Cytotoxic and mitogenic activities in culture media conditioned by mouse B16 melanoma cells and 3T3 fibroblasts.

abstract：:Eighteen patients with Zollinger-Ellison syndrome were studied with 111In-pentetreotide SPECT in order to localize gastrinoma, the tumour responsible for this pathology. NMR imaging was also carried out. Eight patients were operated. 111In-pentetreotide was reinjected 4 hours before operation and the radioactivity of ...

journal_title：Anticancer research

authors： Scopinaro F,Schillaci O,Delle Fave G,Danieli R,Materia A,Tavolaro R,Angeletti S,Marignani M,Massa R,Gualdi G,Polettini E,Picardi V,Basso N

更新日期：1997-05-01 00:00:00

abstract：:The antioxidative activity and antimutagenic effects of the water-soluble beta-(1-3)-D-glucan derivatives from biotechnologically important species, in particular carboxymethyl-glucan (CM-G) and sulfoethyl-glucan (SE-G) both from the baker's yeast Saccharomyces cerevisiae, and carboxymethyl-chitin-glucan (CM-CG) from ...

journal_title：Anticancer research

authors： Krizková L,Duracková Z,Sandula J,Slamenová D,Sasinková V,Sivonová M,Krajcovic J

更新日期：2003-05-01 00:00:00

abstract：:Bright and dark field microscopy were used to examine interphase nuclei and RBG-banded human chromosomes. In dark field microscopy both chromosomes and interphase chromatin appeared to be composed of similar independent structures alternating between bright and dull light intensity. The position, colour, and number of...

journal_title：Anticancer research

authors： Rønne M,Gyldenholm AO,Storm CO

更新日期：1995-03-01 00:00:00

abstract：BACKGROUND/AIM:Perioperative intra-abdominal infection has been reported as a risk factor for metastasis. The aim of this study was to investigate the mechanism by which peritonitis induces immunosuppression in the lung, which in turn promotes lung metastasis. MATERIALS AND METHODS:C57BL/6 mice were intravenously admi...

journal_title：Anticancer research

authors： Arimoto A,Yamashita K,Hasegawa H,Sugita Y,Fukuoka E,Tanaka T,Suzuki S,Kakeji Y

更新日期：2018-07-01 00:00:00

abstract：BACKGROUND:We have identified a novel cancer/testis antigen, TRAG-3, (Taxol Resistance Associated Gene-3) that was initially discovered in search for new genes involved in drug resistance by differential display. Early study of TRAG-3 revealed minimal to absent expression in various normal tissues and over-expression i...

journal_title：Anticancer research

authors： Feller AJ,Duan Z,Penson R,Toh HC,Seiden MV

更新日期：2000-11-01 00:00:00

abstract：OBJECTIVE:Laboratory rats can develop benign or malignant tumors (TM) spontaneously or following various carcinogenic processes, e.g. irradiation. The effects of irradiation vary according to the irradiation field (RF), the dosage and the strain of rat. Radiation-induced malignant TM in rats are predominantly sarcomas....

journal_title：Anticancer research

authors： Bartel-Friedrich S,Friedrich RE,Arps H,Holzhausen HJ

更新日期：2000-11-01 00:00:00

abstract：BACKGROUND:The development of synthetic taxanes targets at increasing solubility of the drug, improved clinical efficacy and reduced side-effects. We evaluated the sensitivity of head and neck squamous cell carcinoma cell lines to BMS-184476 and BMS-188797 in vitro. MATERIALS AND METHODS:The effects of paclitaxel and ...

journal_title：Anticancer research

authors： Raitanen M,Pulkkinen J,Kulmala J,Grénman R

更新日期：2004-11-01 00:00:00

abstract：BACKGROUND:The prognostic significance of mutant p53 protein, p-glycoprotein (P-gp) and glutathione S-transferase-pi (GST-pi) in patients with unresectable non-small cell lung cancer (NSCLC) has not been established. MATERIALS AND METHODS:We performed immunohistochemical staining of p53, P-gp and GST-pi using transbro...

