Genetic factors responsible for long bone fractures non-union.

Abstract:

INTRODUCTION:Approximately 10-15% of all fractures of long bones heal with delay, prolonged immobilization and repetitive operative interventions. Despite intense investigations, the pathomechanism of impaired healing of skeletal tissue remains unclear. An important role in the pathomechanism of mal-union of close fractures plays subclinically proceeding infections. AIM:The question arises whether colonization and proliferation of bacteria in the fracture gap could be related to the mutation of genes for factors regulating local antimicrobial response, such as pathogen recognizing receptors (PRR), cytokines and chemokines. METHODS:We carried out studies in patients with delayed long bone fractures estimating the frequency of mutation of genes crucial for pathogen recognition (TLR2, TLR4 and CD14), and elimination (CRP, IL-6, IL-1ra), as well as wound healing (TGF-β). The molecular milieu regulating healing process (IGF-1, COLL1a, TGF-β, BMP-2, and PDGF) was validated by Western blot analysis of the gap tissue. RESULTS:Microbiological investigations showed the presence of viable bacterial strains in 34 out of 108 gaps in patients with non-healing fractures (31.5%) and in 20 out of 122 patients with uneventful healing (16.4%) (P < 0.05). The occurrence of mutated TLR4 1/W but not 2/W gene was significantly higher (P < 0.05) in the non-healing infected than sterile group. In the non-healing infected group 1/W mutated gene frequency was also higher than in healing infected. In the TGF-β codon 10 a significantly higher frequency of mutated homozygote T and heterozygote C/T in the non-healing infected versus non-healing sterile subgroup was observed (P < 0.05). Similar difference was observed in the non-healing infected versus healing infected subgroup (P < 0.05). The CRP (G1059C), IL1ra (genotype 2/2), IL-6 (G176C), CD14 (G-159T), TLR2 (G2259A) and TLR4/2 (Thr399Ile) polymorphisms did not play evident role in the delay of fracture healing. CONCLUSIONS:Individuals bearing the mutant TLR 4 gene 1/W (Asp299Gly) and TGF-β gene codon 10 mutant T and T/C allele may predispose to impaired pathogen recognition and elimination, leading to prolonged pathogen existence in the fracture gaps and healing delays.

authors

Szczęsny G,Olszewski WL,Zagozda M,Rutkowska J,Czapnik Z,Swoboda-Kopeć E,Górecki A

doi

10.1007/s00402-010-1171-7

subject

Has Abstract

pub_date

2011-02-01 00:00:00

pages

275-81

issue

2

eissn

0936-8051

issn

1434-3916

journal_volume

131

pub_type

杂志文章
  • Clinical and radiological outcomes after reverse shoulder arthroplasty with less medialized endoprosthesis after mean follow-up time of 45 months.

    abstract:INTRODUCTION:The purpose of this study was to evaluate outcomes after reverse shoulder arthroplasty for the treatment of complex three- and four-fragment proximal humeral fractures after mean follow-up time of 45 months and to compare our results with the results published by other authors. MATERIALS AND METHODS:Retro...

    journal_title:Archives of orthopaedic and trauma surgery

    pub_type: 杂志文章

    doi:10.1007/s00402-017-2751-6

    authors: Jonušas J,Banytė R,Ryliškis S

    更新日期:2017-09-01 00:00:00

  • Posterior-only surgical correction with heavy halo-femoral traction for the treatment of extremely severe and rigid adolescent idiopathic scoliosis (> 130°).

    abstract:INTRODUCTION:The treatment of extremely severe and rigid spinal deformities was a great surgical challenge. Pulmonary impairment often occurred, which increased the challenges to already daunting surgical approaches. The present study was performed to evaluate the safety and efficacy of posterior-only surgical correcti...

    journal_title:Archives of orthopaedic and trauma surgery

    pub_type: 杂志文章

    doi:10.1007/s00402-020-03720-z

    authors: Zhang HQ,Deng A,Guo CF,Tang MX,Alonge E

    更新日期:2021-01-23 00:00:00

  • Three-dimensional computed tomography reconstruction improves the reliability of tibial pilon fracture classification and preoperative surgical planning.

    abstract:PURPOSE:In the present study, we aimed to evaluate the impact of two-dimensional multi-planar computed tomography (2D-MP-CT) scans and three-dimensional surface rendering computed tomography reconstruction (3D-SR-CT) on the inter- and intra-observer reliability of four commonly used classification systems for tibial pi...

