Abstract:
OBJECTIVE:The purpose of the present study was to investigate the predictive power of sexual hormones and tumor markers in endometrial cancer. METHODS:A total of 135 healthy women were prospectively compared with 135 women who had histopathologically confirmed endometrial cancer. Both the groups of women were matched by age and body mass index. RESULTS:When compared with healthy controls, women with endometrial cancer had significantly higher serum levels of CA-125, CA 19-9, prolactin and thyroid-stimulating hormone, whereas significantly lower serum concentrations of alpha-fetoprotein, CA 15-3, follicle-stimulating hormone and luteinizing hormone (LH). Tumor stage correlated positively and significantly with serum levels of prolactin, CA-125 and CA 19-9 as did tumor grade with serum concentrations of LH, estradiol, prolactin and CA-125. Serum CA-125 levels >35 U/ml were found to have a sensitivity of 42.2%, specificity of 87.4%, positive-predictive value of 77.0% and negative-predictive value of 60.2%. Besides endometrial cancer could be diagnosed with 16.3% sensitivity, 100.0% specificity, 100.0% positive- and 54.4% negative-predictive values with serum prolactin levels >30 ng/ml. CONCLUSIONS:Because serum concentrations of CA-125 can be elevated in various malignancies, it is obvious that it is neither specific nor accurately diagnostic for endometrial tumors. What is more, the distinct effects of physiological factors on prolactin secretion shadow the credibility of this hormone in early diagnosis of endometrial tumors. Thus, either prolactin or CA-125 is far from being utilized as the sole entity for screening endometrial cancer. Therefore, both parameters should be regarded as the components of a biochemical screening panel that is to be developed in future.
journal_name
Arch Gynecol Obstetjournal_title
Archives of gynecology and obstetricsauthors
Kanat-Pektas M,Yenicesu O,Gungor T,Bilge Udoi
10.1007/s00404-009-1228-4subject
Has Abstractpub_date
2010-04-01 00:00:00pages
709-15issue
4eissn
0932-0067issn
1432-0711journal_volume
281pub_type
杂志文章abstract:OBJECTIVES:Assessment of the maternal complications in molecularly confirmed diandric and digynic triploid pregnancies. METHODS:Sonographic features, biochemical results, and clinical presentation were analyzed. Beta-hCG level was controlled after diandric triploidy. RESULTS:The study included nine diandric and twelv...
journal_title:Archives of gynecology and obstetrics
pub_type: 杂志文章,评审
doi:10.1007/s00404-020-05515-4
更新日期:2020-05-01 00:00:00
abstract:PURPOSE:The role of thyroid function in biochemical markers of first trimester screening has not been assessed. The aim of the present study was to investigate if there were any relation between maternal thyroid hormones and free-beta subunit of human chorionic gonadotropin (fβ-hCG) and pregnancy-associated plasma prot...
journal_title:Archives of gynecology and obstetrics
pub_type: 杂志文章
doi:10.1007/s00404-013-2712-4
更新日期:2013-06-01 00:00:00
abstract:OBJECTIVE:Osseous metaplasia is a rare pathological entity that affects the uterus and usually appears following abortion, chronic endometritis, metabolic disorders or following LEEP excision of the cervix. CASE:Herein, we present the occurrence of osseous metaplasia in a 27-year-old patient with a history of an abort...
journal_title:Archives of gynecology and obstetrics
pub_type: 杂志文章
doi:10.1007/s00404-007-0515-1
更新日期:2008-06-01 00:00:00
abstract:OBJECTIVE:To report the treatment results of 16 monochorionic and diamniotic gestations cases, which had complications due to the twin-to-twin transfusion syndrome (TTTS), the neonatal and other possible complications of the septostomy associated to the amniodrainage. METHOD:Based on ultrasonographic findings, 16 preg...