journal_title：Anticancer research

authors： Miyatake K,Gemba K,Ueoka H,Nishii K,Kiura K,Tabata M,Shibayama T,Takigawa N,Kawaraya M,Tanimoto M

更新日期：2003-05-01 00:00:00

abstract：AIM:We performed a pharmacokinetic phase I trial of the combination of S-1 granules and nedaplatin for head and neck squamous cell carcinoma (HNSCC). PATIENTS AND METHODS:Patients were treated with both nedaplatin on day 1 at a dose starting at 80 mg/m(2) (level 1) escalating up to 90 mg/m(2) (level 2), and S-1 granul...

journal_title：Anticancer research

authors： Hayashi H,Okamoto I,Ueda S,Tanaka K,Okamoto K,Kawakami H,Nishina S,Takeda M,Fujisaka Y,Satoh T,Terao K,Nishimura Y,Doi K,Nakagawa K

更新日期：2013-12-01 00:00:00

abstract：OBJECTIVE:To analyze the prognostic value of DNA multiploidy in a prospective study on frozen surgical tissue samples from primary colorectal cancer. SUMMARY BACKGROUND DATA:Survival data from eleven prospective studies collectively comprising about thirteen hundred patients showed that aneuploidy correlated with a 5-...

journal_title：Anticancer research

authors： Cosimelli M,D'Agnano I,Tedesco M,D'Angelo C,Botti C,Giannarelli D,Vasselli S,Cavaliere F,Zupi G,Cavaliere R

更新日期：1998-05-01 00:00:00

abstract：:Pegylated liposomal doxorubicin is associated with a lower risk of cardiotoxocity than conventional formulations of doxorubicin, allowing the use of higher cumulative doses. In this Phase II study, 25 patients aged over 70 years (median 79, range 75-82 years) with aggressive non-Hodgkin's lymphoma (NHL) (International...

journal_title：Anticancer research

authors： Tsavaris N,Kosmas C,Vadiaka M,Giannouli S,Siakantaris MP,Vassilakopoulos T,Pangalis GA

更新日期：2002-05-01 00:00:00

abstract：BACKGROUND:Chkl is a checkpoint gene that is activated after DNA damage. It phosphorylates and inactivates Cdc25C at the late G2 phase. The inactivation of Cdc25C and consequently, the inactivation of Cdc2, are required for the G2 arrest induced by DNA damage. METHODS:We treated 184B5 cell line and its E6 transformed ...

journal_title：Anticancer research

authors： Luo Y,Rockow-Magnone SK,Joseph MK,Bradner J,Butler CC,Tahir SK,Han EK,Ng SC,Severin JM,Gubbins EJ,Reilly RM,Rueter A,Simmer RL,Holzman TF,Giranda VL

更新日期：2001-01-01 00:00:00

abstract：AIM:The present study investigated the clinical significance of tartrate-resistant acid phosphatase type-5 (ACP5) expression in gastric cancer. MATERIALS AND METHODS:In 150 specimens of gastric cancer and adjacent normal mucosa, expression of ACP5 protein and mRNA and was determined by immunohistochemical staining and...

journal_title：Anticancer research

authors： Kawamura M,Tanaka K,Toiyama Y,Okugawa Y,Okigami M,Yasuda H,Saigusa S,Ohi M,Inoue Y,Uchida K,Mohri Y,Kusunoki M

更新日期：2014-07-01 00:00:00

abstract：BACKGROUND:A case control association study was carried out to investigate polymorphisms in genes CYP1A1 (3801T > C), GSTM1, and GSTT1 (null genotypes) and oral squamous cell carcinoma (OSCC), including a correlation with some histopathological findings (tumor size, lymph node invasion and degree of tumor differentiati...

journal_title：Anticancer research

authors： Losi-Guembarovski R,Cólus IM,De Menezes RP,Poliseli F,Chaves VN,Kuasne H,Leichsenring A,Guembarovski AL,Oliveira BW,Ramos G,Cavalcanti TC,Mizuno LT,Cavalli IJ,Ribeiro EM