    journal_title:Archives of orthopaedic and trauma surgery

    pub_type: 杂志文章

    doi:10.1007/s00402-019-03259-8

    authors: Keiler A,Riechelmann F,Thöni M,Brunner A,Ulmar B

    更新日期:2020-02-01 00:00:00

  • Is hospital volume associated with length of stay, re‑admissions and reoperations for total hip replacement? A population‑based register analysis of 78 hospitals and 54,505 replacements.

    abstract:INTRODUCTION:Hospital volume has been suggested to be a significant determinant of the outcome of joint replacement surgery. We updated previously published data on the effect of hospital volume on length of stay, re-admissions, and reoperations for total hip replacement (THR) at the population level in Finland. MATER...

    journal_title:Archives of orthopaedic and trauma surgery

    pub_type: 杂志文章

    doi:10.1007/s00402-013-1860-0

    authors: Pamilo KJ,Peltola M,Mäkelä K,Häkkinen U,Paloneva J,Remes V

    更新日期:2013-12-01 00:00:00

  • Pott's disease and extrapleural anterior decompression. Results of 108 consecutive cases.

    abstract::Between 1973 and 1988, 108 patients with a preoperative diagnosis of spinal tuberculosis were treated by anterior extirpation and interbody fusion at Ankara University Medical Faculty, Orthopedic Surgery and Traumatology Department. In 96 cases the operations were performed intrapleurally, as Hogston described. For 12...

    journal_title:Archives of orthopaedic and trauma surgery

    pub_type: 杂志文章

    doi:10.1007/BF00932444

    authors: Korkusuz Z,Binnet MS,Isiklar ZU

    更新日期:1989-01-01 00:00:00

  • Comparison of ultrasound-, palpation-, and scintigraphy-guided steroid injections in the treatment of plantar fasciitis.

    abstract:BACKGROUND:The aim of the study was to compare the efficacies of steroid injections guided by scintigraphy, ultrasonography, and palpation in plantar fasciitis. METHODS:A total of 35 heels of 27 patients were randomly assigned to three steroid injection groups: palpation-guided (pg), ultrasound-guided (ug), and scinti...

    journal_title:Archives of orthopaedic and trauma surgery

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s00402-008-0760-1

    authors: Yucel I,Yazici B,Degirmenci E,Erdogmus B,Dogan S

    更新日期:2009-05-01 00:00:00

  • No difference in clinical outcome, bone density and polyethylene wear 5-7 years after standard navigated vs. conventional cementfree total hip arthroplasty.

    abstract:INTRODUCTION:The purpose of this investigation was to compare clinical outcome, component loosening, polyethylene cup wear and periprosthetic bone mineral density between "cup first" navigated and conventional cementless total hip arthroplasty (THA) 5-7 years after surgery. MATERIALS AND METHODS:Fifty patients who rec...

    journal_title:Archives of orthopaedic and trauma surgery

    pub_type: 杂志文章

    doi:10.1007/s00402-015-2201-2

    authors: Keshmiri A,Schröter C,Weber M,Craiovan B,Grifka J,Renkawitz T

    更新日期:2015-05-01 00:00:00

  • Sagittal alignment of the lower extremity while standing in Japanese male.

    abstract::There is little information available regarding the sagittal mechanical axis of the lower extremity of normal subjects under weight-bearing conditions. The purpose of this study was to determine the sagittal alignment of the lower extremity under such conditions. Anteroposterior and lateral radiographs were taken of t...

    journal_title:Archives of orthopaedic and trauma surgery

    pub_type: 杂志文章

    doi:10.1007/s00402-007-0528-z

    authors: Minoda Y,Kobayashi A,Iwaki H,Sugama R,Iwakiri K,Kadoya Y,Ohashi H,Takaoka K

    更新日期:2008-04-01 00:00:00

  • Comparison of pain relief between patient-controlled epidural analgesia and patient-controlled intravenous analgesia for patients undergoing spinal fusion surgeries.

    abstract:INTRODUCTION:This meta-analysis aimed to compare the postoperative analgesic effects of patient-controlled epidural analgesia (PCEA) and patient-controlled intravenous analgesia (PCIA) for patients undergoing spinal fusion surgeries. METHOD:Relevant articles were identified using computerized and manual search strateg...

    journal_title:Archives of orthopaedic and trauma surgery

    pub_type: 杂志文章,meta分析,评审

    doi:10.1007/s00402-015-2263-1

    authors: Lu S,Ma SC,Wang YY,Zhu ZH,Fan HW,Zhao GQ

    更新日期:2015-09-01 00:00:00

  • Intrathoracic shoulder dislocation causing rupture of the right main bronchus.

