Abstract:
:Chronic hepatitis C virus (HCV) infections are a significant medical problem worldwide. The NS5B Polymerase of HCV plays a central role in virus replication and is a prime target for the discovery of new treatment options. We recently disclosed 1H-benzo[de]isoquinoline-1,3(2H)-diones as allosteric inhibitors of NS5B Polymerase. Structural and SAR information guided us in the modification of the core structure leading to new templates with improved activity and toxicity/activity window.
journal_name
Bioorg Med Chemjournal_title
Bioorganic & medicinal chemistryauthors
Malancona S,Donghi M,Ferrara M,Martin Hernando JI,Pompei M,Pesci S,Ontoria JM,Koch U,Rowley M,Summa Vdoi
10.1016/j.bmc.2010.03.024subject
Has Abstractpub_date
2010-04-15 00:00:00pages
2836-48issue
8eissn
0968-0896issn
1464-3391pii
S0968-0896(10)00228-2journal_volume
18pub_type
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