Abstract:
:Nanoparticle-based therapeutics have received increasing attention, as these systems can alleviate many drawbacks of conventional therapy. Metal-organic frameworks (MOFs), a new class of hybrid materials composed of metal ions and organic bridging ligands, have emerged as a promising platform for drug delivery, owing to their high drug loadings, biodegradability, and versatile functionality. The bulk MOF materials can absorb and release large amounts of therapeutics including ibuprofen, procainamide, and nitric oxide. Scale-down of MOFs to the nanoregime yields nanoscale metal-organic frameworks (NMOFs) that are more applicable as delivery vehicles, such as selective delivery of cisplatin prodrugs. Although progress has been made in utilizing NMOFs for drug delivery, many improvements must occur before they can become viable nanotherapeutics.
journal_name
Curr Opin Chem Bioljournal_title
Current opinion in chemical biologyauthors
Huxford RC,Della Rocca J,Lin Wdoi
10.1016/j.cbpa.2009.12.012subject
Has Abstractpub_date
2010-04-01 00:00:00pages
262-8issue
2eissn
1367-5931issn
1879-0402pii
S1367-5931(09)00203-8journal_volume
14pub_type
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