Causes for hospitalization and death in Iranian patients with β-thalassemia major.

Abstract:

:There are limited studies that have focused on the causes for hospitalization as an indicator of morbidity in patients with β-thalassemia major (BTM). A cross-sectional study was conducted to determine the main causes for hospitalization and death in hospitalized BTM patients in a referral hospital in Shiraz, southern Iran. During a 5-year period, 555 BTM patients were admitted to the hospital, of which 390 (67.7%) were 10 to 20 years of age. The most frequent causes for hospitalization were splenectomy (23%), heart failure (22.6%), liver biopsy (22.2%), uncontrolled diabetes (10.9%), arrhythmia (7.2%), cholecystectomy (3.8%), hypoparathyroidism (2.1%), and sepsis (2%). Of the hospitalized patients, 65 (11%), with a mean age of 16.1 ± 4.2 years, died. The most common causes of death were cardiomyopathy (72.3%), infections (17%), malignancies (3.1%), and cerebrovascular accidents (3.1%). Survival of our patients was less than in developed countries and cardiac complications were the most common cause of mortality and morbidity in these patients. Regarding the key role of iron chelation in prevention of different complications in BTM, correction of iron chelation regimen should be well considered.

journal_name

Pediatr Hematol Oncol

authors

Bazrgar M,Peiravian F,Abedpour F,Karimi M

doi

10.3109/08880018.2010.503336

subject

Has Abstract

pub_date

2011-03-01 00:00:00

pages

134-9

issue

2

eissn

0888-0018

issn

1521-0669

journal_volume

28

pub_type

杂志文章
  • MRI changes in the "normal" pineal gland following chemotherapy for suprasellar germ cell tumors.

    abstract::Primary CNS germ cell tumors (GCT) arise in the suprasellar and pineal regions. Suprasellar GCT may remain radiographically occult during the early symptomatic period. Although theoretically possible, it is more difficult to identify presymptomatic disease in the pineal region. Given the sensitivity of GCT to cytotoxi...

    journal_title:Pediatric hematology and oncology

    pub_type: 杂志文章

    doi:10.1080/08880010701665777

    authors: MacDonald SM,Desai N,Heller G,Rolnitzky L,Allen JC

    更新日期:2008-01-01 00:00:00

  • Central venous line thrombosis in children and young adults with thalassemia major.

    abstract::High doses of intravenous deferoxamine via central venous line (CVL) has recently been shown to improve survival in patients with noncompliant thalassemia major (TM). The aim of this retrospective study was to evaluate the extent of CVL-related thrombosis and to determine the presence of prothrombotic factors in child...

    journal_title:Pediatric hematology and oncology

    pub_type: 杂志文章

    doi:10.1080/08880010490457042

    authors: Finkelstein Y,Yaniv I,Berant M,Zilber R,Garty BZ,Epstein O,Lahav J,Tamary H

    更新日期:2004-07-01 00:00:00

  • Avascular necrosis of femoral head as the initial manifestation of CML.

    abstract::A 12-year-old female is reported who presented with right hip pain for 6 months. With massive splenohepatomegaly and leukocytosis, CML was suspected and confirmed on bone-marrow examination and cytogenetics. Further investigations confirmed avascular necrosis (AVN) of the right femoral head. CML was treated by hydroxy...

    journal_title:Pediatric hematology and oncology

    pub_type: 杂志文章

    doi:10.3109/08880018.2013.831961

    authors: Kumar S,Bansal D,Prakash M,Sharma P

    更新日期:2014-09-01 00:00:00

  • Association of maternal education with the neuroblastoma susceptibility in children: a meta-analysis.

    abstract::Maternal education might be an important factor for the neuroblastoma risk in children, but it was conflicting. This meta-analysis was performed to evaluate the relationship between maternal education and neuroblastoma susceptibility and to explore whether maternal education was an important indicator to be associated...

    journal_title:Pediatric hematology and oncology

    pub_type: 杂志文章,meta分析

    doi:10.3109/08880018.2012.742605

    authors: Wang P,Liao N,Liao XH,Liang B,Huang CX,Li W

    更新日期:2013-02-01 00:00:00

  • Prognostic significance of methotrexate and 6-mercaptopurine dosage during maintenance chemotherapy for childhood acute lymphoblastic leukemia.

    abstract::Tolerance of full-dose methotrexate/6-mercaptopurine (MTX/6MP) maintenance therapy for childhood acute lymphoblastic leukemia (ALL) without side effects could reflect insufficient systemic drug exposure, and drug withdrawals due to toxicity might reduce the chance of cure. The present study included 122 children with ...

