Tissue-engineered fascia from vaginal fibroblasts for patients needing reconstructive pelvic surgery.

Abstract:

INTRODUCTION AND HYPOTHESIS:Mesh-augmented reconstructive surgery for pelvic organ prolapse (POP) does not meet clinical expectations. A tissue-engineered fascia equivalent needs to be developed. METHODS:Human vaginal fibroblasts (HVFs) from 10 patients were characterized in vitro. Eligible HVFs and a biodegradable scaffold were used to fabricate a fascia equivalent, which was then transplanted in vivo. RESULTS:The cultured HVFs were divided into high (n = 6) or low (n = 4) collagen I/III ratio groups. Cells of the high-ratio group exhibited significantly higher proliferation potential than those of the low-ratio group (P < 0.05). A fascia equivalent was made with HVFs of the high-ratio group. In the subsequent animal study, a well-organized neo-fascia formation containing HVFs could be traced up to 12 weeks after transplantation. CONCLUSIONS:Our results suggest that a tissue-engineered fascia could be developed from HVFs in vitro and in vivo, which might be an effective treatment for POP in the future.

journal_name

Int Urogynecol J

authors

Hung MJ,Wen MC,Hung CN,Ho ES,Chen GD,Yang VC

doi

10.1007/s00192-010-1168-3

subject

Has Abstract

pub_date

2010-09-01 00:00:00

pages

1085-93

issue

9

eissn

0937-3462

issn

1433-3023

journal_volume

21

pub_type

杂志文章
  • Joint report on the terminology for surgical procedures to treat stress urinary incontinence in women.

    abstract:INTRODUCTION AND HYPOTHESIS:Standardized terminology for surgical procedures commonly performed to treat stress urinary incontinence in women is needed to facilitate research, clinical care, and teaching in female pelvic medicine and reconstructive surgery. METHODS:This report combines the input of members of the Amer...

    journal_title:International urogynecology journal

    pub_type: 杂志文章

    doi:10.1007/s00192-020-04237-0

    authors: Developed by the Joint Writing Group of the American Urogynecologic Society and the International Urogynecological Association.

    更新日期:2020-03-01 00:00:00

  • Mesh retraction correlates with vaginal pain and overactive bladder symptoms after anterior vaginal mesh repair.

    abstract:INTRODUCTION AND HYPOTHESIS:The aim of the present study was to determine possible correlations between mesh retraction after anterior vaginal mesh repair and de novo stress urinary incontinence (SUI), overactive bladder (OAB), and vaginal pain symptoms. METHODS:One hundred and three women with symptomatic prolapse of...

    journal_title:International urogynecology journal

    pub_type: 杂志文章

    doi:10.1007/s00192-013-2131-x

    authors: Rogowski A,Bienkowski P,Tosiak A,Jerzak M,Mierzejewski P,Baranowski W

    更新日期:2013-12-01 00:00:00

  • Anxiety and depression associated with incontinence in middle-aged women: a large Norwegian cross-sectional study.

    abstract:INTRODUCTION AND HYPOTHESIS:Several studies have indicated depression and anxiety to be associated with urinary incontinence (UI), however, the strength of the associations varies widely. The objective of this study was to determine these associations in a large survey. METHODS:In a cross-sectional population-based su...

    journal_title:International urogynecology journal

    pub_type: 杂志文章

    doi:10.1007/s00192-011-1564-3

    authors: Felde G,Bjelland I,Hunskaar S

    更新日期:2012-03-01 00:00:00

  • Validation of the Patient Global Impression of Improvement (PGI-I) for urogenital prolapse.

    abstract:INTRODUCTION AND HYPOTHESIS:Currently, there is no global outcome assessment index in prolapse research. Patient Global Impression of Improvement (PGI-I) has only been validated in incontinence. Our aim was to validate its use following prolapse surgery. METHODS:Women with prolapse were recruited from waiting lists an...

    journal_title:International urogynecology journal

    pub_type: 杂志文章

    doi:10.1007/s00192-009-1069-5

    authors: Srikrishna S,Robinson D,Cardozo L

    更新日期:2010-05-01 00:00:00

  • Effects of mode of delivery on sexual functions of parturients in Nigeria: a prospective cohort study.

