Abstract:
BACKGROUND:To study the effects of two variants of Roux-en-Y gastric bypass (RYGBP) on plasma ghrelin concentrations according to different exposure of gastric fundus to the nutrient pathway. METHODS:A prospective longitudinal 2-year follow-up study was conducted. Ninety-six morbidly obese (MO) patients (age range: 41.6 +/- 9.6 years, body mass index: 53 +/- 9.5 kg/m(2)) were assigned to two bariatric surgical (BS) procedures: one that preserves food contact with gastric fundus (ringed RYGBP, n = 50) and the other that avoids it (modified RYGBP, n = 46). Different anthropometric and biochemical parameters were studied, focusing on ghrelin concentrations at baseline and 6, 12, and 24 months post-BS. RESULTS:At 24 months post-BS, all metabolic parameters studied had improved in all patients compared with those at 1-year follow-up and baseline (p < 0.05). However, high-density lipoprotein cholesterol concentrations took 2 years to normalise in 80% of patients, interleukin-6 decreased significantly in relation to baseline only after 2 years from BS (p < 0.001), and tumour necrosis factor alpha concentrations did not significantly decrease during the 2 years of follow-up. Plasma ghrelin concentrations increased in both surgical groups compare to baseline during the first year (24.6% in modified RYGBP and 36.62% in ringed RYGBP) and remained stable at the second year of follow-up, with no statistical differences between groups. CONCLUSIONS:In the second year of follow-up after BS, morbidity continued to improve in MO patients despite a lesser weight loss in relation to the first year. An increase in plasma ghrelin concentrations was found, regardless of nutrient contact with gastric fundus. Furthermore, changes in plasma ghrelin concentrations appeared to be independent of weight loss.
journal_name
Obes Surgjournal_title
Obesity surgeryauthors
Pérez-Romero N,Serra A,Granada ML,Rull M,Alastrué A,Navarro-Díaz M,Romero R,Fernández-Llamazares Jdoi
10.1007/s11695-009-0035-0subject
Has Abstractpub_date
2010-05-01 00:00:00pages
600-9issue
5eissn
0960-8923issn
1708-0428journal_volume
20pub_type
杂志文章相关文献
OBESITY SURGERY文献大全abstract:BACKGROUND:Despite reported effectiveness, weight loss surgery (WLS) still remains one of the least preferred options for outpatient providers, especially in Germany. The aim of this study was to examine the effect of stigma and knowledge on recommendation of WLS and referral to a surgeon by general practitioners (GPs)...
journal_title:Obesity surgery
pub_type: 杂志文章
doi:10.1007/s11695-016-2104-5
更新日期:2016-10-01 00:00:00
abstract:BACKGROUND:Obesity impairs quality of life, but the perception of the impairment could be different from one country to another. The purpose was to compare weight-related quality of life (QOL) between cohorts from Spain and North America. METHODS:A cross-sectional case-control study was performed between two populatio...
journal_title:Obesity surgery
pub_type: 杂志文章,多中心研究
doi:10.1007/s11695-012-0791-0
更新日期:2013-04-01 00:00:00
abstract:PURPOSE:Obesity and breast density are both associated with an increased risk of breast cancer and are potentially modifiable. Weight loss surgery (WLS) causes a significant reduction in the amount of body fat and a decrease in breast cancer risk. The effect of WLS on breast density and its components has not been docu...
journal_title:Obesity surgery
pub_type: 杂志文章
doi:10.1007/s11695-016-2415-6
更新日期:2017-04-01 00:00:00
abstract:BACKGROUND:Dumping syndrome is not infrequent after laparoscopic Roux-en-Y gastric bypass and could result in dreaded complications, such as hypoglycemia or syncope. Those patients who failed medical therapy and diet modification, regarded as intractable dumping syndrome, may be considered as candidates for revisional ...
journal_title:Obesity surgery
pub_type: 杂志文章
doi:10.1007/s11695-015-1607-9
更新日期:2015-05-01 00:00:00
abstract:BACKGROUND:The most common reason for readmission after bariatric surgery is postoperative nausea and vomiting (PONV). The aim of this study was to compare the incidence and severity of PONV between patients undergoing laparoscopic sleeve gastrectomy (SG) and gastric bypass (GB). METHODS:This was a prospective observa...
journal_title:Obesity surgery
pub_type: 杂志文章
doi:10.1007/s11695-018-3605-1
更新日期:2019-03-01 00:00:00
abstract:BACKGROUND:Laparoscopic sleeve gastrectomy (LSG) is the most preferred technique in morbidly obese patients for weight loss. There is a controversy about the routine preoperative evaluation of the stomach and the routine microscopic examination of all LSG specimens. Our aim is to analyze the results of both preoperativ...
journal_title:Obesity surgery
pub_type: 杂志文章
doi:10.1007/s11695-017-3014-x
更新日期:2018-05-01 00:00:00
abstract:BACKGROUND:Patients undergoing bariatric surgery with a gastric bypass lose about 66% of excess weight. Although this procedure induces weight loss, it is unknown whether it leads to protein malnutrition, which is studied here. METHODS:One hundred ten obese patients (body mass index, 47.9 +/- 8.6 kg/m(2)) undergoing g...
