Islet cell antibody-positive versus -negative phenotypic type 2 diabetes in youth: does the oral glucose tolerance test distinguish between the two?

Abstract:

:OBJECTIVE Using the clamp technique, youths with a clinical diagnosis of type 2 diabetes (CDx-type 2 diabetes) and positive pancreatic autoantibodies (Ab(+)) were shown to have severe impairment in insulin secretion and less insulin resistance than their peers with negative antibodies (Ab(-)). In this study, we investigated whether oral glucose tolerance test (OGTT)-derived indexes of insulin secretion and sensitivity could distinguish between these two groups. RESEARCH DESIGN AND METHODS A total of 25 Ab(-), 11 Ab(+) CDx-type 2 diabetic, and 21 obese control youths had an OGTT. Fasting and OGTT-derived indexes of insulin sensitivity (including the Matsuda index, homeostasis model assessment [HOMA] of insulin resistance, quantitative insulin sensitivity check index, and glucose-to-insulin ratio) and insulin secretion (HOMA of insulin secretion and 30-min insulogenic and C-peptide indexes) were used. Glucagon and glucagon-like peptide (GLP)-1 responses were assessed. RESULTS Fasting C-peptide and C-peptide-to-glucose ratio, and C-peptide area under the curve (AUC) were significantly lower in the Ab(+) CDx-type 2 diabetic patients. Other OGTT-derived surrogate indexes of insulin sensitivity and secretion were not different between the Ab(+) versus Ab(-) patients. GLP-1 during the OGTT was highest in the Ab(+) youths compared with the other two groups, but this difference disappeared after adjusting for BMI. Ab(+) and Ab(-) CDx-type 2 diabetes had relative hyperglucagonemia compared with control subjects. CONCLUSIONS The clinical measures of fasting and OGTT-derived surrogate indexes of insulin sensitivity and secretion, except for fasting C-peptide and C-peptide AUC, are less sensitive tools to distinguish metabolic/pathopysiological differences, detected by the clamp, between Ab(+) and Ab(-) CDx-type 2 diabetic youths. This underscores the importance of using more sensitive methods and the importance of determining antibody status in obese youths with CDx-type 2 diabetes.

journal_name

Diabetes Care

journal_title

Diabetes care

authors

Tfayli H,Bacha F,Gungor N,Arslanian S

doi

10.2337/dc09-0305

subject

Has Abstract

pub_date

2010-03-01 00:00:00

pages

632-8

issue

3

eissn

0149-5992

issn

1935-5548

pii

dc09-0305

journal_volume

33

pub_type

杂志文章
  • Accelerated insulin degradation: an alternate mechanism for insulin resistance.

    abstract::We have examined insulin and glucagon degrading activities of muscle and fat tissues in 11 subjects (4 lean controls, 3 insulin-resistant obese subjects, 2 non-insulin-dependent diabetic subjects, and 2 insulin-treated diabetic subjects) and correlated degrading activity with (1) basal insulin level and (2) state of i...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.2.5.414

    authors: Kitabchi AE,Stentz FB,Cole C,Duckworth WC

    更新日期:1979-09-01 00:00:00

  • Comparing Type 2 Diabetes, Prediabetes, and Their Associated Risk Factors in Asian Indians in India and in the U.S.: The CARRS and MASALA Studies.

    abstract:OBJECTIVE:To assess the prevalence of diabetes and prediabetes and the associated risk factors in two Asian Indian populations living in different environments. RESEARCH DESIGN AND METHODS:We performed cross-sectional analyses, using representative samples of 2,305 Asian Indians aged 40-84 years living in Chennai, Ind...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc15-0032

    authors: Gujral UP,Narayan KM,Pradeepa RG,Deepa M,Ali MK,Anjana RM,Kandula NR,Mohan V,Kanaya AM

    更新日期:2015-07-01 00:00:00

  • Bariatric/Metabolic Surgery to Treat Type 2 Diabetes in Patients With a BMI

    abstract:OBJECTIVE:Global usage of bariatric surgery has been dictated for the past quarter century by National Institutes of Health recommendations restricting these operations to individuals with a BMI ≥35 kg/m(2). Strong evidence now demonstrates that bariatric procedures markedly improve or cause remission of type 2 diabete...

    journal_title:Diabetes care

    pub_type: 杂志文章,meta分析

    doi:10.2337/dc16-0350

    authors: Cummings DE,Cohen RV

    更新日期:2016-06-01 00:00:00

  • Short-term exenatide treatment leads to significant weight loss in a subset of obese women without diabetes.

