Abstract:
OBJECTIVES:To estimate the gender-specific risk of mortality from cardiovascular disease according to smoking status and time since smoking cessation among former smokers in Japan. DESIGN:Prospective study. SETTING:140,026 males and 156,810 females aged 40-79 years who participated in one of three cohort studies conducted in Japan between 1980 and 1990. OUTCOME:The gender-specific hazard ratios (HRs) for cardiovascular disease mortality were calculated after adjustment for age and cohort. RESULTS:The age-adjusted and cohort-adjusted HRs for current smokers compared with lifelong non-smokers were 1.51 (95% CI 1.38 to 1.64) for total cardiovascular diseases, 2.19 (95% CI 1.79 to 2.67) for coronary heart disease and 1.24 (95% CI 1.10 to 1.41) for total stroke in males, and were 1.85 (95% CI 1.65 to 2.06), 2.84 (95% CI 2.24 to 3.60) and 1.70 (95% CI 1.44 to 2.01), respectively, in females. The age-adjusted and cohort-adjusted HRs for former smokers compared with current smokers according to the time period since smoking cessation decreased by approximately 5 years after smoking cessation and reached the same level as lifelong non-smokers approximately 10 years after smoking cessation among both males and females. CONCLUSIONS:The present study confirmed the association between smoking and mortality from cardiovascular disease in both males and females. Smoking cessation is a crucial preventive measure against death from cardiovascular disease.
journal_name
Tob Controljournal_title
Tobacco controlauthors
Honjo K,Iso H,Tsugane S,Tamakoshi A,Satoh H,Tajima K,Suzuki T,Sobue Tdoi
10.1136/tc.2009.029751subject
Has Abstractpub_date
2010-02-01 00:00:00pages
50-7issue
1eissn
0964-4563issn
1468-3318pii
tc.2009.029751journal_volume
19pub_type
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