Mutations of the KRAS oncogene in endometrial hyperplasia and carcinoma.

Abstract:

:The aim of this study was to examine the prevalence and clinicopathological significance of KRAS point mutation in endometrial hyperplasia and carcinoma. We analysed KRAS in 11 cases of complex atypical hyperplasia and in 49 endometrial carcinomas using polymerase chain reaction associated with restriction fragment length polymorphism (PCR-RFPL). Point mutations at codon 12 of KRAS oncogene were identified in 7 of 49 (14,3%) tumor specimens and in 2 of 11 (18,2%) hyperplasias. No correlation was found between KRAS gene mutation and age at onset, histology, grade of differentiation and clinical stage. We conclude that KRAS mutation is a relatively common event in endometrial carcinogenesis, but with no prognostic value.

authors

Dobrzycka B,Terlikowski SJ,Mazurek A,Kowalczuk O,Niklińska W,Chyczewski L,Kulikowski M

doi

10.2478/v10042-009-0014-2

subject

Has Abstract

pub_date

2009-01-01 00:00:00

pages

65-8

issue

1

eissn

0239-8508

issn

1897-5631

pii

X946860U3535450K

journal_volume

47

pub_type

杂志文章
  • Investigations of hippocampal astrocytes in lipopolysaccharide-preconditioned rats in the pilocarpine model of epilepsy.

    abstract::The present paper is the first work to determine the effect of lipopolysaccharide (LPS) in the pilocarpine model of epilepsy on the morphology of rat hippocampal astrocytes in vivo. The study involved adult male Wistar rats, which 72 hours prior to administration of pilocarpine hydrochloride (PILO) were intraperitonea...

    journal_title:Folia histochemica et cytobiologica

    pub_type: 杂志文章

    doi:10.5603/fhc.2011.0030

    authors: Jaworska-Adamu J,Dmowska M,Cybulska R,Krawczyk A,Pawlikowska-Pawlęga B

    更新日期:2011-01-01 00:00:00

  • SSTR1 and SSTR5 subtypes are the dominant forms of somatostatin receptor in neuroendocrine tumors.

    abstract::The effectiveness of the long acting somatostatin analogues like octreotide and lanreotide depends on the expression of specific somatostatin receptors on the target cells. The immunohistochemical method performed on surgically removed tumors searches the expression of receptors at the level of receptor protein and gi...

    journal_title:Folia histochemica et cytobiologica

    pub_type: 杂志文章

    doi:10.2478/v10042-008-0103-7

    authors: Pisarek H,Pawlikowski M,Kunert-Radek J,Kubiak R,Winczyk K

    更新日期:2010-01-01 00:00:00

  • Total matrix metalloproteinase-8 serum levels in patients labouring preterm and patients with threatened preterm delivery.

    abstract::Preterm labour and prematurity are still a main cause of perinatal morbidity nowadays. The aim of our study was to assess the role of MMP-8 as a predictive marker of preterm delivery. Four groups of patients were involved to the study: I - pregnant women at 24-34 weeks of gestation with any symptoms of threatened pret...

    journal_title:Folia histochemica et cytobiologica

    pub_type: 杂志文章

    doi:10.2478/v10042-010-0037-8

    authors: Kuć P,Lemancewicz A,Laudański P,Krętowska M,Laudański T

    更新日期:2010-09-30 00:00:00

  • Histopathological evaluation of recurrent goiter.

    abstract::The recurrent goiter is the regrowth of thyroid tissue after thyroidectomy. An inadequate surgical removal of the thyroid gland, lack of substitution therapy and pathological stimulation of the thyroid growth can all promote the recurrence. The aim of this study was to find the connection between the histopathological...

    journal_title:Folia histochemica et cytobiologica

    pub_type: 杂志文章

    doi:10.2478/v10042-010-0036-9

    authors: Rudnicki J,Agrawal AK,Jelen M,Sebastian M,Sroczyński M,Zyśko D

    更新日期:2010-09-30 00:00:00

  • Complement inhibitory proteins expression in placentas of thrombophilic women.

    abstract::Factors controlling complement activation appear to exert a protective effect on pregnancy. This is particularly important in women with thrombophilia. The aim of this study was to determine the transcript and protein levels of complement decay-accelerating factor (DAF) and membrane cofactor protein (MCP) in the place...

