Evaluation of hypoglycemic activity of inorganic constituents in Nelumbo nucifera seeds on streptozotocin-induced diabetes in rats.

Abstract:

:The seeds of Nelumbo nucifera (Lotus) have been used in the traditional system of medicine for various ailments including diabetes. The present study was aimed at analyzing the levels of biologically important trace elements in the lotus seeds by atomic absorption spectroscopy and evaluating the hypoglycemic properties of seed ash on streptozotocin-induced diabetes in rats. Diabetic rats treated with lotus seed ash at a concentration of 200 mg/kg body weight orally for 30 days exhibited significant hypoglycemic activity. The presence of trace elements in appreciable amounts in the seeds may play a direct or indirect role on insulin secretion or its action in a synergetic manner. The hypoglycemic activity of the ash was comparable with glyclazide. The role of trace elements in disorders related to diabetes is also discussed briefly.

journal_name

Biol Trace Elem Res

authors

Mani SS,Subramanian IP,Pillai SS,Muthusamy K

doi

10.1007/s12011-010-8614-4

subject

Has Abstract

pub_date

2010-12-01 00:00:00

pages

226-37

issue

1-3

eissn

0163-4984

issn

1559-0720

journal_volume

138

pub_type

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