Beta-ionone activates and bleaches visual pigment in salamander photoreceptors.

Abstract:

:Vision begins with photoisomerization of 11-cis retinal to the all-trans conformation within the chromophore-binding pocket of opsin, leading to activation of a biochemical cascade. Release of all-trans retinal from the binding pocket curtails but does not fully quench the ability of opsin to activate transducin. All-trans retinal and some other analogs, such as beta-ionone, enhance opsin's activity, presumably on binding the empty chromophore-binding pocket. By recording from isolated salamander photoreceptors and from patches of rod outer segment membrane, we now show that high concentrations of beta-ionone suppressed circulating current in dark-adapted green-sensitive rods by inhibiting the cyclic nucleotide-gated channels. There were also decreases in circulating current and flash sensitivity, and accelerated flash response kinetics in dark-adapted blue-sensitive (BS) rods and cones, and in ultraviolet-sensitive cones, at concentrations too low to inhibit the channels. These effects persisted in BS rods even after incubation with 9-cis retinal to ensure complete regeneration of their visual pigment. After long exposures to high concentrations of beta-ionone, recovery was incomplete unless 9-cis retinal was given, indicating that visual pigment had been bleached. Therefore, we propose that beta-ionone activates and bleaches some types of visual pigments, mimicking the effects of light.

journal_name

Vis Neurosci

journal_title

Visual neuroscience

authors

Isayama T,McCabe England SL,Crouch RK,Zimmerman AL,Makino CL

doi

10.1017/S0952523809090105

subject

Has Abstract

pub_date

2009-05-01 00:00:00

pages

267-74

issue

3

eissn

0952-5238

issn

1469-8714

pii

S0952523809090105

journal_volume

26

pub_type

杂志文章
  • Alpha ganglion cells of the rabbit retina lose antagonistic surround responses under dark adaptation.

    abstract::Alpha ganglion cells from the midperiphery of the rabbit retina were recorded intracellularly under visual control, in a superfused everted eyecup, and labeled with HRP. Their physiology and large somata with broad dendritic arbors identified them as uniform populations of ON- and OFF-center alpha ganglion cells, whic...

    journal_title:Visual neuroscience

    pub_type: 杂志文章

    doi:10.1017/s0952523800011512

    authors: Muller JF,Dacheux RF

    更新日期:1997-03-01 00:00:00

  • Wide-field cone bipolar cells and the blue-ON pathway to color-coded ganglion cells in rabbit retina.

    abstract::Wide-field cone bipolar cells with sparse dendritic branching and proposed connectivity to blue cones were first identified in rabbit and cat. In rabbit, these were subdivided into type a (wa) and type b (wb), with axonal branching in sublamina a, and sublamina b, respectively, of the inner plexiform layer (IPL). Rece...

    journal_title:Visual neuroscience

    pub_type: 杂志文章

    doi:10.1017/S0952523808080061

    authors: Famiglietti EV

    更新日期:2008-01-01 00:00:00

  • Visual tracking of moving targets by freely flying honeybees.

    abstract::The ability of freely-flying honeybees to track moving targets was examined by training them to collect a reward on a target, and then videotaping their approach to the target while it was in motion. Training experiments were carried out with several groups of bees, using various colors for the target and the backgrou...

    journal_title:Visual neuroscience

    pub_type: 杂志文章

    doi:10.1017/s0952523800004582

    authors: Zhang SW,Wang XA,Liu ZL,Srinivasan MV

    更新日期:1990-04-01 00:00:00

  • Two types of cone bipolar cells express voltage-gated Na+ channels in the rat retina.

    abstract::Two groups of retinal cone bipolar cells (CBCs) in rats were found to express voltage-gated Na+ channels. The axon terminals of the first group stratify in sublamina 2 of the inner plexiform layer (IPL) and partially overlap with the OFF-cholinergic band. This group was identified as type 3 CBCs. The axon terminals of...

