当前位置： SCI文献检索 > OPHTHALMOLOGY期刊下所有文献 > Reticular pseudodrusen are subretinal drusenoid deposits.

Reticular pseudodrusen are subretinal drusenoid deposits.

Abstract：

PURPOSE:To characterize reticular pseudodrusen, a potential risk factor for late age-related macular degeneration. DESIGN:Retrospective, observational case series. PARTICIPANTS:Fifty-eight eyes of 33 patients with pseudodrusen (20 female). METHODS:Consecutive patients with reticular pseudodrusen, diagnosed by their typical appearance and distribution using ophthalmoscopy, the blue channel of color fundus photographs, and near infrared images. The patients were imaged by spectral domain optical coherence tomography (SD OCT), and correlations were made between the near infrared images and the SD OCT images. The SD OCT findings in patients with pseudodrusen were compared with previously reported histologic findings of subretinal drusenoid deposits. The histologic specimens were reevaluated with the additional knowledge of the clinical information. MAIN OUTCOME MEASURES:Spectral domain optical coherence tomography and histologic characteristics of pseudodrusen. RESULTS:The mean age of the 33 patients was 81.7 years. The correlating SD OCT scans showed collections of granular hyperreflective material above the retinal pigment epithelium (RPE), in the subretinal space located primarily between the RPE and the boundary between the inner and outer segments of the photoreceptors (IS/OS boundary). In a more advanced stage, this material formed small mounds that broke through the IS/OS boundary. There were no correlates to the deposits seen under the RPE or in the choroid. These findings were similar in character to previously reported histologic characterization of subretinal drusenoid deposits, which had identified the presence of membranous debris, unesterified cholesterol, and complement within the deposits. CONCLUSIONS:Pseudodrusen seen by clinical examination may be subretinal drusenoid deposits seen by histologic examination. This unexpected location suggests that potential pathophysiologic mechanisms on both sides of the RPE need to be taken into account in theories related to the development of age-related macular degeneration.

journal_name

Ophthalmology

journal_title

Ophthalmology

authors

Zweifel SA,Spaide RF,Curcio CA,Malek G,Imamura Y

doi

10.1016/j.ophtha.2009.07.014

subject

Has Abstract

pub_date

2010-02-01 00:00:00

pages

303-12.e1

issue

2

eissn

0161-6420

issn

1549-4713

pii

S0161-6420(09)00756-8

journal_volume

117

pub_type

杂志文章

相关文献

OPHTHALMOLOGY文献大全
  • The repair of rhegmatogenous retinal detachments. American Academy of Ophthalmology.

    abstract：:Current techniques of rhegmatogenous retinal detachment repair allow most retinal detachments to be repaired successfully. The success of repair depends on a careful preoperative examination and choice of an appropriate surgical procedure. The surgical procedure must be tailored to the individual eye based on a detail...

    journal_title：Ophthalmology

    pub_type： 杂志文章,评审

    doi：10.1016/s0161-6420(90)32376-x

    authors：

    更新日期：1990-11-01 00:00:00

  • Clinical outcomes after complete ring implantation in corneal ectasia using the femtosecond technology: a pilot study.

    abstract：PURPOSE:To evaluate the clinical outcomes after implantation of the MyoRing (DIOPTEX GmBH, Linz, Austria) by means of femtosecond laser technology in eyes with corneal ectasia. DESIGN:Retrospective, consecutive, nonrandomized, case series. PARTICIPANTS:A total of 12 eyes of 11 patients with ages ranging from 17 to 50...

    journal_title：Ophthalmology

    pub_type： 杂志文章

    doi：10.1016/j.ophtha.2010.12.012

    authors： Alio JL,Piñero DP,Daxer A

    更新日期：2011-07-01 00:00:00

  • Hemorrhagic corneal pannus simulating a spontaneous expulsive hemorrhage.

    abstract：:An elderly, Spanish-speaking patient, who was a poor historian, presented with a hemorrhagic corneal condition that was mistakenly diagnosed as a spontaneous expulsive choroidal hemorrhage leading to enucleation of the globe. The enucleation specimen revealed pathologically a diffuse hemorrhagic pannus without corneal...

    journal_title：Ophthalmology

    pub_type： 杂志文章

    doi：10.1016/s0161-6420(81)34964-1

    authors： Crowell D,Jakobiec FA

    更新日期：1981-07-01 00:00:00

  • A phase I/II study of subconjunctival carboplatin for intraocular retinoblastoma.