更新日期：2008-03-01 00:00:00

abstract：:Urachal cancer is a rare malignancy and the standard treatment is surgical resection. The prognosis of recurrent and metastatic urachal cancer is extremely poor because there is no established chemotherapy regimen. Here, the response of one patient with recurrent urachal cancer to combination chemotherapy of gemcitabi...

journal_title：Anticancer research

authors： Miyata Y,Sagara Y,Matsuo T,Ohba K,Takahashi H,Sakai H,Kanetake H

更新日期：2011-06-01 00:00:00

abstract：BACKGROUND:A pitfall of immunotherapy with dendritic cells (DCs) for patients with malignant tumor is that certain patients have already been treated with Dexamethasone (DEX) prior to vaccination. Therefore, it is important to investigate whether DEX has negative effects on induction of antitumor immune response in den...

journal_title：Anticancer research

authors： Takagi Y,Kikuchi T,Niimura M,Ohno T

更新日期：2003-05-01 00:00:00

abstract：:The aim of the study was the evaluation of the detectability of treated liver metastases using one FDG-PET measurement. The study includes 42 patients (80 lesions) from different primary tumours. Standardized Uptake Values (SUV) as well as the tumour to liver Ratio (T/L) were used for evaluation. A T/L > 1.0 was consi...

journal_title：Anticancer research

authors： Mantaka P,Strauss AD,Strauss LG,Moehler M,Goldschmidt H,Oberdorfer F,Kontaxakis G,Van Kaick G

更新日期：1999-09-01 00:00:00

abstract：BACKGROUND/AIM:Long interspersed nuclear element-1 (LINE-1) methylation status is a marker for global DNA methylation. However, the relationship between LINE-1 methylation and the biology of lung adenocarcinoma remains unclear. Here, we aimed to examine the role of LINE-1 in lung cancer. MATERIALS AND METHODS:LINE-1 m...

journal_title：Anticancer research

authors： Kitahara H,Okamoto T,Shimamatsu S,Kohno M,Morodomi Y,Tagawa T,Kitao H,Okano S,Oda Y,Maehara Y,Mori M

更新日期：2020-10-01 00:00:00

abstract：BACKGROUND/AIM:To evaluate the effectiveness of enzalutamide in Italian patients with hormone-refractory metastatic castration-resistant prostate cancer, progressing after chemotherapy with docetaxel plus prednisone. PATIENTS AND METHODS:A total of 60 patients were enrolled. Reduction in serum prostate-specific antige...

journal_title：Anticancer research

authors： Cicero G,DE Luca R,Dorangricchia P,Dieli F

更新日期：2017-03-01 00:00:00

abstract：:Several human and murine tumor cell lines were evaluated in an in vitro cytotoxicity assay as prescreens for fermentation extracts and pure materials subsequently tested in vivo against P388 leukemia or B16 melanoma. Each material, regardless of its in vitro cytotoxicity, was evaluated in vivo. At the criteria levels ...

journal_title：Anticancer research

authors： Rose WC,Schurig JE,Meeker JB

更新日期：1988-05-01 00:00:00

abstract：:Renal cell carcinoma (RCC) is one of the few tumour types metastatic to the pancreas. In order to evaluate the outcome following resection of pancreatic metastases of RCC a retrospective review of surgical patients was performed. The initial histopathological staging, disease-free interval, surgical outcome and surviv...

journal_title：Anticancer research

authors： Schauer M,Vogelsang H,Siewert JR

更新日期：2008-01-01 00:00:00

abstract：:Thirty-two patients (30 men, 2 women), median age 68 years (range 47-85) with histologically confirmed advanced bladder carcinoma (Stages T3 and T4 according to the International Union Against Cancer staging system), who were poor surgical candidates, were prospectively treated with 1-6 (median 4) cycles of intra-arte...

journal_title：Anticancer research

authors： Mantadakis E,Panagiotidis C,Delakas D,Samonis G

更新日期：2003-11-01 00:00:00

abstract：PURPOSE:Circulating tumor cells (CTCs) can be detected in the peripheral blood of around 50% of patients with metastatic breast cancer. Their numbers are an independent predictor of the patient's progression-free survival (PFS) and of overall survival (OS). However, to date, none of the studies carried out with the mos...

