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Fibroepithelial lesions of the breast with pleomorphic stromal giant cells: a clinicopathologic study of 4 cases and review of the literature.

Abstract：

:Pleomorphic stromal giant cells are occasionally found as an incidental finding in breast tissue but are only rarely seen in fibroepithelial lesions. In this report, we describe 4 fibroadenoma-like lesions of the breast with pleomorphic stromal giant cells. Two cases had focal stromal hypercellularity, one of which was with architectural features borderline between a fibroadenoma and a phyllodes tumor, but none was considered diagnostic of phyllodes tumor. One lesion had up to 4 mitotic figures per 10 high-power fields, including rare atypical mitotic figures. The remaining 3 cases lacked mitotic activity. Follow-up for 3 cases at 16 to 59 months revealed no evidence of tumor recurrence. The fourth case was lost to follow-up. It appears that the presence of pleomorphic stromal giant cells in an otherwise benign fibroepithelial lesion has no adverse clinical significance. The clinicopathologic features of each case are discussed, and a review of the literature is provided.

journal_name

Ann Diagn Pathol

journal_title

Annals of diagnostic pathology

authors

Huo L,Gilcrease MZ

doi

10.1016/j.anndiagpath.2009.03.007

subject

Has Abstract

pub_date

2009-08-01 00:00:00

pages

226-32

issue

4

eissn

1092-9134

issn

1532-8198

pii

S1092-9134(09)00034-3

journal_volume

13

pub_type

杂志文章,评审

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