New friedelane triterpenoids with antimicrobial activity from the stems of Drypetes paxii.

Abstract:

:Two new friedelane-type triterpenes named 12alpha-hydroxyfriedelane-3,15-dione and 3beta-hydroxyfriedelan-25-al, together with six known compounds were isolated from the stems of Drypetes paxii Hutch. (Euphorbiaceae). Their structures were established on the basis of conventional 1 dimensional (1D) NMR methods, 2D shift-correlated NMR experiments and mass spectra. The five friedelane-type triterpene derivatives and one olean-12-ene triterpene saponin were tested for antimicrobial activity against some gram-positive and gram-negative bacteria, and they appeared to be modestly active.

authors

Chiozem DD,Trinh-Van-Dufat H,Wansi JD,Mbazoa Djama C,Fannang VS,Seguin E,Tillequin F,Wandji J

doi

10.1248/cpb.57.1119

subject

Has Abstract

pub_date

2009-10-01 00:00:00

pages

1119-22

issue

10

eissn

0009-2363

issn

1347-5223

pii

JST.JSTAGE/cpb/57.1119

journal_volume

57

pub_type

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