[Active surveillance for screen-detected prostate cancer - a strategy for the future?].

Abstract:

:For good reasons, newly detected prostate cancer must not necessarily be treated with curative -intent: Prostate-specific antigen screening leads to overdiagnosis in 54 %. Current international guidelines on the treatment of prostate cancer take this development into account by recommending "active surveillance" (AS) as an equitable treatment option for low-risk prostate cancer. Data on the natural history of prostate cancer indicates that only few men with localised prostate cancer profit from active therapy. Currently, there are 6 series on AS with more than 2000 patients documented in the literature, 200 of them having a follow-up of ten years or more. Disease-specific survival is 99-100 %, and there is no hint at that progression was detected too late for effective treatment. The rates of biochemical recurrence and pathohistological findings of deferred treatment compare well with those of immediate intervention. Thus AS is a safe treatment option for a well-defined patient cohort that has only a small chance of benefit but a high risk of harm from curative treatment.

journal_name

Aktuelle Urol

journal_title

Aktuelle Urologie

authors

Weissbach L,Schaefer C

doi

10.1055/s-0030-1247461

subject

Has Abstract

pub_date

2010-07-01 00:00:00

pages

239-44

issue

4

eissn

0001-7868

issn

1438-8820

journal_volume

41

pub_type

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