Language lateralization in children using functional transcranial Doppler sonography.

Abstract:

AIM:Language lateralization with functional transcranial Doppler sonography (fTCD) and lexical word generation has been shown to have high concordance with the Wada test and functional magnetic resonance imaging in adults. We evaluated a nonlexical paradigm to determine language dominance in children. METHOD:In 23 right-handed children (12 females, 11 males; age range 6-11y; mean age 8y 4mo, SD 1y 7mo) and in 22 adolescents (14 females, 8 males; age range 12-18y; mean age 14y 8mo, SD 2y 5 mo) cerebral blood flow velocity (CBFV) was measured in both middle cerebral arteries during picture description and in adolescents additionally during lexical word generation. For each individual/paradigm a lateralization index (LI; side difference in CBFV during mental activity) and its standard error of the mean (SEM; representing variability of the LI throughout task repetition) were computed. RESULTS:Fourteen of 23 children (mean LI=0.74, SD 4.22; SEM 1.05, SD 0.51) and 14 of 21 adolescents (LI=2.35, SD 4.65; SEM 1.09, SD 0.61) showed left hemispheric dominance during picture description compared with 20 of 21 adolescents during word generation (LI=3.72 SD 1.93; SEM 0.99, SD 0.41). Indicated by similarity in mean SEM, variability of the LI throughout task repetition did not differ between age groups or paradigms. INTERPRETATION:Functional TCD proved to be well tolerated in children, with similar data quality as in adolescents. However, the picture description paradigm failed to show left hemispheric dominance in a substantial number of participants. This emphasizes the need to evaluate further paradigms for fTCD language lateralization in children.

journal_name

Dev Med Child Neurol

authors

Haag A,Moeller N,Knake S,Hermsen A,Oertel WH,Rosenow F,Hamer HM

doi

10.1111/j.1469-8749.2009.03362.x

subject

Has Abstract

pub_date

2010-04-01 00:00:00

pages

331-6

issue

4

eissn

0012-1622

issn

1469-8749

pii

DMCN3362

journal_volume

52

pub_type

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