    abstract::An intrathoracic shoulder dislocation is a rare injury, usually the result of high-energy trauma [Hawkes et al. in Am J Orthop 43(4):E74-E78, 2014; Tsai et al. in Ann Thorac Cardiovasc Surg 20:592-594, 2014, in Rupprecht et al. Bull Emerg Trauma 5(3):212-214, 2017; Abellan et al. J Orthop Surg (Hong Kong)18(2):254-257...

    journal_title:Archives of orthopaedic and trauma surgery

    pub_type: 杂志文章

    doi:10.1007/s00402-019-03242-3

    authors: Hayes N,White J,Lillie P,Bennetts JS,Tu CG,Bain GI

    更新日期:2020-04-01 00:00:00

  • Fracture of the anterior extremity of calcaneus together with calcaneocuboid joint dislocation.

    abstract::The calcaneocuboid joint is very stable, and dislocation or fracture is rare. We report a very rare case of dislocation fracture at the anterior articular surface of the calcaneocuboid joint. This is, to our knowledge, the first report of calcaneus fracture. ...

    journal_title:Archives of orthopaedic and trauma surgery

    pub_type: 杂志文章

    doi:10.1007/s00402-009-0834-8

    authors: Hagino T,Tonotsuka H,Ochiai S,Hamada Y

    更新日期:2009-12-01 00:00:00

  • Development of a German version of the knee outcome survey for daily activities.

    abstract:INTRODUCTION:The knee outcome survey-activities of daily living scale (KOS-ADLS) is a patient-reported specific measure of knee function. The KOS-ADLS includes items related to both symptoms and functional limitations experienced during ADL. The purpose of this study was to examine the reliability and validity of a cro...

    journal_title:Archives of orthopaedic and trauma surgery

    pub_type: 杂志文章

    doi:10.1007/s00402-006-0200-z

    authors: Bizzini M,Gorelick M

    更新日期:2007-11-01 00:00:00

  • Return to play following ACL reconstruction: survey among experienced arthroscopic surgeons (AGA instructors).

    abstract:PURPOSE:There is a lack of consensus regarding appropriate criteria attesting patient's unrestricted sports activities after ACL reconstruction. The purpose of this study was to perform a survey among experienced arthroscopic surgeons regarding their return to play guidelines in these patients. METHODS:A six-item ques...

    journal_title:Archives of orthopaedic and trauma surgery

    pub_type: 杂志文章

    doi:10.1007/s00402-013-1746-1

    authors: Petersen W,Zantop T

    更新日期:2013-07-01 00:00:00

  • Percutaneous screw fixation for a femoral head fracture: a case report.

    abstract::Femoral head fracture associated with hip dislocation is relatively rare but very severe injury. Due to its severity and the need of joint exposure for the reduction of femoral head fracture, the surgical treatment cannot but accompany many complications, including the osteonecrosis of the femoral head, heterotopic os...

    journal_title:Archives of orthopaedic and trauma surgery

    pub_type: 杂志文章

    doi:10.1007/s00402-013-1888-1

    authors: Homma Y,Miyahara S,Mogami A,Morohashi I,Baba T,Kaneko K

    更新日期:2014-03-01 00:00:00

  • Surgeon preferences regarding antibiotic prophylaxis for ballistic fractures.

    abstract:BACKGROUND:Scant evidence exists to support antibiotic use for low velocity ballistic fractures (LVBF). We therefore sought to define current practice patterns. We hypothesized that most surgeons prescribe antibiotics for LVBF, prescribing is not driven by institutional protocols, and that decisions are based on protoc...

    journal_title:Archives of orthopaedic and trauma surgery

    pub_type: 杂志文章

    doi:10.1007/s00402-016-2450-8

    authors: Marecek GS,Earhart JS,Gardner MJ,Davis J,Merk BR

    更新日期:2016-06-01 00:00:00

  • Growth plate fractures of the distal tibia: is CT imaging necessary?

    abstract:PURPOSE:Comparison of conventional radiographs (CR) of distal tibial growth plate fractures [Salter-Harris (SH) fracture types I-V/triplane fractures I-III] with computed tomography (CT) as the reference standard and assessment of diagnostic benefit of CT imaging in the affected patients. MATERIALS AND METHODS:We retr...

    journal_title:Archives of orthopaedic and trauma surgery

    pub_type: 杂志文章

    doi:10.1007/s00402-010-1140-1

    authors: Lemburg SP,Lilienthal E,Heyer CM

    更新日期:2010-11-01 00:00:00

  • Amphiphilic bonder improves adhesion at the acrylic bone cement-bone interface of cemented acetabular components in total hip arthroplasty: in vivo tests in an ovine model.