    journal_title:Pediatric hematology and oncology

    pub_type: 杂志文章

    doi:10.3109/08880019109028803

    authors: Schmiegelow K

    更新日期:1991-10-01 00:00:00

  • Bone fracture: an unusual presentation of acute megakaryoblastic leukemia.

    abstract::Some clinical manifestations of acute leukemia in children can mimic orthopedic conditions, and t is variable presentation often makes diagnosis difficult. Bone changes in leukemia are well documented, but there are only a few accounts of children with acute leukemia who present with bone fractures. This report descri...

    journal_title:Pediatric hematology and oncology

    pub_type: 杂志文章

    doi:10.1080/08880010802434818

    authors: Alioglu B,Tuncay IC,Ozyurek E,Avci Z,Ozbek N

    更新日期:2009-01-01 00:00:00

  • Should healthy children who will undergo minor surgery be screened for coagulation disorder?

    abstract::The objective of this study is to analyze the major causes of abnormal findings seen in the preoperative coagulation tests of asymptomatic pediatric patients and to discuss the usefulness of coagulation tests prior to minor surgery. Among patients who received minor surgery in Kyung Hee University Medical Center from ...

    journal_title:Pediatric hematology and oncology

    pub_type: 杂志文章

    doi:10.3109/08880018.2016.1166537

    authors: Kang S,Yoon HS,Lee EH

    更新日期:2016-05-01 00:00:00

  • Disaccharidases activity in the intestinal mucosa after methotrexate therapy.

    abstract::Disaccharidases activity in the intestinal mucosa samples of rats was examined after intragastric and intramuscular methotrexate therapy. Methotrexate was given on a twice a week schedule (1 mg/kg body weight). The animals were sacrificed after 2 weeks, 1 month, and 2 months of this therapy. A statistically significan...

    journal_title:Pediatric hematology and oncology

    pub_type: 杂志文章

    doi:10.3109/08880019009033397

    authors: Dyduch A,Steplewski Z,Koehler M,Piszka B

    更新日期:1990-01-01 00:00:00

  • Etiology, drug sensitivity profiles and clinical outcome of bloodstream infections: A retrospective study of 784 pediatric patients with hematological and neoplastic diseases.

    abstract::Bloodstream infections (BSI) represent one of the most serious complications in patients in the hematology-oncology unit. In this study, the prevalence, distribution, drug sensitivity profiles, and clinical outcome of BSI were analyzed in pediatric patients with hematological malignancies. Patients admitted to the ped...

    journal_title:Pediatric hematology and oncology

    pub_type: 杂志文章

    doi:10.1080/08880018.2019.1667462

    authors: Chen S,Liu S,Yuan X,Mai H,Lin J,Wen F

    更新日期:2019-11-01 00:00:00

  • Two CD34+ stem cells from umbilical cord blood enrichment methods.

    abstract::The authors describe the relation between clamping time and blood volume collected, and two enrichment systems of CD34+ stem cells from umbilical cord blood, to determine an excellent recovery with high proliferate ability and bone marrow reconstitution. After an obstetrician-based cord blood collection, the purificat...

    journal_title:Pediatric hematology and oncology

    pub_type: 杂志文章

    doi:10.1080/08880010252899406

    authors: Pafumi C,Bosco P,Cavallaro A,Farina M,Leonardi I,Pernicone G,Bandiera S,Russo A,Giardina P,Chiarenza M,Calogero AE

    更新日期:2002-06-01 00:00:00

  • The influence of risk factors in promoting thrombosis during childhood: the role of acquired factors.

    abstract::Thrombo-embolism in childhood is a multifactorial disorder. The present study is a case-control study that investigated the role of genetic and acquired risk factors in 60 children with thrombosis and compared the results with the controls. Acquired and inherited risk factors precipitating thrombosis were present in 7...

    journal_title:Pediatric hematology and oncology

    pub_type: 杂志文章

    doi:10.1080/08880010600646324

    authors: Günes AM,Baytan B,Günay U

    更新日期:2006-07-01 00:00:00

  • Clinical and genetic studies of familial hemophagocytic lymphohistiocytosis in Oman: need for early treatment.

    abstract::Hemophagocytic lymphohistiocytosis (HLH) embraces the frequently indistinguishable conditions of familial hemophagocytic lymphohistiocytosis (FHL) and virus-associated hemophagocytic syndrome (VAHS). Without therapy FHL is invariably fatal, but successful therapy, including chemotherapy and immunotherapy followed by b...

