Abstract:
:Exercise induced proteinuria is a common phenomenon in high performance sports. Based on the appearance of so called "effort urines" in routine doping analysis the purpose of this study was to investigate the influence of exercise induced proteinuria on IEF profiles and SDS-PAGE relative mobility values (rMVs) of endogenous human erythropoietin (EPO). Twenty healthy subjects performed cycle-ergometer exercise until exhaustion. VO (2)max, blood lactate, urinary proteins and urinary creatinine were analysed to evaluate the exercise performance and proteinuria. IEF and SDS-PAGE analyses were performed to test for differences in electrophoretic behaviour of the endogenous EPO before and after exercise. All subjects showed increased levels of protein/creatinine ratio after performance (8.8+/-5.2-26.1+/-14.4). IEF analysis demonstrated an elevation of the relative amount of basic band areas (13.9+/-11.3-36.4+/-12.6). Using SDS-PAGE analysis we observed a decrease in rMVs after exercise and no shift in direction of the recombinant human EPO (rhEPO) region (0.543+/-0.013-0.535+/-0.012). Following identification criteria of the World Anti Doping Agency (WADA) all samples were negative. The implementation of the SDS-PAGE method represents a good solution to distinguish between results influenced by so called effort urines and results of rhEPO abuse. Thus this method can be used to confirm adverse analytical findings.
journal_name
Int J Sports Medjournal_title
International journal of sports medicineauthors
Voss S,Lüdke A,Romberg S,Schänzer E,Flenker U,deMarees M,Achtzehn S,Mester J,Schänzer Wdoi
10.1055/s-0030-1249083subject
Has Abstractpub_date
2010-06-01 00:00:00pages
367-71issue
6eissn
0172-4622issn
1439-3964journal_volume
31pub_type
杂志文章abstract::The purpose of this study was to compare Anaerobic Work Capacity (AWC) measured on an isoinertial or an isokinetic bicycle ergometer. Twelve male participants completed two randomly ordered exercise testing sessions including a torque-velocity test followed by a 30-s all-out test on an isokinetic ergometer, or a force...
journal_title:International journal of sports medicine
pub_type: 杂志文章
doi:10.1055/s-0029-1233466
更新日期:2010-02-01 00:00:00
abstract::Spatio-temporal, metabolic and psychometric responses during and after a 400-m freestyle swim trial were investigated for gender and skill-level effects. Thirty-four men and women, 18 national and international competitors and 16 recreational swimmers, were compared. Mean speed, stroke rate (SR), and stroke length (SL...
journal_title:International journal of sports medicine
pub_type: 杂志文章
doi:10.1055/s-2006-924208
更新日期:2007-02-01 00:00:00
abstract::Cardiac vagal tone (CVT), a key determinant of resting heart rate (HR), is progressively withdrawn with incremental exercise and nearly abolished at maximal effort. While maximal HR decreases with age, there remains a large interindividual variability of results for any given age. In the present study, we hypothesized...
journal_title:International journal of sports medicine
pub_type: 杂志文章
doi:10.1055/s-0032-1323818
更新日期:2013-06-01 00:00:00
abstract::Considerable interindividual variation in the response of blood pressure to exercise has been found. In this study the response of systolic blood pressure during a progressive maximal bicycle ergometer test was investigated in 747 physically active male subjects over age of 40 years with normal, borderline elevated, a...
journal_title:International journal of sports medicine
pub_type: 杂志文章
doi:10.1055/s-2007-1025042
更新日期:1988-12-01 00:00:00
abstract::The aim of this study was to examine the effect of defensive pressure on movement behaviour during an under-18 basketball game. 20 international male players (age: M=16.05, SD=2.09 years old; weekly practice: M=10.9, SD=1.94 h; playing experience: M=7.1, SD=1.1 years) played two 10-min basketball quarters, using man-t...
journal_title:International journal of sports medicine
pub_type: 杂志文章
doi:10.1055/s-0033-1363237
更新日期:2014-08-01 00:00:00
abstract::Previous studies have demonstrated that full recovery from weight loss may take months or years. The present investigation examined short-term recovery (5 wks "post") of physical performance (muscular strength, muscular power, vertical jump), body composition, metabolic hormones (testosterone, luteinizing hormone, sex...
journal_title:International journal of sports medicine
pub_type: 杂志文章
doi:10.1055/s-2007-972640
更新日期:1997-07-01 00:00:00
abstract::The aim of the present study was to compare the effects of using different intensities and types of aerobic exercise (i. e., cycle ergometer or running) during concurrent training on neuromuscular adaptations. A total of 44 young women were randomly assigned to 1 of 4 groups: concurrent strength and continuous running...
journal_title:International journal of sports medicine
pub_type: 杂志文章,随机对照试验
doi:10.1055/s-0031-1299698
更新日期:2012-08-01 00:00:00
abstract::The purpose of this study was to investigate the effects of short-term, high-intensity sprint training on the root mean squared (RMS) and median frequency (MF) derived from surface electromyography (EMG), as well as peak power, mean power, total work, and plasma lactate levels in trained cyclists when performed concur...