    journal_title:Folia histochemica et cytobiologica

    pub_type: 杂志文章

    doi:10.5603/19758

    authors: Wirstlein PK,Jasiński P,Rajewski M,Goździewicz T,Skrzypczak J

    更新日期:2012-10-08 00:00:00

  • Morphological and molecular aspects of cancerogenesis in the lung.

    abstract::Morphology and some molecular aspects of hyperplastic (bronchial basal cell hyperplasia and alveolar cell hyperplasia), metaplastic (squamous metaplasia), preneoplastic and early neoplastic (dysplasia in squamous metaplasia, cancer in situ and atypical alveolar cell hyperplasia) changes were studied in 180 lungs resec...

    journal_title:Folia histochemica et cytobiologica

    pub_type: 杂志文章

    doi:

    authors: Chyczewski L,Chyczewska E,Nikliński J,Niklińska W,Sulkowska M,Naumnik W,Kovalchuk O

    更新日期:2001-01-01 00:00:00

  • Proliferating cell nuclear antigen (PCNA) expression in pituitary adenomas: relationship to the endocrine phenotype of adenoma.

    abstract::The expression of proliferating cell nuclear antigen (PCNA) correlates to cell proliferation and for this reason it is commonly considered as one of proliferation markers. Since proliferation rate is an important factor determining the tumor aggressiveness, the evaluation of PCNA index (the percentage of PCNA-immunopo...

    journal_title:Folia histochemica et cytobiologica

    pub_type: 杂志文章

    doi:

    authors: Pawlikowski M,Gruszka A,Kurnatowska I,Winczyk K,Kunert-Radek J,Radek A

    更新日期:2006-01-01 00:00:00

  • Comparison of nuclear protein SH/DNA ratio in species differing in 2C DNA content and dynamics of DNA endoreplication.

    abstract::Double fluorescence staining with o-phthalaldehyde (OPT) and propidium diiodide (PI) was applied to measure the nuclear protein SH/DNA ratio in species differing in 2C DNA content. It has been shown that protein SH/DNA ratio decreases along with the increase in 2C DNA content. In endosperm, this ratio is higher than i...

    journal_title:Folia histochemica et cytobiologica

    pub_type: 杂志文章

    doi:

    authors: Marciniak K

    更新日期:1993-01-01 00:00:00

  • The effect of acute heat exposure on rat pituitary corticotroph activation: the role of vasopressin.

    abstract::The increased ambient temperature affects the function of hypothalamic-pituitary-adrenal (HPA) axis. Since the correlation among vasopressin (VP), adrenocorticotropic hormone (ACTH) and corticosterone (CORT) responses to various stressors have been long recognized, the aim of this study was to reveal the aforementione...

    journal_title:Folia histochemica et cytobiologica

    pub_type: 杂志文章

    doi:10.2478/v10042-010-0071-6

    authors: Jasnic N,Korac A,Velickovic K,Golic I,Djordjevic J,Djurasevic S,Djordjevic I,Vujovic P,Cvijic G

    更新日期:2010-12-01 00:00:00

  • Histochemistry and elemental composition of the stomach cells in Littorina littorea (L.).

    abstract::The present work deals with the histochemical, histoenzymological and micro-analytical study of the stomach of Littorina Littorea (L.). The results suggest the existence of intracellular digestion within the stomach cells. Thus, the occurrence of lysosomes in the mid-cytoplasm of stomach cells has been revealed by dem...

    journal_title:Folia histochemica et cytobiologica

    pub_type: 杂志文章

    doi:

    authors: Soto M,Gil JM,Marigomez JA,Angulo E

    更新日期:1990-01-01 00:00:00

  • Loading and localization of Fluo-3 and Fluo-3/AM calcium indicators in sinapis alba root tissue.

    abstract::Stimulus-induced changes in free cytosolic Ca2+ in different types of plant cells have been monitored with the aid of fluorescent calcium indicator dyes. However, there is no simple and convenient method for introducing these dyes into the plant cell cytoplasm. This paper reports tests of different procedures for load...

    journal_title:Folia histochemica et cytobiologica

    pub_type: 杂志文章

    doi:

    authors: Tretyn A,Kado RT,Kendrick RE

    更新日期:1997-01-01 00:00:00

  • Localization of a proteasomal antigen in human spermatozoa: immunohistochemical electron microscopic study.