    abstract：PURPOSE:To evaluate the efficacy and toxicity of subconjunctival carboplatin for intraocular retinoblastoma. DESIGN:A phase I/II clinical trial (noncomparative case series). PARTICIPANTS:Eleven children with bilateral retinoblastoma who had 13 eyes containing active tumor. METHODS:Subconjunctival carboplatin (1.4-2....

    journal_title：Ophthalmology

    pub_type： 临床试验,杂志文章

    doi：10.1016/S0161-6420(99)90406-2

    authors： Abramson DH,Frank CM,Dunkel IJ

    更新日期：1999-10-01 00:00:00

  • Risk factors associated with age-related nuclear and cortical cataract : a case-control study in the Age-Related Eye Disease Study, AREDS Report No. 5.

    abstract：OBJECTIVE:To investigate possible risk factors for age-related nuclear and cortical cataracts in participants in the Age-Related Eye Disease Study (AREDS). DESIGN:Case-control study. PARTICIPANTS:Of the 4757 persons enrolled in AREDS, 4477 age 60 to 80 years are included in the study. MAIN OUTCOME MEASURES:Slit-lamp...

    journal_title：Ophthalmology

    pub_type： 临床试验,杂志文章,多中心研究,随机对照试验

    doi：10.1016/s0161-6420(01)00626-1

    authors： Age-Related Eye Disease Study Research Group.

    更新日期：2001-08-01 00:00:00

  • Iridocorneal endothelial syndrome with contralateral guttate endothelial dystrophy. A light and electron microscopic study.

    abstract：:Both eyes from a 75-year-old woman who had unilateral closed-angle glaucoma, characteristic endothelial specular microscopic findings, and slowly progressive tractional iris abnormalities consistent with essential iris atrophy were obtained postmortem and studied by light, scanning, and transmission electron microscop...

    journal_title：Ophthalmology

    pub_type： 杂志文章

    doi：10.1016/s0161-6420(87)33541-9

    authors： Eagle RC Jr,Shields JA

    更新日期：1987-07-01 00:00:00

  • Downgaze eyelid position in patients with blepharoptosis.

    abstract：PURPOSE:To prospectively examine the change in upper eyelid position on downgaze in patients with blepharoptosis. METHODS:Upper eyelid margin to corneal light reflex distance (uMRD) was measured in primary gaze and in 30 degrees to 40 degrees downgaze in 50 consecutive patients with acquired ptosis and 10 consecutive ...

    journal_title：Ophthalmology

    pub_type： 杂志文章

    doi：10.1016/s0161-6420(95)30837-8

    authors： Meyer DR,Rheeman CH

    更新日期：1995-10-01 00:00:00

  • Subconjunctival lidocaine before laser treatment: a randomized trial.

    abstract：PURPOSE:The aim of the study was to determine whether subconjunctival anesthesia is effective at reducing pain associated with laser retinopexy. DESIGN:This was a single-center, prospective, patient-masked, randomized, controlled trial. PARTICIPANTS:In the primary study group, 65 patients were recruited. Thirty-two p...

    journal_title：Ophthalmology

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.ophtha.2010.01.036

    authors： Tesha PE,Giavedoni LR,Berger AR,Altomare F,Chow DR,Navajas EV,Yoganathan P,Wong DT,Principe A

    更新日期：2010-09-01 00:00:00

  • Aphakic keratoplasty: visual acuity and optical errors.

    abstract：:Sixty-four consecutive patients with aphakic penetrating keratoplasty and penetrating keratoplasty combined with intracapsular cataract extraction were reviewed in a prospective fashion with a minimum of a one-year follow-up. Five were lost to follow-up. There were seven graft failures at the end of one year. Five of ...

    journal_title：Ophthalmology

    pub_type： 杂志文章

    doi：10.1016/s0161-6420(80)35187-7

    authors： Olson RJ,Mattingly TP,Waltman SR,Kaufman HE

    更新日期：1980-07-01 00:00:00

  • Diabetic dense premacular hemorrhage. A possible indication for prompt vitrectomy.

    abstract：:A review was undertaken of nine eyes of nine patients who suffered tightly bound dense premacular hemorrhage as a complication of proliferative diabetic retinopathy. Patients who did not receive vitrectomy within four weeks of the onset of the hemorrhage all progressed to late macular traction and visual acuity no bet...

    journal_title：Ophthalmology

    pub_type： 杂志文章

    doi：10.1016/s0161-6420(85)34014-9

    authors： O'Hanley GP,Canny CL

    更新日期：1985-04-01 00:00:00

  • The importance of initial management in the treatment of severe infectious corneal ulcers.

