Abstract：
:The present study reports on the antifilarial activity of a marine sponge Haliclona exigua (phylum Porifera). The crude methanol extract and n-butanol-soluble fraction killed adult Brugia malayi at 31.25-microg/ml concentration (both in motility and 3-(4,5 dimethylthiazol-2-yl)-2,5 diphenyl tetrazolium bromide assay) while the chloroform fraction was lethal at a lower concentration of 15.6 microg/ml. The activity could be located in a single molecule araguspongin C which brought about mortality of worm at 15.6 microg/ml. In vivo evaluation of the crude extract (5 x 500 mg/kg, orally) and the chloroform fraction (5 x 250 mg/kg, orally) in B. malayi-infected rodent host, Mastomys coucha, did not show any significant microfilaricidal actions; however, microfilarial densities in both the treated groups were significantly much lower than those of untreated group in contrast to standard filaricide diethylcarbamazine which exerted 79% microfilaricidal action on day 8 of treatment. Both these extracts also demonstrated adulticidal (macrofilaricidal) activity which was more pronounced in the chloroform fraction (50.2%). In addition, there was moderate adverse effect on the reproductive potential of female worms (crude extract 46.5%; chloroform 58.6%). The findings suggest that the marine sponge H. exigua possesses adulticidal and embryostatic action against human lymphatic filarial parasite B. malayi in experimental rodent model and this activity could be attributed to the presence of araguspongin C.
journal_name
Parasitol Resjournal_title
Parasitology researchauthors
Lakshmi V,Srivastava S,Kumar Mishra S,Misra S,Verma M,Misra-Bhattacharya Sdoi
10.1007/s00436-009-1555-1subject
Has Abstractpub_date
2009-10-01 00:00:00pages
1295-301issue
5eissn
0932-0113issn
1432-1955journal_volume
105pub_type
杂志文章abstract：:The acanthocephalan Acanthocephalus dirus is a trophically transmitted parasite that modifies both the physiology and behavior of its intermediate host (isopod) prior to transmission to its definitive host (fish). Infected isopods often contain multiple A. dirus individuals and we examined the relationships between ho...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-016-5279-8
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abstract：:Thelaziasis is an ocular infection of several mammals caused by nematodes of the genus Thelazia (Spirurida, Thelaziidae). The adults live in the lachrymal ducts and conjunctival sacs of infected animals, and transmission occurs by means of different species of muscids. T. rhodesi, T. skrjabini, and T. gulosa affect ma...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-006-0432-4
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journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-008-1067-4
更新日期：2008-09-01 00:00:00
abstract：:The C57BL/6J strain of Mus musculus is susceptible to the terrestrial trematode Brachylaima cribbi. The duration of infection in these mice is generally 9-12 weeks with a peak excretion of eggs at 4 weeks post-infection (wpi). The effects of age and sex on the course of infection were investigated by comparing infecti...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-002-0642-3
更新日期：2002-07-01 00:00:00
abstract：:A molecular approach was used to analyse a focus of cercarial dermatitis in northeastern France (Lake Der-Chantecoq), including both cercariae and snails,by sequencing the internal transcribed spacers (ITS1 for ocellate furcocercariae and ITS2 for snails). Lymnaea stagnalis were found infected with the furcocercariae ...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-004-1273-7
更新日期：2005-01-01 00:00:00
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journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-004-1172-y
更新日期：2004-09-01 00:00:00
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journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/BF00932413
更新日期：1995-01-01 00:00:00
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journal_title：Parasitology research
pub_type： 杂志文章,多中心研究,随机对照试验
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journal_title：Parasitology research
pub_type： 杂志文章,评审
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journal_title：Parasitology research
pub_type： 杂志文章
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更新日期：2017-01-01 00:00:00
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journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-010-1835-9
更新日期：2010-06-01 00:00:00
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journal_title：Parasitology research
pub_type： 杂志文章
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pub_type： 杂志文章
doi：10.1007/s00436-013-3674-y
更新日期：2014-02-01 00:00:00
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journal_title：Parasitology research
pub_type： 杂志文章
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更新日期：2018-06-01 00:00:00
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journal_title：Parasitology research
pub_type： 杂志文章
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journal_title：Parasitology research
pub_type： 杂志文章
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journal_title：Parasitology research
pub_type： 杂志文章
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journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/BF00931729
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journal_title：Parasitology research
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doi：10.1007/s00436-017-5702-9
更新日期：2018-01-01 00:00:00
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journal_title：Parasitology research
pub_type： 杂志文章
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更新日期：2009-01-01 00:00:00
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journal_title：Parasitology research
pub_type： 杂志文章
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journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-006-0382-x
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journal_title：Parasitology research
pub_type： 杂志文章
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journal_title：Parasitology research
pub_type： 杂志文章
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更新日期：2001-04-01 00:00:00
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journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/BF00931056
更新日期：1990-01-01 00:00:00
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journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-017-5662-0
更新日期：2018-01-01 00:00:00
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journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-017-5664-y
更新日期：2018-01-01 00:00:00
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journal_title：Parasitology research
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