Abstract：
:The expression of CD30 is restricted to cells of the immune system and strictly regulated under physiological conditions. However, active immune cells express CD30 and soluble CD30 (sCD30) is released. Several investigators reported the relevance for sCD30 as a predictive marker for allograft rejection following organ transplantation. We investigated the role of sCD30 in 30 patients undergoing allogeneic hematopoietic stem cell transplantation for hematologic malignancies. sCD30 was measured at different time points until day 120 post transplant. There was a great variety of sCD30 at baseline before transplantation. At time of engraftment, patients who developed no or only mild signs of acute graft-versus-host-disease (aGvHD) until day 120 had significant lower levels of sCD30 than patients who developed severe aGvHD. Moreover, all patients with aGvHD degrees III/IV showed a clear increase in sCD30 levels before clinical signs of aGvHD. Levels of sCD30 decreased if patients responded to aGvHD-therapy. We suggest a potential role of sCD30 serum levels in prediction of aGvHD following allogeneic stem cell transplantation.
journal_name
Transpl Immunoljournal_title
Transplant immunologyauthors
Hübel K,Cremer B,Heuser E,von Strandmann EP,Hallek M,Hansen HPdoi
10.1016/j.trim.2010.07.001subject
Has Abstractpub_date
2010-08-01 00:00:00pages
215-9issue
4eissn
0966-3274issn
1878-5492pii
S0966-3274(10)00087-0journal_volume
23pub_type
杂志文章abstract：:Chronic allograft dysfunction is one of the most important reasons for late graft loss after renal transplantation. Its etiology is multifactorial and combines immunological as well as non-immunological mechanisms. It is known from large registry data that MHC mismatches are inversely correlated to long term allograft...
journal_title：Transplant immunology
pub_type： 杂志文章
doi：10.1016/j.trim.2009.09.007
更新日期：2010-02-01 00:00:00
abstract：:Rabbit anti-rat thymoglobulin (rATG) administered to donors with brain death (BD) may improve organs quality. We explored the effects of rATG administered to BD donors in the histology of heart, lungs and small bowel in a rat experimental model. Animals were randomly assigned to 3 groups: V (n=5) no BD, 2h ventilation...
journal_title：Transplant immunology
pub_type： 杂志文章
doi：10.1016/j.trim.2013.04.002
更新日期：2013-06-01 00:00:00
abstract：:Induction of donor-specific hyporesponsiveness would minimize the need for intensive immunosuppression in the clinical setting of graft rejection and dendritic cells (DCs) might be useful tools for this purpose. Besides their ability to induce immunogenic T-cell responses, these antigen presenting cells can lead to T-...
journal_title：Transplant immunology
pub_type： 杂志文章
doi：10.1016/j.trim.2006.03.001
更新日期：2006-06-01 00:00:00
abstract：:Calcineurin a calmodulin-dependent phosphatase plays a critical role in calcium-dependent activation of T-lymphocytes and is the major target for the inhibitory actions of the immunosuppressive drugs Tacrolimus (FK506) and Cyclosporin A (CsA). Calcineurin is a dimeric protein consisting of distinct A (catalytic) and B...
journal_title：Transplant immunology
pub_type： 杂志文章
doi：10.1016/s0966-3274(00)00020-4
更新日期：2000-06-01 00:00:00
abstract：:Persistent rejection in the face of treatment and multiple episodes of rejection are associated with the development of chronic rejection and graft loss in solid organ transplantation. The factors that create an environment for rejection that persists in the face of treatment are as yet not understood. The objective o...
journal_title：Transplant immunology
pub_type： 杂志文章
doi：10.1016/j.trim.2004.11.001
更新日期：2005-03-01 00:00:00
abstract：:RNA interference (RNAi) has recently emerged as an efficient method to silence gene expression in mammalian cells by transfection of small interfering RNAs (siRNAs). The Janus kinase 3 (JAK3) is also pertinent to the development of a new immuno-suppressant. This study aimed to inhibit JAK3 expression using RNAi to det...
journal_title：Transplant immunology
pub_type： 杂志文章
doi：10.1016/j.trim.2009.02.004
更新日期：2009-05-01 00:00:00
abstract：:Adoptive cell therapies involving cell manipulation to achieve tolerance are increasingly being studied in animal models and in human trials. We have demonstrated that the specific removal of allo-stimulated dividing cells (or "pruning") promotes long-term allograft survival across a major MHC mismatch in transplant m...
journal_title：Transplant immunology
pub_type： 杂志文章
doi：10.1016/j.trim.2014.03.002
更新日期：2014-05-01 00:00:00
abstract：:Organ transplantation is an effective way to treat many end-stage diseases. In order to overcome post-transplant rejection, immunosuppressive agents have been widely used, but the long-term survival of transplanted organs still has not been achieved in the clinic. For decades, tolerance is the "holy grail" that transp...
