Dasatinib treatment of chronic-phase chronic myeloid leukemia: analysis of responses according to preexisting BCR-ABL mutations.

abstract：:Neutrophils exposed to fluoride ion (F-) respond with a delayed and sustained burst of superoxide anion release that is both preceded by and dependent on the influx of Ca2+ from the extracellular medium. The results of this study demonstrate a similarly delayed and sustained generation of 1,2-diglyceride in F(-)-treat...

journal_title：Blood

authors： English D,Taylor G,Garcia JG

更新日期：1991-06-15 00:00:00

abstract：:The mechanisms of tissue necrosis and vascular damage characteristics of certain Epstein-Barr virus (EBV)-associated lymphoproliferative disorders are unknown. The CXC chemokines interferon-gamma-inducible protein-10 (IP-10) and the monokine induced by interferon-gamma (Mig) caused tissue necrosis and vascular damage ...

journal_title：Blood

authors： Teruya-Feldstein J,Jaffe ES,Burd PR,Kanegane H,Kingma DW,Wilson WH,Longo DL,Tosato G

更新日期：1997-11-15 00:00:00

abstract：:We have developed a novel cotransplantation system in which gene-transduced human CD34+ progenitor cells are transplanted into immunodeficient (bnx) mice together with primary human bone marrow (BM) stromal cells engineered to produce human interleukin-3 (IL-3). The IL-3-secreting stroma produced sustained circulating...

journal_title：Blood

authors： Nolta JA,Hanley MB,Kohn DB

更新日期：1994-05-15 00:00:00

abstract：:Immunosuppression with antithymocyte globulin, (methyl)prednisolone, and cyclosporin A is considered the treatment of choice for the patient with aplastic anemia without a donor for standard-risk stem cell transplantation. This consensus is supported by the results of several series, including a randomized German tria...

journal_title：Blood

authors： Frickhofen N,Heimpel H,Kaltwasser JP,Schrezenmeier H,German Aplastic Anemia Study Group.

更新日期：2003-02-15 00:00:00

abstract：:Intestinal mucosal mast cells (IMMC) express granule neutral proteases that are regulated by T-cell-derived cytokines, including interleukin-3 (IL-3) and IL-9, and by stem cell factor (SCF). The IMMC-specific chymase, mouse mast cell protease-1 (mMCP-1), is released in substantial quantities into the blood stream duri...

journal_title：Blood

authors： Miller HR,Wright SH,Knight PA,Thornton EM

更新日期：1999-05-15 00:00:00

abstract：:To investigate the heterogeneous cellular structure of human acute myeloid leukemia (AML), subpopulations of cells were distinguished by two combined criteria: proliferation and differentiation. Purified blast cells were fractionated from blood or bone marrow of patients with newly diagnosed AML and colonies and clust...

journal_title：Blood

authors： Wouters R,Löwenberg B

更新日期：1984-03-01 00:00:00

abstract：:Interleukin-2 (IL-2) induces differential secretion of lymphokines by IL-2 receptor (IL-2R)-positive and IL-2R-negative T cells. We studied T cell IL-2R-specific modulation of adult bone marrow erythropoiesis by recombinant IL-2 (rIL-2). I3-2R were induced by CD3 T cell surface determinant-triggering and analyzed by c...

journal_title：Blood

authors： Burdach SE,Levitt LJ

更新日期：1987-05-01 00:00:00

abstract：:In vitro studies suggest that Ras activation is necessary for erythroid cell development. However, genetic inactivation of the Ras isoforms H-Ras, N-Ras, and K-Ras in mice reportedly did not affect adult or fetal erythropoiesis, though K-Ras(-/-) embryos were anemic. Given these discrepancies, we performed a more deta...

journal_title：Blood

authors： Khalaf WF,White H,Wenning MJ,Orazi A,Kapur R,Ingram DA

更新日期：2005-05-01 00:00:00

abstract：:Relapse following remission induction chemotherapy remains a barrier to survival in approximately 20% of children suffering from acute lymphoblastic leukemia (ALL). To investigate the mechanism of relapse, 27 matched diagnosis and relapse ALL samples were analyzed for clonal populations using polymerase chain reaction...

journal_title：Blood

authors： Choi S,Henderson MJ,Kwan E,Beesley AH,Sutton R,Bahar AY,Giles J,Venn NC,Pozza LD,Baker DL,Marshall GM,Kees UR,Haber M,Norris MD

更新日期：2007-07-15 00:00:00

abstract：:After invading human red blood cells (RBCs) the malaria parasite Plasmodium falciparum remodels the host cell by trafficking proteins to the RBC compartment. The virulence protein P. falciparum erythrocyte membrane protein 1 (PfEMP1) is responsible for cytoadherence of infected cells to host endothelial receptors. Thi...

journal_title：Blood

authors： Knuepfer E,Rug M,Klonis N,Tilley L,Cowman AF

更新日期：2005-05-15 00:00:00

abstract：:Monocytes/macrophages exert a series of important functions in vivo. To facilitate detailed investigation of their functional capacity and the mechanism leading to their differentiation, several cell lines have been established from primary material. We present here a new human monoblastic cell line, designated UG3. U...