journal_title:International journal of sports medicine
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1055/s-2004-819945
更新日期:2004-02-01 00:00:00
abstract::Caffeine enhances endurance performance; however, its effect on accumulated lactate remains unclear. Conversely, taurine, which also enhances endurance performance, decreases accumulated lactate. In this study, the effect of combination of caffeine and taurine on endurance performance was assessed. Mice ran on a tread...
journal_title:International journal of sports medicine
pub_type: 杂志文章
doi:10.1055/s-0028-1104574
更新日期:2009-07-01 00:00:00
abstract::This study investigated the validity of determining the final work rates of cycling and walking ramp-incremented maximal cardiopulmonary exercise tests (CPETs) using a non-exercise model to predict maximal oxygen uptake VO2max and the American College of Sports Medicine ACSM's metabolic equations. The validity of usin...
journal_title:International journal of sports medicine
pub_type: 杂志文章
doi:10.1055/s-0034-1395590
更新日期:2015-10-01 00:00:00
abstract::Here, we compared the maximal lactate steady state velocity (vMLSS) estimated from a single-visit protocol (v5×2000) to the traditional multi-day protocol (vMLSS). Furthermore, we determined whether there was a lactate steady state during the time limits (Tlim) at vMLSS or v5×2000. Eight runners completed a half marat...
journal_title:International journal of sports medicine
pub_type: 杂志文章,随机对照试验
doi:10.1055/s-0031-1283178
更新日期:2011-11-01 00:00:00
abstract::We have studied, on blood samples, the level of immunocompetence (concentration of immune cells, phagocytic process of polymorphonuclear neutrophils, proliferative response of lymphocytes to mitogens), the ascorbic acid content of such immunocompetent cells and the "stress hormone" status (cortisol, ACTH and beta-endo...
journal_title:International journal of sports medicine
pub_type: 杂志文章
doi:10.1055/s-2007-972900
更新日期:1996-11-01 00:00:00
abstract::Skeletal muscle, as a producer of glutamine, is important for lymphocytes, monocytes and macrophages. Exercise-induced muscle damage could burden the immune system by concurrently eliciting a local inflammatory response and decreasing glutamine availability. The aim of this study was to determine whether blood leukocy...
journal_title:International journal of sports medicine
pub_type: 杂志文章
doi:10.1055/s-2007-971138
更新日期:1999-07-01 00:00:00
abstract::Leptin, the product of the ob-gene, is specifically released by adipocytes. In addition to its metabolic function it seems to affect the feedback-mechanisms of the hypothalamic-pituitary-gonadal-axis. We studied 13 female juvenile elite gymnasts with anorexia athletica (AA) and 9 female patients with anorexia nervosa ...
journal_title:International journal of sports medicine
pub_type: 杂志文章
doi:10.1055/s-1999-8834
更新日期:1999-10-01 00:00:00
abstract::The lipolytic and the cardiac responses to 30 min of two different forms of stress--a standardized mental stress test and submaximal bicycle exercise--were investigated in non-obese healthy subjects. This was done by microdialysis of the extracellular space in the abdominal subcutaneous adipose tissue in order to dete...
journal_title:International journal of sports medicine
pub_type: 杂志文章
doi:10.1055/s-2007-1021079
更新日期:1994-10-01 00:00:00
abstract::Rhinitis has been demonstrated to impose a significant disease burden upon the general population. We sought to determine the prevalence of rhinitis in athletes; to investigate its relationship with co-existing allergic symptoms; and to quantify the impact of rhinitis on quality of life in the athlete.3 subgroups were...
journal_title:International journal of sports medicine
pub_type: 杂志文章
doi:10.1055/s-0042-108200
更新日期:2017-01-01 00:00:00
abstract::We investigated the possible influence of an exhaustive physical exercise on mental stress biomarkers (serotonin, tryptophan, and beta-endorphin) along with dopamine, noradrenaline and free fatty acids in an ultramarathon race in which 45 km was run on the first day and 90 km on the second. We obtained serum samples a...
journal_title:International journal of sports medicine
pub_type: 杂志文章
doi:10.1055/s-2008-1038490
更新日期:2008-11-01 00:00:00
abstract::Because metabolic heat production is proportional to the amount of work performed, the differences in core body temperature (Tcore) of humans exercising at similar absolute exercise intensities are due to differences in their efficiency of heat dissipation. The purpose of this paper is to delineate the effects of trai...
journal_title:International journal of sports medicine
pub_type: 杂志文章,评审
doi:10.1055/s-2007-971969
更新日期:1998-06-01 00:00:00
abstract::We studied 12 highly trained athletes, 6 male ice-hockey players and 6 cross-country skiers (2 females, 4 males). All of them participated in a maximal electrically braked bicycle ergometer test in a hypobaric chamber at the simulated altitude of 3000m (520 mmHg) and in normobaric conditions two days apart in random o...