    abstract：PURPOSE:To identify factors that influence the outcome of patients with severe infectious corneal ulcers. METHOD:A retrospective review was performed of the hospital records of all such patients admitted to the Doheny Eye Hospital during a 30 month period. Outcome variables examined were change in visual acuity, durat...

    journal_title：Ophthalmology

    pub_type： 杂志文章

    doi：10.1016/s0161-6420(95)30771-3

    authors： McLeod SD,LaBree LD,Tayyanipour R,Flowers CW,Lee PP,McDonnell PJ

    更新日期：1995-12-01 00:00:00

  • Lidocaine 2% gel versus lidocaine 4% unpreserved drops for topical anesthesia in cataract surgery: a randomized controlled trial.

    abstract：OBJECTIVE:To compare intracameral levels and clinical efficacy of lidocaine 2% gel with lidocaine 4% unpreserved drops. DESIGN:Double-blind, randomized, one-surgeon, controlled trial. PARTICIPANTS:One hundred seven consecutive cataract cases eligible for topical anesthesia. INTERVENTION:Patients were randomly assign...

    journal_title：Ophthalmology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/s0161-6420(02)01562-2

    authors： Bardocci A,Lofoco G,Perdicaro S,Ciucci F,Manna L

    更新日期：2003-01-01 00:00:00

  • Early vascular changes induced by transpupillary thermotherapy of choroidal neovascularization.

    abstract：OBJECTIVE:To study early direct effects of transpupillary thermotherapy (TTT) on choroidal neovascularization (CNV) and choroid. DESIGN:Retrospective, noncomparative interventional case series. PARTICIPANTS:Sixty-four eyes with subfoveal CNV. INTERVENTION:TTT was delivered using a diode laser at 810 nm through a con...

    journal_title：Ophthalmology

    pub_type： 杂志文章

    doi：10.1016/s0161-6420(02)01034-5

    authors： Lanzetta P,Michieletto P,Pirracchio A,Bandello F

    更新日期：2002-06-01 00:00:00

  • The utility of the monocular trial: data from the ocular hypertension treatment study.

    abstract：OBJECTIVE:To determine whether adjusting the intraocular pressure (IOP) change of the trial eye for the IOP change of the fellow eye (i.e., monocular trial) is a better assessment of medication response than testing each eye independently. DESIGN:Analysis of data from a prospective, randomized, clinical trial. PARTIC...

    journal_title：Ophthalmology

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1016/j.ophtha.2010.02.020

    authors： Bhorade AM,Wilson BS,Gordon MO,Palmberg P,Weinreb RN,Miller E,Chang RT,Kass MA,Ocular Hypertension Treatment Study Group.

    更新日期：2010-11-01 00:00:00

  • Repeated intravitreal high-dosage injections of triamcinolone acetonide for diffuse diabetic macular edema.

    abstract：OBJECTIVE:To report the results of repeated intravitreal injections of triamcinolone acetonide for treatment of diffuse diabetic macular edema. DESIGN:Retrospective interventional comparative study. PARTICIPANTS:The investigation included a study group (the responders) of 19 patients (22 eyes) with diffuse diabetic m...

    journal_title：Ophthalmology

    pub_type： 杂志文章

    doi：10.1016/j.ophtha.2006.01.002

    authors： Jonas JB,Spandau UH,Kamppeter BA,Vossmerbaeumer U,Harder B,Sauder G

    更新日期：2006-05-01 00:00:00

  • Complex microcirculation patterns detected by confocal indocyanine green angiography predict time to growth of small choroidal melanocytic tumors: MuSIC Report II.

    abstract：PURPOSE:Multiple independent laboratories have confirmed the histologic observation that some tumor microcirculation patterns (MCPs) in uveal melanomas are associated strongly with death resulting from metastatic disease. Because these patterns are imageable with confocal indocyanine green angiography (ICG), we designe...

    journal_title：Ophthalmology

    pub_type： 临床试验,杂志文章

    doi：10.1016/s0161-6420(02)01266-6

    authors： Mueller AJ,Freeman WR,Schaller UC,Kampik A,Folberg R

    更新日期：2002-12-01 00:00:00

  • Familial corneal scarring: a new dystrophy?

    abstract：:A 34-year-old white man with skin manifestations of the epidermal nevus syndrome was found to have anesthetic corneas, dry eyes, and localized opaque nodular elevations of both corneas. Similar corneal lesions, unassociated with corneal anesthesia, were found in four family members. Histology of corneal biopsies from ...

    journal_title：Ophthalmology

    pub_type： 杂志文章

    doi：10.1016/s0161-6420(84)34320-2

    authors： Hirst LW,Farmer ER,Green WR,Silver A,Walsh FB

    更新日期：1984-02-01 00:00:00

  • Using Uniocular Visual Acuity Substantially Underestimates the Impact of Visual Impairment on Quality of Life Compared with Binocular Visual Acuity.