journal_title:Archives of gynecology and obstetrics
pub_type: 杂志文章
doi:10.1007/s00404-006-0266-4
更新日期:2007-05-01 00:00:00
abstract:BACKGROUND:Often, internet can bring a sense of anxiety rather than information and understanding to the patient. Our aim was to assess the quality of information available for patients on the management of polycystic ovarian syndrome (PCOS) on the internet. MATERIALS AND METHODS:Five search engines were searched usin...
journal_title:Archives of gynecology and obstetrics
pub_type: 杂志文章,评审
doi:10.1007/s00404-010-1378-4
更新日期:2010-05-01 00:00:00
abstract::We report a young woman of normal body weight who was diagnosed with polycystic ovary syndrome (PCOS) and had an odd variation of 75 g oral glucose tolerance test (OGTT). This woman underwent the 75 g OGTT to evaluate the association between PCOS and insulin secretion capacity. Although the blood sugar levels were wit...
journal_title:Archives of gynecology and obstetrics
pub_type: 杂志文章
doi:10.1007/s00404-006-0275-3
更新日期:2007-05-01 00:00:00
abstract:OBJECTIVE:To evaluate effectiveness and safety of titrated oral misoprostol solution (OMS) in comparison with vaginal dinoprostone for cervix ripening and labor induction in term pregnant women. METHODS:A multicenter randomized controlled trial of women with term singleton pregnancy with indications for labor inductio...
journal_title:Archives of gynecology and obstetrics
pub_type: 杂志文章
doi:10.1007/s00404-015-4000-y
更新日期:2016-09-01 00:00:00
abstract:INTRODUCTION:Gestational choriocarcinoma associated with ectopic pregnancy is an extremely rare event. We report a case of a choriocarcinoma arising from a cornual pregnancy. CASE:The patient is a 35-year-old G8 P2052 who was referred to our department due to failure of treatment for a suspected ectopic pregnancy. The...
journal_title:Archives of gynecology and obstetrics
pub_type: 杂志文章,评审
doi:10.1007/s00404-007-0394-5
更新日期:2007-12-01 00:00:00
abstract:OBJECTIVE:The objective of this research was to identify the rate of unexpected malignancies after laparoscopic-assisted supracervical hysterectomies (LASH) and describe the therapy regime. METHODS:The research is based on a retrospective chart analysis of patients undergoing a simple hysterectomy in the gynecological...
journal_title:Archives of gynecology and obstetrics
pub_type: 杂志文章
doi:10.1007/s00404-012-2559-0
更新日期:2013-03-01 00:00:00
abstract:OBJECTIVE:To investigate the level of cytokines and immune cells in the peripheral blood (PB) and peritoneal fluid (PF) of different stages of endometriosis. METHODS:A prospective study was conducted to include 97 women with (n 60) and without (n 37) histopathologically confirmed endometriosis. Based on rASRM classifi...
journal_title:Archives of gynecology and obstetrics
pub_type: 杂志文章
doi:10.1007/s00404-008-0844-8
更新日期:2009-06-01 00:00:00
abstract:PURPOSE:The unacceptable multiple gestation rate currently associated with in vitro fertilization (IVF) would be substantially alleviated if the routine practice of transferring more than one embryo were reconsidered. While transferring a single embryo is an effective method to reduce the clinical problem of multiple g...
journal_title:Archives of gynecology and obstetrics
pub_type: 杂志文章,评审
doi:10.1007/s00404-012-2396-1
更新日期:2012-09-01 00:00:00
abstract:PURPOSE:To assess sexual function among married women and determine associated risk factors for sexual dysfunction. PARTICIPANTS AND METHOD:Cross-sectional hospital-based study involving 509 non-pregnant married females 20-59 years old who were enrolled into the study after approval of the ethics committee. The study ...
journal_title:Archives of gynecology and obstetrics
pub_type: 杂志文章
doi:10.1007/s00404-012-2677-8
更新日期:2013-06-01 00:00:00
abstract:OBJECTIVE:To evaluate the neovascularization in placental polyp tissue by computed tomographic angiography and to determine the need for uterine artery embolization before hysteroscopic resection. STUDY DESIGN:Seventeen consecutive women with suspected placental polyp were enrolled in this retrospective study. Neovasc...
