Abstract:
PURPOSE:To evaluate the ability of the GDx Variable Corneal Compensation (VCC) Guided Progression Analysis (GPA) software for detecting glaucomatous progression. DESIGN:Observational cohort study. PARTICIPANTS:The study included 453 eyes from 252 individuals followed for an average of 46+/-14 months as part of the Diagnostic Innovations in Glaucoma Study. At baseline, 29% of the eyes were classified as glaucomatous, 67% of the eyes were classified as suspects, and 5% of the eyes were classified as healthy. METHODS:Images were obtained annually with the GDx VCC and analyzed for progression using the Fast Mode of the GDx GPA software. Progression using conventional methods was determined by the GPA software for standard automated achromatic perimetry (SAP) and by masked assessment of optic disc stereophotographs by expert graders. MAIN OUTCOME MEASURES:Sensitivity, specificity, and likelihood ratios (LRs) for detection of glaucoma progression using the GDx GPA were calculated with SAP and optic disc stereophotographs used as reference standards. Agreement among the different methods was reported using the AC(1) coefficient. RESULTS:Thirty-four of the 431 glaucoma and glaucoma suspect eyes (8%) showed progression by SAP or optic disc stereophotographs. The GDx GPA detected 17 of these eyes for a sensitivity of 50%. Fourteen eyes showed progression only by the GDx GPA with a specificity of 96%. Positive and negative LRs were 12.5 and 0.5, respectively. None of the healthy eyes showed progression by the GDx GPA, with a specificity of 100% in this group. Inter-method agreement (AC(1) coefficient and 95% confidence intervals) for non-progressing and progressing eyes was 0.96 (0.94-0.97) and 0.44 (0.28-0.61), respectively. CONCLUSIONS:The GDx GPA detected glaucoma progression in a significant number of cases showing progression by conventional methods, with high specificity and high positive LRs. Estimates of the accuracy for detecting progression suggest that the GDx GPA could be used to complement clinical evaluation in the detection of longitudinal change in glaucoma.
journal_name
Ophthalmologyjournal_title
Ophthalmologyauthors
Alencar LM,Zangwill LM,Weinreb RN,Bowd C,Vizzeri G,Sample PA,Susanna R Jr,Medeiros FAdoi
10.1016/j.ophtha.2009.08.012subject
Has Abstractpub_date
2010-03-01 00:00:00pages
462-70issue
3eissn
0161-6420issn
1549-4713pii
S0161-6420(09)00901-4journal_volume
117pub_type
杂志文章相关文献
OPHTHALMOLOGY文献大全abstract:OBJECTIVE:To develop a simulator for training in phacoemulsification to be used as a learning device for both beginners and experienced surgeons to shorten the learning curve. DESIGN:Experimental study. METHODS:The system consists of a personal computer, a 3-dimensional visual interface, a phacoemulsification handpie...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2003.06.023
更新日期:2004-04-01 00:00:00
abstract:PURPOSE:To evaluate the epidemiology, possible etiologic factors, complications encountered, and treatment administered to a group of patients with ocular involvement in the erythema multiforme/Stevens-Johnson syndrome/toxic epidermal necrolysis disease spectrum who were seen at two large tertiary referral centers over...
journal_title:Ophthalmology
pub_type: 杂志文章,多中心研究
doi:10.1016/s0161-6420(95)30811-1
更新日期:1995-11-01 00:00:00
abstract:PURPOSE:To evaluate components of the integrated ocular surface/lacrimal gland unit in a series of patients before and after undergoing bilateral laser in situ keratomileusis (LASIK). DESIGN:Prospective, noncomparative case series. PARTICIPANTS:Forty-eight eyes of 14 men and 34 women (age range, 26-54; mean, 39.2 yea...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(01)00623-6
更新日期:2001-07-01 00:00:00
abstract:PURPOSE:To evaluate and compare the structural differences of the ciliary body in eyes with and without malignant glaucoma. DESIGN:Cross-sectional study. PARTICIPANTS:Twenty-seven consecutive patients diagnosed with malignant glaucoma in 1 eye after trabeculectomy were recruited. They were all originally diagnosed wi...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2013.10.035
更新日期:2014-04-01 00:00:00
abstract:PURPOSE:Previous approaches using deep learning (DL) algorithms to classify glaucomatous damage on fundus photographs have been limited by the requirement for human labeling of a reference training set. We propose a new approach using quantitative spectral-domain (SD) OCT data to train a DL algorithm to quantify glauco...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2018.12.033
更新日期:2019-04-01 00:00:00
abstract::Glaucoma after pediatric cataract surgery, once well recognized, now occurs only rarely after modern lensectomy/vitrectomy. The authors performed directed glaucoma evaluations of 34 eyes of 26 children. Based on intraocular pressures of 26 mmHg or greater, glaucoma was diagnosed in 8 (24%) eyes of 7 (27%) children. Gl...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(91)32235-8
更新日期:1991-05-01 00:00:00
abstract::Immunologic differences exist between the peripheral and central cornea. The peripheral cornea is closer to the conjunctiva, which has all of the immunologic machinery necessary to generate an immune response. The peripheral cornea has more Langerhans' cells and IgM than the central cornea. The peripheral cornea also ...
