Usability and safety of ventricular assist devices: human factors and design aspects.

abstract：:Lipid apheresis has developed from a heroic treatment into a routine clinical therapy and currently is the major indication for performing extracorporeal plasma therapy. Whereas it was once reserved for patients with homozygous familial hypercholesterolemia, today it has a place in the secondary prevention of severe c...

journal_title：Artificial organs

authors： Bosch T

更新日期：1996-05-01 00:00:00

abstract：:A small and light direct-drive centrifugal pump has been developed for cardiopulmonary bypass. In the development process, blood compatibility studies including a hemolysis study, an in vitro fluid dynamic performance study, and in vivo durability and feasibility studies were performed. The centrifugal pump with a 50 ...

journal_title：Artificial organs

authors： Jikuya T,Sasaki T,Aizawa T,Shiono M,Glueck JA,Smith CP,Feldman L,Sakuma I,Sekela ME,Noda T

更新日期：1992-12-01 00:00:00

abstract：:Centrifugal blood pumps are considered to be generally superior to the traditionally used roller pumps in cardiopulmonary bypass. In our institute a new lightweight centrifugal sealless blood pump with a unique spherical thrust bearing and with a magnetic coupling was developed, the HiFlow. The small design makes the ...

journal_title：Artificial organs

authors： Göbel C,Eilers R,Reul H,Schwindke P,Jörger M,Rau G

更新日期：1997-07-01 00:00:00

abstract：:Cardiopulmonary bypass (CPB) requirement in infants presents a unique challenge because of the large prime volume-to-blood volume ratio. Packed red blood cells (PRBCs) tend to deteriorate with long-term storage owing to their unphysiological composition and osmolality. Given that blood priming is inevitable in neonate...

journal_title：Artificial organs

authors： Gholampour Dehaki M,Niknam S,Bakhshandeh H,Azarfarin R

更新日期：2020-03-01 00:00:00

abstract：:The combination of plasma exchange and continuous hemofiltration was applied to patients with acute liver failure, and its clinically advantageous effects were evaluated. This procedure was found to be a powerful approach in decreasing patient morbidity; however, the effect was temporary and the patients finally died....

journal_title：Artificial organs

authors： Matsubara S

更新日期：1994-05-01 00:00:00

abstract：:A microcapsule suspension, a substitute for animal blood in hemolysis tests, has been developed for evaluation of the absolute hemolytic properties of circulatory artificial organs. The microcapsule suspension was made by dispersing microcapsule slurry into an ethylene glycol sodium chloride solution. The microcapsule...

journal_title：Artificial organs

authors： Maruyama O,Yamane T,Tsunemoto N,Nishida M,Tsutsui T,Jikuya T

更新日期：1999-03-01 00:00:00

abstract：:Biomechanical actuation of an implanted ventricular assist device (VAD) is an attractive means of providing long-term circulatory support. Studies show that energy from electrically stimulated skeletal muscle can, in principle, be used to provide tether-free cardiac assistance without the need for percutaneous driveli...

journal_title：Artificial organs

authors： Trumble DR

更新日期：2011-07-01 00:00:00

abstract：:Stimulation of different spinal cord segments in humans is a widely developed clinical practice for modification of pain, altered sensation, and movement. The human lumbar cord has become a target for modification of motor control by epidural and, more recently, by transcutaneous spinal cord stimulation. Posterior col...

journal_title：Artificial organs

authors： Danner SM,Hofstoetter US,Ladenbauer J,Rattay F,Minassian K

更新日期：2011-03-01 00:00:00

abstract：:Pyridoxalated-hemoglobin-polyoxyethylene conjugate (PHP), which is made from out-dated human red blood cells by two major chemical modifications, namely pyridoxalation and conjugation with polyoxyethylene (POE), is currently under development as a physiological oxygen carrier. This study assessed the effects of PHP-88...

journal_title：Artificial organs

authors： Takahashi T,Iwasaki K,Malchesky PS,Harasaki H,Matsushita M,Nosé Y,Rolin H 3rd,Hall PM

更新日期：1993-03-01 00:00:00

abstract：:The outgrowth of endothelial cells in an expanded polytetrafluoroethylene graft implanted in the canine inferior vena cava was studied by scanning electron microscopy. The adjacent endothelial cells of the vena cava started to invade the anastomotic area three days after the implantation and reached approximately the ...

journal_title：Artificial organs

authors： Ishimaru S,Berglin E,Hansson HA,Teger-Nilsson AC,William-Olsson G

更新日期：1981-11-01 00:00:00

abstract：:No standardized treatment algorithm exists for the management of continuous-flow left ventricular assist device (CF-LVAD)-specific infections. The aim of this systematic review and meta-analysis was to compare the outcomes of CF-LVAD-specific infections as managed by device exchange to other treatment modalities not i...

