Identification of molecular targets associated with ethanol toxicity and implications in drug development.

abstract：:Cancers which damage the human skeleton include multiple myeloma, where the primary tumour colonises bone directly, or breast and prostate cancer, where malignant cells travel from the primary tumour to form clonal outgrowths within the bone. Owing to the interaction of tumour cells with those normally found in the bo...

journal_title：Current pharmaceutical design

authors： Buckle CH,Neville-Webbe HL,Croucher PI,Lawson MA

更新日期：2010-01-01 00:00:00

abstract：:The oncoproteins MDM2 and MDMX negatively regulate the activity and stability of the p53 tumor suppressor, directly contributing to the development and progression of many tumors harboring wild type p53. Antagonizing MDM2 and MDMX to activate the p53 pathway has thus become an attractive new strategy for anticancer dr...

journal_title：Current pharmaceutical design

authors： Zhan C,Lu W

更新日期：2011-01-01 00:00:00

abstract：:Regulation of cellular redox balances is important for the homeostasis of human health. Thus, many important human diseases, such as inflammation, diabetes, glaucoma, cancers, ischemia and neurodegenerative diseases, have been investigated in the field of reactive oxygen species (ROS) and oxidative stress. To overcome...

journal_title：Current pharmaceutical design

authors： Noda M,Fujita K,Lee CH,Yoshioka T

更新日期：2011-01-01 00:00:00

abstract：:Diabetic patients are considered as high risk for development of atherosclerotic disease. Cholesterol treatment is of paramount importance in order to optimise cardiovascular outcomes in this subset of patients. Although statins are regarded as the mainstay of treatment, these may not be tolerated or as efficacious as...

journal_title：Current pharmaceutical design

authors： Felekos I,Karamasis GV,Pavlidis AN

更新日期：2020-06-17 00:00:00

abstract：:The development of targeted therapy drugs acting on tumor growth and progression is greatly expanding these last years. Among them kinase inhibitors have a prominent position and have demonstrated efficacy and clinical benefits in solid and hematologic malignancies. Compared to conventional systemic cytotoxic chemothe...

journal_title：Current pharmaceutical design

authors： Levade M,Severin S,Gratacap MP,Ysebaert L,Payrastre B

更新日期：2016-01-01 00:00:00

abstract：:There is growing evidence for the involvement of glutamatergic abnormalities in schizophrenia. Uncompetitive NMDA receptor (NMDAR) antagonists induce effects closely resembling both the positive and negative symptoms of schizophrenia; candidate risk genes for schizophrenia converge on the NMDAR expressing synapse; and...

journal_title：Current pharmaceutical design

authors： Stone JM

更新日期：2009-01-01 00:00:00

abstract：:Histone deacetylases (HDACs), which act on acetylated histones and/or other non-histone protein substrates, represent validated epigenetic targets for the treatment of cancer and other human diseases. The inhibition of HDAC activity was shown to induce cell cycle arrest, differentiation, apoptosis as well as a decreas...

journal_title：Current pharmaceutical design

authors： Kollar J,Frecer V

更新日期：2015-01-01 00:00:00

abstract：:The comorbid prevalence of major depressive disorder (MDD) with obesity and type II diabetes mellitus reflects the existence of a subset of individuals with a complex common pathophysiology and overlapping risk factors. Such comorbid disease presentations imply a number of difficulties, including: decreased treatment ...

journal_title：Current pharmaceutical design

authors： Slyepchenko A,Maes M,Machado-Vieira R,Anderson G,Solmi M,Sanz Y,Berk M,Köhler CA,Carvalho AF

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:Primary aldosteronism is the most common causes of secondary hypertension. Patients suffering from this clinical syndrome have an increased cardiovascular risk and target organ damage. Mineralocorticoid receptor antagonists are the optimal pharmaceutical option for the management of such patients. OBJECTIVE...

journal_title：Current pharmaceutical design

authors： Stavropoulos K,Papadopoulos C,Koutsampasopoulos K,Lales G,Mitas C,Doumas M

更新日期：2018-01-01 00:00:00

abstract：:Periodontal diseases are common inflammatory conditions of the supporting apparatus of the teeth which lead to early tooth loss. This review discusses the evidence for a role of reactive oxygen species in inducing periodontal tissue damage and focuses on recent evidence showing increased local and systemic alterations...

journal_title：Current pharmaceutical design

authors： Nibali L,Donos N

更新日期：2013-01-01 00:00:00

abstract：:Recent decades mark a great progress in the treatment of HIV infection. What was once a deadly disease is now a chronic infection. However, HIV-infected patients are prone to develop comorbidities, which severely affect their daily functions. For example, a large population of patients develop a variety of neurologica...