journal_title:Obesity surgery
pub_type: 杂志文章
doi:10.1007/s11695-008-9627-3
更新日期:2009-07-01 00:00:00
abstract::A peculiar category of persons with obesity lacking common metabolic disturbances has been depicted and termed as metabolically healthy obesity (MHO). Yet, although MHO patients are free of obesity-associated complications, they might not be entirely precluded from developing cardio-metabolic disorders. Among patients...
journal_title:Obesity surgery
pub_type: 杂志文章,评审
doi:10.1007/s11695-019-03964-8
更新日期:2019-09-01 00:00:00
abstract:PURPOSE:Esophageal dysmotility and disorders of the lower esophageal sphincter are well documented in morbidly obese patients. Esophageal achalasia has been reported in up to 1% of obese patients but the development of such esophageal motility disorder after laparoscopic sleeve gastrectomy (LSG) is extremely rare. The ...
journal_title:Obesity surgery
pub_type: 杂志文章
doi:10.1007/s11695-020-05114-x
更新日期:2020-11-24 00:00:00
abstract:INTRODUCTION:Obesity is a serious lifestyle disease with various comorbidities and an augmented risk of cancer. Laparoscopic sleeve gastrectomy (LSG) has recently become the most popular bariatric procedure worldwide. While the cost-effectiveness is a major healthcare providers' concern, the point of histological exam ...
journal_title:Obesity surgery
pub_type: 杂志文章
doi:10.1007/s11695-018-3485-4
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND:The BioEnterics Intragrastric Balloon (BIB) together with restricted diet has been used for the treatment of obesity and morbid obesity. METHODS:A prospective study was conducted on 100 patients who had undergone the BIB procedure between February 2005 and February 2007. RESULTS:Mean age, mean weight, and ...
journal_title:Obesity surgery
pub_type: 杂志文章
doi:10.1007/s11695-008-9565-0
更新日期:2008-09-01 00:00:00
abstract::Adipose tissue is considered as an endocrine organ, which is developed in specific depots, distinguished either as subcutaneous or visceral. Lipectomy, by means of liposuction or abdominoplasty, is a common plastic surgery procedure, which can remove substantial amounts of subcutaneous fat. This systematic review aims...
journal_title:Obesity surgery
pub_type: 杂志文章,评审
doi:10.1007/s11695-015-1797-1
更新日期:2015-10-01 00:00:00
abstract:BACKGROUND:Abnormal glucose profiles have been described after Roux-en-Y gastric bypass (RYGB) with intense postprandial hyperglycemic peaks in some but not all the patients. The underlying mechanisms of these anomalies are not totally understood. OBJECTIVE:The aim of this study is to determine whether or not the comp...
journal_title:Obesity surgery
pub_type: 杂志文章
doi:10.1007/s11695-015-1930-1
更新日期:2016-07-01 00:00:00
abstract::A technique is described to create a wide enteroenterostomy or Roux-en-Y anastomosis. ...
journal_title:Obesity surgery
pub_type: 杂志文章
doi:10.1381/096089203765887822
更新日期:2003-06-01 00:00:00
abstract:BACKGROUND:Patients undergoing either Roux-en-Y gastric bypass (RYGBP) or biliopancreatic diversion (BPD) with RYGBP are at risk of developing metabolic sequelae secondary to malabsorption. We compared the differences in nutritional complications between these two bariatric operations. METHODS:A retrospective analysis...
journal_title:Obesity surgery
pub_type: 杂志文章
doi:10.1381/096089202762252334
更新日期:2002-08-01 00:00:00
abstract::Gastric bypass with jejunal interposition is a version of the distal Roux-en-Y. Ninety cm of the jejunum is interposed between the gastric stoma and the ileum. This new procedure initially was used in super-obese patients mainly to facilitate the gastric anastomosis. ...
journal_title:Obesity surgery
pub_type: 杂志文章
doi:10.1381/096089293765559584
更新日期:1993-05-01 00:00:00
abstract:BACKGROUND:Previous studies have reported that risk factors for elevated mortality after Roux-en-Y gastric bypass include male gender, as well as a very elevated BMI. The present study was aimed at determining whether these same risk factors applied to patients undergoing the duodenal switch (DS) operation. MATERIALS ...
journal_title:Obesity surgery
pub_type: 杂志文章
doi:10.1381/0960892053923699
更新日期:2005-05-01 00:00:00
abstract::Healthcare today is a complex environment, and many states, regions and hospitals have been having problems in being solvent. Insurance co-payments have decreased, and the contract made with the physician depends on market leverage. We address contract problems in bariatric surgery and discuss how to try to divide bar...
journal_title:Obesity surgery
pub_type: 杂志文章
doi:10.1381/096089206777822395
更新日期:2006-07-01 00:00:00
abstract:BACKGROUND:Because perioperative complications of unrecognized obstructive sleep apnea (OSA) can be severe, many bariatric surgery programs routinely screen all patients. However, many obese non-bariatric surgery patients do not get screened. We wanted to evaluate the need for routine preoperative OSA screening. METHO...
