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Designing dendrimers for ocular drug delivery.

Abstract：

:New series of phosphorus-containing dendrimers, having one quaternary ammonium salt as core and carboxylic acid terminal groups have been synthesized from generation 0 (3 carboxylic acid terminal groups) to generation 2 (12 carboxylic acid terminal groups). These dendrimers react with the neutral form of carteolol (an ocular anti-hypertensive drug used to treat glaucoma) to afford ion pair (saline) species. The solubility in water of these charged dendrimers depends on the generation considered: generation 0 (3 carteolol) is well soluble, whereas generation 1 (6 carteolol) and generation 2 (12 carteolol) are poorly soluble. These dendrimers have been tested in vivo, as vehicle for ocular drug delivery of carteolol to rabbits.

journal_name

Eur J Med Chem

journal_title

European journal of medicinal chemistry

authors

Spataro G,Malecaze F,Turrin CO,Soler V,Duhayon C,Elena PP,Majoral JP,Caminade AM

doi

10.1016/j.ejmech.2009.10.017

subject

Has Abstract

pub_date

2010-01-01 00:00:00

pages

326-34

issue

1

eissn

0223-5234

issn

1768-3254

pii

S0223-5234(09)00519-4

journal_volume

45

pub_type

杂志文章

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