Abstract:
OBJECTIVE:The aim of this study is to analyze the morphology and proliferation of human osteoblastic cells in vitro on five commercially available titanium surfaces. MATERIALS AND METHODS:Human primary cells of the osteoblastic lineage were obtained from bone explants. The cells were plated on polished (T1), machined (T2), sand-blasted/acid-etched (T3), sand-blasted/acid-etched, modified with hydrogen peroxide rinse (T4), and plasma-sprayed titanium (T5) disks. Cell morphology was studied after 6, 24, 72 h, 7 and 14 days of culture by scanning electron microscopy. The formation and distribution of focal adhesions was investigated by immunocytochemical staining at 3, 6 and 24 h. Cell growth was measured by an MTT assay after 3, 7 and 9 days of culture. Moreover, the production of osteocalcin and osteoprotegerin (OPG) was evaluated in the supernatants by ELISA. RESULTS:Morphological analysis revealed that substrate topography profoundly affected cells' shape and their anchoring structures. Large lamellipodia were formed on polished and machined surfaces, while thin filopodia were more frequently observed on T3 and T4 samples. Moreover, cells formed stronger focal adhesions on T3 and T4 surfaces, and cell proliferation was higher on rough surfaces. Osteocalcin production was higher on the T4 surface, whereas OPG steadily increased on every surface. CONCLUSIONS:Taken together, these data show that all the surfaces allowed cell attachment, adhesion and proliferation, but T4 and T5 surfaces appeared to be a better substrate for the adhesion, proliferation and differentiation of cells of the osteoblastic lineage.
journal_name
Clin Oral Implants Resjournal_title
Clinical oral implants researchauthors
Passeri G,Cacchioli A,Ravanetti F,Galli C,Elezi E,Macaluso GMdoi
10.1111/j.1600-0501.2009.01906.xsubject
Has Abstractpub_date
2010-07-01 00:00:00pages
756-65issue
7eissn
0905-7161issn
1600-0501pii
CLR1906journal_volume
21pub_type
杂志文章abstract:OBJECTIVES:The aims of this study were (i) to evaluate the efficacy of ridge preservation and repair procedures involving the application of SocketKAP(™) and SocketKAGE(™) devices following tooth removal and (ii) to evaluate alveolar bone volumetric changes at 6 months post-extraction in intact sockets or those with fa...
journal_title:Clinical oral implants research
pub_type: 杂志文章,随机对照试验
doi:10.1111/clr.12687
更新日期:2016-06-01 00:00:00
abstract::The purpose of this study was to determine the peri-implant soft tissue dimension (PSD) and peri-implant bone level (BL) of dental implants with different designs and surface modifications after functional loading without oral hygiene. Three types of dental implants were placed in the posterior jaws of adult baboons, ...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/j.1600-0501.2005.01217.x
更新日期:2006-04-01 00:00:00
abstract:OBJECTIVES:To investigate: (1) sinus membrane thickness in patients receiving lateral window sinus augmentation via cone-beam computed tomography (CBCT) and (2) the influence of Schneiderian membrane thickness upon membrane perforation during lateral window approach. MATERIAL AND METHODS:A total of 73 subjects with 81...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/clr.12646
更新日期:2016-05-01 00:00:00
abstract:OBJECTIVES:The aim of this study is twofold: to assess the esthetic outcome of single dental implant restorations in the anterior maxillary area after up to 3 years of function, and to evaluate the relationship between the esthetic outcome and oral health-related quality of life. MATERIALS AND METHODS:Twenty patients ...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/clr.12922
更新日期:2017-09-01 00:00:00
abstract::Although a two-stage procedure with symphyseal oral implants can lead to a long-term (15 years) 99% cumulative survival rate, a one-stage approach with immediate loading via prefabricated elements seems to offer a short-term acceptable outcome with significantly lower costs. A series of 50 consecutive patients, not el...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/j.1600-0501.2004.01069.x
更新日期:2004-06-01 00:00:00
abstract:OBJECTIVES:The aim of the present systematic review was to analyze the survival and complication rates of zirconia-based and metal-ceramic implant-supported single crowns (SCs). MATERIALS AND METHODS:An electronic MEDLINE search complemented by manual searching was conducted to identify randomized controlled clinical ...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/clr.13306
更新日期:2018-10-01 00:00:00
abstract:OBJECTIVES:Interforaminal implant surgery requires anatomical knowledge of the area and adequate information on the location of the various landmarks of significance such as the mental foramen, the anterior loop of the inferior alveolar nerve and the mandibular incisive canal. Cone beam computed tomography (CBCT) is a ...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/j.1600-0501.2011.02261.x
更新日期:2012-09-01 00:00:00
abstract:OBJECTIVES:To compare the effectiveness of free-handed (FH), pilot-drill guided (PG) and fully guided (FG) implant surgery by means of the apical global deviation (AGD) in relation to the additional financial cost and time spent. MATERIALS AND METHODS:Thirty-three partially edentulous patients in need of ≥2 implants i...
