Abstract:
AIM:To determine the effect of two different contrast agent volumes on quantitative and semi-quantitative vascular parameters as measured by perfusion computed tomography (CT) in colorectal cancer. MATERIALS AND METHODS:Following ethical approval and informed consent, eight prospectively recruited patients with proven colorectal adenocarcinoma underwent two separate perfusion CT studies on the same day after (a) 100 ml and (b) 50 ml of a 340 mg/ml iodinated contrast medium, respectively. Quantitative (blood volume, blood flow, permeability surface area product) and semi-quantitative (peak enhancement, time to peak enhancement) tumour vascular parameters were determined using commercial software based on distributed parameter analysis and compared using t-testing. RESULTS:Tumour blood volume, blood flow, and permeability surface area product were not substantially different following the injection of 100ml and 50 ml contrast medium: 6.12 versus 6.23 ml/100 g tissue; 73.4 versus 71.3 ml/min/100 g tissue; 15.6 versus 15.3 ml/min/100 g tissue for 100 and 50 ml, respectively; p>0.05. Tumour peak enhancement and time to peak were significantly greater following the injection of 100ml versus 50 ml contrast medium: 41.2 versus 28.5 HU; 16.1 versus 11.8 s for 100ml and 50 ml, respectively; p=0.002; p=0.0003. CONCLUSION:Quantitative parameters do not appear to change substantially with a higher contrast agent volume suggesting a combined diagnostic staging-perfusion CT study following a single injection is feasible for colorectal cancer.
journal_name
Clin Radioljournal_title
Clinical radiologyauthors
Goh V,Bartram C,Halligan Sdoi
10.1016/j.crad.2008.08.018subject
Has Abstractpub_date
2009-04-01 00:00:00pages
368-72issue
4eissn
0009-9260issn
1365-229Xpii
S0009-9260(08)00436-4journal_volume
64pub_type
杂志文章abstract:AIM:The aim of this study was to assess the CT manifestations of bronchocentric granulomatosis. SUBJECTS AND METHODS:The CT results of five patients with bronchocentric granulomatosis were retrospectively analysed. The patients ranged from 20 to 72 years of age and included three men and two women. The diagnosis of br...
journal_title:Clinical radiology
pub_type: 杂志文章
doi:10.1053/crad.1999.0380
更新日期:2000-04-01 00:00:00
abstract::Radiation therapy of the length of the spinal column presents various clinical and physical problems. The completed plan may be complicated to set up, be time-consuming and require daily variation to achieve reasonable dose homogeneity. A case of medulloblastoma is used to illustrate the steps in producing a plan for ...
journal_title:Clinical radiology
pub_type: 杂志文章
doi:10.1016/s0009-9260(85)80126-4
更新日期:1985-03-01 00:00:00
abstract::Between January 1949 and June 1955 a clinical trial was held in which patients with operable breast carcinoma were subjected to a radical mastectomy and then randomised to either have immediate post-operative radiotherapy (radiated group) or delayed radiotherapy on recurrence (watched group). Data relating to the 1461...
journal_title:Clinical radiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0009-9260(89)80099-6
更新日期:1989-03-01 00:00:00
abstract:AIM:To demonstrate that carbon dioxide (CO2) microbubble contrast enhancement depicts blood vessels when used for x-ray examinations. MATERIALS AND METHODS:Microbubbles were generated by cavitation of physiological saline to which CO2 gas had been added using an ejector-type microbubble generator. The input pressure v...
journal_title:Clinical radiology
pub_type: 杂志文章
doi:10.1016/j.crad.2012.08.011
更新日期:2013-04-01 00:00:00
abstract:AIM:To describe the computed tomography (CT) and magnetic resonance imaging (MRI) findings that differentiate solid pseudopapillary carcinomas (SPC) from benign solid pseudopapillary tumours (SPT) of the pancreas. MATERIALS AND METHODS:Preoperative CT or MRI images for 26 patients (eight patients with SPC and 18 patie...
journal_title:Clinical radiology
pub_type: 杂志文章
doi:10.1016/j.crad.2008.04.007
更新日期:2008-09-01 00:00:00
abstract:AIM:To evaluate the mixed-reality (MR) hologram, a novel technology based on two-dimensional images, which simulates three-dimensional (3D) images and provides a dynamic and interactive alternative, for its usefulness in the diagnosis and surgical planning of double outlet of the right ventricle (DORV). MATERIALS AND ...
journal_title:Clinical radiology
pub_type: 杂志文章
doi:10.1016/j.crad.2020.10.017
更新日期:2020-12-09 00:00:00
abstract:AIM:To report a case series in which the radiological features of the subcutaneous use of calcium hydroxylapatite (CaHa) dermal fillers are described for the first time. MATERIALS AND METHODS:Five patients with facial hyperattenuating hypermetabolic subcutaneous lesions were identified on 2- [(18)F]-fluoro-2-deoxy-D-g...