    journal_title:Pediatric hematology and oncology

    pub_type: 杂志文章

    doi:

    authors: Al-Lamki Z,Wali YA,Pathare A,Ericson KG,Henter JI

    更新日期:2003-12-01 00:00:00

  • Characterization of bone marrow stromal abnormalities in a patient with constitutional trisomy 8 mosaicism and myelodysplastic syndrome.

    abstract::The development of myeloid leukemias and myelodysplastic syndrome (MDS) is common in children with trisomy 8 mosaicism. However, the mechanisms by which the presence of an additional chromosome 8 translates to an increased risk of leukemias and MDS is currently unknown. The authors describe the analysis of stromal cel...

    journal_title:Pediatric hematology and oncology

    pub_type: 杂志文章

    doi:10.1080/08880010490276917

    authors: Narendran A,Hawkins LM,Ganjavi H,Vanek W,Gee MF,Barlow JW,Johnson G,Malkin D,Freedman MH

    更新日期:2004-04-01 00:00:00

  • Allogeneic hemopoietic stem cell transplantation for childhood acute lymphoblastic leukemia in second complete remission-similar outcomes after matched related and unrelated donor transplant: a study of the Spanish Working Party for Blood and Marrow Trans

    abstract::The authors report the results of 58 children with ALL in 2CR after related (n = 31) or unrelated (n = 27) AHSCT. Characteristics at diagnosis and initial and after relapse antileukemic treatment were similar in the related donor (RD) and the unrelated donor (UD) groups. Conditioning consisted of TBI/CY +/- VP-16 for ...

    journal_title:Pediatric hematology and oncology

    pub_type: 杂志文章

    doi:10.1080/08880010802016557

    authors: Muñoz A,Diaz-Heredia C,Diaz MA,Badell I,Verdeguer A,Martinez A,Gomez P,Perez-Hurtado JM,Bureo E,Fernandez-Delgado R,Gonzalez-Valentin ME,Maldonado MS

    更新日期:2008-06-01 00:00:00

  • Successful multimodal therapy for kaposiform hemangioendothelioma complicated by Kasabach-Merritt phenomenon: case report and review of the literature.

    abstract::We present the management challenge provided by a patient with kaposiform hemangioendothelioma associated with Kasabach-Merritt phenomenon. A female child presented at 14 months of age with an ecchymotic swelling of her right upper arm and axilla. Subsequently, she developed profound thrombocytopenia and hypofibrinoge...

    journal_title:Pediatric hematology and oncology

    pub_type: 杂志文章,评审

    doi:10.3109/08880019809014013

    authors: Blei F,Karp N,Rofsky N,Rosen R,Greco MA

    更新日期:1998-07-01 00:00:00

  • Association of absolute lymphocyte count and peripheral blood lymphocyte subsets percentage with minimal residual disease at the end of induction in pediatric B cell acute lymphoblastic leukemia.

    abstract::Absolute lymphocyte count (ALC) has been associated with overall survival (OS) and event-free survival, but we do not know if ALC is associated with minimal residual disease (MRD) at the end of induction (EOI) and whether it can be used as surrogate marker in resource limited settings. Immunological differences betwee...

    journal_title:Pediatric hematology and oncology

    pub_type: 杂志文章

    doi:10.1080/08880018.2019.1594469

    authors: Pushpam D,Rajput N,Chopra A,Vishnubhatla S,Kumari M,Kumar R,Bakhshi S

    更新日期:2019-04-01 00:00:00

  • Low Vitamin D Levels: Are Associated with Both Iron Deficiency and Anemia in Children and Adolescents?

    abstract::We have read, with great interest, the recent article by Lee. In this excellent study, the authors investigated the association between vitamin D deficiency and anemia in a nationally representative sample of Korean children and adolescents. They concluded that vitamin D deficiency is associated with increased risk of...

    journal_title:Pediatric hematology and oncology

    pub_type: 杂志文章

    doi:10.3109/08880018.2015.1022916

    authors: Kartal Ö,Kartal AT

    更新日期:2015-01-01 00:00:00

  • Relapse of primitive mediastinal lymphoma as a myeloid mass following beam autologous transplant and subsequent refractoriness to matched unrelated umbilical cord blood allograft.

