Differentiation of first-episode schizophrenia patients from healthy controls using ROI-based multiple structural brain variables.

Abstract:

BACKGROUND:Brain morphometric measures from magnetic resonance imaging (MRI) have not been used to discriminate between first-episode patients with schizophrenia and healthy subjects. METHODS:Magnetic resonance images were acquired from 34 (17 males, 17 females) first-episode schizophrenia patients and 48 (24 males, 24 females) age- and parental socio-economic status-matched healthy subjects. Twenty-nine regions of interest (ROI) were measured on 1-mm-thick coronal slices from the prefrontal and central parts of the brain. Linear discriminant function analysis was conducted using standardized z scores of the volumes of each ROI. RESULTS:Discriminant function analysis with cross-validation procedures revealed that brain anatomical variables correctly classified 75.6% of male subjects and 82.9% of female subjects, respectively. The results of the volumetric comparisons of each ROI between patients and controls were generally consistent with those of the previous literature. CONCLUSIONS:To our knowledge, this study provides the first evidence of MRI-based successful classification between first-episode patients with schizophrenia and healthy controls. The potential of these methods for early detection of schizophrenia should be further explored.

authors

Takayanagi Y,Kawasaki Y,Nakamura K,Takahashi T,Orikabe L,Toyoda E,Mozue Y,Sato Y,Itokawa M,Yamasue H,Kasai K,Kurachi M,Okazaki Y,Matsushita M,Suzuki M

doi

10.1016/j.pnpbp.2009.09.004

subject

Has Abstract

pub_date

2010-02-01 00:00:00

pages

10-7

issue

1

eissn

0278-5846

issn

1878-4216

pii

S0278-5846(09)00301-7

journal_volume

34

pub_type

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