Abstract:
OBJECTIVES:Few studies have examined whether exposure to chlorinated solvents is associated with multiple myeloma. We evaluated associations between multiple myeloma and occupational exposure to six chlorinated solvents: 1,1,1-trichloroethane, trichloroethylene (TCE), methylene chloride (DCM), perchloroethylene, carbon tetrachloride and chloroform. METHODS:In-person interviews obtained occupational histories and information on jobs with likely solvent exposure. We assigned exposure metrics of probability, frequency, intensity and confidence using job-exposure matrices modified by job-specific questionnaire information. We used logistic regression to estimate ORs and 95% CIs for associations between multiple myeloma and ever exposure to each, and any, chlorinated solvent and analysed whether associations varied by duration and cumulative exposure. We also considered all occupations that were given the lowest confidence scores as unexposed and repeated all analyses. RESULTS:Risk of multiple myeloma was elevated for subjects ever exposed to 1,1,1-trichloroethane (OR (95% CI): 1.8 (1.1 to 2.9)). Ever exposure to TCE or DCM also entailed elevated, but not statistically significant, risks of multiple myeloma; these became statistically significant when occupations with low confidence scores were considered unexposed (TCE: 1.7 (1.0 to 2.7); DCM: 2.0 (1.2 to 3.2)). Increasing cumulative exposure to perchloroethylene was also associated with increasing multiple myeloma risk. We observed non-significantly increased multiple myeloma risks with exposure to chloroform; however, few subjects were exposed. CONCLUSIONS:Evidence from this relatively large case-control study suggests that exposures to certain chlorinated solvents may be associated with increased incidence of multiple myeloma; however, the study is limited by relatively low participation (52%) among controls.
journal_name
Occup Environ Medjournal_title
Occupational and environmental medicineauthors
Gold LS,Stewart PA,Milliken K,Purdue M,Severson R,Seixas N,Blair A,Hartge P,Davis S,De Roos AJdoi
10.1136/oem.2009.054809subject
Has Abstractpub_date
2011-06-01 00:00:00pages
391-9issue
6eissn
1351-0711issn
1470-7926pii
oem.2009.054809journal_volume
68pub_type
杂志文章abstract:OBJECTIVES:To investigate the frequency, circumstances, and causes of occupational accidents aboard merchant ships in international trade, and to identify risk factors for the occurrence of occupational accidents as well as dangerous working situations where possible preventive measures may be initiated. METHODS:The s...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.59.2.85
更新日期:2002-02-01 00:00:00
abstract:AIMS:To investigate work related and individual factors as predictors for incident neck pain among office employees working with video display units (VDUs). METHODS:Employees in three administrative units of a medium sized city in Finland (n = 515) received mailed questionnaires in the baseline survey in 1998 and in t...
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更新日期:2006-07-01 00:00:00
abstract:OBJECTIVE:To assess the effectiveness of lumbar supports, education, and exercise in the prevention of back pain in industry. METHODS:A computerised search for controlled clinical trials was conducted. A criteria list was used to assess the methodological quality of the studies. The available evidence for the effectiv...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章,meta分析
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abstract:OBJECTIVES:Animal evidence shows that N-nitrosamines and similar xenobiotic compounds are pancreatic carcinogens. We aimed to determine whether occupational exposure to N-nitrosamines or to pesticides increases risk of pancreatic cancer development. METHODS:Participants (504 cases, 643 controls) in a population-based ...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oemed-2014-102522
更新日期:2015-09-01 00:00:00
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doi:10.1136/oemed-2016-103808
更新日期:2017-03-01 00:00:00
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journal_title:Occupational and environmental medicine
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doi:10.1136/oemed-2019-105902
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journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oemed-2011-100556
更新日期:2012-10-01 00:00:00
abstract:OBJECTIVES:To better understand the relations between occupational exposure, blood antioxidant enzyme activities, total plasma antioxidant concentration, and the severity of coal workers' pneumoconiosis (CWP). METHODS:Blood samples were obtained from miners without CWP exposed to low dust concentrations for > or = 4 y...
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pub_type: 杂志文章
doi:10.1136/oem.55.8.533
更新日期:1998-08-01 00:00:00
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journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.2003.012492
更新日期:2005-04-01 00:00:00
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journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oemed-2015-102902
更新日期:2015-10-01 00:00:00
abstract:OBJECTIVES:Structural impairment of the renal proximal tubular epithelium induced by cadmium (Cd) was investigated by measuring the concentration of neutral endopeptidase 24.11 (NEP), an ectoenzyme of the apical brush border, in the urine of 106 male workers employed in a Cd smelter (among whom 52 were occupationally e...