    abstract::Outlining the treatment for an unclassifiable lymphoid malignancy is often difficult. A highly undifferentiated lymphomatous mass that relapsed in spite of intense chemotherapy and autologous transplant is reported. At relapse, there was differentiation into myeloid lineage. Though remission was achieved with AML-type...

    journal_title:Pediatric hematology and oncology

    pub_type: 杂志文章

    doi:10.1080/08880010902754883

    authors: Anoop P,Lancaster DL,Ethell ME,Potter MN,Wotherspoon A

    更新日期:2009-03-01 00:00:00

  • Spontaneous acute cerebral hematoma in a child with factor XIII deficiency.

    abstract::Factor XIII deficiency is a very rare bleeding disorder. We report here on the clinical outcome of a young child with intracranial bleeding due to factor XIII deficiency. Clinicians should bear in mind that severe factor XIII deficiency is associated with a significant risk of unexpected intracranial hemorrhage (ICH)....

    journal_title:Pediatric hematology and oncology

    pub_type: 杂志文章

    doi:10.3109/08880018.2013.798059

    authors: Bay A,Sirikci A,Dogan A,Leblebisatan G,Yilmaz F

    更新日期:2013-11-01 00:00:00

  • Spontaneous apoptosis and retinoic acid receptor incidence in neuroblastomas and peripheral neuroectodermal tumors.

    abstract::Twelve cases of neuroblastoma (NB) (7 boys and 5 girls) and 4 cases of primitive peripheral neuroectodermal tumor (PNET) (3 boys and 1 girl) were investigated for the presence of apoptosis and retinoic acid receptor (RAR) by immunhistochemical method. The apoptotic index in NB was zero or 1% in 8 children and relative...

    journal_title:Pediatric hematology and oncology

    pub_type: 杂志文章

    doi:10.1080/088800100276307

    authors: Farid P,Babosa M,Hauser P,Schuler D,Szende B

    更新日期:2000-06-01 00:00:00

  • Health-related quality of life among teenagers during cancer treatment in a developing country: patients' and proxies' reports.

    abstract::Few studies have been performed during adolescents' cancer treatment to evaluate its interference on health-related quality of life (HRQL). The purpose of this prospective cohort study was to evaluate adolescents' HRQL during cancer treatment. The Health Utilities Index (HUI) was used for scoring. Forty-five individua...

    journal_title:Pediatric hematology and oncology

    pub_type: 杂志文章

    doi:10.3109/08880018.2013.775617

    authors: Rodrigues KE,Machado ST,Ferreira MA,Martins TF,Viana MB,Oliveira BM

    更新日期:2013-05-01 00:00:00

  • Prenatal diagnosis of hemoglobinopathies in Hacettepe University, Turkey.

    abstract::Between 1983 and 2008, prenatal diagnostic procedures for identifying hemoglobinopathies were performed in 947 at-risk fetuses. Seventy-six percent of the fetuses were at risk for β-thalassemia major and 16% for sickle cell anemia; only a small percentage (7%) were at risk for compound heterozygosity of β-thalassemia ...

    journal_title:Pediatric hematology and oncology

    pub_type: 杂志文章

    doi:10.3109/08880018.2010.507690

    authors: Beksac MS,Gumruk F,Gurgey A,Cakar N,Mumusoglu S,Ozyuncu O,Altay C

    更新日期:2011-02-01 00:00:00

  • The mTOR signaling pathway in pediatric neuroblastoma.

    abstract::Neuroblastoma (NB) is the most common extracranial malignant solid tumors of childhood, and the majority of these high-risk tumors is resistant to nearly all the treatments and has a significantly worse outcome. The mammalian target of rapamycin (mTOR) plays a critical role in oncogenesis and cancer progression of man...

    journal_title:Pediatric hematology and oncology

    pub_type: 杂志文章,评审

    doi:10.3109/08880018.2013.798058

    authors: Mei H,Wang Y,Lin Z,Tong Q

    更新日期:2013-10-01 00:00:00

  • Cerebrospinal fluid and plasma methotrexate levels following high-dose regimen given as a 3-hour intravenous infusion in children with nonHodgkin's lymphoma.

    abstract::In the French nonHodgkin's lymphoma protocols, central nervous system prophylaxis is provided by high-dose methotrexate (HD-MTX), given as a 3-hour IV infusion of 3 g/m2 MTX along with intrathecal MTX injection. The incidence of CNS relapse is less than 3%. We designed a study to evaluate the MTX transfer across the b...