    abstract:INTRODUCTION AND HYPOTHESIS:Female sexual function disorders (FSFDs) have received less attention than male sexual function disorders, despite being more prevalent. Furthermore, most available literature is on the effect of vaginal delivery (VD) on sexual function, and studies on the effect of caesarean section (CS) ar...

    journal_title:International urogynecology journal

    pub_type: 杂志文章

    doi:10.1007/s00192-020-04541-9

    authors: Ugwu EO,Dim CC,Eleje GU

    更新日期:2020-10-10 00:00:00

  • High uterosacral vault suspension vs Sacrocolpopexy for treating apical defects: a randomized controlled trial with twelve months follow-up.

    abstract:INTRODUCTION AND HYPOTHESIS:The high uterosacral vault suspension (HUVS) is a vaginal approach for treating apical prolapse that provides shorter operative and recovery times and is associated with lower morbidity rates. Success rates reported for this technique are comparable with the abdominal sacrocolpopexy (SCP); h...

    journal_title:International urogynecology journal

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s00192-015-2666-0

    authors: Rondini C,Braun H,Alvarez J,Urzúa MJ,Villegas R,Wenzel C,Descouvieres C

    更新日期:2015-08-01 00:00:00

  • Large solitary paravaginal hydatid cyst: a rare cause of urethral injury.

    abstract::Hydatid cyst is a parasitic infectious disease caused by Echinococcus granulosus. Although the most common site for this parasite is liver, it can be seen in almost all organs. Extrahepatic localization is reported in 14-19% of all cases of abdominal hydatid disease. We report the case of a large echinococcal cyst loc...

    journal_title:International urogynecology journal

    pub_type: 杂志文章

    doi:10.1007/s00192-010-1201-6

    authors: Ozcan S,Karayalçin R,Ozyer S

    更新日期:2010-12-01 00:00:00

  • Surgery for stress urinary incontinence in Finland 1987-2009.

    abstract:INTRODUCTION AND HYPOTHESIS:To estimate the incidence rates of stress urinary incontinence (SUI) surgery among Finnish women from 1987 to 2009 by age, and to evaluate the trends in SUI surgery. METHODS:We conducted a retrospective register-based study. All SUI procedures on adult women over age 18 years in Finland wer...

    journal_title:International urogynecology journal

    pub_type: 杂志文章

    doi:10.1007/s00192-015-2926-z

    authors: Kurkijärvi K,Aaltonen R,Gissler M,Mäkinen J

    更新日期:2016-07-01 00:00:00

  • The use of transvaginal synthetic mesh for anterior vaginal wall prolapse repair: a randomized controlled trial.

    abstract:INTRODUCTION AND HYPOTHESIS:The aim of the study was to compare the efficacy and safety of transvaginal trocar-guided polypropylene mesh insertion with traditional colporrhaphy for treatment of anterior vaginal wall prolapse. METHODS:This is a randomized controlled trial in which women with advanced anterior vaginal w...

    journal_title:International urogynecology journal

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s00192-013-2092-0

    authors: Delroy CA,Castro Rde A,Dias MM,Feldner PC Jr,Bortolini MA,Girão MJ,Sartori MG

    更新日期:2013-11-01 00:00:00

  • Apical suspension is underutilized for repair of stage IV pelvic organ prolapse: an analysis of national practice patterns in the United States.

    abstract:INTRODUCTION AND HYPOTHESIS:Support of the vaginal apex is paramount for a durable repair of pelvic organ prolapse (POP). Our aim is to assess national utilization of apical suspension procedures for the surgical treatment of complete POP. We hypothesize that there might be a high rate of apical suspension with advance...

    journal_title:International urogynecology journal

    pub_type: 杂志文章

    doi:10.1007/s00192-020-04342-0

    authors: Slopnick EA,Chapman GC,Roberts K,Sheyn DD,El-Nashar S,Mahajan ST

    更新日期:2020-06-08 00:00:00

  • Long-term effect of thermoablative fractional CO2 laser treatment as a novel approach to urinary incontinence management in women with genitourinary syndrome of menopause.

    abstract:INTRODUCTION AND HYPOTHESIS:The aim of this study was to evaluate the long-term effect of thermoablative fractional CO2 laser (TACO2L) as an alternative treatment for early stages of stress urinary incontinence (SUI) in postmenopausal women with genitourinary syndrome of menopause. METHODS:A total of 161 postmenopausa...

