Combined positron emission tomography-computed tomography and tumor markers for detecting recurrent ovarian cancer.

Abstract:

OBJECTIVE:To evaluate the accuracy of integrated FDG-PET/CT and tumor markers for the depiction of recurrent ovarian carcinoma. METHODS:Patients with pathologically proven ovarian cancer, who underwent cytoreductive surgery and 3-6 cycles of adjuvant chemotherapy, were included in this study. They all underwent a thorough physical examination, tumor marker determination, and FDG-PET/CT imaging. The sensitivity, specificity, accuracy, and positive and negative predictive values for the tumor detection with PET/CT versus different tumor markers were performed in relation to the results at histological analysis after second-look surgery or clinical follow-up. RESULTS:A total of 37 patients underwent FDG-PET/CT scans. Among them, 22 patients underwent exploratory laparotomy and 15 had diagnostic laparoscopy. Overall, 24 patients were documented to have ovarian cancer recurrence after second operation. FDG-PET/CT had sensitivity, specificity, accuracy, and positive and negative predictive values of 100, 85, 94, 92, and 100%, respectively. CONCLUSION:Our study has shown that PET/CT is a sensitive tool to assist in the early identification and recurrent ovarian cancer, amenable to secondary cytoreduction.

journal_name

Arch Gynecol Obstet

authors

Pan HS,Lee SL,Huang LW,Chen YK

doi

10.1007/s00404-010-1404-6

subject

Has Abstract

pub_date

2011-02-01 00:00:00

pages

335-41

issue

2

eissn

0932-0067

issn

1432-0711

journal_volume

283

pub_type

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