journal_title:Archives of gynecology and obstetrics
pub_type: 杂志文章
doi:10.1007/s00404-009-1161-6
更新日期:2010-05-01 00:00:00
abstract:PURPOSE:The purpose of this study was to investigate the fertility outcomes of infertile patients having proximal tubal obstruction treated with hysteroscopic tubal catheterization (HCT) for recanalization under diagnostic laparoscopy. METHODS:From January 2000 to December 2008, diagnostic laparoscopy was used to asse...
journal_title:Archives of gynecology and obstetrics
pub_type: 杂志文章
doi:10.1007/s00404-011-2007-6
更新日期:2011-12-01 00:00:00
abstract:INTRODUCTION:There is evidence of a probable key role of the activator protein-2 γ (AP-2γ) in placental development. It is still an open question whether AP-2γ expression may be influenced by preeclampsia, which is a serious pregnancy complication, or by smoking, which has deleterious effects on trophoblastic developme...
journal_title:Archives of gynecology and obstetrics
pub_type: 杂志文章
doi:10.1007/s00404-014-3473-4
更新日期:2015-05-01 00:00:00
abstract::The fertility and pregnancy outcomes of the patients were studied, who previously underwent preservative operation for malignant tumors, including those of borderline malignancy, in our ward from 1981 to 1995. For each of the 9 patients, unilateral ovary was preserved, the range of their ages before operation was 10 t...
journal_title:Archives of gynecology and obstetrics
pub_type: 杂志文章
doi:10.1007/s004040000094
更新日期:2000-11-01 00:00:00
abstract:PURPOSE:The present study aimed to assess the risk of obstetric anal sphincter injuries (OASIS) of a subsequent delivery after the previous OASIS in countries with low (Finland) and high rates (Norway and Sweden) of OASIS. METHODS:This population-based case-control study included women who experienced OASIS 1997-2002....
journal_title:Archives of gynecology and obstetrics
pub_type: 杂志文章
doi:10.1007/s00404-020-05550-1
更新日期:2020-06-01 00:00:00
abstract:PURPOSE:More than 370 million women will experience recurrent vulvovaginal candidiasis (RVVC) during their lifetime. However, RVVC is often trivialized as clinically insignificant and not worthy of research funding. We evaluated the influence of RVVC on the quality of life in affected women. METHODS:The validated Worl...
journal_title:Archives of gynecology and obstetrics
pub_type: 杂志文章
doi:10.1007/s00404-019-05228-3
更新日期:2019-09-01 00:00:00
abstract:PURPOSE:Epithelial-mesenchymal transition (EMT) endows cells with migratory and invasive properties, a prerequisite for the establishment of endometriotic lesions. However, the role EMT might play in the pathophysiology of endometriosis is still unknown. Therefore, we examined five recognized markers for EMT in endomet...
journal_title:Archives of gynecology and obstetrics
pub_type: 杂志文章
doi:10.1007/s00404-013-3040-4
更新日期:2014-04-01 00:00:00
abstract::We present a case report about bilateral multicystic dysplastic kidneys (MCDKs). Pregnancy was terminated at 21 weeks' gestation and the fetus was examined by autopsy. The kidneys were replaced by many cysts and there was no parenchyma. However, on histological examination, there was normal nephrogenesis amid the cyst...
journal_title:Archives of gynecology and obstetrics
pub_type: 杂志文章
doi:10.1007/s004040100188
更新日期:2002-07-01 00:00:00
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journal_title:Archives of gynecology and obstetrics
pub_type: 杂志文章
doi:10.1007/s00404-010-1715-7
更新日期:2011-09-01 00:00:00
abstract:PURPOSE:The objective of this study was to determine the changes in total plasma thiols (homocysteine, cysteine and cysteinylglycine), lipid peroxidation and nitric oxide concentrations during normal pregnancy. METHODS:These variables were measured in 28 uncomplicated pregnant women at first, second and third trimeste...