journal_title:Clinical oral implants research
pub_type: 杂志文章,随机对照试验
doi:10.1111/clr.13399
更新日期:2019-02-01 00:00:00
abstract::In the present study, the influence of initial instability on the healing of titanium implants was studied in 9 lop-eared rabbits. Titanium implants (Brånemark System) were inserted in the tibiae, a location with cortical bone only, in such a way that they were either stable (control), rotation-mobile, or totally mobi...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:
更新日期:1996-06-01 00:00:00
abstract::This study was undertaken to evaluate the use of tissue-engineered bone as grafting material for alveolar augmentation with simultaneous implant placement. Twelve adult hybrid dogs were used in this study. One month after the extraction of teeth in the mandible region, bone defects on both sides of the mandible were i...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/j.1600-0501.2006.01246.x
更新日期:2006-10-01 00:00:00
abstract::The purpose of this study was to examine the healing potential and re-osseointegration in peri-implant infection defects adjacent to various implant surfaces. In 7 female Beagle dogs, a total of 41 titanium oral implants (ITI, Straumann, Waldenburg; Switzerland) with a sink depth of 6 mm (diameter 2.8 mm) were placed ...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1034/j.1600-0501.1999.100205.x
更新日期:1999-04-01 00:00:00
abstract:OBJECTIVES:The aim of this study was to investigate the outcomes of the installation of two implant-supported overdentures until such treatment is complete. Although this treatment is well established in the literature, there are no studies comparing what happens to muscles and the quality of life (QoL) of patients dur...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/clr.12980
更新日期:2017-10-01 00:00:00
abstract:OBJECTIVES:Electrospun cotton wool-like nanocomposite (ECWN) is a novel synthetic bone substitute that incorporates amorphous calcium phosphate nanoparticles into a biodegradable synthetic copolymer poly(lactide-co-glycolide). The objectives of this study were to develop a tooth extraction socket model in sheep for bon...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/clr.12673
更新日期:2016-07-01 00:00:00
abstract:AIM:This study compared the effects of Escherichia-coli-produced recombinant human bone morphogenetic protein 2 (ErhBMP-2) with a biphasic calcium phosphate (BCP) carrier to those of deproteinized bovine bone in human maxillary sinus floor augmentation. MATERIAL AND METHODS:Screening for this clinical trial selected 5...
journal_title:Clinical oral implants research
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1111/clr.12471
更新日期:2015-12-01 00:00:00
abstract::The effect of bioactive glass (BG) and calcium carbonate (CC) granules on bone formation around titanium and BG implants projecting into the medullary space of rabbit tibia was studied. The bone marrow tissue was removed and the medullary space was filled either with BG or CC (Biocoral) granules (phi 630-800 microns)....
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1034/j.1600-0501.1997.080204.x
更新日期:1997-04-01 00:00:00
abstract:UNLABELLED:Osseointegration failure is a complex, multifactorial trait shown to concentrate in some treated populations. There has been shown evidence for genetic contribution to dental implant loss. Genetic polymorphisms have been classically considered as genetic risk factors for several diseases and, more recently, ...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/j.1600-0501.2008.01532.x
更新日期:2008-08-01 00:00:00
abstract:OBJECTIVES:This study aimed at evaluating the biological response of titanium implants coated with UV-irradiated 7-dehydrocholesterol (7-DHC) and vitamin E (VitE) in vivo and analyzing the effects of aging on their stability and bioactivity in vitro. MATERIAL AND METHODS:Titanium surfaces were coated with 7-DHC and Vi...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/clr.12815
更新日期:2017-04-01 00:00:00
abstract::The present paper is part of a comprehensive study of dental conditions and attitudes in a Swedish county population aged 45-69 years. A questionnaire was mailed to 3000 randomly-sampled individuals. The response rate was 79.4%. Part of the questionnaire contained questions about subjective need for implant treatment....