journal_title：Artificial organs

authors： Bauer TM,Choi JH,Luc JGY,Weber MP,Moncho Escrivá E,Patel S,Maynes EJ,Boyle AJ,Samuels LE,Entwistle JW,Morris RJ,Massey HT,Tchantchaleishvili V

更新日期：2019-05-01 00:00:00

abstract：:The blood flow through the hemofilter device is the key point for ultrafiltrate production during continuous arteriovenous hemofiltration. It mainly depends on arteriovenous pressure gradient and vascular access, which is the major problem for arteriovenous hemofiltration in infants and small children. In infants, we ...

journal_title：Artificial organs

authors： Zobel G,Trop M,Beitzke A,Ring E

更新日期：1988-02-01 00:00:00

abstract：:We studied 22 patients with residual pulmonary hypertension or symptoms of postoperative pulmonary hypertensive crisis. They received low-dose inhalation (10 ppm) of nitric oxide (NO), a selective pulmonary vasodilator, after total correction for congenital heart anomalies. Fifteen minutes of NO inhalation improved th...

journal_title：Artificial organs

authors： Matsui J,Yahagi N,Kumon K,Hayashi H,Watanabe Y,Haruna M,Tanigami H,Yagihara T,Takamoto S,Kamiya T

更新日期：1997-01-01 00:00:00

abstract：:The major restrictions to the transport of solute and solvent across the peritoneum are the limited peritoneal blood flow, area and permeability. Recent investigations have demonstrated that several vasoactive drugs influence transport parameters. Isoproterenol, nitroprusside, dipyridamole and dopamine exemplify drugs...

journal_title：Artificial organs

authors： Maher JF

更新日期：1979-08-01 00:00:00

abstract：:Recent studies show that oxytocin has various effects on cellular behaviors. Oxytocin is reported to stimulate cardiomyogenesis of embryonic stem cells and endothelial cell proliferation. Mesenchymal stem cells (MSCs) are widely used for cardiac repair, and we elucidated the effect of oxytocin on umbilical cord derive...

journal_title：Artificial organs

authors： Kim YS,Kwon JS,Hong MH,Kim J,Song CH,Jeong MH,Cho JG,Park JC,Kang JC,Ahn Y

更新日期：2010-06-01 00:00:00

abstract：:The characteristic depressed hemodynamic state and gradually declining circulatory function in Fontan patients necessitates alternative postoperative management strategies incorporating a system level approach. In this study, the single-ventricle Fontan circulation is modeled by constructing a practical in vitro bench...

journal_title：Artificial organs

authors： Dur O,Lara M,Arnold D,Vandenberghe S,Keller BB,DeGroff C,Pekkan K

更新日期：2009-11-01 00:00:00

abstract：:Cardiopulmonary bypass (CPB), an integral part of valve surgery, is known to cause hemodilution, which can lead to a need for blood transfusion as well as a systemic inflammatory reaction. Our aim was to evaluate a reduced priming (RP) system for CPB with regard to clinical outcomes in patients undergoing valve surger...

journal_title：Artificial organs

authors： Sato K,Namura O,Sogawa M,Shimada K,Tosaka Y,Hayashi J

更新日期：2006-08-01 00:00:00

abstract：:The specific timing for discontinuing renal replacement therapy (RRT) in acute kidney injury (AKI) patients is debatable. The predictive abilities of variables at the time of discontinuation of RRT for the long-term prognoses of patients have not been explored. This study aimed to explore the prognostic factors upon d...

journal_title：Artificial organs

authors： Yang T,Sun S,Lin L,Han M,Liu Q,Zeng X,Zhao Y,Li Y,Su B,Huang S,Yang L

更新日期：2017-12-01 00:00:00

abstract：:Aortic arch repair in newborns and infants has traditionally been accomplished using a period of deep hypothermic circulatory arrest. To reduce neurologic and cardiac dysfunction related to circulatory arrest and myocardial ischemia during complex aortic arch surgery, an alternative and novel strategy for cerebro-myoc...

journal_title：Artificial organs

authors： Hoxha S,Abbasciano RG,Sandrini C,Rossetti L,Menon T,Barozzi L,Linardi D,Rungatscher A,Faggian G,Luciani GB

更新日期：2018-04-01 00:00:00

abstract：:Contamination of a ventriculoatrial shunt (VAS) with skin organisms that are usually nonpathogenic may be followed by an immunologically mediated renal injury. The bacteria characteristically involved are coagulase-negative Staphylococci (e.g., Staphylococcus epidermidis), which strongly adhere to the plastic surface ...

journal_title：Artificial organs

authors： Samtleben W,Bauriedel G,Bosch T,Goetz C,Klare B,Gurland HJ

更新日期：1993-08-01 00:00:00

abstract：:To avoid using sensors with low biocompatibility and low durability in implantable total artificial heart (TAH) systems, the authors previously proposed a new method for estimating instantaneous values of flow rate and pressure head on the basis of voltage, current, and rotational speed in a motor driven centrifugal p...

