Abstract:
BACKGROUND:Low-density gas mixtures and oxygen (O₂) supplementation are known to improve physical performance and ventilatory adaptation during incremental maximal exercise in COPD. We investigated whether their combined use during intense physical training is also effective in ameliorating exercise tolerance in patients affected by moderate to severe COPD. METHODS:Thirty patients (FEV₁ < 60% of predicted) underwent a 2-month rehabilitation program. Leg-cycle training was conducted thrice weekly at 80% of the initial peak work rate for at least 20 min breathing room air, a 60% helium and 40% O₂ mixture, or supplemental O₂ (40%) inhaled from a Douglas bag. The study was randomized with a double-blind design. Before and at the end of the training period the subjects were tested for spirometry, arterial gas tension, diffusing lung capacity for CO, and incremental and constant work rate exercise test on a cycle ergometer. RESULTS:Physical training resulted in a significant improvement in peak oxygen consumption and power output (P < .01 for both) and in exercise endurance time (P < .05) independently of the kind of inhaled gas during the rehabilitation program (P ≥ .42). No changes were observed in lung function tests or gas exchange. CONCLUSIONS:We concluded that the use of a low-density gas mixture or O₂ supplementation does not contribute to improved exercise performance in patients with moderate to severe COPD without a significantly decreased diffusion lung capacity for CO who are able to tolerate intense physical training.
journal_name
Chestjournal_title
Chestauthors
Scorsone D,Bartolini S,Saporiti R,Braido F,Baroffio M,Pellegrino R,Brusasco V,Crimi Edoi
10.1378/chest.10-0120subject
Has Abstractpub_date
2010-11-01 00:00:00pages
1133-9issue
5eissn
0012-3692issn
1931-3543pii
S0012-3692(10)60590-9journal_volume
138pub_type
杂志文章,随机对照试验相关文献
CHEST文献大全abstract:OBJECTIVES:To describe the anatomy and neurophysiology of the cough reflex. METHODS:A review of the literature was carried out using PubMed and the ISI Web of Knowledge from 1951 to 2004. Most of the referenced studies were carried out in animals CONCLUSIONS:Studies carried out in animals provide suggestive but incon...
journal_title:Chest
pub_type: 杂志文章,评审
doi:10.1378/chest.129.1_suppl.33S
更新日期:2006-01-01 00:00:00
abstract:STUDY OBJECTIVES:To investigate the roles of human alpha-defensin (HAD), human beta-defensin (HBD)-1, and HBD-2, novel antimicrobial peptides, in patients with Mycobacterium avium-intracellulare infection (MAI). PATIENTS:The study included 25 patients (10 men) with MAI who visited our hospital between June 1998 and Au...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.119.4.1131
更新日期:2001-04-01 00:00:00
abstract:OBJECTIVE:The epigenetic basis for human asthma is not well studied, particularly among older adults. This study investigated the methylation profiles in sputum DNA among older adults with asthma, using a population of smokers. METHODS:This was a cross-sectional study using the Lovelace Smokers Cohort, a population of...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.11-2519
更新日期:2012-08-01 00:00:00
abstract:BACKGROUND:To develop an evidence-based approach to follow-up of patients after curative intent therapy for lung cancer. METHODS:Guidelines on lung cancer diagnosis and management published between 2002 and December 2005 were identified by a systematic review of the literature, and supplemental material appropriate to...
journal_title:Chest
pub_type: 杂志文章,实务指引
doi:10.1378/chest.07-1390
更新日期:2007-09-01 00:00:00
abstract::The timing of surgical treatment of empyema remains controversial. Traditionally, thoracotomy is performed either within three weeks of diagnosis or delayed until presumed pleurodesis occurs. Often, these patients are moribund and the duration of illness impossible to determine. We report our surgical results in seven...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.90.4.511
更新日期:1986-10-01 00:00:00
abstract::Lung scans with technetium sulfur colloid were performed in ten patients with life-threatening hemoptysis and nondiagnostic chest roentgenograms. Localized deposition of radionuclide was demonstrated in five of the six patients who were studied during active bleeding. These abnormalities were confirmed bronchoscopical...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.86.2.208
更新日期:1984-08-01 00:00:00
abstract:STUDY OBJECTIVES:Pulmonary rehabilitation (PR) that includes exercise training can improve exercise tolerance and quality of life for patients with COPD. However, the degree of benefit from PR is variable. We hypothesized that the exercise response to PR varies depending on the initial factors that limit exercise. DES...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.127.1.110
更新日期:2005-01-01 00:00:00
abstract::Thirty-three patients with T3,N2,M0 or T4,N2,M0, non-small-cell lung cancer (NSCLC) took part in a phase 2 study in an attempt to evaluate the feasability of neoadjuvant chemotherapy followed by surgery and thoracic radiotherapy. Chemotherapy consisted of daily administration of the following treatment: etoposide, 100...