    journal_title:International urogynecology journal

    pub_type: 杂志文章

    doi:10.1007/s00192-017-3352-1

    authors: González Isaza P,Jaguszewska K,Cardona JL,Lukaszuk M

    更新日期:2018-02-01 00:00:00

  • Partially absorbable mesh or native tissue repair for pelvic organ prolapse: a randomized controlled trial.

    abstract:INTRODUCTION AND HYPOTHESIS:The objective was to compare medium-term efficacy and safety of a partially absorbable mesh kit and native tissue repair in pelvic organ prolapse (POP). MATERIALS AND METHODS:Women with primary POP stage ≥ II were randomized to transvaginal trocar-guided partially absorbable mesh (81 women)...

    journal_title:International urogynecology journal

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1007/s00192-018-3757-5

    authors: Steures P,Milani AL,van Rumpt-van de Geest DA,Kluivers KB,Withagen MIJ

    更新日期:2019-04-01 00:00:00

  • Effects of soy isoflavones on the uterus and urethra of ovariectomized rats.

    abstract:OBJECTIVE:To evaluate the effect of soy isoflavone extract (SIE) on the uterus and urethra of castrated female rats. METHODS:Ovariectomized adult virgin Wistar rats (n = 45) received, for 30 days: placebo (GI); SIE from day 5 of castration (GII); or day 28 of castration (GIII). A standardized SIE was administered by g...

    journal_title:International urogynecology journal

    pub_type: 杂志文章

    doi:10.1007/s00192-009-0995-6

    authors: Santos ET,Sampaio MD,Cecon PR,Simões Mde J,Sartori MG,Girão MJ

    更新日期:2010-01-01 00:00:00

  • A new validated score for detecting patient-reported success on postoperative ICIQ-SF: a novel two-stage analysis from two large RCT cohorts.

    abstract:INTRODUCTION AND HYPOTHESIS:The Patient Global Impression of Improvement (PGI-I) and International Consultation of Incontinence Questionnaire - Short Form (ICIQ-SF) are validated instruments for the assessment of patient reported outcome measures (PROM) following treatment of stress urinary incontinence (SUI). However,...

    journal_title:International urogynecology journal

    pub_type: 杂志文章

    doi:10.1007/s00192-016-3070-0

    authors: Karmakar D,Mostafa A,Abdel-Fattah M

    更新日期:2017-01-01 00:00:00

  • The experience of genitourinary syndrome of menopause (GSM) among Thai postmenopausal women: the non-reporting issue.

    abstract::Genitourinary syndrome of menopause (GSM) is common among postmenopausal women, but, in general, not all of the patients seek medical advice as this sensitive issue can cause them embarrassment. OBJECTIVES:To explore the prevalence of GSM among Thai postmenopausal women and their disclosure of and attitude towards GS...

    journal_title:International urogynecology journal

    pub_type: 杂志文章

    doi:10.1007/s00192-019-03991-0

    authors: Srisukho S,Pantasri T,Piyamongkol W,Phongnarisorn C,Morakote N

    更新日期:2019-11-01 00:00:00

  • Simple and effective: transvaginal vesico-vaginal fistula repair with a modified Latzko technique.

    abstract:INTRODUCTION AND HYPOTHESIS:The incidence of vesico-vaginal fistulas after hysterectomies for benign indications in developed countries is less than one percent. The objective of this video is to demonstrate an easy-to-follow, step-by-step approach to repairing a small, uncomplicated vesico-vaginal fistula transvaginal...

    journal_title:International urogynecology journal

    pub_type: 杂志文章

    doi:10.1007/s00192-017-3471-8

    authors: Cardenas-Trowers O,Heusinkveld J,Hatch K

    更新日期:2018-05-01 00:00:00

  • Enterococcus osteomyelitis secondary to pyelonephritis.

    abstract::We report a case of enterococcus lumbar osteomyelitis that developed after post-operative pyelonephritis. A 78-year-old G2P2 with Stage III uterovaginal prolapse and genuine stress urinary incontinence who underwent laparoscopic-assisted vaginal hysterectomy, high uterosacral ligament suspension, tension-free vaginal ...

    journal_title:International urogynecology journal

    pub_type: 杂志文章

    doi:10.1007/s00192-012-1836-6

    authors: Kow N,Ferzandi TR

    更新日期:2013-04-01 00:00:00

  • The impact of the 2011 US Food and Drug Administration transvaginal mesh communication on utilization of synthetic mid-urethral sling procedures.

