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Ethnicity, race, and clinically significant macular edema in the Veterans Affairs Diabetes Trial (VADT).

Abstract：

OBJECTIVE:To determine risk factors in clinically significant macular edema (CSME) and if increased CSME in minorities is due to ethnicity or other factors in the Veterans Affairs Diabetes Trial (VADT). METHODS:CSME prevalence based on 7-field stereo fundus photographs in 1268 patients with type 2 diabetes was related to ethnicity, demographics and biochemistries by univariate and multivariate analyses. RESULTS:Hispanics (H) made up 17.5% and African Americans (AA) 17.7% of the cohort. CSME prevalence was 10%. In univariate analysis, CSME was more prevalent in H, 18%, and AA, 15.6% than in non-Hispanic Whites (NHW), 6.3%, p<0.01. Univariate regression of CSME associated with younger age, younger onset of diabetes; longer duration; retinopathy severity; and high HbA1c, BP, urine albumin/creatinine, and amputation, all p<0.01. In multivariate regression, CSME was associated with ethnicity/race (Hispanic White vs. non-Hispanic White, OR, (95% CI), 2.30, (1.35-3.92), p<0.01; African American vs. non-Hispanic White, 2.30, (1.33-4.00), p<0.01), diastolic BP (1.13 per 5 mm Hg, (1.02-1.23), p=0.03), amputation (3.0, (1.11-8.13), p=0.04), and retinopathy severity ( approximately 30, ( approximately 17 to approximately 59), p<0.01). CONCLUSION:The prevalence of CSME in the VADT is associated with ethnicity as well as diastolic BP, amputation, and retinopathy severity.

journal_name

Diabetes Res Clin Pract

journal_title

Diabetes research and clinical practice

authors

Emanuele N,Moritz T,Klein R,Davis MD,Glander K,Khanna A,Thottapurathu L,Bahn G,Duckworth W,Abraira C,Veterans Affairs Diabetes Trial Study Group.

doi

10.1016/j.diabres.2009.08.001

subject

Has Abstract

pub_date

2009-11-01 00:00:00

pages

104-10

issue

2

eissn

0168-8227

issn

1872-8227

pii

S0168-8227(09)00338-6

journal_volume

86

pub_type

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