    abstract：PURPOSE:Although the impact of vision-related quality of life (VRQoL) is assessed optimally using binocular visual acuity (VA), uniocular VA remains the preferred measurement method in clinic-based and epidemiologic studies. We compared the impact of distance presenting binocular VA and uniocular VA in the better-seein...

    journal_title：Ophthalmology

    pub_type： 杂志文章

    doi：10.1016/j.ophtha.2020.01.056

    authors： Kidd Man RE,Liang Gan AT,Fenwick EK,Thakur S,Gupta P,Teo ZL,Cheng CY,Wong TY,Lamoureux EL

    更新日期：2020-09-01 00:00:00

  • The retinal nerve fiber layer in normal eyes.

    abstract：:The retinal nerve fiber layer is different in normal and glaucomatous eyes. The authors used red-free photographs to examine the retinal nerve fiber layer in 234 normal eyes. The retinal nerve fiber layer was most visible in the inferior temporal arcade, followed by the superior temporal arcade, then by the temporal m...

    journal_title：Ophthalmology

    pub_type： 杂志文章

    doi：10.1016/s0161-6420(89)32838-7

    authors： Jonas JB,Nguyen NX,Naumann GO

    更新日期：1989-05-01 00:00:00

  • Risk factors for conversion to neovascular age-related macular degeneration based on longitudinal morphologic and visual acuity data.

    abstract：PURPOSE:To use longitudinal quantitative morphologic and visual acuity (VA) data to investigate the risk of choroidal neovascularization (CNV) event occurrence in eyes with dry age-related macular degeneration (AMD). DESIGN:Prospective observational study. PARTICIPANTS:A total of 513 participants (844 eyes) followed ...

    journal_title：Ophthalmology

    pub_type： 杂志文章

    doi：10.1016/j.ophtha.2012.02.048

    authors： Friberg TR,Bilonick RA,Brennen PM

    更新日期：2012-07-01 00:00:00

  • Whole-Exome Sequencing in Age-Related Macular Degeneration Identifies Rare Variants in COL8A1, a Component of Bruch's Membrane.

    abstract：PURPOSE:Genome-wide association studies and targeted sequencing studies of candidate genes have identified common and rare variants that are associated with age-related macular degeneration (AMD). Whole-exome sequencing (WES) studies allow a more comprehensive analysis of rare coding variants across all genes of the ge...

    journal_title：Ophthalmology

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.ophtha.2018.03.040

    authors： Corominas J,Colijn JM,Geerlings MJ,Pauper M,Bakker B,Amin N,Lores Motta L,Kersten E,Garanto A,Verlouw JAM,van Rooij JGJ,Kraaij R,de Jong PTVM,Hofman A,Vingerling JR,Schick T,Fauser S,de Jong EK,van Duijn CM,Hoyng CB

    更新日期：2018-09-01 00:00:00

  • Whipple's syndrome (uveitis, B27-negative spondylarthropathy, meningitis, and lymphadenopathy) associated with Arthrobacter sp. infection.

    abstract：OBJECTIVE:To report an unusual case of Whipple's disease, including uveitis, seronegative spondylarthropathy, meningitis, and lymphadenopathy, associated with an Arthrobacter sp. infection. DESIGN:Interventional case report. PATIENT AND INTERVENTION:A 60-year-old white man presenting with severe chronic uveitis and s...

    journal_title：Ophthalmology

    pub_type： 杂志文章

    doi：10.1016/S0161-6420(98)91036-3

    authors： Bodaghi B,Dauga C,Cassoux N,Wechsler B,Merle-Beral H,Poveda JD,Piette JC,LeHoang P

    更新日期：1998-10-01 00:00:00

  • Foscarnet in the treatment of cytomegalovirus retinitis in acquired immune deficiency syndrome.

    abstract：:Cytomegalovirus (CMV) retinitis is the major cause of visual loss in acquired immune deficiency syndrome (AIDS). Thirty-one patients with active CMV retinitis were treated with the new antiviral drug, Foscarnet (trisodium phosphonoformate). After a 3-week course of induction therapy, the retinitis improved in 29 of 31...

    journal_title：Ophthalmology

    pub_type： 杂志文章

    doi：10.1016/s0161-6420(89)32824-7

    authors： Lehoang P,Girard B,Robinet M,Marcel P,Zazoun L,Matheron S,Rozenbaum W,Katlama C,Morer I,Lernestedt JO

