Rat small intestine expresses the reelin-Disabled-1 signalling pathway.

Abstract:

:Expression of reelin, reelin receptors [apolipoprotein E receptor 2 (ApoER2) and very low density lipoprotein receptor (VldlR)] and the Disabled-1 (Dab1) protein was investigated in rat intestinal mucosa. Intestinal reelin and Dab1 mRNA levels were maximal in the early stages of life, reaching adult levels in 1-month-old rats. Expression of reelin mRNA was restricted to fibroblasts, whereas mRNAs of Dab1, ApoER2, VldlR and integrins alpha3 and beta1 were observed in enterocytes, crypts and fibroblasts. Reelin protein was only observed in isolated intestinal fibroblasts and in a cell layer subjacent to the villus epithelium, which seems to be composed of myofibroblasts because it also reacted to alpha-smooth muscle actin. The Disabled-1 and VldlR protein signals were detected in the crypt and villus cells, and they were particularly abundant in the terminal web domain of the enterocytes. The ApoER2 protein signal was detected in the upper half of the villi but not in the crypts. This is the first report showing that rat intestinal mucosa expresses the reelin-Disabled-1 signalling system.

journal_name

Exp Physiol

journal_title

Experimental physiology

authors

García-Miranda P,Peral MJ,Ilundain AA

doi

10.1113/expphysiol.2009.050682

subject

Has Abstract

pub_date

2010-04-01 00:00:00

pages

498-507

issue

4

eissn

0958-0670

issn

1469-445X

pii

expphysiol.2009.050682

journal_volume

95

pub_type

杂志文章
  • Effects of inspiratory muscle strength and inspiratory resistance on neck inspiratory muscle activation during controlled inspirations.

    abstract:NEW FINDINGS:What is the central question of this study? What factors influence the onset and magnitude of activation of the neck inspiratory muscles during inspiration? What is the main finding and its importance? Recruitment of the sternocleidomastoid and scalene muscles during inspiration, measured by means of surfa...

    journal_title:Experimental physiology

    pub_type: 杂志文章

    doi:10.1113/EP087247

    authors: Washino S,Mankyu H,Kanehisa H,Mayfield DL,Cresswell AG,Yoshitake Y

    更新日期:2019-04-01 00:00:00

  • The mode of action of several opioids on cardiac muscle.

    abstract::The objective of the experiments was to investigate the cellular basis of the inotropic effect on myocardium of several opioids which have been implicated in producing cardiotoxic effects in human poisoning. Opioids exerted negative inotropic effects, with half-maximal concentrations between 10 microM (dextropropoxyph...

    journal_title:Experimental physiology

    pub_type: 杂志文章

    doi:10.1113/expphysiol.1997.sp004021

    authors: Wu C,Fry CH,Henry J

    更新日期:1997-03-01 00:00:00

  • The pulmonary vasculature--lessons from Tibetans and from rare diseases of oxygen sensing.

    abstract:NEW FINDINGS:What is the topic of this review? This review is principally concerned with results from studies of the pulmonary vasculature in humans, particularly in relation to hypoxia and rare diseases that affect oxygen sensing. What advances does it highlight? This review highlights the degree to which the hypoxia-...

    journal_title:Experimental physiology

    pub_type: 杂志文章,评审

    doi:10.1113/expphysiol.2014.080507

    authors: Frise MC,Robbins PA

    更新日期:2015-11-01 00:00:00

  • Characterizing the plasma metabolome during 14 days of live-high, train-low simulated altitude: A metabolomic approach.

    abstract:NEW FINDINGS:What is the central question of this study? Does 14 days of live-high, train-low simulated altitude alter an individual's metabolomic/metabolic profile? What is the main finding and its importance? This study demonstrated that ∼200 h of moderate simulated altitude exposure resulted in greater variance in m...

    journal_title:Experimental physiology

    pub_type: 杂志文章

    doi:10.1113/EP087159

    authors: Lawler NG,Abbiss CR,Gummer JPA,Broadhurst DI,Govus AD,Fairchild TJ,Thompson KG,Garvican-Lewis LA,Gore CJ,Maker GL,Trengove RD,Peiffer JJ

    更新日期:2019-01-01 00:00:00

  • Coronary flow and left ventricular pressure during diastole in the anaesthetized dog.

