Allosteric inhibitors of hepatitis C virus NS5B polymerase thumb domain site II: structure-based design and synthesis of new templates.

Abstract:

:Chronic hepatitis C virus (HCV) infections are a significant medical problem worldwide. The NS5B Polymerase of HCV plays a central role in virus replication and is a prime target for the discovery of new treatment options. We recently disclosed 1H-benzo[de]isoquinoline-1,3(2H)-diones as allosteric inhibitors of NS5B Polymerase. Structural and SAR information guided us in the modification of the core structure leading to new templates with improved activity and toxicity/activity window.

journal_name

Bioorg Med Chem

authors

Malancona S,Donghi M,Ferrara M,Martin Hernando JI,Pompei M,Pesci S,Ontoria JM,Koch U,Rowley M,Summa V

doi

10.1016/j.bmc.2010.03.024

subject

Has Abstract

pub_date

2010-04-15 00:00:00

pages

2836-48

issue

8

eissn

0968-0896

issn

1464-3391

pii

S0968-0896(10)00228-2

journal_volume

18

pub_type

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