    journal_title:Visual neuroscience

    pub_type: 杂志文章

    doi:10.1017/S0952523808080851

    authors: Cui J,Pan ZH

    更新日期:2008-09-01 00:00:00

  • Pharmacological inactivation of pretectal nuclei reveals different modulatory effects on retino-geniculate transmission by X and Y cells in the cat.

    abstract::The modulatory influence of pretectal neurons on retino-geniculate transmission in the cat was studied by cross-correlation analysis of single-unit activity simultaneously recorded from the dorsal lateral geniculate nucleus (dLGN) and the pretectum (PT) and with reversible inactivation of the PT by GABA microiontophor...

    journal_title:Visual neuroscience

    pub_type: 杂志文章

    doi:10.1017/s0952523800007288

    authors: Funke K,Eysel UT

    更新日期:1995-01-01 00:00:00

  • Expression of CB2 cannabinoid receptor mRNA in adult rat retina.

    abstract::To date, two cannabinoid receptors, CB1 and CB2, have been cloned. The CB1 receptor has been found in a variety of tissues, particularly in the brain. CB2 receptor mRNA is mainly expressed in the immune system, though one group has found it in mouse cerebellum. Previous immunostaining studies in our lab demonstrated t...

    journal_title:Visual neuroscience

    pub_type: 杂志文章

    doi:10.1017/s0952523800171093

    authors: Lu Q,Straiker A,Lu Q,Maguire G

    更新日期:2000-01-01 00:00:00

  • Sensitivity transformation for vertebrate vision.

    abstract::The visual response to a flash given in the dark is known to saturate according to the Michaelis-Menten relationship. Nevertheless, the incremental response from increasing levels of mean luminance tends to follow a Weber-Fechner relationship well into the saturation range determined from the Michaelis-Menten results....

    journal_title:Visual neuroscience

    pub_type: 杂志文章

    doi:10.1017/s0952523800006593

    authors: Chappell RL,Naka K

    更新日期:1991-04-01 00:00:00

  • The multifaceted role of inhibitory interneurons in the dorsal lateral geniculate nucleus.

    abstract::Intrinsic interneurons within the dorsal lateral geniculate nucleus (dLGN) provide a feed-forward inhibitory pathway for afferent visual information originating from the retina. These interneurons are unique because in addition to traditional axodendritic output onto thalamocortical neurons, these interneurons have pr...

    journal_title:Visual neuroscience

    pub_type: 杂志文章,评审

    doi:10.1017/S0952523817000141

    authors: Cox CL,Beatty JA

    更新日期:2017-01-01 00:00:00

  • Development of multibank rod retinae in deep-sea fishes.

    abstract::We studied the development of multibank rod retinae by monitoring the size-related addition of new layers of rod inner and outer segments in four species of deep-sea fishes and found two different growth paradigms. In the mesopelagic Chauliodus sloani, new banks of rod inner and outer segments are added as long as the...

    journal_title:Visual neuroscience

    pub_type: 杂志文章

    doi:10.1017/s095252389815304x

    authors: Fröhlich E,Wagner HJ

    更新日期:1998-05-01 00:00:00

  • Color space distortions in patients with type 2 diabetes mellitus.

    abstract::Color vision impairment was examined in patients with type 2 diabetes mellitus (DM2) without retinopathy. We assessed the type and degree of distortions of individual color spaces. DM2 patients (n = 32), and age-matched controls (n = 20) were tested using the Farnsworth D-15 and the Lanthony D-15d tests. In addition, ...

    journal_title:Visual neuroscience

    pub_type: 杂志文章

    doi:10.1017/S0952523806233546

    authors: Feitosa-Santana C,Oiwa NN,Paramei GV,Bimler D,Costa MF,Lago M,Nishi M,Ventura DF

    更新日期:2006-05-01 00:00:00

  • Eel visual pigments revisited: the fate of retinal cones during metamorphosis.

    abstract::During their complex life history, anguilliform eels go through a major metamorphosis when developing from a fresh water yellow eel into a deep-sea silver eel. In addition to major changes in body morphology, the visual system also adapts from a fresh water teleost duplex retina with rods and cones, to a specialized d...

