Abstract:
OBJECTIVES:Recent reports have unambiguously identified the presence and the growth-modulatory role of transient receptor potential vanilloid-1 (TRPV1), a central integrator of pain sensation, on numerous non-neuronal cell types and, of great importance, in certain malignancies. In this study, we have investigated the molecular expression of TRPV1 in the human tongue and its high-incidence malignant (squamous cell carcinoma, SCC) and premalignant (leukoplakia) conditions. METHODS:Immunohistochemistry, Western blotting and quantitative 'real-time' Q-PCR were performed to define the expression of TRPV1. RESULTS:A weak and sparse TRPV1-specific immunoreactivity was identified in the basal layers of the healthy human tongue epithelium. By contrast, we observed a dramatically elevated TRPV1-immunoreactivity in all layers of the epithelium both in precancerous and malignant samples. Furthermore, statistical analysis revealed that the marked overexpression of TRPV1 found in all grades of SCC showed no correlation with the degree of malignancy of the tumours. Finally, the molecular expression of TRPV1 was also identified in an SCC-derived cell line and was shown to be increased in parallel with the accelerated growth of the cells. CONCLUSION:Collectively, our findings identify TRPV1 as a novel, promising target molecule in the supportive treatment and diagnosis of human tongue SCC.
journal_name
Oral Disjournal_title
Oral diseasesauthors
Marincsák R,Tóth BI,Czifra G,Márton I,Rédl P,Tar I,Tóth L,Kovács L,Bíró Tdoi
10.1111/j.1601-0825.2009.01526.xsubject
Has Abstractpub_date
2009-07-01 00:00:00pages
328-35issue
5eissn
1354-523Xissn
1601-0825pii
ODI1526journal_volume
15pub_type
杂志文章相关文献
ORAL DISEASES文献大全abstract:OBJECTIVES:To investigate tooth ultrastructure and mutation of two patients in a family affected with osteogenesis imperfecta (OI) type IV and dentinogenesis imperfecta (DGI). METHODS:Mutations were detected by whole exome and Sanger sequencing. The permanent second molar obtained from the proband (DGI1) and the prima...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1111/odi.13657
更新日期:2020-09-29 00:00:00
abstract:OBJECTIVE:Odontogenic keratocyst (OKC) is a benign lesion that tends to recur after surgical treatment. In an attempt to clarify the molecular basis underlining the OKC pathobiology, we aimed to analyze its proteomic profile. MATERIALS AND METHODS:We compared the proteomic profiles of five OKC and matched normal oral ...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1111/odi.13598
更新日期:2020-08-09 00:00:00
abstract:OBJECTIVE:The aim of this study was to establish a possible association between the degree of differentiation of squamous cell carcinomas (SCC) derived from rat oral tissues treated in vivo with carcinogen 4NQO, and the expression of TGF-beta on epithelial cells and the distribution of extracellular matrix proteins (la...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1111/j.1601-0825.1996.tb00198.x
更新日期:1996-03-01 00:00:00
abstract:OBJECTIVE:Prognosis of patients with head and neck squamous cell carcinoma (HNSCC) is still poor. Novel therapeutic approaches are of great interest to improve the effects of radiochemotherapy. We evaluated the effects of tyrosine kinase inhibitor neratinib on HNSCC cell lines CAL27, SCC25 and FaDu as a single agent an...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1111/odi.12552
更新日期:2016-11-01 00:00:00
abstract:OBJECTIVE:To establish whether an intra-oral lubricating device for dry mouth alters the oral environment. DESIGN:A single-blind randomized cross-over study. METHOD:Twenty-nine dentate subjects from the Sjogren's syndrome clinic attended on five occasions at 4-week intervals. They were randomized, having the device f...
journal_title:Oral diseases
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1111/j.1601-0825.2005.01161.x
更新日期:2006-01-01 00:00:00
abstract:OBJECTIVES:To test whether the submandibular/sublingual (SMSL) salivary secretion, mucin concentration and candida carriage status were altered in human immunodeficiency virus-positive (HIV+) patients. SUBJECTS AND METHODS:SMSL saliva collected from 48 HIV-infected and 31 HIV-negative men were analyzed for flow rates,...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1111/j.1601-0825.2009.01514.x
更新日期:2009-04-01 00:00:00
abstract:OBJECTIVE:To determine the impact of highly active antiretroviral therapy (HAART) on salivary gland function in human immunodeficiency virus (HIV) positive women from the Women's Interagency HIV Study (WIHS). DESIGN:Longitudinal cohort study. SUBJECTS AND METHODS:A total of 668 HIV positive women from the WIHS cohort...