journal_title：Current pharmaceutical design

authors： Bertrand L,Nair M,Toborek M

更新日期：2016-01-01 00:00:00

abstract：:The plants of the Colchicum family were known during the archaic period in Greece for their deleterious properties. Later on, they were used for the treatment of podagra. The treatment was introduced by the ancient Greek physicians and passed on to the Byzantine and Arabian physicians to endure until nowadays. The fir...

journal_title：Current pharmaceutical design

authors： Tsoucalas G,Papaioannou T,Panayiotakopoulos G,Saridaki Z,Vrachatis DA,Karamanou M

更新日期：2018-01-01 00:00:00

abstract：:There is extensive evidence that changes in immune system activation accompany the pathological changes of Alzheimer's disease (AD), but a mechanistic understanding of how the immune system actually participates in disease pathogenesis is still largely lacking. Because of the complexity of the immunological response, ...

journal_title：Current pharmaceutical design

authors： Nelson RB

更新日期：2005-01-01 00:00:00

abstract：:Exosomes are phospholipid bilayer-enclosed membrane vesicles derived and constitutively secreted by various metabolically active cells. They are capable of mediating hetero- and homotypic intercellular communication by transferring multiple cargos from donor cells to recipient cells. Nowadays, non-coding RNAs (ncRNAs)...

journal_title：Current pharmaceutical design

authors： Tu C,He J,Chen R,Li Z

更新日期：2019-01-01 00:00:00

abstract：:Regulatory T lymphocytes (Tregs) are specialized for immune suppression and are important regulators of the immune response in various settings. Tregs actively suppress enteroantigen-reactive cells and contribute to the maintenance of intestinal immune homeostasis. Distinct Treg subsets coexist in the intestinal mucos...

journal_title：Current pharmaceutical design

authors： Mizrahi M,Ilan Y

更新日期：2009-01-01 00:00:00

abstract：:In the mid seventies a drug design programme using the Amanita muscaria constituent muscimol (7) as a lead structure, led to the design of guvacine (23) and (R)-nipecotic acid (24) as specific GABA uptake inhibitors and the isomeric compounds isoguvacine (10) and isonipecotic acid (11) as specific GABAA receptor agoni...

journal_title：Current pharmaceutical design

authors： Krogsgaard-Larsen P,Frølund B,Frydenvang K

更新日期：2000-08-01 00:00:00

abstract：:Stimulant use disorders are an unrelenting public health concern worldwide. Agonist replacement therapy is among the most effective strategies for managing substance use disorders including nicotine and opioid dependence. The present paper reviewed clinical data from human laboratory self-administration studies and cl...

journal_title：Current pharmaceutical design

authors： Stoops WW,Rush CR

更新日期：2013-01-01 00:00:00

abstract：:Over the last decade, much was learned about the biology of several types of stem and progenitor cells. It has become apparent that various cell sources may have the capacity to promote cardiomyogenesis and new blood vessel formation through different mechanisms, forming the rationale for cell-based therapy in patient...

journal_title：Current pharmaceutical design

authors： Rodrigo SF,Ramshorst Jv,Beeres SL,Bax JJ,Schalij MJ,Atsma DE

更新日期：2011-10-01 00:00:00

abstract：:Curcumin is a natural polyphenol product derived from the rhizome of the Curcuma longa. In vivo and in vitro studies have uncovered many important bioactivities of curcumin, such as antioxidant activity, inducing cell apoptosis, inhibiting cell proliferation, anti-cell adhesion and motility, anti-angiogenesis and anti...

journal_title：Current pharmaceutical design

authors： Fan X,Zhang C,Liu DB,Yan J,Liang HP

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Carbon dioxide (CO2) exists in nature around us. In the middle of the 20th century, the intraluminal injection of CO2 demonstrated similar results to those of Digital Subtraction Angiography (DSA) with an iodinated contrast agent (ICA). Since then, the technology behind CO2 DSA has developed significantly. ...

journal_title：Current pharmaceutical design

authors： Patelis N,Doulaptsis M,Kykalos S,Spartalis E,Maskanakis A,Georgopoulos S

更新日期：2019-01-01 00:00:00

abstract：:The drug discovery process in general is a very resource intensive undertaking that has existed for a very long time. In the last two decades, performing molecular simulations that determine the level of interaction between a protein and ligand have been refined to the point where they are now an essential part of the...