    abstract::There is controversy about the effect of left ventricular pressure on resistance of the intramyocardial coronary vessels. In anaesthetized dogs the effect of left ventricular pressure on coronary flow during diastole was studied using an extracorporeal circulation and allowing the heart to contract and relax isovolumi...

    journal_title:Experimental physiology

    pub_type: 杂志文章

    doi:10.1113/expphysiol.1992.sp003602

    authors: Gattullo D,Linden RJ,Losano G,Pagliaro P,Westerhof N

    更新日期:1992-03-01 00:00:00

  • Effect of adrenaline and alpha-agonists on net rate of liquid absorption from the pleural space of rabbits.

    abstract::Indirect evidence supporting a solute-coupled liquid absorption from the pleural space of rabbits has recently been provided; moreover, the beta 2-adrenoceptor agonist terbutaline has been found to increase this absorption. In this study the effect of adrenaline and alpha-adrenoceptor agonists on net rate of liquid ab...

    journal_title:Experimental physiology

    pub_type: 杂志文章

    doi:10.1113/expphysiol.1997.sp004043

    authors: Zocchi L,Raffaini A,Agostoni E

    更新日期:1997-05-01 00:00:00

  • Effects of exercise intensity on absorption of ingested fluids in man.

    abstract::Plasma 2H accumulation was measured in six male volunteers after ingestion of drinks containing trace amounts of 2H2O. Subjects fasted overnight and remained seated at rest or exercised on a cycle ergometer at 42, 61 or 80% of their maximum oxygen uptake (VO2, max). The rate of plasma 2H accumulation was faster at res...

    journal_title:Experimental physiology

    pub_type: 临床试验,杂志文章

    doi:10.1113/expphysiol.1990.sp003419

    authors: Maughan RJ,Leiper JB,McGaw BA

    更新日期:1990-05-01 00:00:00

  • Long non-coding RNA activated by transforming growth factor-β promotes proliferation and invasion of cervical cancer cells by regulating the miR-144/ITGA6 axis.

    abstract:NEW FINDINGS:What is the central question of this study? This study was designed to investigate the molecular mechanism and biological roles of long non-coding RNA activated by transforming growth factor-β (lncRNA ATB) in the progression of cervical cancer. What is the main finding and its importance? Our study provide...

    journal_title:Experimental physiology

    pub_type: 杂志文章

    doi:10.1113/EP087656

    authors: Zhu Y,Wu Y,Yang L,Dou X,Jiang J,Wang L

    更新日期:2019-06-01 00:00:00

  • Control of exercise hyperpnoea: Contributions from thin-fibre skeletal muscle afferents.

    abstract:NEW FINDINGS:What is the topic of this review? In this review, we examine the evidence for control mechanisms underlying exercise hyperpnoea, giving attention to the feedback from thin-fibre skeletal muscle afferents, and highlight the frequently conflicting findings and difficulties encountered by researchers using a ...

    journal_title:Experimental physiology

    pub_type: 杂志文章,评审

    doi:10.1113/EP087649

    authors: Bruce RM,Jolley C,White MJ

    更新日期:2019-11-01 00:00:00

  • Evidence for simultaneous bidirectional fluid flux across synovial lining in knee joints of anaesthetized rabbits.

    abstract::A recent model predicted a local synovial circulation of extravascular fluid in which capillary filtrate entered a joint cavity and fluid simultaneously drained out of the cavity via intercellular pathways distant from capillaries. Here, solutions of albumin (10-250 g l-1) were infused continuously into the knee joint...

    journal_title:Experimental physiology

    pub_type: 杂志文章

    doi:10.1113/expphysiol.1992.sp003613

    authors: McDonald JN,Levick JR

    更新日期:1992-05-01 00:00:00

  • Foramen ovale blood flow and cardiac function after main pulmonary artery occlusion in fetal sheep.

    abstract:NEW FINDINGS:What is the central question of this study? At near-term gestation, foramen ovale blood flow accounts for a significant proportion of fetal left ventricular output. Can the foramen ovale increase its volume blood flow when right ventricular afterload is increased by main pulmonary artery occlusion? What is...