    journal_title:Visual neuroscience

    pub_type: 杂志文章

    doi:10.1017/S0952523808080152

    authors: Bowmaker JK,Semo M,Hunt DM,Jeffery G

    更新日期:2008-05-01 00:00:00

  • Morphology and visual pigment content of photoreceptors from injured goldfish retina.

    abstract::Adult teleost fish retinas can regenerate neurons following either surgical or pharmacological injury. The cellular milieu of the damaged retina within which regenerated neurons are produced might be different in these two model systems of retinal injury, and thus the phenotypic attributes of regenerated neurons in th...

    journal_title:Visual neuroscience

    pub_type: 杂志文章

    doi:10.1017/s0952523800174115

    authors: Cameron DA,Powers MK

    更新日期:2000-07-01 00:00:00

  • Multifocal visual evoked potential responses to pattern-reversal, pattern-onset, pattern-offset, and sparse pulse stimuli.

    abstract::The purpose of the present study was to compare standard multifocal visual evoked potential (mfVEP) pattern-reversal responses with those produced by pattern-onset, pattern-offset, and pulsed pattern stimuli. mfVEP recordings were obtained from five normal subjects using VERIS and a 4-electrode array. The standard rev...

    journal_title:Visual neuroscience

    pub_type: 杂志文章

    doi:10.1017/S0952523808080954

    authors: Fortune B,Demirel S,Bui BV

    更新日期:2009-03-01 00:00:00

  • Contacts of dopaminergic interplexiform cells in the outer retina of the blue acara.

    abstract::Dopaminergic interplexiform cells in the retina of the blue acara were investigated using an antiserum against tyrosine hydroxylase and PAP visualization. In whole-mount preparations, we observed a homogeneous distribution of cell bodies throughout the retina without any indication of regional specialization. At the f...

    journal_title:Visual neuroscience

    pub_type: 杂志文章

    doi:10.1017/s0952523800010737

    authors: Wagner HJ,Wulle I

    更新日期:1992-09-01 00:00:00

  • Effects of ON channel blockade with 2-amino-4-phosphonobutyrate (APB) on brightness and contrast perception in monkeys.

    abstract::Four experiments were performed to assess the effects of ON channel blockade with the glutamate analog 2-amino-4-phosphonobutyrate (APB) on brightness and contrast perception in monkeys. In Experiment 1, we demonstrate that stimuli brighter than background (incremental stimuli) appear less bright following ON channel ...

    journal_title:Visual neuroscience

    pub_type: 杂志文章

    doi:10.1017/s095252380001107x

    authors: Dolan RP,Schiller PH

    更新日期:1994-01-01 00:00:00

  • Screening of gap junction antagonists on dye coupling in the rabbit retina.

    abstract::Many cell types in the retina are coupled via gap junctions and so there is a pressing need for a potent and reversible gap junction antagonist. We screened a series of potential gap junction antagonists by evaluating their effects on dye coupling in the network of A-type horizontal cells. We evaluated the following c...

    journal_title:Visual neuroscience

    pub_type: 杂志文章

    doi:10.1017/S0952523807070472

    authors: Pan F,Mills SL,Massey SC

    更新日期:2007-07-01 00:00:00

  • Psychophysical analysis of contrast processing segregated into magnocellular and parvocellular systems in asymptomatic carriers of 11778 Leber's hereditary optic neuropathy.

    abstract::We examined achromatic contrast discrimination in asymptomatic carriers of 11778 Leber's hereditary optic neuropathy (LHON 18 controls) and 18 age-match were also tested. To evaluate magnocellular (MC) and Parvocellular (PC) contrast discrimination, we used a version of Pokorny and Smith's (1997) pulsed/steady-pedesta...

    journal_title:Visual neuroscience

    pub_type: 杂志文章

    doi:10.1017/S0952523808080462

    authors: Gualtieri M,Bandeira M,Hamer RD,Costa MF,Oliveira AG,Moura AL,Sadun F,De Negri AM,Berezovsky A,Salomão SR,Carelli V,Sadun AA,Ventura DF

