Estimating tissue permeability and other bioelectrical parameters using membrane voltage and short-circuit current.

Abstract:

:Evaluating the acute toxic effects of drugs or toxins is based mainly on studies which require the use of light microscopy. Recently, the effects of such substances on biological membranes, such as the nasal membrane, has been studied using the traditional Ussing chambers, which make it possible to study the transepithelial flux of drugs across membranes and to measure some bioelectrical parameters. A model is described, with which the changes in the membrane permeability, for sodium, potassium and chlorine, can be calculated directly, based on values obtained from the Ussing chamber system. Also, an experiment is described for evaluating the toxic effects of the cholera toxin B subunit, by measuring these changes in isolated rabbit nasal mucosa.

authors

Gizurarson S,Tamura S,Kurata T

doi

10.1248/cpb.39.1636

subject

Has Abstract

pub_date

1991-06-01 00:00:00

pages

1636-7

issue

6

eissn

0009-2363

issn

1347-5223

journal_volume

39

pub_type

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