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Immunity to islet grafts transduced with adenovirus vectors does not inhibit long-term islet function.

Abstract：

:Adenoviral gene transfer is a potential ex vivo gene therapy for islet transplantation. However, the immunogenicity of adenoviral vectors can potentially impair vector efficacy in transplants where long-term gene expression is required. We investigated the effect of this antiviral immunity on vector expression and islet graft function. Syngeneic murine islets transduced with adenovirus encoding beta-galactosidase (AdCMVnt-betagal) were transplanted under the renal capsule. At different time points after transplant, blood glucose and glucose tolerance, intragraft cellular infiltration and IgG, IgM productions, and expression of transgene, cytokines and chemokines/receptors were assessed. Splenocytes and sera were analyzed to evaluate the systemic anti-adenoviral immune response. Diabetes was reversed in 1 day in recipients of a marginal amount (200) of untransduced islets, while AdCMVnt-betagal-transduced islets failed to reverse diabetes until 10 days post-transplant (p

journal_name

Transpl Immunol

journal_title

Transplant immunology

authors

Cheng J,Sun J,Sung RS

doi

10.1016/j.trim.2009.02.001

subject

Has Abstract

pub_date

2009-05-01 00:00:00

pages

33-42

issue

1

eissn

0966-3274

issn

1878-5492

pii

S0966-3274(09)00018-5

journal_volume

21

pub_type

杂志文章

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