    更新日期：1989-06-01 00:00:00

  • Management of advanced retinopathy of prematurity in the older patient.

    abstract：:The authors studied 11 eyes of 10 patients who complained of a recent decrease in vision and whose eyes had the clinical appearance of stage 5 retinopathy of prematurity (ROP) as diagnosed by the presence of a dense, opaque retrolenticular membrane. Patients ranged in age from 4 to 33 years, and birth weights ranged f...

    journal_title：Ophthalmology

    pub_type： 杂志文章

    doi：10.1016/s0161-6420(91)32170-5

    authors： Bradford JD,Trese MT

    更新日期：1991-07-01 00:00:00

  • Neuropathic Corneal Pain: Approaches for Management.

    abstract：:Neuropathic pain is caused by a primary lesion or dysfunction of the nervous system and can occur in the cornea. However, neuropathic corneal pain (NCP) is currently an ill-defined disease. Patients with NCP are extremely challenging to manage, and evidence-based clinical recommendations for the management of patients...

    journal_title：Ophthalmology

    pub_type： 杂志文章,评审

    doi：10.1016/j.ophtha.2017.08.004

    authors： Dieckmann G,Goyal S,Hamrah P

    更新日期：2017-11-01 00:00:00

  • Outcomes of surgical bleb revision for complications of trabeculectomy.

    abstract：OBJECTIVE:To describe the results of revision surgery for complications of trabeculectomy in a case series from an academic glaucoma service. DESIGN:Retrospective case series. PARTICIPANTS:A total of 177 eyes of 167 adult patients who underwent revision of trabeculectomy at the Wilmer Eye Institute between 1994 and 2...

    journal_title：Ophthalmology

    pub_type： 杂志文章

    doi：10.1016/j.ophtha.2009.04.003

    authors： Radhakrishnan S,Quigley HA,Jampel HD,Friedman DS,Ahmad SI,Congdon NG,McKinnon S

    更新日期：2009-09-01 00:00:00

  • Ocular complications of pediatric uveitis.

    abstract：PURPOSE:To determine the cumulative proportion and the visual significance of ocular complications of pediatric uveitis. DESIGN:Cohort study. PARTICIPANTS:Patients with onset of endogenous or infectious uveitis before or at age 16 years. METHODS:Retrospective review of existing records at a university-based uveitis ...

    journal_title：Ophthalmology

    pub_type： 杂志文章

    doi：10.1016/j.ophtha.2004.06.014

    authors： Rosenberg KD,Feuer WJ,Davis JL

    更新日期：2004-12-01 00:00:00

  • Krupin disk implantation for complicated glaucomas.

    abstract：BACKGROUND:The Krupin Eye Valve with Disk (Krupin disk) is a glaucoma shunt that incorporates a slit valve intended to minimize early postoperative hypotony. METHODS:The medical records of all patients who have undergone Krupin disk implantation at the Doheny Eye Institute between July 1990 and December 1992 (25 eyes ...

    journal_title：Ophthalmology

    pub_type： 杂志文章

    doi：10.1016/s0161-6420(13)31724-2

    authors： Fellenbaum PS,Almeida AR,Minckler DS,Sidoti PA,Baerveldt G,Heuer DK

    更新日期：1994-07-01 00:00:00

  • Diagnostic capability of optical coherence tomography (Stratus OCT 3) in early glaucoma.

    abstract：PURPOSE:To evaluate the diagnostic capability of optical coherence tomography (Stratus OCT 3) for early glaucoma in Asian Indian eyes. DESIGN:Cross-sectional observational study. PARTICIPANTS:Two groups of patients (early glaucoma and normal) who satisfied the inclusion and exclusion criteria were included. Early gla...

    journal_title：Ophthalmology

    pub_type： 杂志文章

    doi：10.1016/j.ophtha.2007.03.005

    authors： Parikh RS,Parikh S,Sekhar GC,Kumar RS,Prabakaran S,Babu JG,Thomas R

    更新日期：2007-12-01 00:00:00

  • Clinical results of keratophakia and keratomileusis.

    abstract：:Thirteen keratophakia patients were followed for 13 to 35 months. Eighteen cases of hyperopic keratomileusis or hyperopic keratomileusis using preserved corneal tissue were followed for 2 to 30 months. All 13 patients who underwent keratophakia achieved 20/50 or better acuity. All seven patients having hyperopic kerat...

    journal_title：Ophthalmology

    pub_type： 杂志文章

    doi：10.1016/s0161-6420(81)34957-4

    authors： Friedlander MH,Werblin TP,Kaufman HE,Granet NS

    更新日期：1981-08-01 00:00:00