journal_title:Clinical radiology
pub_type: 杂志文章
doi:10.1016/j.crad.2009.05.004
更新日期:2009-09-01 00:00:00
abstract::The heart and mediastinal structures can be overlooked at CT pulmonary angiogram (CTPA). This pictorial review will demonstrate the features of cardiac disease that may be evident on a CTPA. CTPA allows assessment of not only the pulmonary arteries for embolism, but also of the bronchi, lung parenchyma, mediastinum an...
journal_title:Clinical radiology
pub_type: 杂志文章,评审
doi:10.1016/j.crad.2004.07.005
更新日期:2005-01-01 00:00:00
abstract:AIM:To investigate the innervation pattern of extra-ocular muscles in patients with clinically diagnosed Duane's ocular retraction syndrome (DRS) using magnetic resonance imaging (MRI). MATERIALS AND METHODS:The study population consisted of 11 patients. Six patients had type I DRS (eight eyes), four patients had type...
journal_title:Clinical radiology
pub_type: 杂志文章
doi:10.1016/j.crad.2013.12.010
更新日期:2014-05-01 00:00:00
abstract::Duplex Doppler imaging was used to study the effect of pancreatic and bile duct tumours on portal vein and hepatic artery blood flow and the specific Doppler signals recorded from these tumours. Chaotic portal vein flow occurred in 35% (14) of pancreatic and 20% (6) of biliary tumours and complete portal vein occlusio...
journal_title:Clinical radiology
pub_type: 杂志文章
doi:10.1016/s0009-9260(05)80637-3
更新日期:1992-03-01 00:00:00
abstract::Fibrous dysplasia affecting the spine is unusual. A further 11 cases are reported and the radiological features are described. The complications and difficulties with the diagnosis of this condition are discussed. ...
journal_title:Clinical radiology
pub_type: 杂志文章
doi:10.1016/s0009-9260(88)80222-8
更新日期:1988-09-01 00:00:00
abstract::There is a pressing clinical need to develop accurate, efficient non-contrast magnetic resonance angiography (NC-MRA) techniques. Our efforts in the field have focused on a novel non-subtractive technique called quiescent-interval slice-selective (QISS) MRA. Compared with other NC-MRA techniques, QISS has the advantag...
journal_title:Clinical radiology
pub_type: 杂志文章,评审
doi:10.1016/j.crad.2017.12.003
更新日期:2019-01-01 00:00:00
abstract::This study was undertaken to determine whether three commonly used combinations of CT display window settings permit accurate measurement of pulmonary nodule size during thoracic CT examination. Forty-five rounded nodules of synthetic material of approximate soft tissue density (+70 Hounsfield units; HU), varying in s...
journal_title:Clinical radiology
pub_type: 杂志文章
doi:10.1016/s0009-9260(05)81130-4
更新日期:1993-04-01 00:00:00
abstract::Magnetic resonance imaging (MRI) has greatly advanced evaluation of marrow diseases of the paediatric skeleton. As with many other aspects of paediatric radiology it is important to recognize the normal variations in the appearance of the marrow that occur in the growing child. These normal variations need to be diffe...
journal_title:Clinical radiology
pub_type: 杂志文章,评审
doi:10.1016/j.crad.2004.02.001
更新日期:2004-08-01 00:00:00
abstract:AIM:The purpose of this study was to determine the feasibility of echocardiogram (ECG)-gated multi-slice CT angiography (MCTA) in patients with clinical suspicion of acute venous thromboembolism (VTE), to investigate the effect of ECG-gating on cardiac motion artefacts, and to determine the diagnostic reader agreement ...
journal_title:Clinical radiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0009-9260(03)00348-9
更新日期:2003-11-01 00:00:00
abstract::Primary congenital coronary artery fistula is diagnosed in two of every thousand patients investigated by angiocardiography. Males and females are equally affected and most frequently present under the age of 10 years. Fistulae originate from right and left coronary arteries in almost equal proportion but over 90% dra...
journal_title:Clinical radiology
pub_type: 杂志文章
doi:10.1016/s0009-9260(80)80223-6
更新日期:1980-05-01 00:00:00
abstract:AIM:To compare readers' performance in detecting architectural distortion (AD) compared with other breast cancer types using digital mammography. MATERIALS AND METHODS:Forty-one experienced breast screen readers (20 US and 21 Australian) were asked to read a single test set of 30 digitally acquired mammographic cases....
journal_title:Clinical radiology
pub_type: 杂志文章
doi:10.1016/j.crad.2015.10.009
更新日期:2016-01-01 00:00:00
abstract:OBJECTIVE:To assess three-dimensional computed tomography 'bronchoscopic' (3-DCTB) reconstruction of routine CT data as a non-invasive method of airway visualization, and compare it with fibreoptic bronchoscopy (FOB). METHODS:Fourteen datasets were acquired from 13 patients undergoing both FOB and CT examination of th...
journal_title:Clinical radiology
pub_type: 临床试验,杂志文章
doi:10.1016/s0009-9260(97)80077-3
更新日期:1997-11-01 00:00:00
abstract::High-kilovoltage (kV) radiography of the chest using an air gap results in magnification of the heart and thorax despite the use of a longer focus-to-film distance. One hundred patients had their recent high-kV chest radiograph compared with their previous low-kV film. There was a significant increase in all cardiac p...
