and scored as "CIN" or "negative for CIN". Each of the 50 controls was correctly scored. Of the 100 cases, 62...

journal_title：Annals of diagnostic pathology

authors： Nuovo G

更新日期：2020-06-01 00:00:00

abstract：:Pancreatic ectopia in the mediastinum is rare, and there are no reports that it has ever given rise to malignancy. Here we report a case of adenocarcinoma arising in ectopic pancreatic tissue in the mediastinum of a 66-year-old woman. The tumor arose in a partially cystic and partially solid ectopic pancreas containin...

journal_title：Annals of diagnostic pathology

authors： St Romain P,Muehlebach G,Damjanov I,Fan F

更新日期：2012-12-01 00:00:00

abstract：:Sclerosing hemangioma of the lung is a rare neoplasm with polymorphic histologic features. Despite various patterns, there are 2 unifying cellular components: "surface cells" and "round cells." Although histogenesis has been debated for decades, most ultrastructural, immunocytochemical, and molecular studies strongly ...

journal_title：Annals of diagnostic pathology

authors： Kalhor N,Staerkel GA,Moran CA

更新日期：2010-02-01 00:00:00

abstract：:Fat mass and obesity associated (FTO) is a protein-coding gene, also known as the obesity gene. It has been reported previously to be associated with a variety of malignant cancers, such as breast, thyroid and acute myeloid leukemia. The aim of the present study was to investigate the FTO mRNA expression in human clea...

journal_title：Annals of diagnostic pathology

authors： Wen L,Yu Y,Lv H,He Y,Yang B

更新日期：2019-02-01 00:00:00

abstract：:Recently, renal angiomyoadenomatous tumor (RAT) has been identified. However, there are no descriptions about clear cell renal cell carcinoma (RCC) with focal RAT-like features. A 33-year-old Japanese man was found to have a tumor in the left kidney. Macroscopically, the tumor extended into the perinephric fat tissue,...

journal_title：Annals of diagnostic pathology

authors： Kuroda N,Hosokawa T,Michal M,Hes O,Sima R,Ohe C,Lee GH

更新日期：2011-06-01 00:00:00

abstract：:Intraductal lesions of the pancreas are an uncommon but increasingly recognized group of entities mainly because of advances in imaging technology. In the past, precise categorization and understanding of true pancreatic intraduct neoplasms were hampered not only by their relative rarity but also because of the pletho...

journal_title：Annals of diagnostic pathology

authors： Chelliah A,Kalimuthu S,Chetty R

更新日期：2016-10-01 00:00:00

abstract：:Radiographic identification of an abnormal lesion in the esophagus routinely occurs during workup of patients with symptomatic dysphagia. Leiomyoma is the most common benign finding; however, plexiform leiomyoma, a distinctive but rare variant, follows an unusual pattern of growth which can be a challenging surgical r...

journal_title：Annals of diagnostic pathology

authors： Jaroszewski DE,Lam-Himlin D,Gruden J,Lidner TK,Etxebarria AA,De Petris G

更新日期：2011-10-01 00:00:00

abstract：:Because of its characteristic morphologic appearance, small cell osteosarcoma (SCO) can be confused with other small round cell malignancies of the bone, most importantly with Ewing sarcoma, making this distinction difficult. A specific tool used in separating SCO from Ewing sarcoma has been the detection of Ewing sar...

journal_title：Annals of diagnostic pathology

authors： Dragoescu E,Jackson-Cook C,Domson G,Massey D,Foster WC

更新日期：2013-08-01 00:00:00

abstract：:An antibody cocktail directed against p63, cytokeratin (CK)5/14, and CK7/18 is reported to be useful in distinguishing noninvasive from invasive breast lesions and for the characterization of intraductal epithelial proliferations. However, limited studies evaluate its use in clinical practice. A retrospective review o...

journal_title：Annals of diagnostic pathology

authors： Reisenbichler ES,Ross JR,Hameed O

更新日期：2014-12-01 00:00:00

abstract：:Adenolipomas are rare benign neoplasms composed of mature adipose tissue and glandular elements. We report 6 patients with adenolipomas of the head and neck region: 3 in the parathyroid, 2 in the thyroid, and 1 in the parotid gland. The patients were 4 women and 2 men, ranging in age from 21 to 70 years (mean, 62.5 ye...

journal_title：Annals of diagnostic pathology

authors： Daboin KP,Ochoa-Perez V,Luna MA

更新日期：2006-04-01 00:00:00

abstract：:A polypoid malignant rhabdoid tumor of the duodenum is presented. The pattern of metastatic spread in this 58-year-old man included multiple duodenal and small intestinal transmural tumor implants and a large peribronchial lymph node causing superior vena cava syndrome. Microscopically, the tumor was composed of a dif...

journal_title：Annals of diagnostic pathology

authors： Lee JR,Chamberlain CR,Gerrity RG,McKee EM,Gadacz TR,Rao RN

更新日期：1998-02-01 00:00:00

abstract：INTRODUCTION:Increased expression of Programmed death ligand-1 (PD-L1) on cancer cells and immune cells predict response to PD-1/PDL1 inhibitors. Data regarding frequency and pattern of PD-L1 expression in NSCLC from India is not available. OBJECTIVES:To analyse PD-L1 expression on tumour cells (TC) and immune cells (...

journal_title：Annals of diagnostic pathology

authors： Vallonthaiel AG,Malik PS,Singh V,Kumar V,Kumar S,Sharma MC,Mathur S,Arava S,Guleria R,Jain D