    abstract::The ultrastructural localization of a proteasomal antigen in human spermatozoa was studied by means of immunolabeling with the MPC21 monoclonal antibody and secondary gold labeled antibody with 1.4 nm gold particles in combination with silver enhancement reaction using pre-embedding technique. The labeling was found i...

    journal_title:Folia histochemica et cytobiologica

    pub_type: 杂志文章

    doi:

    authors: Biały LP,Ziemba HT,Marianowski P,Fracki S,Bury M,Wójcik C

    更新日期:2001-01-01 00:00:00

  • Alcohol abuse and glycoconjugate metabolism.

    abstract::The relationship between alcohol consumption and glycoconjugate metabolism is complex and multidimensional. This review summarizes the advances in basic and clinical research on the molecular and cellular events involved in the metabolic effects of alcohol on glycoconjugates (glycoproteins, glycolipids, and proteoglyc...

    journal_title:Folia histochemica et cytobiologica

    pub_type: 杂志文章,评审

    doi:10.2478/18690

    authors: Waszkiewicz N,Szajda SD,Zalewska A,Szulc A,Kępka A,Minarowska A,Wojewódzka-Żelezniakowicz M,Konarzewska B,Chojnowska S,Ladny JR,Zwierz K

    更新日期:2012-04-24 00:00:00

  • Microtubule heterogeneity of Ornithogalum umbellatum ovary epidermal cells: non-stable cortical microtubules and stable lipotubuloid microtubules.

    abstract::Lipotubuloids, structures containing lipid bodies and microtubules, are described in ovary epidermal cells of Ornithogalum umbellatum. Microtubules of lipotubuloids can be fixed in electron microscope fixative containing only buffered OsO(4) or in glutaraldehyde with OsO(4) post-fixation, or in a mixture of OsO(4) and...

    journal_title:Folia histochemica et cytobiologica

    pub_type: 杂志文章

    doi:10.5603/fhc.2011.0040

    authors: Kwiatkowska M,Stępiński D,Polit JT,Popłońska K,Wojtczak A

    更新日期:2011-01-01 00:00:00

  • Correlation between hepatocyte growth factor receptor and vascular endothelial growth factor-A in breast carcinoma.

    abstract::The aim of the study was to evaluate the prognostic value of the vascular endothelial growth factor A (VEGF-A) and hepatocyte growth factor receptor (HGFR, c-met) expressions in homogenous group of breast cancer patients. Tumor samples were collected from 98 patients with invasive ductal breast carcinoma stage II trea...

    journal_title:Folia histochemica et cytobiologica

    pub_type: 杂志文章

    doi:10.2478/v10042-010-0016-0

    authors: Gisterek I,Matkowski R,Suder E,Hałoń A,Szelachowska J,Łata E,Łacko A,Biecek P,Kornafel J

    更新日期:2010-01-01 00:00:00

  • Reproductive biology of the endangered percid Zingel asper in captivity: a histological description of the male reproductive cycle.

    abstract::The endemic Rhodanian percid Zingel asper (Linnaeus, 1758), is usually found throughout the Rhône basin, but this fish is now in sharp decline. Understanding its reproductive physiology is important so as to be able to artificially control its reproduction with a view to re-introducing it. This study was carried out o...

    journal_title:Folia histochemica et cytobiologica

    pub_type: 杂志文章

    doi:10.5603/fhc.2011.0069

    authors: Chevalier C,de Conto C,Exbrayat JM

    更新日期:2011-01-01 00:00:00

  • Dexamethasone effects on Bax expression in the mouse testicular germ cells.

    abstract::Exposure to glucocorticoids (GCs) leads to numerous changes in various biological systems including the reproductive system. The aim of the present study was to find out whether dexamethasone (Dex), a widely used GC, would influence the apoptosis and expression of Bax, an important proapoptotic protein, in the mouse t...

    journal_title:Folia histochemica et cytobiologica

    pub_type: 杂志文章

    doi:10.2478/v10042-009-0041-z

    authors: Mahmoud H,Mahmoud O,Layasadat K,Naeim A

    更新日期:2009-01-01 00:00:00

  • Ghrelin and obestatin in thyroid gland - immunohistochemical expression in nodular goiter, papillary and medullary cancer.