journal_title：Current pharmaceutical design

authors： Haga JH,Ichikawa K,Date S

更新日期：2016-01-01 00:00:00

abstract：:Active pharmaceutical ingredients (APIs) can exist in different polymorphic forms as well as in amorphous state. Polymorphic and amorphous forms of APIs can differ in physicochemical properties which in turn can significantly influence their therapeutic safety and effectiveness of the treatment. This review focuses on...

journal_title：Current pharmaceutical design

authors： Talaczynska A,Dzitko J,Cielecka-Piontek J

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:Cardiac resynchronization therapy (CRT) is a valuable intracardiac device--based treatment option for a subgroup of patients with advanced heart failure (HF) and QRS prolongation. However, still a significant proportion of patients do not benefit from CRT implantation, labeled as non-responders. OBJECTIVES:...

journal_title：Current pharmaceutical design

authors： Debska-Kozlowska A,Ksiazczyk M,Warchol I,Lubinski A

更新日期：2019-01-01 00:00:00

abstract：:This study was designed to evaluate the distribution of Tregs/Th17/Th1 cells in type 2 diabetic patients with foot disease before and after human umbilical cord blood mesenchymal stem cell (hUCB-MSCs) transplantation. Fifteen diabetic patients with foot disease under insulin therapy received hUCB-MSC transplantation. ...

journal_title：Current pharmaceutical design

authors： Li XY,Zheng ZH,Li XY,Guo J,Zhang Y,Li H,Wang YW,Ren J,Wu ZB

更新日期：2013-01-01 00:00:00

abstract：:In the last two decades a tremendous development has been noticed in our understanding of the purinergic system, consisting of heterogeneously expressed purinoceptor subtypes and its classical agonists: e.g., adenosine triphosphate, uridine triphosphate or complex dinucleoside polyphosphates. These agonists exert mult...

journal_title：Current pharmaceutical design

authors： Schuchardt M,Tölle M,van der Giet M

更新日期：2012-01-01 00:00:00

abstract：:G protein receptor kinase 2 (GRK2) has been for years mainly considered the negative regulator of the cardiac β adrenergic signaling. However GRK2 is a ubiquitous molecule and its kinase activity and scaffold properties brought to several investigations which have evidenced its involvement in pathophysiology of extra-...

journal_title：Current pharmaceutical design

authors： Ciccarelli M,Cipolletta E,Iaccarino G

更新日期：2012-01-01 00:00:00

abstract：:Reducing sugars can react non-enzymatically with amino groups of proteins and lipids to form irreversibly cross-linked macroprotein derivatives called as advanced glycation end products (AGEs). Cross-linking modification of extracellular matrix proteins by AGEs deteriorate their tertiary structural integrity and funct...

journal_title：Current pharmaceutical design

authors： Yamagishi SI,Matsui T,Ishibashi Y,Isami F,Abe Y,Sakaguchi T,Higashimoto Y

更新日期：2017-01-01 00:00:00

abstract：:Alzheimer disease (AD) is the leading cause of dementia among elderly. Currently, no effective treatment is available for AD. Analysis of transgenic mouse models of AD has facilitated our understanding of disease mechanisms and provided valuable tools for evaluating potential therapeutic strategies. In this review, we...

journal_title：Current pharmaceutical design

authors： Kitazawa M,Medeiros R,Laferla FM

更新日期：2012-01-01 00:00:00

abstract：:Pulmonary surfactant, a complex of lipids and proteins, functions to keep alveoli from collapsing at expiration. Surfactant proteins A (SP-A) and D (SP-D) belong to the collectin family and play pivotal roles in the innate immunity of the lung. Pulmonary collectins directly bind with broad specificities to a variety o...

journal_title：Current pharmaceutical design

authors： Takahashi H,Sano H,Chiba H,Kuroki Y

更新日期：2006-01-01 00:00:00

abstract：:Naoxintong (NXT), a Chinese Materia Medica standardized product, extracted from 16 various kinds of Chinese traditional herbal medicines including Salvia miltiorrhiza, Angelica sinennsis, Astragali Radix, is clinically effective in treating atherosclerosisrelated diseases. Here, we tested the hypothesis that the anti-...

journal_title：Current pharmaceutical design

authors： Zhao J,Zhu H,Wang S,Ma X,Liu X,Wang C,Zhao H,Fan S,Jin X,Zhao B,Zhao T,Jia L,Wang K,Zou Y,Hu K,Sun A,Ge J

更新日期：2013-01-01 00:00:00