journal_title:Clinical radiology
pub_type: 杂志文章
doi:10.1016/s0009-9260(85)80086-6
更新日期:1985-05-01 00:00:00
abstract::The radiopharmaceuticals gallium-67 and indium-111 labelled leucocytes have been compared in 15 patients with a painful joint prosthesis in an attempt to identify those patients with periprosthetic infection. Gallium-67 images were abnormal in five out of six patients with periprosthetic infection and normal in seven ...
journal_title:Clinical radiology
pub_type: 杂志文章
doi:10.1016/s0009-9260(84)80148-8
更新日期:1984-05-01 00:00:00
abstract:AIM:To evaluate whether radiologists can accurately differentiate Wilms' tumours from other paediatric abdominal masses with renal involvement using modern imaging methods alone. METHODS:From February 1993 to June 1997, 23 patients presented to the Paediatric Oncology Service at The Royal Hospital for Sick Children, E...
journal_title:Clinical radiology
pub_type: 杂志文章
doi:10.1016/s0009-9260(99)90563-9
更新日期:1999-05-01 00:00:00
abstract::Two cases are reported in which accidental inhalation of barium contrast medium occurred owing to disordered swallowing in elderly women. In each case there was a pulmonary inflammatory reaction followed within a few hours by death. Experimental and clinical reports of barium inhalation are reviewed and the hazard of ...
journal_title:Clinical radiology
pub_type: 杂志文章
doi:10.1016/s0009-9260(89)80135-7
更新日期:1989-07-01 00:00:00
abstract:AIM:To explore possible correlations between tumour apparent diffusion coefficient (ADC), morphological tumour volume, and clinical and histological characteristics in endometrial carcinomas and to evaluate interobserver agreement for preoperative staging by MRI and for ADC measurements. MATERIALS AND METHODS:Preopera...
journal_title:Clinical radiology
pub_type: 杂志文章
doi:10.1016/j.crad.2014.12.016
更新日期:2015-05-01 00:00:00
abstract::T1-weighted Magnetic Resonance Imaging (MRI) of 72 temporomandibular joints (TMJs) of symptomatic patients and normal subjects was performed after they had been clinically classified. The images were then interpreted by two radiologists, blinded to the clinical classification. The technique of imaging used a head coil...
journal_title:Clinical radiology
pub_type: 杂志文章
doi:10.1016/s0009-9260(05)81189-4
更新日期:1993-02-01 00:00:00
abstract::Twenty-eight patients with non-Hodgkin's lymphoma of the thyroid were treated between 1954 and 1981. The duration of follow-up ranged from 39 to 176 months. The overall 5 year survival was 51%. Twenty deaths have been recorded of which 12 were attributed to non-Hodgkin's lymphoma. Eight patients relapsed following ini...
journal_title:Clinical radiology
pub_type: 杂志文章
doi:10.1016/s0009-9260(87)80067-3
更新日期:1987-05-01 00:00:00
abstract::An unusual case of multiple myeloma is reported in a 61-year-old man presenting with hepatomegaly and multiple hypoechoic lesions in the liver seen on ultrasound. Following cytotoxic chemotherapy the size and number of the lesions within the liver had significantly reduced. ...
journal_title:Clinical radiology
pub_type: 杂志文章
doi:10.1016/s0009-9260(05)82970-8
更新日期:1995-01-01 00:00:00
abstract::Solid-state, digital radiography (DR) detectors, designed specifically for standard projection radiography, emerged just before the turn of the millennium. This new generation of digital image detector comprises a thin layer of x-ray absorptive material combined with an electronic active matrix array fabricated in a t...
journal_title:Clinical radiology
pub_type: 杂志文章,评审
doi:10.1016/j.crad.2007.10.014
更新日期:2008-05-01 00:00:00
abstract::Variations of normal development and benign incidental anomalies are frequently observed on diagnostic neuroimaging. It is important these are recognised for what they are, as misinterpretation may result in unnecessary further investigation, follow-up imaging and anxiety. In this article, we review benign intracrania...
journal_title:Clinical radiology
pub_type: 杂志文章,评审
doi:10.1016/j.crad.2017.06.118
更新日期:2017-10-01 00:00:00
abstract::Five patients with deep pelvic abscesses underwent computed tomography (CT)-guided catheter drainage using a transrectal approach. The use of an outer removable plastic sheath over the catheter to facilitate positioning and prevent inadvertent damage to the mucosal wall is described. This new approach using CT guidanc...
journal_title:Clinical radiology
pub_type: 杂志文章
doi:10.1016/s0009-9260(05)80007-8
更新日期:1992-04-01 00:00:00
abstract::The anterior cruciate ligaments of 20 patients with suspected pathology in one ligament were studied by thin-section computed tomography (CT) and reformating techniques. In 19 patients, the suspect anterior cruciate ligament was abnormal and this was confirmed by subsequent arthroscopy or arthrotomy in thirteen. Thin-...
journal_title:Clinical radiology
pub_type: 杂志文章
doi:10.1016/s0009-9260(84)80111-7
更新日期:1984-07-01 00:00:00