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1034/j.1600-0501.1991.020301.x
更新日期:1991-07-01 00:00:00
abstract:OBJECTIVES:The aim of the study was to investigate whether bone marrow aspirates (BMA) and concentrates (BMAC) influence the grafts' stability when added to deproteinized bovine bone mineral (DBBM) within the first 6 months after maxillary sinus augmentation. MATERIAL AND METHODS:26 CT data of 13 patients undergoing b...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/clr.12101
更新日期:2014-02-01 00:00:00
abstract::Microbiologic examinations of implants have shown that certain microorganisms described as periodontal pathogens may have an influence on the development and the progression of peri-implant disease. This experimental study aimed to examine the bactericidal effect of irradiation with a soft laser on bacteria associated...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1034/j.1600-0501.1997.080401.x
更新日期:1997-08-01 00:00:00
abstract::The aim of this controlled, parallel design clinical study was to compare the effectiveness of an Er:YAG laser (ERL) to that of mechanical debridement using plastic curettes and antiseptic therapy for nonsurgical treatment of peri-implantitis. Twenty patients with moderate to advanced peri-implantitis lesions were ran...
journal_title:Clinical oral implants research
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1111/j.1600-0501.2004.01051.x
更新日期:2005-02-01 00:00:00
abstract:OBJECTIVES:To evaluate a possible relationship between gingival biotypes and gingival thickness, papilla height and gingival width. MATERIAL AND METHODS:Thirty-six adult subjects were stratified by their gingival biotype (GB), as defined by transparency of a periodontal probe through the buccal gingival margin, into "...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/clr.12356
更新日期:2015-08-01 00:00:00
abstract:OBJECTIVES:To evaluate implant survival, peri-implant marginal bone loss, technical, and biological complications as well as aesthetic outcomes of zirconia implants in clinical studies. MATERIAL AND METHODS:Electronic (Medline, Embase) and hand searches were performed to identify clinical studies published between Jan...
journal_title:Clinical oral implants research
pub_type: 杂志文章,meta分析
doi:10.1111/clr.13352
更新日期:2018-10-01 00:00:00
abstract::The aim of the study was to evaluate two bioresorbable polylactic acid (PLA) filler materials in a guided bone regeneration (GBR) model system. The first was Polyfibre, a fibrous PLA filler material. Polyfoam, the second material tested, consisted of a spongy PLA filler material. In each group there were eight rabbits...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1046/j.0905-7161.2003.00930.x
更新日期:2003-12-01 00:00:00
abstract:OBJECTIVES:The purpose of the present study was to evaluate the survival rate of dental implants in previously failed implant sites. In addition, factors that might affect the outcome of these redo procedures were also explored. MATERIAL AND METHODS:Patients that had failed dental implants, which were replaced with th...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/j.1600-0501.2007.01466.x
更新日期:2008-03-01 00:00:00
abstract:OBJECTIVE:To evaluate osseointegration in rabbit tibiae and to investigate surface characteristics of novel zirconia implants made by powder injection molding (PIM) technique, using molds with and without roughened inner surfaces. MATERIAL AND METHODS:A total of 20 rabbits received three types of external hex implants...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/j.1600-0501.2012.02468.x
更新日期:2013-05-01 00:00:00
abstract:OBJECTIVES:The aim of this study was to evaluate the long-term results of the surgical treatment of single peri-implantitis intrabony defects, by means of deproteinized bovine bone mineral with 10% collagen (DBBMC). MATERIAL AND METHODS:The original population consisted of 26 patients with one crater-like defect, arou...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/clr.13028
更新日期:2017-12-01 00:00:00
abstract::Ultra-sonic bone surgery (USBS) has been recently introduced as a novel osteotomic technique. This clinical study reports on the application of this new technique to perform ridge-split procedures. Over a period of 3.5 years, 57 patients underwent a split-crest procedure with the aim to place 230 implants, 78 in the m...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/j.1600-0501.2006.01206.x
更新日期:2006-12-01 00:00:00
abstract:BACKGROUND:The placement of different graft materials and/or the use of occlusive membranes to cover the extraction socket entrance are techniques aimed at preserving/reducing alveolar ridge resorption. The use of grafting materials in fresh extraction sockets has, however, been questioned because particles of the graf...
journal_title:Clinical oral implants research
pub_type: 临床试验,杂志文章
doi:10.1034/j.1600-0501.2003.00970.x
更新日期:2003-10-01 00:00:00
abstract::Breakdown of bone around oral implants following occlusal overload or plaque accumulation was evaluated in monkeys. 5 screw-type implants of pure titanium (Astra Tech) were inserted in the mandible of 4 monkeys (Macaca Fascicularis). 6 months after insertion of the implants a fixed partial prosthesis was mounted on th...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/j.1600-0501.1997.tb00001.x
更新日期:1997-02-01 00:00:00