A game with many players: control of gdh transcription in Corynebacterium glutamicum.

Abstract:

:Glutamate dehydrogenase is a central enzyme connecting nitrogen and carbon metabolism via its precursors ammonium and oxoglutarate and its product glutamate. In Corynebacterium glutamicum glutamate dehydrogenase is especially important, since it is a key enzyme for the biotechnological production of the flavour enhancer L-glutamate. In this study, the regulation of gdh transcription was investigated. While originally described as a constitutively expressed gene, we could show that gdh transcription is highly variable depending on environmental conditions. Regulation of the gdh gene by the C. glutamicum nitrogen control protein AmtR was analyzed in detail in this study.

journal_name

J Biotechnol

journal_title

Journal of biotechnology

authors

Hänssler E,Müller T,Palumbo K,Patek M,Brocker M,Krämer R,Burkovski A

doi

10.1016/j.jbiotec.2009.04.007

subject

Has Abstract

pub_date

2009-06-15 00:00:00

pages

114-22

issue

2

eissn

0168-1656

issn

1873-4863

pii

S0168-1656(09)00179-5

journal_volume

142

pub_type

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