    abstract:INTRODUCTION:Even following the introduction of the "third generation" cementing technique, an improvement of the fixation of the acetabular component similar to that of the femoral has not been shown in clinical studies. The goal of the present study was to achieve a better stability with the use of an amphiphilic bon...

    journal_title:Archives of orthopaedic and trauma surgery

    pub_type: 杂志文章

    doi:10.1007/s00402-007-0408-6

    authors: Müller-Rath R,Wirtz DC,Siebert CH,Andereya S,Gravius S,Hermanns-Sachweh B,Marx R,Mumme T

    更新日期:2008-07-01 00:00:00

  • Evaluation of the muscles around the knee in rabbits whose anterior cruciate and/or medial collateral ligaments were dissected.

    abstract:INTRODUCTION:The biological response of the muscles around the knee in chronic ligamentous instability was investigated in an animal study. MATERIALS AND METHODS:There were four groups of 6- to 9-month-old adult New Zealand albino rabbits (2500-3300 g). The animals were divided into groups according to the ligament th...

    journal_title:Archives of orthopaedic and trauma surgery

    pub_type: 杂志文章

    doi:10.1007/s00402-003-0633-6

    authors: Kilic BA,Dingil O,Erkula G,Elmas C,Erdogan D,Atik OS

    更新日期:2004-11-01 00:00:00

  • Biomechanics of vertebral compression fractures and clinical application.

    abstract::Local biomechanical factors in the etiology of vertebral compression fractures are reviewed. The vertebral body is particularly vulnerable to compression fracture when its bone mineral density (BMD) falls with age. However, the risk of fracture, and the type of fracture produced, does not depend simply on BMD. Equally...

    journal_title:Archives of orthopaedic and trauma surgery

    pub_type: 杂志文章,评审

    doi:10.1007/s00402-011-1355-9

    authors: Adams MA,Dolan P

    更新日期:2011-12-01 00:00:00

  • Is proximal femoral nailing a good procedure for teaching in orthogeriatrics?

    abstract:BACKGROUND:Proximal femoral nailing is a common operation in orthogeriatrics and a highly standardized procedure. For teaching purposes, this operation is often performed by residents and supervised by attending physicians. The objective of this study is to investigate if teaching this operation influences the surgical...

    journal_title:Archives of orthopaedic and trauma surgery

    pub_type: 杂志文章

    doi:10.1007/s00402-012-1511-x

    authors: Biber R,Grüninger S,Singler K,Sieber CC,Bail HJ

    更新日期:2012-07-01 00:00:00

  • Combined tears of the subscapularis and supraspinatus tendon: clinical outcome, rotator cuff strength and structural integrity following open repair.

    abstract:BACKGROUND:Anterosuperior rotator cuff tears involving the subscapularis and supraspinatus tendons are less common than other tears of the rotator cuff. The purpose of this study was to report the clinical outcome, rotator cuff strength and structural integrity of open repair of combined anterosuperior rotator cuff tea...

    journal_title:Archives of orthopaedic and trauma surgery

    pub_type: 临床试验,杂志文章

    doi:10.1007/s00402-011-1400-8

    authors: Bartl C,Senftl M,Eichhorn S,Holzapfel K,Imhoff A,Salzmann G

    更新日期:2012-01-01 00:00:00

  • Rotational open wedge osteotomy in a patient aged older than 7 years with Perthes' disease--a preliminary report.

    abstract::Rotational open wedge osteotomy was performed on 20 hips in 19 older patients with Perthes' disease with an extensive lesion. All subjects had little viable bone in the posterolateral epiphysis preoperatively. The repair process was observed radiographically until 1 year postoperatively. The patients' mean age at the ...

    journal_title:Archives of orthopaedic and trauma surgery

    pub_type: 杂志文章

    doi:10.1007/s00402-002-0408-5

    authors: Atsumi T,Yoshiwara S

    更新日期:2002-07-01 00:00:00

  • Remodeling of the spine in spondylodiscitis of children at the age of 3 years or younger.

    abstract::Spondylitis/spondylodiscitis is still an uncommon diagnosis often with a delay in diagnosis and treatment due to the uncharacteristic symptoms. The aim of this study is to increase the awareness and outline a pattern of investigation and treatment. We present six children with an average age of 23 months (19-33 months...

    journal_title:Archives of orthopaedic and trauma surgery

    pub_type: 杂志文章

    doi:10.1007/s00402-007-0316-9

    authors: Waizy H,Heckel M,Seller K,Schroten H,Wild A

    更新日期:2007-08-01 00:00:00

  • Outcome after severe brain trauma associated with epidural hematoma.