journal_title：Blood

authors： Ikeda T,Sasaki K,Ikeda K,Yamaoka G,Kawanishi K,Kawachi Y,Uchida T,Takahara J,Irino S

更新日期：1998-06-15 00:00:00

abstract：:Growing evidence supports a pathophysiological role for platelets during the manifestation of postischemic reperfusion injury; in the current study, we investigated the nature and the molecular determinants of platelet-endothelial cell interactions induced by ischemia/reperfusion (I/R). Platelet-endothelium and leukoc...

journal_title：Blood

authors： Massberg S,Enders G,Leiderer R,Eisenmenger S,Vestweber D,Krombach F,Messmer K

更新日期：1998-07-15 00:00:00

abstract：:The developmental relationship between the blood and endothelial cell (EC) lineages remains unclear. In the extra-embryonic blood islands of birds and mammals, ECs and blood cells are closely intermixed, and blood island precursor cells in the primitive streak express many of the same molecular markers, leading to the...

journal_title：Blood

authors： Myers CT,Krieg PA

更新日期：2013-12-05 00:00:00

abstract：:A monoclonal antibody raised against cytochrome b558 reacted specifically with the 22- to 23-Kd protein, the small subunit of this cytochrome. Cytochemical studies showed that the epitope was located on the surfaces of human neutrophils and monocytes. The small subunit of cytochrome b558, therefore, was expressed at l...

journal_title：Blood

authors： Nakamura M,Sendo S,van Zwieten R,Koga T,Roos D,Kanegasaki S

更新日期：1988-11-01 00:00:00

abstract：:Autologous hematopoietic cell transplant (AHCT) for HIV-infected patients is largely limited to centers with HIV-specific expertise. The Blood and Marrow Transplant Clinical Trials Network 0803/AIDS Malignancy Consortium 071 trial is a multicenter phase 2 study of AHCT for patients with HIV-related lymphoma (HRL). Eli...

journal_title：Blood

authors： Alvarnas JC,Le Rademacher J,Wang Y,Little RF,Akpek G,Ayala E,Devine S,Baiocchi R,Lozanski G,Kaplan L,Noy A,Popat U,Hsu J,Morris LE Jr,Thompson J,Horowitz MM,Mendizabal A,Levine A,Krishnan A,Forman SJ,Navarro WH,

更新日期：2016-08-25 00:00:00

abstract：:Combination cytokine therapy continues to be evaluated in an effort to stimulate multilineage hematopoietic reconstitution after bone marrow myelosuppression. This study evaluated the efficacy of combination therapy with the synthetic interleukin-3 receptor agonist, Synthokine-SC55494, and recombinant methionyl human ...

journal_title：Blood

authors： MacVittie TJ,Farese AM,Herodin F,Grab LB,Baum CM,McKearn JP

更新日期：1996-05-15 00:00:00

abstract：:Mutations within exon 3 of the beta-globin gene are relatively uncommon, and many of these mutations produce a dominant thalassemia-like phenotype. We describe a novel thalassemic hemoglobinopathy caused by a single nucleotide substitution (CTG-->CCG) at codon 114 resulting in a leucine to proline substitution and des...

journal_title：Blood

authors： de Castro CM,Devlin B,Fleenor DE,Lee ME,Kaufman RE

更新日期：1994-02-15 00:00:00

abstract：:Recent studies suggest that the evolutionary history of a cancer is important in forecasting clinical outlook. To gain insight into the clonal dynamics of multiple myeloma (MM) and its possible influence on patient outcomes, we analyzed whole exome sequencing tumor data for 333 patients from Myeloma XI, a UK phase 3 t...

journal_title：Blood

authors： Johnson DC,Lenive O,Mitchell J,Jackson G,Owen R,Drayson M,Cook G,Jones JR,Pawlyn C,Davies FE,Walker BA,Wardell C,Gregory WM,Cairns D,Morgan GJ,Houlston RS,Kaiser MF

更新日期：2017-10-05 00:00:00

abstract：:The reduction of nitroblue tetrazolium dye by human neutrophils was measured in the presence of serum in which the complement system had been activated through the alternate pathway by interaction with inulin. Neutrophils incubated with serum inulin supernatants reduced the dye and showed a general increase in oxidati...

journal_title：Blood

authors： Strauss RG,Mauer AM,Asbrock T,Spitzer RE,Stitzel AE

更新日期：1975-06-01 00:00:00

abstract：:Megakaryocytes (MKs) undergo an endomitotic cell cycle, leading to polyploidy. We examined the expression of the flavoproteins and oxidative stress-promoting enzymes, NADPH oxidases (Nox's), in MKs because of their known role in promoting the cell cycle. Although the expression of Nox isoforms varies between cell type...