journal_title：Transplant immunology
pub_type： 杂志文章,评审
doi：10.1016/j.trim.2019.101250
更新日期：2020-02-01 00:00:00
abstract：:Autoimmune diseases are the result of an interplay between predisposing genes and triggering environmental factors, leading to loss of self-tolerance and an immune-mediated destruction of autologous cells and/or tissues. Genes in the HLA complex are among the strongest predisposing genetic factors. The HLA complex gen...
journal_title：Transplant immunology
pub_type： 杂志文章,评审
doi：10.1016/j.trim.2005.03.021
更新日期：2005-08-01 00:00:00
abstract：AIM:To identify the frequency of exposure to sensitizing factors and evaluate the risk ascribable to each sensitizing factor generating HLAabs measured by Luminex. METHODS:This is a retrospective cohort study that included 502 transplanted patients and 51 patients on the waiting list for a deceased donor graft. Patien...
journal_title：Transplant immunology
pub_type： 杂志文章
doi：10.1016/j.trim.2016.08.003
更新日期：2016-09-01 00:00:00
abstract：:Models of severe combined immuno-deficient (SCID) mice reconstituted with a competent human immune system represent a valuable tool for the study of human immune responses in vivo. Reconstitution with human cells can be achieved using large numbers of peripheral blood lymphocytes, but levels of engraftment are poor an...
journal_title：Transplant immunology
pub_type： 杂志文章
doi：10.1016/j.trim.2005.07.002
更新日期：2005-12-01 00:00:00
abstract：:Rituximab is frequently used in the setting of ABO-incompatible renal transplants, and highly sensitized patients. Its interference with B-cell flow cytometric crossmatch (B-FCXM) is well known. However, its effect on the T-cell flow cytometric crossmatch (T-FCXM) has not been described. We aimed to evaluate the effec...
journal_title：Transplant immunology
pub_type： 杂志文章
doi：10.1016/j.trim.2020.101360
更新日期：2021-02-01 00:00:00
abstract：:This study provides data on HLA-A, -B, and -DRB1 frequencies among 861 end-stage renal disease (ESRD) patients from Croatia and estimates the benefit of the kidney exchange program by comparing HLA distribution and assessing HLA mismatches (MMs) within a group of ESRD patients who received kidney grafts from 707 cadav...
journal_title：Transplant immunology
pub_type： 杂志文章
doi：10.1016/j.trim.2020.101318
更新日期：2020-10-01 00:00:00
abstract：BACKGROUND:Acute rejection is a major obstacle in patients with prolonged ischemia in deceased-donor renal transplantation. Chemokines and their receptors play a critical role in leukocyte trafficking, resulting in allograft rejection; therefore, the role of chemokine receptor CXCR3 in acute rejection induced by prolon...
journal_title：Transplant immunology
pub_type： 杂志文章
doi：10.1016/j.trim.2015.08.001
更新日期：2015-10-01 00:00:00
abstract：:Alloreactive T-cell responses directed against minor histocompatibility (H) antigens, which arise from diverse genetic disparities between donor and recipient outside the MHC, are an important cause of rejection of MHC-matched grafts. Because clinically significant responses appear to be directed at only a few antigen...
journal_title：Transplant immunology
pub_type： 杂志文章
doi：10.1016/j.trim.2013.10.005
更新日期：2013-12-01 00:00:00
abstract：BACKGROUND:Graft-versus-host disease is one of the major complications after allogeneic bone marrow transplantation, but it is not easy to anticipate the onset. Cytokines released by type 1 T helper cells are thought to play a pivotal role in acute graft-versus-host disease aGVHD. The ability to predict the likely occu...
journal_title：Transplant immunology
pub_type： 杂志文章
doi：10.1016/j.trim.2005.10.002
更新日期：2006-01-01 00:00:00
abstract：:TIRC7 delivers essential signals during immune activation as antibodies targeting TIRC7 inhibit lymphocyte proliferation and Th1 cytokine expression in vitro and prolonged kidney and heart allograft survival in vivo. Immunohistochemical analysis of biopsy specimens from human renal allografts undergoing rejection desp...
journal_title：Transplant immunology
pub_type： 杂志文章
doi：10.1016/j.trim.2006.09.027
更新日期：2006-11-01 00:00:00
abstract：:Graft-vs.-host disease (GVHD) caused by immunologic activated cells remains a real problem in human allogeneic hematopoetic stem cell transplantation. Mesenchymal stem cells (MSCs) play some important roles on immunomodulatory. We developed a parent-into-F1 model of acute GVHD to evaluate the mechanisms involved in im...
journal_title：Transplant immunology
pub_type： 杂志文章
doi：10.1016/j.trim.2009.08.002
更新日期：2009-12-01 00:00:00
abstract：:Clinical ophthalmologists are highly successful in grafting allogeneic corneas onto healthy eye graft beds--only a small percentage are rejected. By contrast, a high percentage of allografts are rejected when grafted into vascularized or '"high-risk' recipient eyes. The following experiments test the hypothesis that d...