journal_title:International journal of sports medicine
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1055/s-2007-972968
更新日期:1995-02-01 00:00:00
abstract::Metabolic syndrome (MetS) is a cluster of cardiometabolic risk factors with high prevalence among adult populations and elevated costs for public health systems worldwide. Despite the lack of consensus regarding the syndrome definition and diagnosis criteria, it is characterized by the coexistence of risk factors such...
journal_title:International journal of sports medicine
pub_type: 杂志文章
doi:10.1055/a-1263-0898
更新日期:2020-10-19 00:00:00
abstract::The effect of clinically used doses of propranolol, atenolol, nifedipine, propranolol plus nifedipine, and atenolol plus nifedipine on thermoregulatory responses of 11 healthy men was studied during 2-h block-stepping in heat. Drug intervention did not alter ventilation during exercise. In contrast, propranolol and at...
journal_title:International journal of sports medicine
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1055/s-2008-1025631
更新日期:1987-02-01 00:00:00
abstract::The present study evaluated the accuracy of predicting velocity and oxygen consumption (VO2) at the LT lactate threshold and FBLC fixed blood lactate concentrations from a 3200-m time trial in women. Forty-four women (mean age = 31.1 yrs, mean ht = 164.9 cm, mean wt = 65.0 kg) completed a treadmill protocol for the de...
journal_title:International journal of sports medicine
pub_type: 杂志文章
doi:10.1055/s-2007-1024821
更新日期:1990-10-01 00:00:00
abstract::The peripheral adaptation process associated with repeating eccentric training over a longer period of time was studied in m. vastus lateralis of eleven healthy males aged 24 +/- 4 years. The maximal dynamic concentric muscle strength was only slightly improved after 8 weeks of training. However, eccentric work capaci...
journal_title:International journal of sports medicine
pub_type: 杂志文章
doi:10.1055/s-2008-1026031
更新日期:1983-08-01 00:00:00
abstract::Hormonal and metabolic parameters were studied for two teams after a football match. Blood samples were collected before the start, at half-time, at the end, and 45 and 90 min after the end of the game. In the first team, ACTH, cortisol, and lactate levels increased significantly during the whole match to resume basal...
journal_title:International journal of sports medicine
pub_type: 杂志文章
doi:10.1055/s-2008-1025732
更新日期:1986-02-01 00:00:00
abstract::The aim of this study was to compare the effects of aerobic and mental training on cognitive function and to determine if the association of the two techniques shows better results. Thirty-two healthy elderly subjects (60 - 76 years) were assigned to one of four groups: aerobic training, mental training, combined aero...
journal_title:International journal of sports medicine
pub_type: 杂志文章
doi:10.1055/s-2002-33735
更新日期:2002-08-01 00:00:00
abstract::Fitness, and specifically body composition of football referees requires attention in order to achieve the highest possible standards. The aim of the present study was to describe body composition of elite Spanish football referees over 11 years. Data from 2001 to 2012 pre-seasons were analyzed from a total of 470 ref...
journal_title:International journal of sports medicine
pub_type: 杂志文章
doi:10.1055/s-0034-1398582
更新日期:2015-06-01 00:00:00
abstract::The postural control of ten male soccer players with functional instability (FI) of the ankle joint, i.e., recurrent sprains and/or a feeling of giving way, was studied before and after ankle disk training. Postural control was studied by means of stabilometry and an optoelectronic movement recording system. In the pr...
journal_title:International journal of sports medicine
pub_type: 杂志文章
doi:10.1055/s-2007-1024996
更新日期:1988-04-01 00:00:00
abstract::Maximal voluntary contractions (MVC) were performed by five male subjects as repeated knee extensions separated by 13-s rest periods for the purposes of studying performance capability, physiologic responses, and recruitment patterns among fast-twitch (FT) and slow-twitch (ST) extrafusal muscle fibers for this type of...
journal_title:International journal of sports medicine
pub_type: 杂志文章
doi:10.1055/s-2008-1034593
更新日期:1981-05-01 00:00:00
abstract::The aims of this pilot study were to investigate how a novel sagittal plane kinematic measurement - the lower extremity contact angle (LECA) - relates to the landing dynamics of elite male volleyball athletes with and without patellar tendinopathy. The LECA was defined as the angle between the ground and the line conn...
journal_title:International journal of sports medicine
pub_type: 杂志文章
doi:10.1055/s-0034-1395586
更新日期:2015-05-01 00:00:00
abstract::This study compared physiological responses associated with exercise tolerance in girls (G) and women (W) of similar fitness and heat acclimatization level during exercise in a hot and humid outdoor environment (33.4 degrees C and 55.1 % RH; WBGT = 29.9 +/- 0.2 degrees C). Nine pre-menarcheal G (age = 11.3 yr) and nin...
journal_title:International journal of sports medicine
pub_type: 杂志文章
doi:10.1055/s-2006-923863
更新日期:2006-12-01 00:00:00