Effects of soy isoflavones on the uterus and urethra of ovariectomized rats.

Abstract:

OBJECTIVE:To evaluate the effect of soy isoflavone extract (SIE) on the uterus and urethra of castrated female rats. METHODS:Ovariectomized adult virgin Wistar rats (n = 45) received, for 30 days: placebo (GI); SIE from day 5 of castration (GII); or day 28 of castration (GIII). A standardized SIE was administered by gavage at 125 microg genistein/g body weight/day, with a soy-free diet. Average numbers of nuclei (NU), blood vessels (BV) and collagen fibers (CF) in uterus and mid-urethra sections were compared using Dunnett and Tukey tests (95% CI). RESULTS:Uterus: GII and GIII differed from GI in all respects; GII vs. GIII, no differences. Urethra: GIII vs. GI: no differences; GII vs. GI, differences in NU and CF; GII vs. GIII, differences in NU and CF. CONCLUSIONS:Early oral administration of SIE to ovariectomized rats reversed uterine/urethral effects of castration.

journal_name

Int Urogynecol J

authors

Santos ET,Sampaio MD,Cecon PR,Simões Mde J,Sartori MG,Girão MJ

doi

10.1007/s00192-009-0995-6

subject

Has Abstract

pub_date

2010-01-01 00:00:00

pages

111-6

issue

1

eissn

0937-3462

issn

1433-3023

journal_volume

21

pub_type

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