journal_title：Blood

authors： McCrann DJ,Eliades A,Makitalo M,Matsuno K,Ravid K

更新日期：2009-08-06 00:00:00

abstract：:The International Prognostic Index (IPI) has been the basis for determining prognosis in patients with aggressive non-Hodgkin lymphoma (NHL) for the past 20 years. Using raw clinical data from the National Comprehensive Cancer Network (NCCN) database collected during the rituximab era, we built an enhanced IPI with th...

journal_title：Blood

authors： Zhou Z,Sehn LH,Rademaker AW,Gordon LI,Lacasce AS,Crosby-Thompson A,Vanderplas A,Zelenetz AD,Abel GA,Rodriguez MA,Nademanee A,Kaminski MS,Czuczman MS,Millenson M,Niland J,Gascoyne RD,Connors JM,Friedberg JW,Winter JN

更新日期：2014-02-06 00:00:00

abstract：:Red cell concentrates (RCC) are stored for 35 to 42 days in plastic containers manufactured with the liquid plasticizer di(2-ethylhexyl)phthalate (DEHP). DEHP leaches from the polyvinylchloride (PVC) plastic bag, then binds to and stabilizes the RC membrane. This study was undertaken to determine the deformability of ...

journal_title：Blood

authors： Labow RS,Card RT,Rock G

更新日期：1987-07-01 00:00:00

abstract：:It has recently been shown that the ultralarge platelet-recruiting von Willebrand factor (VWF) strings formed immediately at exocytosis from endothelial cells may be anchored to the cell surface by interaction with the integral membrane protein P-selectin. This finding of a new binding partner for VWF immediately prom...

journal_title：Blood

authors： Michaux G,Pullen TJ,Haberichter SL,Cutler DF

更新日期：2006-05-15 00:00:00

abstract：:Scurfy mice develop CD4 T-cell-mediated lymphoproliferative disease leading to death within 4 weeks of age. The scurfy mutation causes loss of function of the foxp3 gene (foxp3(sf)), which is essential for development and maintenance of naturally occurring regulatory CD4 T cells (nTregs). In humans, mutations of the f...

journal_title：Blood

authors： Singh N,Chandler PR,Seki Y,Baban B,Takezaki M,Kahler DJ,Munn DH,Larsen CP,Mellor AL,Iwashima M

更新日期：2007-08-15 00:00:00

abstract：:Although well characterized in the mouse, the role of Notch signaling in the human T-cell receptor alphabeta (TCR-alphabeta) versus TCR-gammadelta lineage decision is still unclear. Although it is clear in the mouse that TCR-gammadelta development is less Notch dependent compared with TCR-alphabeta differentiation, re...

journal_title：Blood

authors： Van de Walle I,De Smet G,De Smedt M,Vandekerckhove B,Leclercq G,Plum J,Taghon T

更新日期：2009-03-26 00:00:00

abstract：:Since its approval in 2011, the Janus kinase 1/2 (JAK1/2) inhibitor ruxolitinib has evolved to become the centerpiece of therapy for myelofibrosis (MF), and its use in patients with hydroxyurea resistant or intolerant polycythemia vera (PV) is steadily increasing. Several other JAK2 inhibitors have entered clinical te...

journal_title：Blood

authors： Bose P,Verstovsek S

更新日期：2017-07-13 00:00:00

abstract：:Hydroxyurea treatment of sickle cell mice improved their survival from pneumococcal pneumonia, counteracting the abnormally elevated inflammatory response and reducing invasion of bacteria into the bloodstream, through down regulation of E-selectin. ...

journal_title：Blood

authors： Hsu LL

更新日期：2012-02-23 00:00:00

abstract：:STI571 induces sustained hematologic remission in patients with chronic myeloid leukemia (CML) in chronic phase. However, in advanced phases, especially blast crisis, the leukemia usually becomes resistant within months. It has been investigated whether resistance to STI571 is stable and immutable or whether it can be...

journal_title：Blood

authors： Tipping AJ,Mahon FX,Lagarde V,Goldman JM,Melo JV

更新日期：2001-12-15 00:00:00

abstract：:Imatinib mesylate (STI571), a potent tyrosine kinase inhibitor, is successfully used in the treatment of chronic myelogenous leukemia and gastrointestinal stromal tumors. However, the intended chronic oral administration of imatinib may lead to development of cellular resistance and subsequent treatment failure. Indee...

journal_title：Blood

authors： Burger H,van Tol H,Boersma AW,Brok M,Wiemer EA,Stoter G,Nooter K

更新日期：2004-11-01 00:00:00

abstract：:Multiple lines of evidence indicate that thrombopoietin (TPO) substantially impacts the number of hematopoietic stem cells and progenitors of all myeloid lineages. Nevertheless, tpo knock-out mice (T(-)) display thrombocytopenia only; blood erythroid and neutrophil levels are normal despite 60% to 85% reductions in st...

journal_title：Blood

authors： Kaushansky K,Fox N,Lin NL,Liles WC

更新日期：2002-05-15 00:00:00