journal_title:Chest
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1378/chest.106.5.1451
更新日期:1994-11-01 00:00:00
abstract::This study describes an unusual patient with X-linked Alport syndrome (XLAS) in whom diffuse alveolar hemorrhage (DAH) developed as a complication of alemtuzumab therapy following renal transplantation. A 26-year-old man with XLAS underwent retransplantation with a cadaveric renal allograft. He received alemtuzumab th...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.07-2354
更新日期:2008-06-01 00:00:00
abstract:BACKGROUND:The World Trade Center (WTC) collapse on September 11, 2001, produced airflow obstruction in a majority of firefighters receiving subspecialty pulmonary evaluation (SPE) within 6.5 years post-September 11, 2001. METHODS:In a cohort of 801 never smokers with normal pre-September 11, 2001, FEV1, we correlated...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.11-1202
更新日期:2012-08-01 00:00:00
abstract:BACKGROUND:In response to the Agency for Healthcare Research and Quality statement questioning the usefulness of “screening spirometry,” the National Heart, Lung, and Blood Institute and the COPD Foundation held a consensus conference in June 2008 to establish a procedure to detect cases of COPD in the general populati...
journal_title:Chest
pub_type: 杂志文章,随机对照试验
doi:10.1378/chest.11-1474
更新日期:2012-08-01 00:00:00
abstract::Advanced or second-degree atrioventricular (AV) heart block pre-existing or developing during atrial pacing (AP) at low heart rates of smaller than 130 per minute, limits the value of AP to stress the left ventricle. When Wenkebach type AV block is present, the heart rate can be increased by administration of atropine...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.67.5.540
更新日期:1975-05-01 00:00:00
abstract::To examine whether changes in respiratory chemosensitivity during the menstrual cycle are related to worsening of airway functions, hypoxic and hypercapnic ventilatory and P0.1 responses, airway function, and serum progesterone levels were studied in 11 female asthmatic patients in both the follicular and luteal phase...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.104.6.1718
更新日期:1993-12-01 00:00:00
abstract:OBJECTIVES:To compare the rapid shallow breathing index (RSBI) under different ventilatory support settings prior to extubation trials. DESIGN:Prospective study. SETTING:Cardiac surgery unit at a university hospital. PATIENTS:A total of 33 coronary artery bypass grafting patients ready for extubation. INTERVENTIONS...
journal_title:Chest
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1378/chest.121.2.475
更新日期:2002-02-01 00:00:00
abstract:BACKGROUND:Morbid obesity produces a variety of ECG alterations, including leftward shifts of the P-wave, QRS, and T-wave axes; disproportionately high frequencies of low QRS voltage; left ventricular hypertrophy and left atrial abnormality; and a high frequency of T-wave flattening in the inferior and lateral leads. T...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.119.2.507
更新日期:2001-02-01 00:00:00
abstract::Impedance measurement of the respiratory system by forced oscillations is a sensitive and accurate method to detect mechanical parameters, especially in normal subjects. The effects of inhalation of 0.2 mg of fenoterol and 0.02 mg of ipratropium bromide on the impedance of the respiratory system was studied in 20 heal...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.97.5.1137
更新日期:1990-05-01 00:00:00
abstract::The eosinophil count and concentrations of eosinophil cationic protein (ECP) were measured in bronchoalveolar lavage fluid (BALF) from patients with idiopathic pulmonary fibrosis (IPF), pulmonary fibrosis associated with a collagen vascular disorder (PF-CVD), sarcoidosis, and healthy controls. The patients with IPF an...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.108.1.48
更新日期:1995-07-01 00:00:00
abstract::A 35-year-old male homosexual, a former intravenous drug abuser, was found to be human immunodeficiency virus (HIV) positive in 1984. He developed AIDS in 1987 and began treatment with zidovudine in 1989. One year later he developed left apical pleural blebs, a pneumothorax and an exudative pleural effusion. A maligna...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.103.4.1268
更新日期:1993-04-01 00:00:00
abstract:BACKGROUND:Pathogenic bacteria colonize the airways of 30% to 40% of patients with COPD and cause approximately 50% of exacerbations. New strains of nontypeable Haemophilus influenzae (NTHI) and Moraxella catarrhalis are associated with exacerbations. Antimicrobial protein/peptides (AMPs) play important roles in innate...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.10-2760
更新日期:2011-09-01 00:00:00
abstract::Nineteen patients were treated at the Los Angeles County Harbor/UCLA Medical Center between 1971 and 1986 for tuberculosis of the spine. Fourteen were immigrants, a high-risk group. A high index of suspicion is required for Pott's disease, which occurs in fewer than 1 percent of patients with tuberculosis, often prese...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.95.1.145
更新日期:1989-01-01 00:00:00
abstract:PURPOSES:To determine the diagnostic accuracy of ultrasound in the diagnosis of pneumothorax in patients with COPD with particular regard to false-positive diagnoses. MATERIALS AND METHODS:This was a single-center, prospective, blinded study. Nine patients with pneumothorax, 9 patients with cystic fibrosis, 17 patient...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.129.3.545
更新日期:2006-03-01 00:00:00
abstract::The role of infection in exacerbations of COPD remains controversial and incompletely understood. Although some investigators believe that bacteria are not important for patients with exacerbation, we disagree and believe that patients with at least two of the three cardinal symptoms of exacerbation should receive ant...
