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Dose-dependent response of serum lutein and macular pigment optical density to supplementation with lutein esters.

Abstract：

:We conducted a study to determine the effect of different doses of a lutein supplement on serum lutein concentration and macular pigment optical density (MPOD). Lutein is one of the major components of human macular pigment. Eighty-seven subjects received daily doses of 5, 10, or 20 mg of lutein, or a placebo, over a 140 day period. Serum lutein concentration was determined by HPLC and MPOD by heterochromatic flicker photometry (HFP). Serum lutein responded positively, except in the placebo group, reaching a plateau that, averaged for each dosage group, was linearly dependent on dose. Likewise MPOD, on average, increased at a rate that varied linearly with dose. For subjects deemed more proficient at HFP, approximately 29% of the variability in MPOD response could be attributed to a linear dependence on the fractional change in serum lutein concentration. We did not detect any significant influence of age on serum lutein uptake or MPOD response.

journal_name

Arch Biochem Biophys

journal_title

Archives of biochemistry and biophysics

authors

Bone RA,Landrum JT

doi

10.1016/j.abb.2010.06.019

subject

Has Abstract

pub_date

2010-12-01 00:00:00

pages

50-5

issue

1

eissn

0003-9861

issn

1096-0384

pii

S0003-9861(10)00238-9

journal_volume

504

pub_type

临床试验,杂志文章

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