    abstract:OBJECTIVE:To investigate the effect of treatment with the glucagon-like peptide 1 receptor agonist exenatide on weight loss and metabolic parameters in obese nondiabetic women. RESEARCH DESIGN AND METHODS:Forty-one obese women (aged 48 ± 11 years and BMI 33.1 ± 4.1 kg/m(2)) participated in a 35-week randomized, double...

    journal_title:Diabetes care

    pub_type: 杂志文章,随机对照试验

    doi:10.2337/dc11-0931

    authors: Dushay J,Gao C,Gopalakrishnan GS,Crawley M,Mitten EK,Wilker E,Mullington J,Maratos-Flier E

    更新日期:2012-01-01 00:00:00

  • A pregnancy and postpartum lifestyle intervention in women with gestational diabetes mellitus reduces diabetes risk factors: a feasibility randomized control trial.

    abstract:OBJECTIVE:To pilot, among women with gestational diabetes mellitus (GDM), the feasibility of a prenatal/postpartum intervention to modify diet and physical activity similar to the Diabetes Prevention Program. The intervention was delivered by telephone, and support for breastfeeding was addressed. RESEARCH DESIGN AND ...

    journal_title:Diabetes care

    pub_type: 杂志文章,随机对照试验

    doi:10.2337/dc10-2221

    authors: Ferrara A,Hedderson MM,Albright CL,Ehrlich SF,Quesenberry CP Jr,Peng T,Feng J,Ching J,Crites Y

    更新日期:2011-07-01 00:00:00

  • Injection site effects on the pharmacokinetics and glucodynamics of insulin lispro and regular insulin.

    abstract:OBJECTIVE:The pharmacokinetics and glucodynamics of a new insulin analog, insulin lispro, and regular human insulin were compared and contrasted after subcutaneous administrations in femoral, deltoid, and abdominal injection sites. RESEARCH DESIGN AND METHODS:Single 0.2 U/kg doses of insulin lispro and regular insulin...

    journal_title:Diabetes care

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.2337/diacare.19.12.1437

    authors: ter Braak EW,Woodworth JR,Bianchi R,Cerimele B,Erkelens DW,Thijssen JH,Kurtz D

    更新日期:1996-12-01 00:00:00

  • Characteristics associated with maintenance of mean A1C

    abstract:OBJECTIVE:To assess the success and baseline predictors of maintaining glycemic control for up to 5 years of therapy using basal insulin glargine or standard glycemic care in people with dysglycemia treated with zero or one oral glucose-lowering agents. RESEARCH DESIGN AND METHODS:Data from 12,537 participants in the ...

    journal_title:Diabetes care

    pub_type: 杂志文章,随机对照试验

    doi:10.2337/dc12-2238

    authors: ORIGIN Trial Investigators.

    更新日期:2013-10-01 00:00:00

  • Impact of early neonatal breast-feeding on psychomotor and neuropsychological development in children of diabetic mothers.

    abstract:OBJECTIVE:In general, breast-feeding positively influences development of psychomotor function and cognition in children. Offspring of diabetic mothers (ODM) have delayed psychomotor and cognitive development. Recently, we observed a dose-dependent negative effect of early neonatal ingestion of breast milk from diabeti...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.28.3.573

    authors: Plagemann A,Harder T,Kohlhoff R,Fahrenkrog S,Rodekamp E,Franke K,Dudenhausen JW

    更新日期:2005-03-01 00:00:00

  • Impact of peripheral neuropathy on bone density in patients with type 1 diabetes.

    abstract:OBJECTIVE:To investigate whether peripheral neuropathy (PN), as part of the microangiopathic complex, affects bone mineral density (BMD) of the peripheral or the axial skeleton in patients with type 1 diabetes. RESEARCH DESIGN AND METHODS:Three study groups were examined. Group 1 comprised 21 males with type 1 diabete...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.22.5.827

    authors: Rix M,Andreassen H,Eskildsen P

    更新日期:1999-05-01 00:00:00

  • The dynamics of diabetes among birth cohorts in the U.S.

    abstract::OBJECTIVE Using a nationally representative sample of the civilian noninstitutionalized U.S. population, we estimated trends in diabetes prevalence across cohorts born 1910-1989 and provide the first estimates of age-specific diabetes incidence using nationally representative, measured data. RESEARCH DESIGN AND METHOD...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc13-1982

    authors: Fishman EI,Stokes A,Preston SH

    更新日期:2014-04-01 00:00:00

  • Serum adiponectin is increased in type 1 diabetic patients with nephropathy.

