Abstract:
:More than 35 years ago double Nobel laureate Linus Carl Pauling published a powerful model of the molecular mechanism of general anesthesia, generally referred to as the hydrate-microcrystal (aqueous-phase) theory. This hypothesis, based on the molecular behavior of water molecules, did not receive serious attention during Pauling's life time, when scientific tools for examining complex systems such as the brain were still in their infancy. The situation has since drastically changed, and, now, in the twenty first century, many scientific tools are available for examining different types of complex systems. The discovery of aquaporin-4, a subtype of water channel abundantly expressed in glial systems, further highlighted the concept that the dynamics of water molecules in the cerebral cortex play an important role in important physiological brain functions including consciousness and information processing.
journal_name
Cytotechnologyjournal_title
Cytotechnologyauthors
Nakada Tdoi
10.1007/s10616-009-9216-xsubject
Has Abstractpub_date
2009-04-01 00:00:00pages
145-52issue
3eissn
0920-9069issn
1573-0778journal_volume
59pub_type
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