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Peripheral oxytocin treatment modulates central dopamine transmission in the mouse limbic structures.

Abstract：

:The effects of subcutaneous (s.c.) oxytocin treatment have been investigated on various parameters of dopaminergic neurotransmission in basal forebrain structures (nucleus olfactorius posterior + nucleus accumbens + septum) of the mouse. Acute oxytocin treatment failed to influence dopamine utilization in the basal forebrain. Following chronic injections of oxytocin (0.2 mg/kg) for 8 8 days, the neuropeptide decreased dopamine utilization. Neither in vivo nor in vitro oxytocin treatment was capable of influencing the in vitro uptake of [(3)H]dopamine in basal forebrain slices. The spontaneous release of [(3)H]dopamine (in the presence of 4.2 mM K(+)) from basal forebrain tissue slices was not affected by in vitro or acute or chronic in vivo oxytocin treatment. The stimulated release of [(3)H]dopamine (in the presence of 30 mM K(+)) was significantly inhibited by chronic in vivo oxytocin administration. Chronic oxytocin treatment decreased the B(max) value of [(3)H]spiroperidol binding in the basal forebrain. The dissociation constant (K(d)) of [(3)H]spiroperidol binding was not influenced by oxytocin. The data indicate that peripheral oxytocin treatment is capable of modifying dopaminergic neurotransmission in mouse basal forebrain regions.

journal_name

Neurochem Int

journal_title

Neurochemistry international

authors

Kovács GL,Faludi M,Falkay G,Telegdy G

doi

10.1016/0197-0186(86)90138-5

subject

Has Abstract

pub_date

1986-01-01 00:00:00

pages

481-5

issue

4

eissn

0197-0186

issn

1872-9754

pii

0197-0186(86)90138-5

journal_volume

9

pub_type

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