    abstract:OBJECTIVE:To elucidate whether serum adiponectin is associated with renal function, low-grade inflammatory markers, metabolic control, and insulin resistance in type 1 diabetic patients with and without nephropathy. RESEARCH DESIGN AND METHODS:A total of 189 type 1 diabetic patients from the Finnish Diabetic Nephropat...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.28.6.1410

    authors: Saraheimo M,Forsblom C,Fagerudd J,Teppo AM,Pettersson-Fernholm K,Frystyk J,Flyvbjerg A,Groop PH,FinnDiane study group.

    更新日期:2005-06-01 00:00:00

  • Cancer arising after pancreas and/or kidney transplantation in a series of 99 diabetic patients.

    abstract:OBJECTIVE:Recipients of solid organ transplants have an increased risk of developing certain types of malignancies as compared with the general population. The majority of the literature has reported on neoplasms in kidney and heart transplant recipients. RESEARCH DESIGN AND METHODS:We describe 9 neoplasms occurring i...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.20.3.272

    authors: Martinenghi S,Dell'Antonio G,Secchi A,Di Carlo V,Pozza G

    更新日期:1997-03-01 00:00:00

  • Continuous subcutaneous insulin infusion. American Diabetes Association.

    abstract::Use of continuous subcutaneous insulin infusion requires continuing available care by skilled professionals, careful selection of patients, meticulous patient monitoring, and provisions for recording and reporting experiences. Insulin pumps prescribed by a physician within these guidelines are a part of treatment and ...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.8.5.516

    authors:

    更新日期:1985-09-01 00:00:00

  • Low-dose bedtime NPH insulin in treatment of secondary failure to glyburide.

    abstract::Secondary failure to oral hypoglycemic agents (OHAs) is a possible outcome for non-insulin-dependent diabetes mellitus (NIDDM) patients and poses a serious therapeutic problem. In this study, we evaluated the effect of adding a single bedtime low-dose NPH insulin injection to the previous ineffective sulfonylurea ther...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.12.8.582

    authors: Trischitta V,Italia S,Borzi V,Tribulato A,Mazzarino S,Squatrito S,Vigneri R

    更新日期:1989-09-01 00:00:00

  • Random blood glucose measurement at antenatal booking to screen for overt diabetes in pregnancy: a retrospective study.

    abstract:OBJECTIVE:To assess random venous blood glucose (RBG) measurement at antenatal booking to detect "overt diabetes in pregnancy" (ODIP). RESEARCH DESIGN AND METHODS:A retrospective analysis of regional hospital obstetric data from 2004-2008 was performed. Universal RBG screening was included at booking. Oral glucose tol...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc11-0533

    authors: Church D,Halsall D,Meek C,Parker RA,Murphy HR,Simmons D

    更新日期:2011-10-01 00:00:00

  • Clinical and genetic determinants of progression of type 2 diabetes: a DIRECT study.

    abstract:OBJECTIVE:To identify the clinical and genetic factors that explain why the rate of diabetes progression is highly variable between individuals following diagnosis of type 2 diabetes. RESEARCH DESIGN AND METHODS:We studied 5,250 patients with type 2 diabetes using comprehensive electronic medical records in Tayside, S...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc13-1995

    authors: Zhou K,Donnelly LA,Morris AD,Franks PW,Jennison C,Palmer CN,Pearson ER

    更新日期:2014-01-01 00:00:00

  • Cognitions Associated With Hypoglycemia Awareness Status and Severe Hypoglycemia Experience in Adults With Type 1 Diabetes.

    abstract:OBJECTIVE:Impaired awareness of hypoglycemia (IAH) and recurrent severe hypoglycemia (RSH) remain problematic for people with type 1 diabetes (T1D), despite major therapeutic advances. We explored beliefs around hypo- and hyperglycemia in adults with T1D with, and without, IAH and RSH. RESEARCH DESIGN AND METHODS:A cr...

    journal_title:Diabetes care

    pub_type: 杂志文章,多中心研究

    doi:10.2337/dc19-0002

    authors: Cook AJ,DuBose SN,Foster N,Smith EL,Wu M,Margiotta G,Rickels MR,Speight J,de Zoysa N,Amiel SA