    journal_title:Experimental physiology

    pub_type: 杂志文章

    doi:10.1113/EP087423

    authors: Lantto J,Erkinaro T,Haapsamo M,Huhta H,Voipio HM,Hohimer AR,Davis LE,Acharya G,Räsänen J

    更新日期:2019-02-01 00:00:00

  • Mitochondrial regulation in skeletal muscle: A role for non-coding RNAs?

    abstract:NEW FINDINGS:What is the topic of this review? This article draws evidence from the current literature to support the hypothesis that non-coding RNA-mediated gene regulation takes place in the mitochondria. An emphasis is put on skeletal muscle. What advances does it highlight? This review highlights the potential role...

    journal_title:Experimental physiology

    pub_type: 杂志文章,评审

    doi:10.1113/EP086846

    authors: Silver J,Wadley G,Lamon S

    更新日期:2018-08-01 00:00:00

  • Human femoral artery and estimated muscle capillary blood flow kinetics following the onset of exercise.

    abstract::The purpose of this study was to compare the kinetics of estimated capillary blood flow (Qcap) to those of femoral artery blood flow (QFA) and estimated muscle oxygen uptake (VO2m). Nine healthy subjects performed a series of transitions from rest to moderate (below estimated lactate threshold, 6 min bouts) knee exten...

    journal_title:Experimental physiology

    pub_type: 临床试验,杂志文章

    doi:10.1113/expphysiol.2005.032904

    authors: Harper AJ,Ferreira LF,Lutjemeier BJ,Townsend DK,Barstow TJ

    更新日期:2006-07-01 00:00:00

  • Effects of muscle composition and architecture on specific strength in obese older women.

    abstract:NEW FINDINGS:What is the central question of this study? Do obesity-specific factors affect skeletal muscle performance in older individuals? What is the main finding and its importance? Older obese women have a larger quadriceps femoris size but develop lower tension per unit of skeletal muscle than their normal-weigh...

    journal_title:Experimental physiology

    pub_type: 杂志文章

    doi:10.1113/EP085273

    authors: Rastelli F,Capodaglio P,Orgiu S,Santovito C,Caramenti M,Cadioli M,Falini A,Rizzo G,Lafortuna CL

    更新日期:2015-10-01 00:00:00

  • Homeobox A5 and C10 genes modulate adaptation of brown adipose tissue during exercise training in juvenile rats.

    abstract:NEW FINDINGS:What is the central question of this study? Exercise can stimulate brown adipose tissue (BAT) with subsequent increase in uncoupling protein 1 expression and mitochondrial biogenesis. In that case, do BAT-specific Hox genes modify BAT functioning and cause uncoupling protein expression changes due to exerc...

    journal_title:Experimental physiology

    pub_type: 杂志文章

    doi:10.1113/EP089114

    authors: Kato H,Ario T,Kishida T,Tadano M,Osawa S,Maeda Y,Takakura H,Izawa T

    更新日期:2020-12-28 00:00:00

  • Endogenous peripheral hydrogen sulfide is propyretic: its permissive role in brown adipose tissue thermogenesis in rats.

    abstract:NEW FINDINGS:What is the central question of this study? In fever, the most striking response in the acute phase reaction of systemic inflammation, plasma H2 S concentration increases. However, the role of endogenous peripheral H2 S in fever is unknown. What is the main finding and its importance? Endogenous peripheral...

    journal_title:Experimental physiology

    pub_type: 杂志文章

    doi:10.1113/EP086775

    authors: Soriano RN,Braga SP,Breder JSC,Batalhao ME,Oliveira-Pelegrin GR,Ferreira LFR,Rocha MJA,Carnio EC,Branco LGS

    更新日期:2018-03-01 00:00:00

  • Extracellular calcium chelation and attenuation of calcium entry decrease in vivo cholinergic-induced eccrine sweating sensitivity in humans.

    abstract:NEW FINDINGS:What is the central question of this study? Calcium is an important second messenger in eccrine sweating; however, whether modulation of extracellular Ca(2+) and Ca(2+) entry has the capacity to modulate sweat rate in non-glabrous human skin has not been explored. What is the main finding and its importanc...

    journal_title:Experimental physiology

    pub_type: 杂志文章

    doi:10.1113/expphysiol.2013.076547

    authors: Metzler-Wilson K,Sammons DL,Ossim MA,Metzger NR,Jurovcik AJ,Krause BA,Wilson TE