    abstract:INTRODUCTION AND HYPOTHESIS:We sought to examine the change in utilization of the midurethral sling (MUS) for the treatment of stress urinary incontinence (SUI) after the 2011 US FDA communication regarding transvaginal mesh. METHODS:This is a retrospective cohort study evaluating surgical utilization of MUS at a mana...

    journal_title:International urogynecology journal

    pub_type: 杂志文章

    doi:10.1007/s00192-020-04597-7

    authors: Berger AA,Tan-Kim J,Menefee SA

    更新日期:2020-11-18 00:00:00

  • Is standardised vaginal sacrospinous ligament fixation a safe teaching procedure for residents?

    abstract:INTRODUCTION AND HYPOTHESIS:Several modifications of sacrospinous ligament fixation (SLF) are described. METHODS:This study presents a standardised SLF technique. Perioperative course and outcome are compared retrospectively after surgery is performed by experienced surgeons or by residents. RESULTS:Two hundred three...

    journal_title:International urogynecology journal

    pub_type: 杂志文章

    doi:10.1007/s00192-010-1341-8

    authors: Sauerwald A,Bruns I,Peveling B,Brunke H,Wolff F

    更新日期:2011-03-01 00:00:00

  • How we perform a posterior sacrospinous ligament fixation by the vaginal route.

    abstract::Posterior sacrospinous fixation (SSF) was first described by Amreich in 1950 and then modified by Richter in 1968. The main difficulty of this technique is the pararectal approach with dissection under visual guidance. Our aim was to teach young surgeons to use this alternative technique for apical suspension and to f...

    journal_title:International urogynecology journal

    pub_type: 杂志文章

    doi:10.1007/s00192-019-04149-8

    authors: Declas E,Giraudet G,Delplanque S,Rubod C,Cosson M

    更新日期:2020-07-01 00:00:00

  • Nocturia × disturbed sleep: a review.

    abstract::In this article, we provide a concise review of the literature on nocturia and its interference with sleep and, consequently, on quality of life. There are few studies addressing the possible influences of nocturia on sleep disruption. Nocturia is a potential contributor to sleep disorders because affected individuals...

    journal_title:International urogynecology journal

    pub_type: 杂志文章,评审

    doi:10.1007/s00192-011-1525-x

    authors: Furtado D,Hachul H,Andersen ML,Castro RA,Girão MB,Tufik S

    更新日期:2012-03-01 00:00:00

  • Biomarkers in the diagnosis and symptom assessment of patients with bladder pain syndrome: a systematic review.

    abstract:INTRODUCTION AND HYPOTHESIS:Bladder pain syndrome (BPS) is a disease of unknown etiology defined as an unpleasant sensation related to the bladder, associated with lower urinary tract symptoms of more than 6 weeks' duration, in the absence of any identifiable causes. Despite its impact on quality of life (QoL) and soci...

    journal_title:International urogynecology journal

    pub_type: 杂志文章

    doi:10.1007/s00192-019-04075-9

    authors: Magalhaes TF,Baracat EC,Doumouchtsis SK,Haddad JM

    更新日期:2019-11-01 00:00:00

  • Deconstructing the genitourinary syndrome of menopause.

    abstract::The concept of genitourinary syndrome of menopause (GSM) was recently introduced and has been gaining widespread use. While some justifications for its introduction are straightforward, others may be questionable. Numerous unspecific symptoms and signs were included in the definition of the syndrome, but the minimum n...

    journal_title:International urogynecology journal

    pub_type: 杂志文章,评审

    doi:10.1007/s00192-017-3295-6

    authors: Vieira-Baptista P,Marchitelli C,Haefner HK,Donders G,Pérez-López F

    更新日期:2017-05-01 00:00:00

  • A new method for the evaluation of pelvic organ prolapse in women using a three-dimensional optic scanner.

    abstract:INTRODUCTION AND HYPOTHESIS:Modern classifications of pelvic floor movements are based on pelvic floor assessment in a static midsagittal plane. This study presents a new and potentially useful 3D noninvasive tool for studying pelvic floor mobility in women with pelvic organ prolapse (POP). MATERIALS AND METHODS:Thirt...