    更新日期:2019-10-01 00:00:00

  • Effects of Pemafibrate, a Novel Selective PPARα Modulator, on Lipid and Glucose Metabolism in Patients With Type 2 Diabetes and Hypertriglyceridemia: A Randomized, Double-Blind, Placebo-Controlled, Phase 3 Trial.

    abstract:OBJECTIVE:Type 2 diabetes is frequently complicated with atherogenic dyslipidemia. This study aimed to evaluate the efficacy and safety of pemafibrate (K-877) in patients with type 2 diabetes comorbid with hypertriglyceridemia. RESEARCH DESIGN AND METHODS:Patients were randomly assigned to three groups and received pl...

    journal_title:Diabetes care

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.2337/dc17-1589

    authors: Araki E,Yamashita S,Arai H,Yokote K,Satoh J,Inoguchi T,Nakamura J,Maegawa H,Yoshioka N,Tanizawa Y,Watada H,Suganami H,Ishibashi S

    更新日期:2018-03-01 00:00:00

  • Risk of Anemia With Metformin Use in Type 2 Diabetes: A MASTERMIND Study.

    abstract:OBJECTIVE:To evaluate the association between metformin use and anemia risk in type 2 diabetes, and the time-course for this, in a randomized controlled trial (RCT) and real-world population data. RESEARCH DESIGN AND METHODS:Anemia was defined as a hemoglobin measure of <11 g/dL. In the RCTs A Diabetes Outcome Progres...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc20-1104

    authors: Donnelly LA,Dennis JM,Coleman RL,Sattar N,Hattersley AT,Holman RR,Pearson ER

    更新日期:2020-10-01 00:00:00

  • Atherosclerotic vascular disease and its risk factors in non-insulin-dependent diabetic and nondiabetic subjects in Finland.

    abstract::A cross-sectional study on the prevalence of atherosclerotic vascular disease (ASVD) and its risk factors in non-insulin-dependent diabetic and nondiabetic subjects was carried out from 1982 to 1984 in East Finland (Kuopio) and West Finland (Turku), two areas known to differ markedly in prevalence of ASVD in the nondi...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.11.6.449

    authors: Laakso M,Rönnemaa T,Pyörälä K,Kallio V,Puukka P,Penttilä I

    更新日期:1988-06-01 00:00:00

  • Cholesterol absorption and synthesis in children with type 1 diabetes.

    abstract:OBJECTIVE:The levels of the surrogate markers of cholesterol absorption (cholestanol and plant sterols) and synthesis (cholesterol precursors) in serum have suggested that in adult type 1 diabetes, cholesterol absorption is high and synthesis is low compared with type 2 diabetic or control subjects. Accordingly, these ...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc05-2235

    authors: Järvisalo M,Raitakari O,Gylling H,Miettinen TA

    更新日期:2006-10-01 00:00:00

  • Valsartan improves {beta}-cell function and insulin sensitivity in subjects with impaired glucose metabolism: a randomized controlled trial.

    abstract:OBJECTIVE:Recently, the Nateglinide and Valsartan in Impaired Glucose Tolerance Outcomes Research Trial demonstrated that treatment with the angiotensin receptor blocker (ARB) valsartan for 5 years resulted in a relative reduction of 14% in the incidence of type 2 diabetes in subjects with impaired glucose metabolism (...

    journal_title:Diabetes care

    pub_type: 杂志文章,随机对照试验

    doi:10.2337/dc10-2224

    authors: van der Zijl NJ,Moors CC,Goossens GH,Hermans MM,Blaak EE,Diamant M

    更新日期:2011-04-01 00:00:00

  • Comparison of two indices of glycemic control in diabetic subjects: glycosylated serum protein and hemoglobin.

    abstract::Glycosylated serum protein (GSP) and glycosylated hemoglobin (GHb) were measured in 263 insulin-dependent and 41 non-insulin-dependent diabetic subjects. Both indices provided useful information in type II diabetes, but were extremely poor in judging control in type I diabetes. In both groups, there was poor correlati...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.6.1.34

    authors: Mehl TD,Wenzel SE,Russell B,Gardner D,Merimee TJ

    更新日期:1983-01-01 00:00:00

  • Gestational diabetes mellitus: NICE for the U.S.? A comparison of the American Diabetes Association and the American College of Obstetricians and Gynecologists guidelines with the U.K. National Institute for Health and Clinical Excellence guidelines.