journal_title：Anticancer research

authors： Martín M,García-Sáenz JA,Maestro De las Casas ML,Vidaurreta M,Puente J,Veganzones S,Rodríguez-Lajusticia L,De la Orden V,Oliva B,De la Torre JC,López-Tarruella S,Casado A,Sastre J,Díaz-Rubio E

更新日期：2009-10-01 00:00:00

abstract：BACKGROUND:We herein report a comparison of the radiolabels 177Lu and 125I bound to the monoclonal antibody HH1 that targets the CD37 antigen expressed on non-Hodgkin B-cell lymphomas. MATERIALS AND METHODS:Mixtures of 177Lu and 125I-labeled HH1 antibody were co-injected into nude mice carrying Ramos xenografts and th...

journal_title：Anticancer research

authors： Repetto-Llamazares A,Abbas N,Bruland ØS,Dahle J,Larsen RH

更新日期：2014-07-01 00:00:00

abstract：:Tissue-specific expression of 25-hydroxyvitamin D-1alpha-hydroxylase (1alpha-OHase) and vitamin D-hydroxylase (24-OHase) may act as the pivotal link between 25-hydroxyvitamin D3 (25(OH)D3) serum levels and the anticancer effects of 1,25-dihydoxyvitamin D3 (1,25(OH)2D3) and alternative splicing of the enzymes may regul...

journal_title：Anticancer research

authors： Fischer D,Becker S,Cordes T,Bücker B,Diedrich K,Friedrich M,Salehin D,Thill M

更新日期：2009-09-01 00:00:00

abstract：AIM:We evaluated mechanisms of interaction between the alkyating agent dacarbazine (DTIC) and the pro-oxidant, imexon, in the human A375 melanoma cell line. MATERIALS AND METHODS:The effect of DTIC and imexon, alone and in combination, was evaluated for growth inhibition (MTT), radiolabeled drug uptake, cellular thiol...

journal_title：Anticancer research

authors： Samulitis BK,Dorr RT,Chow HH

更新日期：2011-09-01 00:00:00

abstract：:Epidemiological studies suggest that nutrition plays an important role in colonic cancer prevention. A possible mechanism of this prevention may be the modulation of carcinogen metabolism and scavenging of reactive intermediates. In particular, dietary fibres are discussed as potentially protective food ingredients. T...

journal_title：Anticancer research

authors： Munjal U,Scharlau D,Glei M

更新日期：2012-12-01 00:00:00

abstract：BACKGROUND:Lung resistance-related protein (LRP) was first detected in a non-P-glycoprotein-mediated multidrug-resistant lung cancer cell line and has been shown to be the major human vault protein. The aim of this study was to evaluate the expression of LRP in germ cell testicular tumors (GCT) and to determine the cor...

journal_title：Anticancer research

authors： Mándoky L,Géczi L,Doleschall Z,Bodrogi I,Csuka O,Kásler M,Bak M

更新日期：2004-03-01 00:00:00

abstract：BACKGROUND:Polymorphisms altering DNA repair capacity may lead to synergistic effects with tobacco carcinogen-induced lung cancer risk. Based on this hypothesis, the relationship between APE1 polymorphism, smoking and the risk of lung cancer was explored. MATERIALS AND METHODS:The distribution of the APE1 Asp148Glu po...

journal_title：Anticancer research

authors： Agaçhan B,Küçükhüseyin O,Aksoy P,Turna A,Yaylim I,Görmüs U,Ergen A,Zeybek U,Dalan B,Isbir T

更新日期：2009-06-01 00:00:00

abstract：:Receptors for peanut agglutinin (PNA) were isolated from Lewis lung carcinoma cells (3LL) by detergent solubilization and affinity chromatography on PNA-agarose. The isolated receptors showed heterogeneous yet distinct molecular species when they were analyzed by SDS gel electrophoresis. In vivo inoculation of the iso...

journal_title：Anticancer research

authors： Adachi M,Mizuta T,Yokota M,Shibusawa H,Yamamura M,Hamada Y,Uetsuji S,Yamamoto M,Miwa H

更新日期：1984-01-01 00:00:00