    journal_title:International urogynecology journal

    pub_type: 临床试验,杂志文章

    doi:10.1007/s00192-016-2948-1

    authors: Kasyan GR,Tupikina NV,Pushkar DY

    更新日期:2016-07-01 00:00:00

  • A comparative study of a single-incision sling and a transobturator sling: clinical efficacy and urodynamic changes.

    abstract:INTRODUCTION:In this retrospective study, a comparison is made of the clinical efficacy of two stress urinary incontinence treatment apparatuses, a single-incision sling and a transobturator sling. METHODS:Eighty-five (single-incision n=43, transobturator n=42) consecutive patients were included in this study. Clinica...

    journal_title:International urogynecology journal

    pub_type: 杂志文章

    doi:10.1007/s00192-012-1942-5

    authors: Sun MJ,Sun R,Li YI

    更新日期:2013-05-01 00:00:00

  • Introduction of laparoscopic sacral colpopexy to a fellowship training program.

    abstract:INTRODUCTION AND HYPOTHESIS:Minimally invasive sacral colpopexy has increased over the past decade, with many senior physicians adopting this new skill set. However, skill acquisition at an academic institution in the presence of postgraduate learners is not well described. This manuscript outlines the introduction of ...

    journal_title:International urogynecology journal

    pub_type: 杂志文章

    doi:10.1007/s00192-013-2085-z

    authors: Kantartzis K,Sutkin G,Winger D,Wang L,Shepherd J

    更新日期:2013-11-01 00:00:00

  • Dynamic magnetic resonance imaging following native tissue vaginal reconstructive surgery; a prospective study.

    abstract:INTRODUCTION AND HYPOTHESIS:To describe the impact of native tissue vaginal reconstruction on pelvic anatomy using dynamic magnetic resonance imaging. METHODS:This prospective single-cohort observational study involved women undergoing native tissue reconstruction with intraperitoneal vaginal vault suspension for pelv...

    journal_title:International urogynecology journal

    pub_type: 杂志文章

    doi:10.1007/s00192-020-04571-3

    authors: Shatkin-Margolis A,Duke E,Ghodsi V,Hill A,Crisp CC,Pauls RN

    更新日期:2020-10-22 00:00:00

  • Robotic-assisted ureteral reimplantation and psoas hitch after ureteral injury during cesarean section.

    abstract:INTRODUCTION AND HYPOTHESIS:Ureteral injury during gynecological surgery can be managed in a variety of ways, from endoscopic stent placement to ureteroneocystotomy with accompanying psoas hitch and/or Boari flap. The majority of these occur during hysterectomy; therefore, gynecologic surgeons may not be as familiar wi...

    journal_title:International urogynecology journal

    pub_type: 杂志文章

    doi:10.1007/s00192-020-04627-4

    authors: Smith W,Dutta R,Matthews C

    更新日期:2021-01-06 00:00:00

  • Predictive approach in managing voiding dysfunction after surgery for deep endometriosis: a personalized nomogram.

    abstract:INTRODUCTION AND HYPOTHESIS:The aim was to develop a nomogram based on clinical and surgical factors to predict the likelihood of voiding dysfunction after surgery for deep endometriosis. METHODS:This was a retrospective study of 789 patients (training set) who underwent surgery for deep endometriosis with colorectal ...

    journal_title:International urogynecology journal

    pub_type: 杂志文章

    doi:10.1007/s00192-020-04428-9

    authors: Vesale E,Roman H,Abo C,Benoit L,Tuech JJ,Darai E,Bendifallah S

    更新日期:2020-07-11 00:00:00

  • Bilateral anterior sacrospinous ligament suspension associated with a paravaginal repair with mesh: short-term clinical results of a pilot study.

    abstract:INTRODUCTION AND HYPOTHESIS:This study aims to assess anatomical and functional results of bilateral anterior sacrospinous ligament suspension associated with paravaginal repair with mesh. METHODS:Forty-eight patients were operated between March 2007 and August 2008. Mean age was 67 years old. Nineteen patients (39.6%...

    journal_title:International urogynecology journal

    pub_type: 临床试验,杂志文章

    doi:10.1007/s00192-009-1036-1

    authors: de Tayrac R,Boileau L,Fara JF,Monneins F,Raini C,Costa P

    更新日期:2010-03-01 00:00:00