journal_title：Artificial organs

authors： Tanaka A,Yoshizawa M,Abe K,Takeda H,Yambe T,Nitta S

更新日期：2003-01-01 00:00:00

abstract：:Bubble blood oxygenators equipped with baffles of various types in the oxygenating column were studied. The rate of hemolysis, the volumetric coefficient for oxygen absorption into blood, and the fractional gas holdup were found to be affected mainly by the superficial gas velocity. When compared with the conventional...

journal_title：Artificial organs

authors： Ohshima N,Yoshido F

更新日期：1979-05-01 00:00:00

abstract：:We developed a novel miniaturized extracorporeal centrifugal pump "BIOFLOAT NCVC (Nipro Corporation Osaka, Japan) as a ventricular assist device (VAD) and performed a preclinical study that is part of the process for its approval as a bridge to decision by the pharmaceutical and medical device agencies. The aim of thi...

journal_title：Artificial organs

authors： Shimamura J,Mizuno T,Takewa Y,Tsukiya T,Naito N,Akiyama D,Iizuka K,Katagiri N,Nishimura T,Ono M,Tatsumi E

更新日期：2019-09-01 00:00:00

abstract：:The present study aimed to determine the feasibility of constructing a reinforced autologous vascular graft by combining the advantages of fibrin gel as an autologous cell carrier material with the inherent mechanical strength of an integrated mesh structure. It was hypothesized that the mesh and dynamic culture condi...

journal_title：Artificial organs

authors： Tschoeke B,Flanagan TC,Cornelissen A,Koch S,Roehl A,Sriharwoko M,Sachweh JS,Gries T,Schmitz-Rode T,Jockenhoevel S

更新日期：2008-10-01 00:00:00

abstract：:The Fas molecule, also designated APO-1/CD95, belongs to the tumor necrosis factor (TNF) receptor family. It is a widely expressed membrane-anchored protein that induces apoptosis by Fas/Fas ligand (Fas-L) mediation. It was reported that Fas-mediated apoptosis plays an important role in regulation of the immune system...

journal_title：Artificial organs

authors： Kawahito K,Misawa Y,Fuse K

更新日期：2000-08-01 00:00:00

abstract：:This work presents results of preliminary studies concerning application of magnetic bearing in a ventricular assist device (VAD) being developed by Dante Pazzanese Institute of Cardiology-IDPC (São Paulo, Brazil). The VAD-IDPC has a novel architecture that distinguishes from other known VADs. In this, the rotor has a...

journal_title：Artificial organs

authors： Horikawa O,de Andrade AJ,da Silva I,Bock EG

更新日期：2008-04-01 00:00:00

abstract：:Electrolyzed water accelerated the healing of full-thickness cutaneous wounds in rats, but only anode chamber water (acid pH or neutralized) was effective. Hypochlorous acid (HOCl), also produced by electrolysis, was ineffective, suggesting that these types of electrolyzed water enhance wound healing by a mechanism un...

journal_title：Artificial organs

authors： Yahagi N,Kono M,Kitahara M,Ohmura A,Sumita O,Hashimoto T,Hori K,Ning-Juan C,Woodson P,Kubota S,Murakami A,Takamoto S

更新日期：2000-12-01 00:00:00

abstract：:Adsorption therapy, which treats the autoimmune disease by the selective removal of pathogenic substances from the blood, is an active subject. In this therapy, bioactive molecules such as antigen, antibodies and protein A are usually used as affinity-ligands. The disadvantages of using these substances as affinity-li...

journal_title：Artificial organs

authors： Yamamoto Y,Sameshima T,Akaike T

更新日期：1990-10-01 00:00:00

abstract：:Flow visualization experiments and computational fluid dynamic (CFD) analyses were performed and the results were compared to clarify the detailed fluid dynamic characteristics for the prototype design of a centrifugal pump, namely, an implantable ventricular assist system from Sun Medical, whose hemocompatibility was...

journal_title：Artificial organs

authors： Yamane T,Miyamoto Y,Tajima K,Yamazaki K

更新日期：2004-05-01 00:00:00

abstract：:Tumor necrosis factor-alpha (TNF-alpha) release has been implicated in a sepsis-like syndrome following cardiopulmonary bypass (CPB). This also may be important in patients who have had a left ventricular assist device (LVAD) implanted. This report investigates the effect of reducing systemic blood flow on hemodynamic...

journal_title：Artificial organs

authors： Uozaki Y,Dihmis WC,Yamauchi H,Moczar M,Miyama M,Pasteau F,Tixier D,Bambang SL,Loisance DY

更新日期：2001-02-01 00:00:00