    更新日期:2008-05-01 00:00:00

  • Light-dependent delay in the falling phase of the retinal rod photoresponse.

    abstract::Using suction electrodes, photocurrent responses to 100-ms saturating flashes were recorded from isolated retinal rods of the larval-stage tiger salamander (Ambystoma tigrinum). The delay period (Tc) that preceded recovery of the dark current by a criterion amount (3 pA) was analyzed in relation to the flash intensity...

    journal_title:Visual neuroscience

    pub_type: 杂志文章

    doi:10.1017/s0952523800006441

    authors: Pepperberg DR,Cornwall MC,Kahlert M,Hofmann KP,Jin J,Jones GJ,Ripps H

    更新日期:1992-01-01 00:00:00

  • Robust directional computation in on-off directionally selective ganglion cells of rabbit retina.

    abstract::The spatial and temporal interactions in the receptive fields of On-Off directionally selective (DS) ganglion cells endow them with directional selectivity. Using a variety of stimuli, such as sinusoidal gratings, we show that these interactions make directional selectivity of the DS ganglion cell robust with respect ...

    journal_title:Visual neuroscience

    pub_type: 杂志文章

    doi:10.1017/S0952523807070666

    authors: Grzywacz NM,Amthor FR

    更新日期:2007-07-01 00:00:00

  • Differential expression of glutamate receptor genes (GluR1-5) in the rat retina.

    abstract::The recent isolation of at least five different cDNAs encoding functional subunits of glutamate receptors (GluR1 to GluR5) has revealed a diversity whose function is not understood. To learn more about how these different receptor subunits are used in the brain, we undertook an in situ hybridization study of the retin...

    journal_title:Visual neuroscience

    pub_type: 杂志文章

    doi:10.1017/s0952523800006489

    authors: Hughes TE,Hermans-Borgmeyer I,Heinemann S

    更新日期:1992-01-01 00:00:00

  • Excitation and inhibition in orientation selectivity of cat visual cortex neurons revealed by whole-cell recordings in vivo.

    abstract::One striking transformation in response properties that occurs in the geniculo-cortical pathway is the appearance of a high degree of orientation selectivity in the cortex. This property may be conceived as arising purely from the excitatory inputs to the cell, as being structured largely by the inhibition a cortical ...

    journal_title:Visual neuroscience

    pub_type: 杂志文章

    doi:10.1017/s0952523800010257

    authors: Volgushev M,Pei X,Vidyasagar TR,Creutzfeldt OD

    更新日期:1993-11-01 00:00:00

  • Intact "biological motion" and "structure from motion" perception in a patient with impaired motion mechanisms: a case study.

    abstract::A series of psychophysical tests examining early and later aspects of image-motion processing were conducted in a patient with bilateral lesions involving the posterior visual pathways, affecting the lateral parietal-temporal-occipital cortex and the underlying white matter (as shown by magnetic resonance imaging stud...

    journal_title:Visual neuroscience

    pub_type: 杂志文章

    doi:10.1017/s0952523800000444

    authors: Vaina LM,Lemay M,Bienfang DC,Choi AY,Nakayama K

    更新日期:1990-10-01 00:00:00

  • Localization of AMPA-selective glutamate receptor subunits in the adult cat visual cortex.

    abstract::We have studied the presence and distribution of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA)-selective glutamate receptor subunits (GluR1, 2, 3, and 4) in the adult cat visual cortical areas 17, 18, 19, and the lateral suprasylvian areas (LSA). Reverse transcription-polymerase chain reaction (RT-PCR) a...

    journal_title:Visual neuroscience

    pub_type: 杂志文章

    doi:10.1017/s0952523800007136

    authors: Gutiérrez-Igarza K,Fogarty DJ,Pérez-Cerdá F,Doñate-Oliver F,Albus K,Matute C

    更新日期:1996-01-01 00:00:00

  • Effects of different forms of monocular deprivation on primary visual cortex maps.

