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Timing dysfunctions in schizophrenia as measured by a repetitive finger tapping task.

Abstract：

:Schizophrenia may be associated with a fundamental disturbance in the temporal coordination of information processing in the brain, leading to classic symptoms of schizophrenia such as thought disorder and disorganized and contextually inappropriate behavior. Although a variety of behavioral studies have provided strong evidence for perceptual timing deficits in schizophrenia, no study to date has directly examined overt temporal performance in schizophrenia using a task that differentially engages perceptual and motor-based timing processes. The present study aimed to isolate perceptual and motor-based temporal performance in individuals diagnosed with schizophrenia using a repetitive finger-tapping task that has previously been shown to differentially engage brain regions associated with perceptual and motor-related timing behavior. Thirty-two individuals with schizophrenia and 31 non-psychiatric control participants completed the repetitive finger-tapping task, which required participants to first tap in time with computer-generated tones separated by a fixed intertone interval (tone-paced tapping), after which the tones were discontinued and participants were required to continue tapping at the established pace (self-paced tapping). Participants with schizophrenia displayed significantly faster tapping rates for both tone- and self-paced portions of the task compared to the non-psychiatric group. Individuals diagnosed with schizophrenia also displayed greater tapping variability during both tone- and self-paced portions of the task. The application of a mathematical timing model further indicated that group differences were primarily attributable to increased timing--as opposed to task implementation--difficulties in the schizophrenia group, which is noteworthy given the broad range of impairments typically associated with the disorder. These findings support the contention that schizophrenia is associated with a broad range of timing difficulties, including those associated with time perception as well as time production.

journal_name

Brain Cogn

journal_title

Brain and cognition

authors

Carroll CA,O'Donnell BF,Shekhar A,Hetrick WP

doi

10.1016/j.bandc.2009.06.009

subject

Has Abstract

pub_date

2009-12-01 00:00:00

pages

345-53

issue

eissn

0278-2626

issn

1090-2147

pii

S0278-2626(09)00106-7

journal_volume

pub_type

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Timing dysfunctions in schizophrenia as measured by a repetitive finger tapping task.