Fibrinogen and histidine-rich glycoprotein in early-onset preeclampsia.

Abstract:

OBJECTIVE:To determine whether plasma levels of fibrinogen and the placental tissue distributions of fibrinogen and histidine-rich glycoprotein (HRG) differ between early- and late-onset preeclampsia. DESIGN:The study comprised 18 women with early-onset (gestational weeks 24-32) and 19 women with late-onset (gestational weeks 35-42) preeclampsia. As controls concerning the plasma levels of fibrinogen, we used samples from non-pregnant fertile women, healthy pregnant women at gestational weeks 24-32 and healthy pregnant women at gestational weeks 35-42. Placental samples from women with healthy pregnancies at gestational weeks 35-42 served as controls in the immunohistochemical staining. SETTING:Uppsala University Hospital, Uppsala. METHODS:Plasma fibrinogen levels were analyzed and the placental tissue expression of fibrinogen and HRG determined by immunohistochemistry. RESULTS:Plasma level of fibrinogen was increased in early-onset, but not late-onset, preeclampsia. Levels of fibrinogen were significantly lower, and that of HRG significantly higher, in placentas from women with early-onset preeclampsia as compared with control placentas (p = 0.01 and 0.001). CONCLUSIONS:HRG and fibrinogen might be involved in the hypercoagulability and the angiogenic imbalance seen in early-onset preeclampsia.

authors

Kårehed K,Wikström AK,Olsson AK,Larsson A,Olovsson M,Akerud H

doi

10.3109/00016340903295618

subject

Has Abstract

pub_date

2010-01-01 00:00:00

pages

131-9

issue

1

eissn

0001-6349

issn

1600-0412

pii

10.3109/00016340903295618

journal_volume

89

pub_type

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