journal_title:Archives of gynecology and obstetrics
pub_type: 杂志文章
doi:10.1007/s00404-011-2150-0
更新日期:2012-05-01 00:00:00
abstract:PURPOSE:The aim of this study was to investigate the impact of bacterial vaginal flora on life-birth rate during ICSI and influence of metronidazole as antibiotic treatment course before ICSI. METHOD:We enrolled 71 women who were undergoing ICSI. At embryo transfer (ET), all of the women had quantitative vaginal cultu...
journal_title:Archives of gynecology and obstetrics
pub_type: 杂志文章
doi:10.1007/s00404-011-1857-2
更新日期:2011-12-01 00:00:00
abstract:PURPOSE:To evaluate the effect of a modified type II radical hysterectomy on maternal morbidities and mortality in cases with abnormally invasive placenta (AIP). METHODS:63 cases with AIP were managed at one of the largest referral centers in Egypt in a prospective study design. This technique entails devascularizatio...
journal_title:Archives of gynecology and obstetrics
pub_type: 杂志文章
doi:10.1007/s00404-018-5027-7
更新日期:2019-03-01 00:00:00
abstract:OBJECTIVE:To assess the impact of pre-hCG elevated progesterone on live birth outcomes during GnRH agonist long down regulated protocol assisted reproduction cycles. DESIGN:Retrospective cohort study. SETTING:Single Centre Private IVF Clinic. PATIENTS:A total of 582 consecutive cycles of IVF/ICSI in 2003. INTERVENT...
journal_title:Archives of gynecology and obstetrics
pub_type: 杂志文章
doi:10.1007/s00404-011-2045-0
更新日期:2012-02-01 00:00:00
abstract:PURPOSE:Our objective was to compare the recollection of preoperative counseling regarding mesh for pelvic organ prolapse (POP) and/or stress urinary incontinence (SUI) among women with or without a mesh-related complication (MRC). We hypothesized that the patients who had MRC would better recollect counseling regardin...
journal_title:Archives of gynecology and obstetrics
pub_type: 杂志文章
doi:10.1007/s00404-020-05919-2
更新日期:2021-01-03 00:00:00
abstract:OBJECTIVE:The aim of this study was to evaluate the effect of postpartum counseling on postpartum contraceptive use. METHODS:One hundred and forty-three women who delivered between 1 January 2004 and 31 September 2004 and counseled about postpartum contraception were included in the study. The participants were interv...
journal_title:Archives of gynecology and obstetrics
pub_type: 杂志文章
doi:10.1007/s00404-006-0287-z
更新日期:2007-06-01 00:00:00
abstract::An unusual case of anuria due to the obstruction caused by blood clot following repair of ruptured uterus is presented. Although the blood clot usually dissolves, the awareness of this complication is important to avoid the unnecessary procedures. ...
journal_title:Archives of gynecology and obstetrics
pub_type: 信件
doi:10.1007/s00404-008-0721-5
更新日期:2008-10-01 00:00:00
abstract::Ectopic pregnancy is the gynaecological emergency par excellence and remains the leading cause of pregnancy-related first trimester deaths in the UK. Its prevalence continues to rise because of increases in the incidence of the risk factors predisposing to ectopic pregnancy. Classically, the diagnosis is based on a hi...
journal_title:Archives of gynecology and obstetrics
pub_type: 杂志文章,评审
doi:10.1007/s00404-008-0731-3
更新日期:2009-04-01 00:00:00
abstract:AIM:To evaluate the efficacy of transcutaneous electrical nerve stimulation (TENS) for decreasing pain related with office endometrial biopsy. METHODS:In this prospective study, 65 women undergoing office endometrial biopsy were randomly allocated to receive 550 mg oral naproxen sodium plus active TENS (Group I, n = 3...
journal_title:Archives of gynecology and obstetrics
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00404-011-2111-7
更新日期:2012-04-01 00:00:00