Antibacterial potential of antagonistic Streptomyces sp. isolated from marine sponge Dendrilla nigra.

Abstract:

:The role of Streptomyces sp. (BTL7) in synthesis of antibacterial agents reported from the marine sponge Dendrilla nigra was evaluated. Selective isolation of actinomycetes was performed on the newly developed selective media, Sponge Agar (SA) 1 and SA 2. The growth rate and antibiotic production were increased on the media supplemented with sponge extract. The chosen isolate BTL7 showed inhibitory interaction with Micrococcus luteus and the extracellular products contained potent antibacterial agents. The minimum inhibitory concentration of BTL7 against M. luteus was 44 microg protein/ml and the minimum bactericidal concentration was 88 microg protein/ml. Peak antibacterial activity was observed at 72 h in batch culture. Based on the findings, it could be inferred that bacterial endosymbionts sponges could form a reliable source for bioprospecting of next generation pharmaceutical agents.

journal_name

FEMS Microbiol Ecol

authors

Selvin J,Joseph S,Asha KR,Manjusha WA,Sangeetha VS,Jayaseema DM,Antony MC,Denslin Vinitha AJ

doi

10.1016/j.femsec.2004.06.007

subject

Has Abstract

pub_date

2004-11-01 00:00:00

pages

117-22

issue

2

eissn

0168-6496

issn

1574-6941

pii

FEM117

journal_volume

50

pub_type

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