    abstract:INTRODUCTION:Previous studies analyzing ghrelin and obestatin expression in thyroid gland tissue are not unanimous and are mostly related to ghrelin. The role of ghrelin and obestatin in the thyroid gland appears very interesting due to their probable involvement in cell proliferation. Furthermore, since the thyroid gl...

    journal_title:Folia histochemica et cytobiologica

    pub_type: 杂志文章

    doi:10.5603/FHC.a2015.0004

    authors: Gurgul E,Kasprzak A,Blaszczyk A,Biczysko M,Surdyk-Zasada J,Seraszek-Jaros A,Ruchala M

    更新日期:2015-01-01 00:00:00

  • Neither axotomy nor target-tissue inflammation changes the NOS- or VIP-synthesis rate in distal bowel-projecting neurons of the porcine inferior mesenteric ganglion (IMG).

    abstract::The present study was aimed at disclosing axotomy- and inflammation-induced changes in the chemical coding of retrogradely labelled distal bowel-projecting neurons in the porcine IMG. Particular attention was paid to the changes in the expression pattern of vasoactive intestinal polypeptide and nitric oxide synthase (...

    journal_title:Folia histochemica et cytobiologica

    pub_type: 杂志文章

    doi:

    authors: Majewski M,Bossowska A,Gonkowski S,Wojtkiewicz J,Brouns I,Scheuermann DW,Adriaensen D,Timmermans JP

    更新日期:2002-01-01 00:00:00

  • Activity of delta(5)3beta-hydroxysteroid dehydrogenase and steroid hormones content in early preimplantation horse embryos.

    abstract::The activity of delta (5)3 beta-hydroxysteroid dehydrogenase was examined histochemically in 6 to 10 days aged horse blastocysts. A positive reaction was noted in the blastomeres of all embryos incubated in medium with substrate. Measurable amounts of progesterone, androgens and estrogens were found in blastocysts on ...

    journal_title:Folia histochemica et cytobiologica

    pub_type: 杂志文章

    doi:

    authors: Paulo E,Tischner M

    更新日期:1985-01-01 00:00:00

  • The lack of correlation between the rate of rRNA transport from nucleoli into cytoplasm and the duration of G1 and G2 phases in root meristem cells.

    abstract::In root meristems of 3 species (Secale cereale L., Vicia faba L. subsp. minor, Allium cepa L.) the durations of cell cycles and their phases were calculated using 3H-thymidine labelling. In the above species and in Helianthus annuus L. (parameters of the cell cycle determined earlier) the G1 and G2 phase durations wer...

    journal_title:Folia histochemica et cytobiologica

    pub_type: 杂志文章

    doi:

    authors: Olszewska MJ,Bilecka A,Kuran H,Marciniak K,Osiecka R

    更新日期:1989-01-01 00:00:00

  • Characteristics of myosin profile in human vastus lateralis muscle in relation to training background.

    abstract::Twenty-four male volunteers (mean +/- SD: age 25.4+/-5.8 years, height 178.6+/-5.5 cm, body mass 72.1+/-7.7 kg) of different training background were investigated and classified into three groups according to their physical activity and sport discipline: untrained students (group A), national and sub-national level en...

    journal_title:Folia histochemica et cytobiologica

    pub_type: 杂志文章

    doi:

    authors: Zawadowska B,Majerczak J,Semik D,Karasinski J,Kolodziejski L,Kilarski WM,Duda K,Zoladz JA

    更新日期:2004-01-01 00:00:00

  • Reversible inhibition of growth of B16 melanoma cells by decreased amino acid nutrition.

    abstract::The effect of limited amino acid nutrition upon the growth of B16 melanoma cells was investigated. It was observed that the cells in Basal Medium Eagle do not proliferate and are inhibited predominantly in the G1 phase of cell cycle. The cells which were inhibited in growth for 7 or 12 days in Basal Medium Eagle were ...

    journal_title:Folia histochemica et cytobiologica

    pub_type: 杂志文章

    doi:

    authors: Korohoda W,Michalik M,Zaporowska-Siwiak E

    更新日期:1993-01-01 00:00:00

  • Tumoricidal effect of macrophages on transplantable melanoma cells with regard to their sensitivity to exogenous cytokines.

    abstract::We studied the correlation between the cytotoxic effect of hamster peritoneal macrophages from animals bearing transplantable melanomas of common origin but differing in many biological features on the cells of those melanomas and the sensitivity of the melanoma cells to exogenous OSM, TNF-alpha and IL6. Our results d...