journal_title:Oral diseases
pub_type: 杂志文章,多中心研究
doi:10.1111/j.1601-0825.2008.01456.x
更新日期:2009-01-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to determine any association between anxiety and salivary cortisol levels in oral lichen planus (OLP) patients by the case-control method. DESIGN RELEVANT: Forty patients with OLP were evaluated. The OLP diagnosis was established through a composite of accepted clinical and histopath...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1034/j.1601-0825.2003.00960.x
更新日期:2003-11-01 00:00:00
abstract:OBJECTIVE:Orofacial clefts (OFCs) are common and etiologically complex birth defects. This study explored potential genetic differences in a pair of Japanese monozygotic (MZ) twins with different forms of OFC using whole-genome sequencing. SUBJECTS AND METHODS:One co-twin (MZ-1) presented with nonsyndromic bilateral c...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1111/odi.12910
更新日期:2018-10-01 00:00:00
abstract:BACKGROUND:Stress and menstrual cycle have been described as factors influencing bad breath, as they can alter oral homeostasis and contribute to the production of volatile sulfur compounds (VSC). OBJECTIVE:Considering that the experimenter's and volunteer's gender may influence the volunteer's responses to stress, th...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1111/odi.12011
更新日期:2013-05-01 00:00:00
abstract:OBJECTIVES:Oral submucous fibrosis (OSMF) is a chronic inflammatory disease and a potentially malignant oral disorder. However, the best therapeutic treatment for OSMF remains uncertain. Our previous study showed that photobiomodulation (PBM) therapy and forskolin could reduce arecoline-induced fibrosis reactions via t...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1111/odi.13409
更新日期:2020-10-01 00:00:00
abstract:OBJECTIVE:To undertake a detailed histological investigation of a large series of adenomatoid odontogenic tumours (AOT) to document the frequency and histomorphology of secretory cells which might indicate an inductive capacity. MATERIALS AND METHODS:Haematoxylin and eosin stained sections of 51 cases of AOT were revi...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1111/j.1601-0825.2007.01399.x
更新日期:2008-07-01 00:00:00
abstract:UNLABELLED:The expression of the inducible nitric oxide synthase enzyme (iNOS) is a response to an inflammatory stimulus and produces a large amount of nitric oxide (NO), which may act as a cytotoxic molecule against the invading microorganism and may be related to both harmful and beneficial effects to tissues. OBJEC...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1034/j.1601-0825.2002.02852.x
更新日期:2002-09-01 00:00:00
abstract:OBJECTIVE:To evaluate the enamel erosive potential of modified acidic soft drinks under controlled conditions in an artificial mouth. MATERIALS AND METHODS:From each of 144 bovine incisors one enamel sample was prepared. Labial surfaces of the samples were ground flat, polished and covered with adhesive tape, leaving ...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1111/j.1601-0825.2004.01056.x
更新日期:2005-01-01 00:00:00
abstract:OBJECTIVE:To investigate the effectiveness of short-term adjunctive subantimicrobial dose doxycycline (SDD) treatment in patients with diabetes mellitus type 2 and chronic periodontitis (CP). METHODS:Thirty-four patients with CP and type 2 diabetes mellitus were included in the placebo-controlled, double-blind study. ...
journal_title:Oral diseases
pub_type: 杂志文章,随机对照试验
doi:10.1111/j.1601-0825.2012.01943.x
更新日期:2012-11-01 00:00:00
abstract:OBJECTIVE:To examine whether transient receptor potential vanilloid 2 (TRPV2) contributes to the changes in intra-oral thermal and mechanical sensitivity following the incision of buccal mucosa. MATERIALS AND METHODS:Buccal mucosal pain threshold was measured after the incision. Changes in the number of TRPV2-immunore...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1111/odi.12853
更新日期:2018-09-01 00:00:00
abstract:OBJECTIVE:Oral squamous cell carcinoma (OSCC) represents 3%-4% of all cancers. Despite the increasing incidence of OSCC distant metastasis and poor prognosis, few animal models of OSCC distant metastasis have been reported. In this study, we established mouse models of OSCC lung metastasis by orthotopic and tail vein i...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1111/odi.13592
更新日期:2020-08-07 00:00:00
abstract:OBJECTIVE:To assess the health-related quality of life (HRQOL) of patients complaining of halitosis at their first visit and at a later time when their complaint had diminished following therapy, using a self-administered questionnaire, the Medical Outcome Study Short Form-36 (SF-36). The aim of this study was to exami...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1111/j.1601-0825.2005.01102.x
更新日期:2005-01-01 00:00:00
abstract:OBJECTIVES:To propose the application of the concept of geriatric syndrome for common geriatric oral and maxillofacial dysfunctions and to suggest the necessity of developing effective evaluation methods for oral and maxillofacial frailty. DESIGN:The concepts of frailty and geriatric syndrome based on multi-morbidity ...