journal_title:Ophthalmology
pub_type: 杂志文章,评审
doi:10.1016/s0161-6420(88)33164-7
更新日期:1988-04-01 00:00:00
abstract:OBJECTIVE:Central retinal vein occlusion (CRVO) is a vision-threatening disease, primarily occurring among patients aged more than 60 years. Several risk factors, including arterial hypertension and diabetes mellitus, have been identified. Compression of the central retinal vein by an atherosclerotic retinal artery at ...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2010.10.014
更新日期:2011-06-01 00:00:00
abstract:PURPOSE:To establish if silicone hydrogel (S-H) contact lenses could be a risk factor for Acanthamoeba infection by facilitating the attachment of trophozoites to their surface and transfer to the cornea and to determine the effect Acanthamoeba culture technique, patient wear, and Pseudomonas biofilm coating have on at...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/S0161-6420(02)01971-1
更新日期:2003-04-01 00:00:00
abstract::Many techniques for repositioning dislocated posterior chamber implants described in the recent literature involve intricate intraocular manipulation of a needle or other sharp instrument. The author describes an improved sulcus fixation technique, which combines the best features of external and internal approaches. ...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(92)32012-3
更新日期:1992-01-01 00:00:00
abstract:PURPOSE:The authors describe the clinical findings of three young women with the previously unreported association of Purtscher's-like retinopathy and chronic renal failure. METHODS:The authors reviewed the clinical records of three women with chronic renal failure who had been seen at the Oregon Health Sciences Unive...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(92)31716-6
更新日期:1992-12-01 00:00:00
abstract:PURPOSE:To illustrate the role of surgical removal of iris nodules (granulomas) in the management of sarcoid uveitis. STUDY DESIGN:Two interventional case reports. METHODS:The authors describe the clinical course of two 10-year-old males with long-standing granulomatous uveitis refractory to medical antiinflammatory ...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(01)00601-7
更新日期:2001-07-01 00:00:00
abstract:PURPOSE:To compare the impact of first eye versus second eye cataract surgery on visual function and quality of life. DESIGN:Cohort study. PARTICIPANTS:A total of 328 patients undergoing separate first eye and second eye phacoemulsification cataract surgeries at 5 veterans affairs centers in the United States. Patien...
journal_title:Ophthalmology
pub_type: 杂志文章,多中心研究
doi:10.1016/j.ophtha.2017.04.014
更新日期:2017-10-01 00:00:00
abstract:OBJECTIVE:To document the long-term effect of argon laser peripheral iridoplasty (ALPI) in eyes with plateau iris syndrome. DESIGN:Retrospective, noncomparative, interventional case series. SETTING:New York Eye and Ear Infirmary. METHODS:The charts of all patients with plateau iris syndrome treated with ALPI from 19...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2003.05.001
更新日期:2004-01-01 00:00:00
abstract::Corneal sensitivity was tested in 145 cases of clear corneal transplants using Cochet-Bonnet aesthesiometer. The central area of corneal transplants was found to be either completely anesthetic or markedly hypesthetic even 32 years following corneal transplantation, as exemplified in a patient who had surgery for kera...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(85)33857-5
更新日期:1985-10-01 00:00:00
abstract:PURPOSE:To report the histopathologic findings of a series of patients from an outbreak of Streptococcal endophthalmitis after intravitreal injection of bevacizumab prepared by a single compounding pharmacy. DESIGN:Case series. PARTICIPANTS:Seven surgical specimens (5 enucleated globes and 2 evisceration specimens) f...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2013.10.015
更新日期:2014-03-01 00:00:00
abstract:OBJECTIVE:To improve the ophthalmic knowledge and eye examination skills of third-year medical students through the development and implementation of a 1-day ophthalmology experience. DESIGN:Noncomparative interventional case series. PARTICIPANTS:One hundred twenty-one third-year medical students at the Penn State Co...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2006.05.066
更新日期:2006-12-01 00:00:00
abstract:OBJECTIVE:To assess the distribution of the macular pigments (MPs) lutein (L) and zeaxanthin (Z) in a healthy sample more representative of the general population than past studies and to determine which dietary factors and personal characteristics might explain the large interindividual differences in the density of t...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(00)00655-2
更新日期:2001-04-01 00:00:00
abstract::Although systemic immunosuppressive chemotherapy is effective in halting progressive necrotizing scleritis, the onset of its action may be too slow to prevent profound scleral thinning and/or traumatic or spontaneous perforation. Scleral homografts may be used to maintain the integrity of the globe until immunosuppres...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(89)32892-2
更新日期:1989-03-01 00:00:00
abstract:OBJECTIVE:Polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes (POEMS) syndrome is a rare disorder. This study investigated the types of ocular signs and symptoms in patients with POEMS and any systemic factors that may be associated with development of such ocular findings. DESIGN:Cas...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2010.08.013
更新日期:2011-04-01 00:00:00
abstract::One hundred sixty eyes of 92 patients with diffuse diabetic maculopathy with or without cystoid macular edema were enrolled in a prospective randomized clinical trial to determine the efficacy of "modified grid" argon (blue-green) laser photocoagulation. At the 12- and 24-month follow-ups, visual acuity significantly ...