    journal_title:Folia histochemica et cytobiologica

    pub_type: 杂志文章

    doi:

    authors: Cichorek M,Zarzeczna M,Kozłowska K

    更新日期:2002-01-01 00:00:00

  • Immunohistochemical demonstration of beta-endorphin in guinea pig sebaceous glands of normal skin and during immune inflammation.

    abstract::Very suggestive evidence for possible role of beta-endorphin (BE) in immune activity has been continuously accumulated in the literature in spite of contradictory results about the involvement of the opiate system in immunological response. The reversed passive Arthus reaction (RPAR) was performed in the dorsal area o...

    journal_title:Folia histochemica et cytobiologica

    pub_type: 杂志文章

    doi:

    authors: Gendek-Kubiak H

    更新日期:1998-01-01 00:00:00

  • Predictive value of ERCC1 single-nucleotide polymorphism in patients receiving platinum-based chemotherapy for locally-advanced and advanced non-small cell lung cancer--a pilot study.

    abstract::Platinum-based chemotherapy is the main type of I-line treatment of advanced and non-operative NSCLC patients without EGFR gene mutation. The excision repair cross-complementation group 1 (ERCC1) is an enzyme that executes the incision of the damaged DNA strand and removes platinum-induced DNA adducts. We investigated...

    journal_title:Folia histochemica et cytobiologica

    pub_type: 杂志文章

    doi:10.2478/18700

    authors: Krawczyk P,Wojas-Krawczyk K,Mlak R,Kucharczyk T,Biernacka B,Milanowski J

    更新日期:2012-04-24 00:00:00

  • Potentially positive ageing-related variations of medial smooth muscle cells in the saphenous veins used as aortocoronary bypass grafts.

    abstract:INTRODUCTION:Currently, elderly people constitute a large proportion of patients undergoing coronary artery bypass grafting (CABG). Activated smooth muscle cells in the tunica media of saphenous vein (SV) grafts are thought to play a key role in the formation of neointima and development of occluding atherosclerotic pl...

    journal_title:Folia histochemica et cytobiologica

    pub_type: 杂志文章

    doi:10.5603/FHC.a2016.0011

    authors: Perek B,Malinska A,Gasowski J,Ostalska-Nowicka D,Perek A,Jemielity M,Zabel M,Nowicki M

    更新日期:2016-01-01 00:00:00

  • Association between fertilin beta, protamines 1 and 2 and spermatid-specific linker histone H1-like protein mRNA levels, fertilization ability of human spermatozoa, and quality of preimplantation embryos.

    abstract::Fertilization involves a series of cellular interactions culminating in the fusion of gamete membranes, creating a zygote and then an embryo. During the process of human fertilization in vivo or in conventional in vitro fertilization (IVF), sperm must be capable of undergoing the acrosome reaction, binding to the zona...

    journal_title:Folia histochemica et cytobiologica

    pub_type: 杂志文章

    doi:

    authors: Depa-Martynów M,Kempisty B,Lianeri M,Jagodziński PP,Jedrzejczak P

    更新日期:2007-01-01 00:00:00

  • Ghrelin-immunoreactive cells in the gastrointestinal tract of hypertensive rats.

    abstract:INTRODUCTION:Ghrelin, an appetite-stimulating hormone secreted by the endocrine cells of the gastrointestinal (GI) tract, has recently been shown to affect the function of the cardiovascular system. This study aimed to assess the number and morphology of ghrelin-immunopositive (GhrIP) cells in the gastrointestinal trac...

    journal_title:Folia histochemica et cytobiologica

    pub_type: 杂志文章

    doi:10.5603/FHC.a2016.0023

    authors: Janiuk I,Kaleczyc J,Kasacka I

    更新日期:2016-01-01 00:00:00

  • Organization of the innervation of the oesophagus and stomach in chinchilla (Chinchilla laniger, Molina).

    abstract::Using the histochemical and histological techniques the morphology and topography of the autonomic plexuses of the oesophagus and stomach in chinchilla (Chinchilla laniger) was investigated. AChE-positive and adrenergic structures in the myenteric and submucosal plexus were observed. According to the results the choli...

    journal_title:Folia histochemica et cytobiologica

    pub_type: 杂志文章

    doi:10.5603/FHC.2013.0018

    authors: Nowak E

    更新日期:2013-01-01 00:00:00