    abstract:OBJECTIVE:The aim of this study was to identify factors contributing to outcomes after severe traumatic brain injury (TBI) associated with epidural hematoma (EDH). METHODS:Between 02/2002 and 4/2010 17 Austrian centers prospectively enrolled 863 patients with moderate and severe TBI into observational studies. Data on...

    journal_title:Archives of orthopaedic and trauma surgery

    pub_type: 杂志文章

    doi:10.1007/s00402-012-1652-y

    authors: Leitgeb J,Mauritz W,Brazinova A,Majdan M,Wilbacher I

    更新日期:2013-02-01 00:00:00

  • Bone transport over an intramedullary nail for reconstruction of long bone defects in tibia.

    abstract:BACKGROUND:Although long bone defects may be treated by callus distraction, frequent complications arise from the long duration of external fixation. To reduce such complications, bone transport over an intramedullary nail (BTON) has been done for tibial bone defect. METHODS:In 12 patients (mean age, 46.1 years) of ch...

    journal_title:Archives of orthopaedic and trauma surgery

    pub_type: 杂志文章

    doi:10.1007/s00402-007-0491-8

    authors: Oh CW,Song HR,Roh JY,Oh JK,Min WK,Kyung HS,Kim JW,Kim PT,Ihn JC

    更新日期:2008-08-01 00:00:00

  • Disseminated hydatid disease causing paraplegia and destruction of the hip.

    abstract::A patient who had had been treated by surgery for spinal echinococcosis in a Mediterranean country emigrated to northern Europe. After surgery, the echinococcosis disseminated and he developed chronic lytic and sinus-draining hydatid disease of the left hip and neuromuscular weakness of the left lower extremity. Seven...

    journal_title:Archives of orthopaedic and trauma surgery

    pub_type: 杂志文章

    doi:10.1007/pl00021231

    authors: Santavirta S,Valtonen M,Pätiälä H,Saarinen O,Konttinen YT

    更新日期:2000-01-01 00:00:00

  • Use of arthroscopy and interporous hydroxyapatite as a bone graft substitute in tibial plateau fractures.

    abstract::Tibial plateau fractures in 17 patients were managed arthroscopically, using interporous hydroxypatite (HA) as a bone graft substitute. Soft-tissue repair and intra-articular lavages were carried out arthroscopically, and depression of the articular surface was done by elevation of the subchondral plate by the bone co...

    journal_title:Archives of orthopaedic and trauma surgery

    pub_type: 杂志文章

    doi:10.1007/BF00453217

    authors: Itokazu M,Matsunaga T,Ishii M,Kusakabe H,Wyni Y

    更新日期:1996-01-01 00:00:00

  • Biomechanical comparison of two biplanar and one monoplanar reconstruction techniques of the acromioclavicular joint.

    abstract:INTRODUCTION:The purpose of this proof-of-concept study was to investigate the biomechanical performance of two surgical techniques, namely (1) the double Tight-Rope fixation with an additional acromioclavicular FiberTape fixation (DTRC) and (2) the fixation of the clavicle to the acromion and coracoid in a bipodal man...

    journal_title:Archives of orthopaedic and trauma surgery

    pub_type: 杂志文章

    doi:10.1007/s00402-019-03137-3

    authors: Schär MO,Jenni S,Fessel G,Snedeker JG,Scheibel M,Zumstein MA

    更新日期:2019-06-01 00:00:00

  • Atypical fractures of the femur: effect of anterolateral bowing of the femur on fracture location.

    abstract:INTRODUCTION:Bisphosphonate therapy has been associated with the development of atypical femoral fractures. The most common sites of bisphosphonate-associated fractures are at the subtrochanteric region followed by the femoral shaft. This retrospective study hypothesizes that increasing anterolateral femoral bow is ass...

    journal_title:Archives of orthopaedic and trauma surgery

    pub_type: 杂志文章

    doi:10.1007/s00402-015-2297-4

    authors: Soh HH,Chua IT,Kwek EB

    更新日期:2015-11-01 00:00:00

  • Weight-bearing restrictions reduce postoperative mobility in elderly hip fracture patients.

    abstract:BACKGROUND AND PURPOSE:Reduced mobility is a severe threat to the clinical outcomes and survival of elderly hip fracture patients. These patients generally struggle to comply with partial weight bearing, yet postoperative weight-bearing restrictions are still recommended by nearly 25% of surgeons. Therefore, we hypothe...

    journal_title:Archives of orthopaedic and trauma surgery

    pub_type: 杂志文章

    doi:10.1007/s00402-019-03193-9

    authors: Pfeufer D,Zeller A,Mehaffey S,Böcker W,Kammerlander C,Neuerburg C

    更新日期:2019-09-01 00:00:00