Bilateral renal tumors; conventional clear cell carcinoma and contralateral t(6;11)/t(X;17)-like tumor Histomorphologic, immunohistochemical, ultrastructural and molecular genetic studies including the report of a novel mutation in the VHL gene.

Abstract:

:A 34-year-old pregnant woman with bilateral kidney tumors 9.5 and 2.5 cm in maximum diameter is presented. The larger tumor was clear renal cell carcinoma. The smaller contralateral tumor was focally HMB45 positive and had unusual histomorphology, including features resembling clear renal cell carcinoma with features of both t(6;11)- and t(X;17)/ASPL-TFE3 carcinomas. This tumor displayed a complex karyotype. A novel germ line mutation in the VHL gene (c.439A>G/p.I147V) was also identified in this patient.

journal_name

Ann Diagn Pathol

authors

Petersson F,Michal M,Vaněček T,Hora M,Trivunic S,Halbhuber Z,Hes O

doi

10.1016/j.anndiagpath.2010.05.004

subject

Has Abstract

pub_date

2011-10-01 00:00:00

pages

362-9

issue

5

eissn

1092-9134

issn

1532-8198

pii

S1092-9134(10)00077-8

journal_volume

15

pub_type

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