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doi:10.1136/oem.54.6.432
更新日期:1997-06-01 00:00:00
abstract:OBJECTIVE:To explore the healthy worker survivor effect (HWSE) in a study of Vermont granite workers by distinguishing "prevalent" from "incident" hires based on date of hire before or after the start of follow-up. METHODS:Records of workers between 1950 and 1982 were obtained from a medical surveillance programme. Pr...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.2006.031369
更新日期:2007-10-01 00:00:00
abstract:OBJECTIVES:Due to recent changes in legislation on occupational health and safety, a national monitor on stress and physical load was developed in The Netherlands to monitor (a) risks and consequences of stress and physical load at work, (b) preventive actions in companies to reduce these risks, and (c) organisational ...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.55.2.73
更新日期:1998-02-01 00:00:00
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journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.2008.045500
更新日期:2010-02-01 00:00:00
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journal_title:Occupational and environmental medicine
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doi:10.1136/oem.2007.035014
更新日期:2008-05-01 00:00:00
abstract:OBJECTIVES:To determine the kinetics of elimination of urinary dialkylphosphate metabolites after oral and dermally applied doses of the organophosphate pesticide chlorpyrifos to human volunteers and to determine whether these doses affected plasma and erythrocyte cholinesterase activity. METHOD:Five volunteers ingest...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.56.1.10
更新日期:1999-01-01 00:00:00
abstract:OBJECTIVE:To find whether continuous ceramic filaments (CCFs) and silicon carbide whiskers (SiCWs), which are used in many industries as reinforcing materials in advanced ceramic composites, are carcinogenic in the intrapleural inoculation assay. METHODS:Samples of SiCWs, CCF, International Union Against Cancer crocid...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.53.12.813
更新日期:1996-12-01 00:00:00
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journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.52.6.415
更新日期:1995-06-01 00:00:00
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journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oemed-2018-105311
更新日期:2019-05-01 00:00:00
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journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oemed-2013-101852
更新日期:2014-06-01 00:00:00
abstract:OBJECTIVE:To investigate associations between cancer incidence and exposure to coal tar pitch volatiles, asbestos, pot emissions (fluorides, sulphur dioxide), heat stress, and magnetic fields in workers from a Norwegian aluminium smelter that operated from 1914 to 1975. METHODS:Cancer incidence between 1953 and 1991 w...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.52.4.250
更新日期:1995-04-01 00:00:00
abstract:OBJECTIVE:To determine the impact of ill health on exit from paid employment in Europe among older workers. METHODS:Participants of the Survey on Health and Ageing in Europe (SHARE) in 11 European countries in 2004 and 2006 were selected when 50-63 years old and in paid employment at baseline (n=4611). Data were colle...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章,多中心研究
doi:10.1136/oem.2009.051730
更新日期:2010-12-01 00:00:00
abstract:OBJECTIVES:To assess the prevalence of enzyme sensitisation in the animal feed industry. METHODS:A cross sectional study was conducted in four animal feed factories, where several enzymes had been used in powder form for 7-9 years. Before this study, enzymes in liquid form had started to be used. Sensitisation to enzy...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.58.2.119
更新日期:2001-02-01 00:00:00
abstract:OBJECTIVE:To explore the relationship between occupations and specific occupational exposures and oesophageal cancer (OC) by histological type. METHODS:A multicentre hospital-based case-control study was conducted in two Mediterranean provinces of Spain. Occupational, sociodemographic and lifestyle information was col...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章,多中心研究
doi:10.1136/oem.2007.037929
更新日期:2008-11-01 00:00:00
abstract:OBJECTIVES:A hospital based case-control study was conducted between 1992 and 1993 in the province of Brescia, a highly industrialised area in northern Italy, to evaluate occupational risk factors of bladder cancer. METHODS:The study evaluated 355 histologically confirmed cases of bladder cancer (275 men, 80 women) an...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.53.1.6
更新日期:1996-01-01 00:00:00
abstract:AIMS:To describe the age standardised prevalence of symptomatic osteoarthritis (OA) in a nationwide cross sectional survey of 10 412 patients in France, and their functional and work limitations. METHODS:Cases in the survey were compared with their expected counterpart by age, gender, and occupational groupings using ...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.60.11.882
更新日期:2003-11-01 00:00:00
abstract:OBJECTIVES:To evaluate if occupational mechanical exposures are associated with an increased risk of surgery for varicose veins (VV) in the lower extremities. METHODS:We conducted a longitudinal study of persons from the Musculoskeletal Research Database at the Danish Ramazzini Centre who were 18-65 years old when the...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oemed-2014-102495
更新日期:2015-05-01 00:00:00
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journal_title:Occupational and environmental medicine
pub_type: 杂志文章,meta分析,评审
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更新日期:2015-01-01 00:00:00
abstract:BACKGROUND:Vibration white finger (VWF) is characterised by arterial hyperresponsiveness and vasoconstriction following cold provocation. Several years after of removal from exposure, most subjects show improved finger systolic blood pressure (FSBP) under conditions of cold challenge, but continue to report cold hands ...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.60.12.962
更新日期:2003-12-01 00:00:00