A retrospective analysis of intramuscular haloperidol and intramuscular olanzapine in the treatment of agitation in drug- and alcohol-using patients.

Abstract:

OBJECTIVE:The treatment of agitation in drug- and alcohol-using emergency patients is understudied. METHOD:We performed a retrospective chart review of 105 agitated emergency department patients who received either intramuscular (IM) haloperidol or IM olanzapine, comparing prescribing patterns, level of agitation, response to treatment and side effects in patients positive for drugs or alcohol [D/A(+)] and patients negative for drugs or alcohol [(D/A(-)]. RESULTS:The haloperidol-benzodiazepine combination was the most frequently prescribed treatment in both groups, although alcohol(+) status biased clinicians toward using haloperidol alone. Overall, D/A(+) and D/A(-) patients responded to the initial intervention at similar rates, although D/A(+) patients were rated as more agitated and had more posttreatment sedation than D/A(-) patients. In D/A(+) patients, haloperidol+benzodiazepine and IM olanzapine performed better than haloperidol alone. There were no serious adverse events with any treatment. CONCLUSION:Findings support the generalization of efficacy data from more rarified agitated samples to populations with high rates of substance use and highlight the need for prospective, inclusive, randomized trials comparing the commonly used haloperidol-benzodiazepine combination with newer injectable antipsychotics.

journal_name

Gen Hosp Psychiatry

authors

MacDonald K,Wilson MP,Minassian A,Vilke GM,Perez R,Cobb P,Tallian K,Becker O,Feifel D

doi

10.1016/j.genhosppsych.2010.04.005

subject

Has Abstract

pub_date

2010-07-01 00:00:00

pages

443-5

issue

4

eissn

0163-8343

issn

1873-7714

pii

S0163-8343(10)00095-2

journal_volume

32

pub_type

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