    journal_title:Pediatric hematology and oncology

    pub_type: 杂志文章

    doi:10.3109/08880019009034320

    authors: Vassal G,Valteau D,Bonnay M,Patte C,Aubier F,Lemerle J

    更新日期:1990-01-01 00:00:00

  • Responsiveness to parenteral iron therapy in children with oral iron-refractory iron-deficiency anemia.

    abstract:UNLABELLED:Intravenous (IV) ferric iron (Fe)-carbohydrate complexes are used for treating Fe deficiency in children with iron-refractory iron-deficiency anemia (IRIDA). An optimal treatment has yet to be determined. There are relatively little publications on the responsiveness to IV iron therapy in children with IRIDA...

    journal_title:Pediatric hematology and oncology

    pub_type: 杂志文章

    doi:10.3109/08880018.2013.829540

    authors: Akin M,Atay E,Oztekin O,Karadeniz C,Karakus YT,Yilmaz B,Erdogan F

    更新日期:2014-02-01 00:00:00

  • Percutaneous transhepatic biliary drainage in an infant with obstructive jaundice caused by neuroblastoma.

    abstract::Neuroblastoma presenting with obstructive jaundice is a rare event. Management of this condition includes surgery, chemotherapy, radiotherapy, temporary cholecystostomy tube, endoscopic retrograde cholangiopancreatography (ERCP), and internal biliary drainage (IBD). We herein describe our experience with one infant af...

    journal_title:Pediatric hematology and oncology

    pub_type: 杂志文章

    doi:10.3109/08880018.2014.981901

    authors: Saettini F,Agazzi R,Giraldi E,Foglia C,Cavalleri L,Morali L,Fasolini G,Spotti A,Provenzi M

    更新日期:2015-04-01 00:00:00

  • Panel reactive antibody in thalassemic serum inhibits proliferation and differentiation of cord blood CD34+ cells in vitro.

    abstract::Thalassemic children are at a high risk of graft rejection in cord blood transplantation. To investigate this possible mechanism, the authors evaluated the effect of panel reactive antibody on the growth of CD34(+) cells in vitro. On semisolid medium, CD34(+) cells derived from cord blood were incubated with thalassem...

    journal_title:Pediatric hematology and oncology

    pub_type: 杂志文章

    doi:10.1080/08880010902976098

    authors: Fang JP,Xu LH,Yang XG,Wu YF,Weng WJ,Xu HG

    更新日期:2009-07-01 00:00:00

  • Euthyroid sick syndrome in children with Hodgkin disease.

    abstract::Euthyroid sick syndrome is related to profound changes in thyroid metabolism induced by nonthyroidal diseases. To determine whether children with newly diagnosed Hodgkin disease might present thyroid abnormalities and to establish their predictive value, the authors performed regular thyroid function testing. Seven ch...

    journal_title:Pediatric hematology and oncology

    pub_type: 杂志文章

    doi:10.1080/08880010151114886

    authors: Mohn A,Di Marzio A,Cerruto M,Angrilli F,Fioritoni C,Chiarelli F

    更新日期:2001-04-01 00:00:00

  • Cryptococcal meningitis following a thrombotic microangiopathy in an unrelated donor bone marrow transplant recipient.

    abstract::In patients undergoing bone marrow transplantation cryptococcosis is rarely encountered. We report a fatal case of Cryptococcus meningitis in a 12-year-old girl with acute lymphoblastic leukemia (ALL) in second remission who had a transplant from a human leukocyte antigen (HLA)-identical unrelated bone marrow donor. T...

    journal_title:Pediatric hematology and oncology

    pub_type: 杂志文章

    doi:10.3109/08880019709028778

    authors: Miniero R,Nesi F,Vai S,De Intinis G,Papalia F,Targhetta R,Busca A,Vassallo E,Giacchino M

    更新日期:1997-09-01 00:00:00

  • All children with malignant rhabdoid tumors should be treated initially with intensive chemotherapy.

    abstract::Malignant rhabdoid tumors (MRT) of soft tissues are aggressive tumors, which can be detected in almost any part of the body. MRT are rare, and very few cases have been reported in the literature. Prognosis of these tumors is extremely poor despite intensive therapy. Some risk factors such as young age or disseminated ...

    journal_title:Pediatric hematology and oncology

    pub_type: 杂志文章

    doi:10.3109/08880018.2014.914112

    authors: Hernández-Marqués C,Lassaletta A,Cormenzana M,García-Esparza E,Madero-López L

    更新日期:2015-04-01 00:00:00