Abstract：
:Steroid receptor coactivators are important in regulating the function of the receptors in endocrine organ development and in cancers, including breast. Androgen receptor (AR) coactivator ARA70, was first identified as a gene fused to the ret oncogene and later characterized as an AR coactivator. We previously reported that the full length ARA70α functions as a tumor suppressor gene and that ARA70β functions as an oncogene in prostate cancer. Here we show that both ARA70α and ARA70β function as AR and estrogen receptor (ER) coactivators in breast cancer cells. However, ARA70α and ARA70β serve different functions in mammary gland development and breast cancer tumorigenesis. We observed hypoplastic development of mammary glands in MMTV driven ARA70α transgenic mice and overgrowth of mammary glands in ARA70β transgenic mice at virgin and pregnant stages. We determined that ARA70α inhibited cell proliferation, and that ARA70β promotes proliferation in MCF7 breast cancer cells. These effects were observed in hormone-free media, or in media with androgen or estrogen, though to varying degrees. Additionally, we observed that ARA70β strongly enhanced the invasive ability of MCF7 breast cancer cells in in vitro Matrigel assays. Significantly, decreased ARA70α expression is associated with increased tendency of breast cancer metastasis. In summary, ARA70α and ARA70β have distinct effects in mammary gland development and in the progression of breast cancer.
journal_name
Breast Cancer Res Treatjournal_title
Breast cancer research and treatmentauthors
Wu X,Chen F,Sahin A,Albarracin C,Pei Z,Zou X,Singh B,Xu R,Daniels G,Li Y,Wei J,Blake M,Schneider RJ,Cowin P,Lee Pdoi
10.1007/s10549-010-1131-5subject
Has Abstractpub_date
2011-07-01 00:00:00pages
391-400issue
2eissn
0167-6806issn
1573-7217journal_volume
128pub_type
杂志文章abstract：:To further clarify risk factors for breast cancer in Japanese women, a self-administered questionnaire was completed by 157 cases with histologically confirmed breast cancer from 1989 to 1993 and by 369 age and residential area matched controls in Gifu, Japan. Conditional logistic regression model was used to assess t...
journal_title：Breast cancer research and treatment
pub_type： 杂志文章
doi：10.1023/a:1005745824388
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journal_title：Breast cancer research and treatment
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journal_title：Breast cancer research and treatment
pub_type： 杂志文章,评审
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pub_type： 杂志文章,多中心研究,随机对照试验
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pub_type： 杂志文章
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更新日期：1997-04-01 00:00:00
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journal_title：Breast cancer research and treatment
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更新日期：2012-09-01 00:00:00
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更新日期：2005-07-01 00:00:00
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journal_title：Breast cancer research and treatment
pub_type： 杂志文章
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更新日期：2010-01-01 00:00:00
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pub_type： 杂志文章
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