journal_title:Chest
pub_type: 评论,杂志文章,评审
doi:10.1378/chest.118.1.204
更新日期:2000-07-01 00:00:00
abstract::The criteria of the American Thoracic Society (ATS) for determining the end-point of the forced vital capacity (FVC) maneuver were compared with an algorithm employed by a computer system (Hewlett-Packard), which yields a later end-point. The 150 subjects tested were divided into five groups of 30 on the basis of the ...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.91.1.100
更新日期:1987-01-01 00:00:00
abstract::We describe a case of unsuspected infrahepatic interruption of the inferior vena cava with hemiazygos continuation in a 67-year-old man presenting with chest pain and evidence of mitral regurgitation. He had no persistent superior vena cava, with the hemiazygos draining directly into the right superior vena cava. Poly...
journal_title:Chest
pub_type: 杂志文章,评审
doi:10.1378/chest.106.5.1626
更新日期:1994-11-01 00:00:00
abstract:BACKGROUND:Inspiratory muscle weakness and abnormalities in breathing pattern and in respiratory drive have been reported in patients with multisystem disorders. In patients with systemic lupus erythematosus (SLE), data on respiratory muscle strength and control of breathing are scarce. METHODS:We studied a subset of ...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.108.3.759
更新日期:1995-09-01 00:00:00
abstract:STUDY OBJECTIVES:This multicenter study was undertaken to characterize the population of ventilator-dependent patients admitted to long-term care hospitals (LTCHs) with weaning programs, and to report treatments, complications, weaning outcome, discharge disposition, and survival in these patients. DESIGN:Observationa...
journal_title:Chest
pub_type: 杂志文章,多中心研究
doi:10.1378/chest.06-1081
更新日期:2007-01-01 00:00:00
abstract:BACKGROUND:COPD is a heterogeneous disease characterized by airflow obstruction and diagnosed by lung function. CT imaging is emerging as an important, noninvasive tool in phenotyping COPD. However, the use of CT imaging in defining the disease heterogeneity above lung function is not fully known. METHODS:Seventy-five...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.10-3007
更新日期:2011-09-01 00:00:00
abstract::We compared the efficacy of corticosteroid therapy initiated as an alternate-day regimen to that of a four-times-daily regimen in patients with stable chronic obstructive pulmonary disease. In this double-blind study, 44 patients with moderate to severe COPD (mean FEV1 740 +/- 310 ml) were hospitalized and randomly al...
journal_title:Chest
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1378/chest.86.4.524
更新日期:1984-10-01 00:00:00
abstract::Imaging and Doppler echocardiography permits assessment of right ventricular size and systolic function and of pulmonary arterial pressures, and it may facilitate detection of thromboemboli within the heart or pulmonary artery. In patients with acute pulmonary embolism of sufficient severity to appreciably increase ri...
journal_title:Chest
pub_type: 杂志文章,评审
doi:10.1378/chest.101.4_supplement.151s
更新日期:1992-04-01 00:00:00
abstract:BACKGROUND:The study documented the emergence of new forms of resistant bacilli (totally drug-resistant [TDR] or super extensively drug-resistant [XDR] tuberculosis [TB] strains) among patients with multidrug-resistant TB (MDR-TB). METHODS:Susceptibility testing against first- and second-line drugs was performed on is...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.08-2427
更新日期:2009-08-01 00:00:00