Abstract:
BACKGROUND:Brain morphometric measures from magnetic resonance imaging (MRI) have not been used to discriminate between first-episode patients with schizophrenia and healthy subjects. METHODS:Magnetic resonance images were acquired from 34 (17 males, 17 females) first-episode schizophrenia patients and 48 (24 males, 24 females) age- and parental socio-economic status-matched healthy subjects. Twenty-nine regions of interest (ROI) were measured on 1-mm-thick coronal slices from the prefrontal and central parts of the brain. Linear discriminant function analysis was conducted using standardized z scores of the volumes of each ROI. RESULTS:Discriminant function analysis with cross-validation procedures revealed that brain anatomical variables correctly classified 75.6% of male subjects and 82.9% of female subjects, respectively. The results of the volumetric comparisons of each ROI between patients and controls were generally consistent with those of the previous literature. CONCLUSIONS:To our knowledge, this study provides the first evidence of MRI-based successful classification between first-episode patients with schizophrenia and healthy controls. The potential of these methods for early detection of schizophrenia should be further explored.
journal_name
Prog Neuropsychopharmacol Biol Psychiatryauthors
Takayanagi Y,Kawasaki Y,Nakamura K,Takahashi T,Orikabe L,Toyoda E,Mozue Y,Sato Y,Itokawa M,Yamasue H,Kasai K,Kurachi M,Okazaki Y,Matsushita M,Suzuki Mdoi
10.1016/j.pnpbp.2009.09.004subject
Has Abstractpub_date
2010-02-01 00:00:00pages
10-7issue
1eissn
0278-5846issn
1878-4216pii
S0278-5846(09)00301-7journal_volume
34pub_type
杂志文章abstract::Depression and impaired quality of life (QOL) are frequently observed in patients suffering from a variety of diseases. In addition, it has been reported that an enhanced degradation of the serotonin precursor tryptophan may contribute to QOL deterioration in some diseases. However, it is unclear whether the correlati...
journal_title:Progress in neuro-psychopharmacology & biological psychiatry
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journal_title:Progress in neuro-psychopharmacology & biological psychiatry
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