journal_title：Transplant immunology
pub_type： 杂志文章
doi：10.1016/s0966-3274(96)80034-7
更新日期：1996-03-01 00:00:00
abstract：:Dendritic cells (DC) are considered to be the major cell type responsible for induction of primary immune responses. While they have been shown to play a critical role in eliciting allosensitization via the direct pathway, there is evidence that maturational and/or activational heterogeneity between DC in different do...
journal_title：Transplant immunology
pub_type： 杂志文章
doi：10.1016/s0966-3274(00)00010-1
更新日期：2000-03-01 00:00:00
abstract：:Allospecific memory T cells are a recognized threat to the maintenance of solid-organ transplants. Limited information exists regarding the development of alloreactive memory T cells when post-transplant immunosuppression is present. The clinical practice of delaying calcineurin inhibitor (CNI) initiation post-transpl...
journal_title：Transplant immunology
pub_type： 杂志文章
doi：10.1016/j.trim.2014.10.001
更新日期：2015-01-01 00:00:00
abstract：BACKGROUND:The transcription factor Forkhead Box P3 (FoxP3) is a marker of regulatory T cells (Tregs) - a subset of T cells known to suppress a wide range of immune responses. These cells are considered to be pivotal for the induction of tolerance to donor antigens in human allografts. We aimed to correlate the number ...
journal_title：Transplant immunology
pub_type： 临床试验,杂志文章
doi：10.1016/j.trim.2013.08.002
更新日期：2013-12-01 00:00:00
abstract：BACKGROUND:Cytomegalovirus (CMV)-specific T-cells are crucial to prevent CMV disease. CMV seropositive recipients transplanted with stem cells from a CMV seronegative allogeneic donor (R+D-) may be at risk for CMV disease due to absence of donor CMV-specific memory T-cells in the graft. METHODS:We analyzed the duratio...
journal_title：Transplant immunology
pub_type： 杂志文章
doi：10.1016/j.trim.2018.04.003
更新日期：2018-08-01 00:00:00
abstract：:Keratinocytes are activated to express MHC class II and ICAM-1 molecules during cutaneous inflammatory reactions. It is controversial how the interaction between these 'nonprofessional' antigen presenting cells (APC) and infiltrating T cells affects the local inflammatory response. To address this issue we analyzed wh...
journal_title：Transplant immunology
pub_type： 杂志文章
doi：10.1016/0966-3274(93)90059-h
更新日期：1993-01-01 00:00:00
abstract：:The induction of antigen-specific T cell tolerance and its maintenance in the periphery are critical for the immune system to prevent autoaggressive immune responses. Our current state of knowledge about the immunoregulatory mechanisms responsible for T cell tolerance in the periphery offers new possibilities for immu...
journal_title：Transplant immunology
pub_type： 杂志文章,评审
doi：10.1016/S0966-3274(03)00057-1
更新日期：2003-07-01 00:00:00
abstract：:HMG-CoA reductase inhibitors, or statins, are effective lipid lowering agents, extensively used in medical practice. Statins have never been shown to be involved in the immune response, although few clinical reports have suggested a better outcome of cardiac transplantation in patients under pravastatin therapy. Major...
journal_title：Transplant immunology
pub_type： 杂志文章,评审
doi：10.1016/s0966-3274(02)00030-8
更新日期：2002-05-01 00:00:00
abstract：BACKGROUND:Results from published studies on the association of donor or recipient IL-6 -174G/C (rs1800795) polymorphism with acute rejection (AR) of renal allograft are conflicting. We performed a meta-analysis to estimate the possible association. METHODS:Studies were identified by searching PUBMED and EMBASE until ...
journal_title：Transplant immunology
pub_type： 杂志文章,meta分析,评审
doi：10.1016/j.trim.2011.10.003
更新日期：2012-01-01 00:00:00
abstract：:There have been several reports that xeno-MHC-restricted T-cells have a cytotoxic function through a direct xenoantigen recognition, but yet no report that they have a helper function. Previously we showed that both xeno-MHC-restricted CD4(+) and CD8(+) T-cells recognized xenoantigens directly in a mouse anti-rat comb...
journal_title：Transplant immunology
pub_type： 杂志文章
doi：10.1016/S0966-3274(02)00158-2
更新日期：2003-04-01 00:00:00
abstract：:Although immunosuppressive therapies have made organ transplantation a common medical procedure worldwide, chronic toxicity is a major issue of long-term treatment. One method to improve such therapies is the application of immunomodulatory agents from parasites, such as Hypoderma lineatum (Diptera: Oestridae). Hypode...
journal_title：Transplant immunology
pub_type： 杂志文章
doi：10.1016/j.trim.2018.09.001
更新日期：2018-12-01 00:00:00
abstract：BACKGROUND:Donor leucocytes (DL) play an important role in rat liver transplant tolerance and their postoperative administration can convert rejection to tolerance. They appear to induce early activation, altered patterns of infiltration and death of recipient alloreactive T cells. The ability of immunosuppressive drug...
journal_title：Transplant immunology
pub_type： 杂志文章
doi：10.1016/j.trim.2004.05.003
更新日期：2004-11-01 00:00:00