    abstract:OBJECTIVE:To compare recent U.S. and U.K. guidelines on gestational diabetes mellitus (GDM). RESEARCH DESIGN AND METHODS:The guidelines from the American Diabetes Association, the American College of Obstetricians and Gynecologists, and the National Institute for Health and Clinical Excellence (NICE) in the U.K. were ...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc09-1376

    authors: Simmons D,McElduff A,McIntyre HD,Elrishi M

    更新日期:2010-01-01 00:00:00

  • The antidiabetogenic effect of GLP-1 is maintained during a 7-day treatment period and improves diabetic dyslipoproteinemia in NIDDM patients.

    abstract:OBJECTIVE:To investigate the long-term antidiabetogenic effect of glucagon-like peptide 1 (GLP-1) and its influence on diabetic dyslipoproteinemia, patients with NIDDM were treated with GLP-1 subcutaneously for 1 week. RESEARCH DESIGN AND METHODS:Twelve patients participated in the study. The 1st week of the study, al...

    journal_title:Diabetes care

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.2337/diacare.19.11.1200

    authors: Juntti-Berggren L,Pigon J,Karpe F,Hamsten A,Gutniak M,Vignati L,Efendic S

    更新日期:1996-11-01 00:00:00

  • Depression and diabetes: a large population-based study of sociodemographic, lifestyle, and clinical factors associated with depression in type 1 and type 2 diabetes.

    abstract:OBJECTIVE:The purpose of this study was to investigate factors associated with depression in type 1 and type 2 diabetes and test whether these differ from factors associated with depression in the nondiabetic population. RESEARCH DESIGN AND METHODS:In an unselected population study comprising 60,869 individuals, poten...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.28.8.1904

    authors: Engum A,Mykletun A,Midthjell K,Holen A,Dahl AA

    更新日期:2005-08-01 00:00:00

  • Trends in health care expenditure in U.S. adults with diabetes: 2002-2011.

    abstract:OBJECTIVE:Direct medical cost of diabetes in the U.S. has been estimated to be 2.3 times higher relative to individuals without diabetes. This study examines trends in health care expenditures by expenditure category in U.S. adults with diabetes between 2002 and 2011. RESEARCH DESIGN AND METHODS:We analyzed 10 years o...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc15-0369

    authors: Ozieh MN,Bishu KG,Dismuke CE,Egede LE

    更新日期:2015-10-01 00:00:00

  • Long-term follow-up of oral glucose tolerance test-derived glucose tolerance and insulin secretion and insulin sensitivity indexes in subjects with glucokinase mutations (MODY2).

    abstract:OBJECTIVE:We investigated the natural history of glucokinase (GCK)-related maturity-onset diabetes of the young type 2 (MODY2), notably the factors associated with deterioration of hyperglycemia over time. RESEARCH DESIGN AND METHODS:We report an 11-year follow-up of glucose tolerance and indexes of insulin secretion ...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc07-2017

    authors: Martin D,Bellanné-Chantelot C,Deschamps I,Froguel P,Robert JJ,Velho G

    更新日期:2008-07-01 00:00:00

  • Correlation of fingerstick blood glucose measurements with GlucoWatch biographer glucose results in young subjects with type 1 diabetes.

    abstract:OBJECTIVE:The purpose of this study was to compare measurements of glucose obtained via iontophoretic extraction with the GlucoWatch automatic glucose biographer (Cygnus, Inc., Redwood City, CA) with capillary blood glucose values that were determined 1) in a controlled outpatient clinic setting and 2) in a home settin...

    journal_title:Diabetes care

    pub_type: 临床试验,杂志文章

    doi:10.2337/diacare.22.10.1708

    authors: Garg SK,Potts RO,Ackerman NR,Fermi SJ,Tamada JA,Chase HP

    更新日期:1999-10-01 00:00:00

  • Prevalence of prediabetes and diabetes and metabolic profile of patients with nonalcoholic fatty liver disease (NAFLD).

    abstract:OBJECTIVE:Prediabetes and type 2 diabetes mellitus (T2DM) are believed to be common and associated with a worse metabolic profile in patients with nonalcoholic fatty liver disease (NAFLD). However, no previous study has systematically screened this population. RESEARCH DESIGN AND METHODS:We studied the prevalence and ...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc11-1849

    authors: Ortiz-Lopez C,Lomonaco R,Orsak B,Finch J,Chang Z,Kochunov VG,Hardies J,Cusi K

    更新日期:2012-04-01 00:00:00