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Actin homolog MreB affects chromosome segregation by regulating topoisomerase IV in Escherichia coli.

Abstract：

:In Escherichia coli, topoisomerase IV, a type II topoisomerase, mediates the resolution of topological linkages between replicated daughter chromosomes and is essential for chromosome segregation. Topo IV activity is restricted to only a short interval late in the cell cycle. However, the mechanism that confers this temporal regulation is unknown. Here we report that the bacterial actin homolog MreB participates in the temporal oscillation of Topo IV activity. We show that mreB mutant strains are deficient in Topo IV activity. In addition, we demonstrate that, depending upon whether it is in a monomeric or polymerized state, MreB affects Topo IV activity differentially. In addition, MreB physically interacts with the ParC subunit of Topo IV. Together, these results may explain how dynamics of the bacterial cytoskeleton are coordinated with the timing of chromosome segregation.

journal_name

Mol Cell

journal_title

Molecular cell

authors

Madabhushi R,Marians KJ

doi

10.1016/j.molcel.2009.01.001

subject

Has Abstract

pub_date

2009-01-30 00:00:00

pages

171-80

issue

2

eissn

1097-2765

issn

1097-4164

pii

S1097-2765(09)00026-4

journal_volume

33

pub_type

杂志文章

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