    更新日期:2014-02-01 00:00:00

  • The role of exercise on long-term effects of alloxan administered in neonatal rats.

    abstract::The present study was designed to analyse the effects of aerobic exercise on the metabolic effects of alloxan. Male Wistar newborn rats (2 days old) received alloxan (200 mg (kg body weight)(-1)) intraperitoneally (A rats). Vehicle-injected rats were used as controls (C rats). At 28 days old, some of the A rats were s...

    journal_title:Experimental physiology

    pub_type: 杂志文章

    doi:10.1113/expphysiol.2004.028241

    authors: de Oliveira CA,Luciano E,de Mello MA

    更新日期:2005-01-01 00:00:00

  • Refinement of analgesia following thoracotomy and experimental myocardial infarction using the Mouse Grimace Scale.

    abstract:NEW FINDINGS:What is the central question of this study? There is an ethical imperative to optimize analgesia protocols for laboratory animals, but this is impeded by our inability to recognize pain reliably. We examined whether the Mouse Grimace Scale (MGS) provides benefits over a standard welfare scoring system for ...

    journal_title:Experimental physiology

    pub_type: 杂志文章

    doi:10.1113/expphysiol.2014.083139

    authors: Faller KM,McAndrew DJ,Schneider JE,Lygate CA

    更新日期:2015-02-01 00:00:00

  • The C57Bl/6 mouse serves as a suitable model of human skeletal muscle mitochondrial function.

    abstract::It is debatable whether differences in mitochondrial function exist across skeletal muscle types and whether mouse skeletal muscle mitochondrial function can serve as a valid model for human skeletal muscle mitochondrial function. The aims of this study were to compare and contrast three different mouse skeletal muscl...

    journal_title:Experimental physiology

    pub_type: 杂志文章

    doi:10.1113/expphysiol.2012.070037

    authors: Jacobs RA,Díaz V,Meinild AK,Gassmann M,Lundby C

    更新日期:2013-04-01 00:00:00

  • Laryngeal movements during the respiratory cycle measured with an endoscopic imaging technique in the conscious horse at rest.

    abstract::A video-laryngoscopic method, implemented with an algorithm for the correction of the deformation inherent in the endoscope optical system, has been used to measure the dorsoventral diameter (Drg) and the cross-sectional area (CSArg) of the rima glottidis in five healthy workhorses during conscious breathing at rest. ...

    journal_title:Experimental physiology

    pub_type: 杂志文章

    doi:

    authors: Lafortuna CL,Albertini M,Ferrucci F,Zucca E,Braghieri M,Clement MG,Saibene F

    更新日期:1999-07-01 00:00:00

  • Mineralocorticoid receptors, inflammation and sympathetic drive in a rat model of systolic heart failure.

    abstract::Appreciation for the role of aldosterone and mineralocorticoid receptors in cardiovascular disease is accelerating rapidly. Recent experimental work has unveiled a strong relationship between brain mineralocorticoid receptors and sympathetic drive, an important determinant of outcome in heart failure and hypertension....

    journal_title:Experimental physiology

    pub_type: 杂志文章,评审

    doi:10.1113/expphysiol.2008.045948

    authors: Felder RB

    更新日期:2010-01-01 00:00:00

  • Ageing augments β-adrenergic cutaneous vasodilatation differently in men and women, with no effect on β-adrenergic sweating.

    abstract:NEW FINDINGS:What is the central question of this study? β-Adrenergic receptor activation modulates cutaneous vasodilatation and sweating in young adults. In this study, we assessed whether age-related differences in β-adrenergic regulation of these responses exist and whether they differ between men and women. What is...

    journal_title:Experimental physiology

    pub_type: 杂志文章

    doi:10.1113/EP088583

    authors: Fujii N,McGarr GW,Amano T,Sigal RJ,Boulay P,Nishiyasu T,Kenny GP

    更新日期:2020-10-01 00:00:00

  • The role of Na+-H+ exchange in fluid and solute transport in the rat efferent ducts.