journal_title:Ophthalmology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0161-6420(86)33638-8
更新日期:1986-07-01 00:00:00
abstract:PURPOSE:Autosomal dominant optic atrophy (DOA) is a major cause of visual impairment in young adults that is characterized by selective retinal ganglion cell loss. To define the prevalence and natural history of this optic nerve disorder, we performed a population-based epidemiologic and molecular study of presumed DOA...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2009.12.038
更新日期:2010-08-01 00:00:00
abstract:OBJECTIVE:This study aimed to develop a protocol to screen and monitor patients with diabetic macular thickening using optical coherence tomography (OCT), a technique for high-resolution cross-sectional imaging of the retina. DESIGN:A cross-sectional pilot study was conducted. PARTICIPANTS:A total of 182 eyes of 107 ...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(98)93601-6
更新日期:1998-02-01 00:00:00
abstract:OBJECTIVE:To determine the histopathologic effects of transpupillary thermotherapy (TTT) on the normal human retina. DESIGN:Prospective, noncomparative small case series. PARTICIPANTS:Three patients with eyes scheduled for enucleation because of the presence of a malignant intraocular tumor. INTERVENTION:Application...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/S0161-6420(02)01561-0
更新日期:2003-02-01 00:00:00
abstract:OBJECTIVE:To determine the prevalence of age-related macular degeneration (AMD) and signs of age-related maculopathy in a population-based sample of blacks and whites 40 years of age or older from East Baltimore. DESIGN:Cross-sectional population-based study. PARTICIPANTS:A total of 5308 black and white subjects rece...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/S0161-6420(99)90267-1
更新日期:1999-06-01 00:00:00
abstract:PURPOSE:To determine the effect of intraoperative application of 5-fluorouracil (5-FU) on the long-term outcome of trabeculectomy in uveitis-related glaucoma. DESIGN:An open, prospective, noncomparative case study to evaluate the use of intraoperative application for 5 minutes of 25 mg/ml 5-FU in primary trabeculectom...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(00)00351-1
更新日期:2000-10-01 00:00:00
abstract:PURPOSE:To evaluate the clinical features, treatment, and prognosis of patients with uveal metastasis from lung cancer. DESIGN:Retrospective chart review. PARTICIPANTS:There were 194 patients with a diagnosis of uveal metastasis from lung cancer. INTERVENTION:Radiotherapy, chemotherapy, enucleation, or observation. ...
journal_title:Ophthalmology
pub_type: 杂志文章,多中心研究
doi:10.1016/j.ophtha.2013.07.014
更新日期:2014-01-01 00:00:00
abstract:PURPOSE:To assess blindness prevalence and that caused specifically by cataract in rural southern China. DESIGN:Population-based, cross-sectional study. PARTICIPANTS:A total of 5342 persons older than 50 years of age. METHODS:Visual acuity and eye examinations were performed in the summer of 1997 in a random sample ...
journal_title:Ophthalmology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/S0161-6420(99)90459-1
更新日期:1999-08-01 00:00:00
abstract::Fifty-eight patients with keratitis sicca were enrolled in a long-term study to test the effectiveness of slow-release artificial tears (SRAT). The average follow up period of 39 weeks, with a range of 9 to 136 weeks. Forty-six (79%) are still being followed. Almost all of these patients have had marked relief from th...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(81)35074-x
更新日期:1981-01-01 00:00:00
abstract:PURPOSE:To determine the refractive predictability, stability, efficacy, and complication rate of femtosecond laser-enabled astigmatic keratotomy for post-keratoplasty astigmatism. DESIGN:A retrospective case series (pilot study). PARTICIPANTS:Thirty-seven eyes of 34 patients. METHODS:All eyes underwent IntraLase-en...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2009.10.041
更新日期:2010-06-01 00:00:00