journal_title:Oral diseases
pub_type: 杂志文章,评审
doi:10.1111/odi.12647
更新日期:2018-04-01 00:00:00
abstract::As the AIDS pandemic has continued, our understanding of the events that occur during the entry and infection of conventional, susceptible cells has increased dramatically, leading to the development of control therapies for HIV-infected individuals. However, an ongoing hole in our understanding is how HIV crosses the...
journal_title:Oral diseases
pub_type: 杂志文章,评审
doi:10.1111/odi.12410
更新日期:2016-04-01 00:00:00
abstract:OBJECTIVE:To review a series of patients with sore, burning mouth treated with alpha-lipoic acid between 2000 and May 2006 and subjectively evaluate improvement in symptoms. DESIGN:Retrospective review of medical records of 195 consecutive patients who sought treatment for sore, burning mouth. Treatment of 47 patients...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1111/j.1601-0825.2007.01414.x
更新日期:2008-09-01 00:00:00
abstract::Dental research over the last century has advanced our understanding of the etiology and pathogenesis of caries lesions. Increasing knowledge of the dynamic demineralization/remineralization processes has led to the current consensus that bacteria-mediated tooth destruction can be arrested or even to some degree rever...
journal_title:Oral diseases
pub_type: 杂志文章,评审
doi:10.1111/j.1601-0825.2004.01030.x
更新日期:2004-09-01 00:00:00
abstract:OBJECTIVE:Patients with burning mouth syndrome (BMS) often represent a clinical challenge as available agents for symptomatic treatment are few and often ineffective. The aim was to evaluate the effect of a bupivacaine lozenge on oral mucosal pain, xerostomia, and taste alterations in patients with BMS. METHODS:Eighte...
journal_title:Oral diseases
pub_type: 杂志文章,随机对照试验
doi:10.1111/odi.12386
更新日期:2016-03-01 00:00:00
abstract:OBJECTIVE:Knowledge of the molecular pathogenesis of oral submucous fibrosis (OSF), a potentially malignant condition with high risk of transition to oral cancer, is meagre. Alterations in the expression of retinoic acid receptor beta (RARbeta) and tumor suppressor gene, p53 are early events in oral tumorigenesis. The ...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1111/j.1601-0825.2004.00993.x
更新日期:2004-07-01 00:00:00
abstract:BACKGROUND:Mandibular osteoradionecrosis (ORN) is a devastating complication secondary to the radiotherapy of head and neck cancer. The nutritional status of ORN patients is compromised, but remains rarely studied. We aimed to evaluate the overall nutritional status of patients with ORN and explore the risk factors beh...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1111/odi.13762
更新日期:2020-12-28 00:00:00
abstract::Oral potentially malignant disorders (OPMDs) are associated with an increased risk of occurrence of cancers of the lip or oral cavity. This paper presents an updated report on the nomenclature and the classification of OPMDs, based predominantly on their clinical features, following discussions by an expert group at a...
journal_title:Oral diseases
pub_type: 杂志文章,评审
doi:10.1111/odi.13704
更新日期:2020-10-31 00:00:00
abstract:OBJECTIVE:To assess whether a relationship existed between the T102C polymorphism of 5-HT2A receptor gene and temporomandibular dysfunction. METHODS:Sixty-three patients with temporomandibular dysfunction, and 54 healthy volunteer controls were included in the study. Molecular analysis of the T102C polymorphism of the...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1111/j.1601-0825.2004.01037.x
更新日期:2004-11-01 00:00:00
abstract:OBJECTIVE: This study is aimed to investigate the association between OLP susceptibility and clinical type in the Thai population and three polymorphisms within the promoter region of the TNF-α at positions -863, -308 and -238 which have putative functional significances. MATERIALS AND METHODS: Genomic DNA from 75 Tha...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1111/j.1601-0825.2010.01722.x
更新日期:2011-03-01 00:00:00
abstract:OBJECTIVES:To explore how various methylation mechanisms function and affect macrophages in periodontitis, with an aim of getting a comprehensive understanding of pathogenesis of the disease. SUBJECT:Alterations in DNA methylation are associated with different periodontitis susceptible factors and disrupt immunity hom...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1111/odi.13654
更新日期:2020-09-29 00:00:00
abstract::Neuralgia-inducing cavitational osteonecrosis remains controversial several years following the initial description. Changing etiologic concepts have led to confusion as well as the significant departures from the concept first defined by Ratner which served as the basis for the explaining the pain syndrome with featu...
journal_title:Oral diseases
pub_type: 杂志文章,评审
doi:10.1111/j.1601-0825.2009.01532.x
更新日期:2009-07-01 00:00:00