    abstract::In vivo microperfusion techniques were used to investigate the role of Na+-H+ exchange in the efferent ducts of the rat. Individual efferent ducts were perfused with a Krebs-Ringer bicarbonate solution (KRB) containing 0, 1, 3, 5 or 7.5 mM amiloride. Concentrations of 1-5 mM amiloride inhibited fluid reabsorption from...

    journal_title:Experimental physiology

    pub_type: 杂志文章

    doi:

    authors: Hansen LA,Clulow J,Jones RC

    更新日期:1999-05-01 00:00:00

  • Age-related electrophysiological changes in mouse taste receptor cells.

    abstract:NEW FINDINGS:What is the central question of this study? Loss of taste or inability to distinguish between different tastes progresses with age. The purpose was to evaluate the age-dependent changes in taste by studying the electrophysiological properties of taste receptor cells. What is the main finding and its import...

    journal_title:Experimental physiology

    pub_type: 杂志文章

    doi:10.1113/EP089104

    authors: Takeuchi K,Yoshii K,Ohtubo Y

    更新日期:2020-11-10 00:00:00

  • Oestrogen receptor ERα and ERβ agonists ameliorate oxidative brain injury and improve memory dysfunction in rats with an epileptic seizure.

    abstract:NEW FINDINGS:What is the central question of this study? Could different hormonally active substances, including oestrogen receptor (ER) agonists, protect against oxidative brain damage and memory impairment induced by a single epileptic seizure in rats? If so, which signalling mechanisms are involved in their anti-inf...

    journal_title:Experimental physiology

    pub_type: 杂志文章

    doi:10.1113/EP087986

    authors: Koyuncuoğlu T,Arabacı Tamer S,Erzik C,Karagöz A,Akakın D,Yüksel M,Yeğen BÇ

    更新日期:2019-12-01 00:00:00

  • Three-dimensional morphology and volume of the free Achilles tendon at rest and under load in people with unilateral mid-portion Achilles tendinopathy.

    abstract:NEW FINDINGS:What is the central question of this study? The aim was to determine the effect of mid-portion Achilles tendinopathy (MAT) on free Achilles tendon three-dimensional morphology and volume at rest and under load in people with unilateral MAT. What is the main finding and its importance? Tendinopathic tendon ...

    journal_title:Experimental physiology

    pub_type: 杂志文章

    doi:10.1113/EP086673

    authors: Nuri L,Obst SJ,Newsham-West R,Barrett RS

    更新日期:2018-03-01 00:00:00

  • Acute systemic hypoxia and the surface ultrastructure and morphological characteristics of rat leucocytes.

    abstract::We have examined the surface ultrastructure and morphological characteristics of leucocytes obtained from control rats breathing air and rats made acutely hypoxic (breathing 6% O2, for 30 min). Striking ultrastructural and morphological changes occurred in the leucocytes of hypoxic rats. These changes included the app...

    journal_title:Experimental physiology

    pub_type: 杂志文章

    doi:10.1113/expphysiol.1993.sp003731

    authors: Mian R,Westwood D,Stanley P,Marshall JM,Coote JH

    更新日期:1993-11-01 00:00:00

  • Double-sigmoid model for fitting fatigue profiles in mouse fast- and slow-twitch muscle.

    abstract::We present a curve-fitting approach that permits quantitative comparisons of fatigue profiles obtained with different stimulation protocols in isolated slow-twitch soleus and fast-twitch extensor digitorum longus (EDL) muscles of mice. Profiles from our usual stimulation protocol (125 Hz for 500 ms, evoked once every ...

    journal_title:Experimental physiology

    pub_type: 杂志文章

    doi:10.1113/expphysiol.2007.041285

    authors: Cairns SP,Robinson DM,Loiselle DS

    更新日期:2008-07-01 00:00:00

  • The gut hormone secretin triggers a gut-brown fat-brain axis in the control of food intake.

    abstract:NEW FINDINGS:What is the topic of this review? Brown fat's role in meal-associated thermogenesis and the related consequences for energy balance regulation with a focus on the gut hormone secretin, which has been identified as the endocrine molecular mediator of meal-associated brown fat thermogenesis. What advances do...

    journal_title:Experimental physiology

    pub_type: 杂志文章

    doi:10.1113/EP087878

    authors: Schnabl K,Li Y,Klingenspor M

    更新日期:2020-08-01 00:00:00