    abstract::Monocular deprivation (MD) by lid suture is one of the classic paradigms for the study of developmental plasticity in the cerebral cortex, and we have detailed knowledge of its anatomical and physiological consequences as well as underlying molecular and cellular mechanisms. However, the effects of other forms of mani...

    journal_title:Visual neuroscience

    pub_type: 杂志文章

    doi:10.1017/S0952523812000260

    authors: Jaffer S,Vorobyov V,Sengpiel F

    更新日期:2012-09-01 00:00:00

  • Behavioral evidence of filling-in at the blind spot of the monkey.

    abstract::In human subjects, the blind spot is perceptually filled-in by color and brightness from the surrounding visual field. The present behavioral study examined the occurrence of color filling-in at the blind spot in monkeys. First, the location of the blind spot was determined using a monocular saccade task. The blind sp...

    journal_title:Visual neuroscience

    pub_type: 杂志文章

    doi:10.1017/s0952523800006921

    authors: Komatsu H,Murakami I

    更新日期:1994-11-01 00:00:00

  • Movement of retinal along cone and rod photoreceptors.

    abstract::Single isolated photoreceptors can be taken through a visual cycle of light adaptation by bleaching visual pigment, followed by dark adaptation when supplied with 11-cis retinal. Light adaptation after bleaching is manifested by faster response kinetics and a permanent reduction in sensitivity to light flashes, presum...

    journal_title:Visual neuroscience

    pub_type: 杂志文章

    doi:10.1017/s0952523800001735

    authors: Jin J,Jones GJ,Cornwall MC

    更新日期:1994-03-01 00:00:00

  • Linking perception to neural activity as measured by visual evoked potentials.

    abstract::Linking propositions have played an important role in refining our understanding of the relationship between neural activity and perception. Over the last 40 years, visual evoked potentials (VEPs) have been used in many different ways to address questions of the relationship between neural activity and perception. Thi...

    journal_title:Visual neuroscience

    pub_type: 杂志文章,评审

    doi:10.1017/S0952523813000205

    authors: Norcia AM

    更新日期:2013-11-01 00:00:00

  • Two opposite effects of ATP on the apparent sensitivity of the cGMP-gated channel of the carp retinal cone.

    abstract::Effects of ATP on the activity of cGMP-gated channels from carp cone photoreceptors were studied. In 29% of the patches examined (N = 45), ATP (1 mM) enhanced a current evoked by cGMP (20 microM, up to about 100%), in 33%. ATP suppressed it by up to about 90%, and in the remaining 38%, ATP had no effect. ATP showed si...

    journal_title:Visual neuroscience

    pub_type: 杂志文章

    doi:10.1017/s0952523800012578

    authors: Watanabe S,Shen J

    更新日期:1997-07-01 00:00:00

  • Visual arrestin in Limulus is phosphorylated at multiple sites in the light and in the dark.

    abstract::Arrestins participate in the termination of phototransduction in both vertebrates and invertebrates. However, the visual arrestins of invertebrates and vertebrates differ significantly from one another in that the invertebrate visual arrestins become phosphorylated rapidly in response to light while those in the photo...

    journal_title:Visual neuroscience

    pub_type: 杂志文章

    doi:10.1017/s0952523800175145

    authors: Battelle BA,Andrews AW,Kempler KE,Edwards SC,Smith WC

    更新日期:2000-09-01 00:00:00

  • Development of excitatory and inhibitory neurotransmitters in transitory cholinergic neurons, starburst amacrine cells, and GABAergic amacrine cells of rabbit retina, with implications for previsual and visual development of retinal ganglion cells.

    abstract::Starburst amacrine cells (SACs), the only acetylcholine (ACh)-releasing amacrine cells (ACs) in adult rabbit retina, contain GABA and are key elements in the retina's directionally selective (DS) mechanism. Unlike many other GABAergic ACs, they use glutamic acid decarboxlyase (GAD)(67), not GAD(65), to synthesize GABA...

    journal_title:Visual neuroscience

    pub_type: 杂志文章

    doi:10.1017/S0952523810000052

    authors: Famiglietti EV,Sundquist SJ

    更新日期:2010-03-01 00:00:00