journal_title:Obesity surgery
pub_type: 杂志文章
doi:10.1007/s11695-012-0806-x
更新日期:2013-03-01 00:00:00
abstract:BACKGROUND:Laparoscopic gastric bypass (LGBP) is being performed widely as a treatment of choice for morbid obesity. Advantages over open gastric bypass (OGBP) have not been well documented in controlled studies. The aim of this study is to evaluate the early postoperative outcomes after LGBP and OGBP using a matched p...
journal_title:Obesity surgery
pub_type: 杂志文章
doi:10.1381/096089203765887624
更新日期:2003-06-01 00:00:00
abstract:BACKGROUND AND AIMS:Minimally invasive therapies for obesity are a bridge between lifestyle interventions and bariatric surgery. We developed a novel device to reduce weight gain rate and evaluated its safety and efficacy in juvenile pigs. METHODS:The intragastric satiety-inducing device (ISD) comprises a self-expanda...
journal_title:Obesity surgery
pub_type: 杂志文章
doi:10.1007/s11695-020-04930-5
更新日期:2020-11-01 00:00:00
abstract:BACKGROUND:The present study aimed to investigate the effects of Roux-en-Y gastric bypass (RYGB) and prosthesis placement on gastric emptying rate in conjunction with serum ghrelin-obestatin-leptin responses in non-obese rats with intact or denervated afferent innervation. METHODS:Under anesthesia, male Sprague-Dawley...
journal_title:Obesity surgery
pub_type: 杂志文章
doi:10.1007/s11695-016-2420-9
更新日期:2017-04-01 00:00:00
abstract::This review examines the energetics and metabolic parameters which influence the effectiveness of gastric restrictive surgery in achieving weight loss in the clinically severely obese patient. Among the subjects discussed are the metabolic determinants and consequences of obesity, energy expenditure and its components...
journal_title:Obesity surgery
pub_type: 杂志文章
doi:10.1381/096089294765558700
更新日期:1994-05-01 00:00:00
abstract:BACKGROUND:Morbid obesity is one of the most important social and medical issues in Western countries. Many authors have adopted a minimally invasive approach to reproduce current bariatric operations. The aim of this study is to present a personal technique for laparoscopic vertical banded gastroplasty (LVBG) and the ...
journal_title:Obesity surgery
pub_type: 杂志文章
doi:10.1381/096089202321019666
更新日期:2002-10-01 00:00:00
abstract:BACKGROUND:The Montpellier bariatric team has recently proposed some technical alternatives to decrease the rate of gastroesophageal reflux disease (GERD) after bariatric surgery and also to offer patients an alternative in case of contraindication to Roux-en-Y gastric bypass (RYGBP): the Nissen-Sleeve (N-Sleeve). OBJ...
journal_title:Obesity surgery
pub_type: 杂志文章
doi:10.1007/s11695-020-04469-5
更新日期:2020-09-01 00:00:00
abstract:BACKGROUND:Obese patients occasionally require either elective or emergency critical care services following bariatric surgery. We describe this subgroup of patients. METHODS:From July 1, 1991 to July 31, 2004, we performed 1,279 bariatric operations; 241 (19%) required admission to the surgical critical care service....
journal_title:Obesity surgery
pub_type: 杂志文章
doi:10.1381/096089205774512681
更新日期:2005-10-01 00:00:00
abstract:BACKGROUND:Binge eating in the obese, specifically those undergoing bariatric surgery, has only recently been investigated. This study is a continuation of a long-term effort to determine the impact of eating disorders on the outcome of bariatric surgery. METHODS:Self-report questionnaires (Binge Eating Scale, Beck De...
journal_title:Obesity surgery
pub_type: 杂志文章
doi:10.1381/096089299765553845
更新日期:1999-02-01 00:00:00
abstract:BACKGROUND:Colorectal cancer incidence is rising in adults < 50 years old, possibly due to obesity. Having bariatric surgery (BRS) should hypothetically reduce this trend, but data are limited. This study compared trends of colorectal cancer (CRC) versus other obesity-related gastrointestinal cancers (OGCs) between mor...
journal_title:Obesity surgery
pub_type: 杂志文章
doi:10.1007/s11695-020-04902-9
更新日期:2020-12-01 00:00:00
abstract:BACKGROUND:The American Society of Bariatric Surgery has initiated a Bariatric Surgery Center of Excellence Program and the American College of Surgeons has followed with their Bariatric Surgery Center Network Accreditation Program. These programs postulate that concentration of weight loss operations in high-volume ce...
journal_title:Obesity surgery
pub_type: 杂志文章
doi:10.1007/s11695-007-9357-y
更新日期:2008-06-01 00:00:00
abstract::Considerable controversy exists about the perioperative management of patients at high risk for obstructive sleep apnea (OSA) in free-standing clinics. Eighty-eight percent of an American Society of Anesthesiologists expert panel felt that upper abdominal laparoscopic surgery could not be performed safely on an outpat...
journal_title:Obesity surgery
pub_type: 杂志文章
doi:10.1007/s11695-011-0381-6
更新日期:2011-10-01 00:00:00