更新日期：2017-12-01 00:00:00

abstract：:The mucosal surfaces represent the third most common site of origin for melanoma, after the skin and ocular uveal tract. However, anorectal mucosal melanoma is a rare neoplasm, usually occurring in the sixth and seventh decades of life. It may often be confused clinically with other pathologic entities, such as prolap...

journal_title：Annals of diagnostic pathology

authors： Ellis ZM,Jassim AD,Wick MR

更新日期：2010-04-01 00:00:00

abstract：:Myoid angioendothelioma of the spleen is an uncommon, benign vascular tumor that is morphologically characterized by a composite of vascular spaces and stromal cells with myoid feature. Herein, we report a case of the myoid angioendothelioma of the spleen, concurrent with rectal adenocarcinoma. A 41-year-old woman pre...

journal_title：Annals of diagnostic pathology

authors： Jang KY,Chung MJ,Moon WS,Sohn MH,Hwang SB,Lee MR,Lee H,Park HS

更新日期：2013-02-01 00:00:00

abstract：:We saw in consultation a biopsy specimen from a 6-year old girl with anaplastic lymphoma kinase (ALK)-positive anaplastic large cell lymphoma (ALCL). The tumor arose in soft tissue of the neck, and diagnostic tissue was obtained by core needle biopsy. Histologically, the neoplasm was cellular without pattern. Immunohi...

journal_title：Annals of diagnostic pathology

authors： Gustafson S,Medeiros LJ,Kalhor N,Bueso-Ramos CE

更新日期：2009-12-01 00:00:00

abstract：:We report a unique case of an extramammary mammary-type myofibroblastoma of the perianal region. The patient was a 40-year old female with no significant past history, who presented with a right side painless perianal mass. Gross examination of the excised mass showed a well-circumscribed, apparently encapsulated, nod...

journal_title：Annals of diagnostic pathology

authors： Zhang Y,Jorda M,Goldblum JR

更新日期：2010-10-01 00:00:00

abstract：OBJECTIVES:Proteins p27 and c-Myc are both key players in the cell cycle. While p27, a tumor suppressor, inhibits progression from G1 to S phase, c-Myc, a proto-oncogene, plays a key role in cell cycle regulation and apoptosis. The objective of our study was to determine the association between expression of c-Myc and ...

journal_title：Annals of diagnostic pathology

authors： Khan F,Ricks-Santi LJ,Zafar R,Kanaan Y,Naab T

更新日期：2018-06-01 00:00:00

abstract：:A 4-cm paravertebral mediastinal tumor was resected in a 70-year-old male patient treated for hypertension. The tumor displayed both paraganglioma and ganglioneuroma areas that were in equal proportion and often merged one into the other. Paraganglioma areas contained synaptophysin and chromogranin-positive chief cell...

journal_title：Annals of diagnostic pathology

authors： de Montpréville VT,Mussot S,Gharbi N,Dartevelle P,Dulmet E

更新日期：2005-04-01 00:00:00

abstract：:Cribriform areas are common features of both adenoid cystic carcinoma and polymorphous low-grade adenocarcinoma. Both are malignant salivary gland tumors that share similar histologic patterns, but with marked distinct clinical behavior. This study was undertaken to improve the accuracy of the histopathology diagnosti...

journal_title：Annals of diagnostic pathology

authors： Araújo VC,Loducca SV,Sousa SO,Williams DM,Araújo NS

更新日期：2001-12-01 00:00:00

abstract：:Triple negative breast cancer (TNBC) represents a small subtype of breast cancer yet it has the worst outcome. Immunotherapy using immune checkpoint inhibitors combined with chemotherapy was recently approved by the FDA raising the hope for an improved outcome. The approval was based on demonstration of a positive PD-...

journal_title：Annals of diagnostic pathology

authors： Al-Jussani GN,Dabbagh TZ,Al-Rimawi D,Sughayer MA

更新日期：2021-01-09 00:00:00

abstract：BACKGROUND:There is contradictory evidence in literature with respect to diagnosis and management of follicular lesions of the thyroid gland. From surgical pathology stand point, pathologists require submission and processing of entire capsule for microscopic evaluation. This can be extremely challenging especially in ...

journal_title：Annals of diagnostic pathology

authors： Hamza A,Khawar S,Alrajjal A,Salehi S

更新日期：2019-04-01 00:00:00

abstract：:Endometrial stromal tumors (ESTs) of the uterine corpus have a striking propensity to display diverse morphological variations, including sex cord-like, smooth muscle, or skeletal muscle differentiation; fibrous change; myxoid change; or bland endometrioid-type glands. They may also contain rhabdoid, foam, clear, or e...

journal_title：Annals of diagnostic pathology

authors： Fadare O,McCalip B,Mariappan MR,Hileeto D,Parkash V

更新日期：2005-06-01 00:00:00

abstract：:Periumbilical skin is unique due to its proximity to intra-abdominal and pelvic structures. In addition to primary skin malignancies, it is a site often involved with metastatic disease. We reviewed the clinical and pathologic features of 77 umbilical malignancies occurring at our institution since 1988. Seventy-seven...

journal_title：Annals of diagnostic pathology

authors： Papalas JA,Selim MA

更新日期：2011-08-01 00:00:00

abstract：:A clear cell variant of solid-pseudopapillary tumor (SPT) of the pancreas was initially reported in 2006 as a tumor that arose in the pancreatic body and tail in young adults; to date, only 4 cases of this entity have been reported. Here, we present the case of a 58-year-old man with clear cell variant of SPT with dis...

journal_title：Annals of diagnostic pathology

authors： Tanino M,Kohsaka S,Kimura T,Tabu K,Nishihara H,Sawa H,Kawami H,Kamada H,Shimizu M,Tanaka S

更新日期：2012-04-01 00:00:00